MetaADEDB 2.0 @ LMMD
Palonosetron
(CPZBLNMUGSZIPR-NVXWUHKLSA-N)
Structure
SMILES
O=C1N(C[C@@H]2c3c1cccc3CCC2)[C@@H]1CN2CCC1CC2
Type(s)
Approved; Investigational
ATC code(s)
A04AA05; A04AA55
Molecular Formula:
C19H24N2O
Molecular Weight:
296.407
Log P:
2.5323
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
0
TPSA:
23.55
CAS Number(s):
135729-56-5; 135729-61-2; 149653-99-6
Synonym(s)
1.
Palonosetron
2.
2-(1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one
3.
2-QHBIQO
4.
Aloxi
5.
Palonosetron Hydrochloride
6.
Palonosetron, (3R)-
7.
Palonosetron, (R-(R*,R*))-isomer
8.
Palonosetron, (R-(R*,S*))-isomer
9.
Palonosetron, (S-(R*,S*))-isomer
10.
RS 25233-197
11.
RS 25233-198
12.
RS 25259
13.
RS 25259-197
14.
RS 25259-198
15.
RS-25233-197
16.
RS-25233-198
17.
RS-25259
18.
RS-25259-197
19.
RS-25259-198
20.
RS 25233 197
21.
RS 25233 198
22.
RS 25233197
23.
RS 25233198
24.
RS 25259 197
25.
RS 25259 198
26.
RS 25259197
27.
RS 25259198
28.
RS25233197
29.
RS25233198
30.
RS25259
31.
RS25259197
32.
RS25259198
External Link(s)
MeSHD000077924
PubChem Compound6337614
BindingDB50417287
ChEBI85161
CHEMBLCHEMBL1189679
DrugBankDB00377
DrugCentral2046
IUPHAR/BPS Guide to PHARMACOLOGY7486
KEGGdr:D07175
Therapeutic Target DatabaseD04FVU
D0A4BR
ZINC3795819
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Abdominal PainFAERS: 1OFFSIDES
SIDER
US FAERS
2ConstipationFAERS: 1SIDER
US FAERS
3Abdominal discomfortOFFSIDES
4Abdominal massOFFSIDES
5Abnormal visionOFFSIDES
6AcidosisOFFSIDES
7AcneOFFSIDES
8ActinomycosisOFFSIDES
9AdenocarcinomaOFFSIDES
10AgraphiaOFFSIDES
11Alanine Aminotransferase IncreasedOFFSIDES
12Albumin globulin ratio decreasedOFFSIDES
13AlopeciaOFFSIDES
SIDER
14AlveolitisOFFSIDES
15AmblyopiaSIDER
16AmphetaminesOFFSIDES
17Anal FissureOFFSIDES
18Anaphylactic shockSIDER
19Anaphylactoid ReactionSIDER
20AneurysmOFFSIDES
21AnhedoniaOFFSIDES
22AnorexiaOFFSIDES
SIDER
23AnxietyOFFSIDES
SIDER
24AphoniaOFFSIDES
25ArteriosclerosisOFFSIDES
26ArthralgiaSIDER
27AscitesOFFSIDES
28Aspartate Aminotransferase IncreasedSIDER
29AsphyxiaOFFSIDES
30Aspiration PneumoniaOFFSIDES
31AstheniaOFFSIDES
SIDER
32AtaxiaOFFSIDES
33Atrial tachycardiaOFFSIDES
34Bacterial sepsisOFFSIDES
35BlepharoptosisOFFSIDES
36BlepharospasmOFFSIDES
37Blood alkaline phosphatase increasedOFFSIDES
38Blood creatinine increasedOFFSIDES
39Blood sodiumOFFSIDES
40Blood urea increasedOFFSIDES
41Blurred visionOFFSIDES
42Bone fragmentationOFFSIDES
43Bone lesionOFFSIDES
44Bone painOFFSIDES
45Bone scan abnormalOFFSIDES
46BradycardiaSIDER
47BronchitisOFFSIDES
48BronchopneumoniaOFFSIDES
49Bulbar palsyOFFSIDES
50CalcinosisOFFSIDES
51Cardioactive drug level increasedOFFSIDES
52Cardiopulmonary BypassOFFSIDES
53Carotid EndarterectomyOFFSIDES
54Carotid bruitOFFSIDES
55Cataract operationOFFSIDES
56Catheter placementOFFSIDES
57Catheter related infectionOFFSIDES
58CellulitisOFFSIDES
59Central nervous system lesionOFFSIDES
60Central venous catheter removalOFFSIDES
61Cerebral atrophyOFFSIDES
62Cervical dysplasiaOFFSIDES
63Cervicitis human papilloma virusOFFSIDES
64Cervicobrachial syndromeOFFSIDES
65Chest PainOFFSIDES
66ChillsSIDER
67Choking sensationOFFSIDES
68CholecystitisOFFSIDES
69Chronic Obstructive Airway DiseaseOFFSIDES
70Chronic sinusitisOFFSIDES
71CirrhosisOFFSIDES
72ClonusOFFSIDES
73Compression fractureOFFSIDES
74ConfabulationOFFSIDES
75Congenital tricuspid valve incompetenceOFFSIDES
76CyanosisSIDER
77Cyst aspirationOFFSIDES
78CystOFFSIDES
79DebridementOFFSIDES
80DehydrationOFFSIDES
81DemyelinationOFFSIDES
82Dental FistulaOFFSIDES
83Dental abscessOFFSIDES
84Dental cariesOFFSIDES
85DermatitisSIDER
86Device related infectionOFFSIDES
87DiarrheaOFFSIDES
88DiscomfortSIDER
89DistentionSIDER
90DiverticulumOFFSIDES
91DizzinessOFFSIDES
SIDER
92Drug withdrawal headacheOFFSIDES
93DysgeusiaOFFSIDES
SIDER
94DyspepsiaOFFSIDES
SIDER
95DysphoniaOFFSIDES
96DystoniaOFFSIDES
97Ear and labyrinth disordersSIDER
98Embolic strokeOFFSIDES
99Emotional distressOFFSIDES
100Endodontic procedureOFFSIDES
101EpistaxisSIDER
102Erythema MultiformeOFFSIDES
103ErythemaOFFSIDES
SIDER
104Euphoric moodSIDER
105Eye irritationSIDER
106Fat necrosisOFFSIDES
107FatigueOFFSIDES
SIDER
108Febrile NeutropeniaOFFSIDES
109Feeling abnormalOFFSIDES
110FibromyalgiaOFFSIDES
111FlatulenceSIDER
112Food PoisoningOFFSIDES
113FormicationOFFSIDES
114GastritisSIDER
115Gastrointestinal PainSIDER
116Gastrointestinal hypomotilitySIDER
117Gastrointestinal perforationOFFSIDES
118General physical health deteriorationOFFSIDES
119GlaucomaOFFSIDES
120GlycosuriaSIDER
121GoiterOFFSIDES
122GranulocytosisOFFSIDES
123Hay feverOFFSIDES
124HeadacheSIDER
125HemiparesisOFFSIDES
126Hepatic necrosisOFFSIDES
127Hepatitis BOFFSIDES
128HiccoughOFFSIDES
129HyperkeratosisOFFSIDES
130HyperreflexiaOFFSIDES
131HypersensitivitySIDER
132HypersomniaSIDER
133HypophagiaOFFSIDES
134HypotensionSIDER
135HypoventilationSIDER
136HypoxiaOFFSIDES
SIDER
137IndurationSIDER
138InfectionSIDER
139Infusion site erythemaOFFSIDES
140Infusion site painOFFSIDES
SIDER
141Infusion site swellingOFFSIDES
142Injection Site ReactionSIDER
143Injection site noduleOFFSIDES
144Intention tremorOFFSIDES
145Intervertebral Disc DegenerationOFFSIDES
146Intervertebral disc disorderOFFSIDES
147Intestinal PerforationOFFSIDES
148Intestinal hypomotilitySIDER
149Jejunal ulcerOFFSIDES
150Joint injuryOFFSIDES
151Joint stiffnessSIDER
152LaryngospasmOFFSIDES
SIDER
153Left Ventricular HypertrophyOFFSIDES
154Left atrial dilatationOFFSIDES
155LeukodystrophyOFFSIDES
156Leukopenia neonatalOFFSIDES
157Life expectancy shortenedOFFSIDES
158Ligament injuryOFFSIDES
159Loose toothOFFSIDES
160Lung consolidationOFFSIDES
161Lung hyperinflationOFFSIDES
162Lymph node palpableOFFSIDES
163LymphedemaOFFSIDES
164Lymphocyte count decreasedOFFSIDES
165Malignant ascitesOFFSIDES
166Malignant neoplasm progressionOFFSIDES
167MalnutritionSIDER
168MastectomyOFFSIDES
169Maxillofacial operationOFFSIDES
170Mental status changesOFFSIDES
171Metabolic acidosisOFFSIDES
SIDER
172Metastatic NeoplasmOFFSIDES
173Modified radical mastectomyOFFSIDES
174Motion SicknessSIDER
175Muscle necrosisOFFSIDES
176Musculoskeletal chest painOFFSIDES
177Musculoskeletal discomfortSIDER
178MyalgiaSIDER
179Nasal discomfortOFFSIDES
180Nausea20552375
21808994
21996961
CTD
OFFSIDES
SIDER
181Nerve Root CompressionOFFSIDES
182Neutropenic infectionOFFSIDES
183Neutropenic sepsisOFFSIDES
184Neutrophil count decreasedOFFSIDES
185NoduleOFFSIDES
186Open woundOFFSIDES
187Oral infectionOFFSIDES
188Oral mucosal exfoliationOFFSIDES
189OsteomyelitisOFFSIDES
190OsteopeniaOFFSIDES
191OsteoporosisOFFSIDES
192OsteoradionecrosisOFFSIDES
193OsteosclerosisOFFSIDES
194OtotoxicityOFFSIDES
195Oxygen supplementationOFFSIDES
196PainOFFSIDES
SIDER
197PallorSIDER
198Pancreatic CystOFFSIDES
199Percutaneous Coronary InterventionOFFSIDES
200Pericardial effusionOFFSIDES
201Periodontal infectionOFFSIDES
202Periodontal operationOFFSIDES
203PeriodontitisOFFSIDES
204Perivascular dermatitisOFFSIDES
205PleurectomyOFFSIDES
206Polymyalgia RheumaticaOFFSIDES
207Portal Vein ThrombosisOFFSIDES
208Portal venous gasOFFSIDES
209Primary sequestrumOFFSIDES
210PrurigoSIDER
211PruritusSIDER
212Purulent dischargeOFFSIDES
213RalesOFFSIDES
214Reflux laryngitisOFFSIDES
215Renal cystOFFSIDES
216Renal tubular necrosisOFFSIDES
217Respiratory FailureSIDER
218Respiratory tract congestionOFFSIDES
219RetrocollisOFFSIDES
220RhinitisOFFSIDES
221Right atrial dilatationOFFSIDES
222SarcoidosisOFFSIDES
223Septic ShockOFFSIDES
224SequestrectomyOFFSIDES
225ShockSIDER
226Sinus ArrhythmiaSIDER
227Sinus TachycardiaSIDER
228Sinus bradycardiaOFFSIDES
SIDER
229Sinus polypOFFSIDES
230SinusitisOFFSIDES
SIDER
231SomnolenceSIDER
232Stem cell transplantOFFSIDES
233Supraventricular tachycardiaOFFSIDES
234TachycardiaSIDER
235Temporal ArteritisOFFSIDES
236TinnitusSIDER
237Tooth ExtractionOFFSIDES
238Tooth LossOFFSIDES
239Tooth repairOFFSIDES
240UlcerOFFSIDES
241Unresponsive to stimuliOFFSIDES
242Urinary RetentionSIDER
243Urinary Tract PainOFFSIDES
244Venoocclusive diseaseOFFSIDES
245Vertebral column massOFFSIDES
246Visual disturbanceOFFSIDES
247Vitamin B 12 DeficiencyOFFSIDES
248Vocal Cord ParalysisOFFSIDES
249Vomiting

View details

CTD
SIDER
250Wheelchair userOFFSIDES
251kyphosisOFFSIDES
252nervous system disorderSIDER
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