zopiclone
(GBBSUAFBMRNDJC-UHFFFAOYSA-N)
Structure
- SMILES
- CN1CCN(CC1)C(=O)OC1c2nccnc2C(=O)N1c1ccc(cn1)Cl
- Type(s)
- Approved
- ATC code(s)
- N05CF01
- Molecular Formula:
- C17H17ClN6O3
- Molecular Weight:
- 388.808
- Log P:
- 1.5088
- Hydrogen Bond Acceptor:
- 9
- Hydrogen Bond Donor:
- 0
- TPSA:
- 91.76
- CAS Number(s):
- 43200-80-2
Synonym(s)
1.
zopiclone
2.
6-(5-chloro-2-pyridyl)-6,7-dihydro- 7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methyl-1- piperazinecarboxylate
3.
Imovane
4.
Limovan
5.
Nu-Zopiclone
6.
Optidorm
7.
RP 27 267
8.
Rhovane
9.
Siaten
10.
Somnosan
11.
Ximovan
12.
Zileze
13.
Zimoclone
14.
Zimovane
15.
Zop
16.
Zopi-Puren
17.
Zopicalm
18.
Zopicalma
19.
Zopiclon AL
20.
Zopiclon AZU
21.
Zopiclon AbZ
22.
Zopiclon Stada
23.
Zopiclon TAD
24.
Zopiclon beta
25.
Zopiclon-TEVA
26.
Zopiclon-neuraxpharm
27.
Zopiclon-ratiopharm
28.
Zopitan
29.
Zorclone
30.
ratio-Zopiclone
31.
zopiclodura
32.
zopiclon von ct
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Amnesia | FAERS: 1 Canada Vigilance: 9 | Canada Vigilance SIDER US FAERS | |
| 2 | Burning sensation | FAERS: 1 | US FAERS | |
| 3 | Completed Suicide | FAERS: 1 | US FAERS | |
| 4 | Dehydration | FAERS: 1 | SIDER US FAERS | |
| 5 | Delirium | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 6 | Drug Dependence | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 7 | Dyspepsia | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 8 | Feeling abnormal | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 9 | Initial insomnia | FAERS: 1 | US FAERS | |
| 10 | Memory impairment | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 11 | Personality Change | FAERS: 1 | US FAERS | |
| 12 | Tension Headache | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 13 | Victim of chemical submission | FAERS: 1 | US FAERS | |
| 14 | Victim of sexual abuse | FAERS: 1 | US FAERS | |
| 15 | Abdominal Pain | 18608866 | CTD SIDER | |
| 16 | Abdominal adhesions | OFFSIDES | ||
| 17 | Abdominal discomfort | Canada Vigilance: 4 | Canada Vigilance OFFSIDES | |
| 18 | Activities of daily living impaired | OFFSIDES | ||
| 19 | Acute graft versus host disease in liver | OFFSIDES | ||
| 20 | Acute kidney injury | 12778435 | CTD | |
| 21 | Acute myocardial infarction | OFFSIDES | ||
| 22 | Agitation | Canada Vigilance: 3 | Canada Vigilance SIDER | |
| 23 | Alcohol abuse | OFFSIDES | ||
| 24 | Alcohol interaction | Canada Vigilance: 1 | Canada Vigilance | |
| 25 | Alcohol poisoning | SIDER | ||
| 26 | Alopecia universalis | OFFSIDES | ||
| 27 | Alopecia | SIDER | ||
| 28 | Altered state of consciousness | Canada Vigilance: 1 | Canada Vigilance | |
| 29 | Amblyopia | SIDER | ||
| 30 | Amputation | OFFSIDES | ||
| 31 | Anal Fissure | OFFSIDES | ||
| 32 | Anal erosion | OFFSIDES | ||
| 33 | Anaphylactic shock | SIDER | ||
| 34 | Anger | SIDER | ||
| 35 | Angioedema | SIDER | ||
| 36 | Anorexia | 18608866 | CTD SIDER | |
| 37 | Anxiety | Canada Vigilance: 7 | Canada Vigilance SIDER | |
| 38 | Apathy | OFFSIDES SIDER | ||
| 39 | Application site pruritus | OFFSIDES | ||
| 40 | Application site rash | OFFSIDES | ||
| 41 | Application site urticaria | OFFSIDES | ||
| 42 | Arthralgia | Canada Vigilance: 3 | Canada Vigilance | |
| 43 | Arthritis | SIDER | ||
| 44 | Arthropathy | SIDER | ||
| 45 | Ascites | OFFSIDES | ||
| 46 | Aspartate Aminotransferase Increased | SIDER | ||
| 47 | Aspiration Pneumonia | OFFSIDES | ||
| 48 | Asthenia | Canada Vigilance: 1 | 18608866 | CTD SIDER Canada Vigilance |
| 49 | Asthma | SIDER | ||
| 50 | Ataxia | SIDER | ||
| 51 | Aura | OFFSIDES | ||
| 52 | Avoidant Personality Disorder | OFFSIDES | ||
| 53 | Back Pain | SIDER | ||
| 54 | Biliary adenoma | OFFSIDES | ||
| 55 | Biopsy breast abnormal | OFFSIDES | ||
| 56 | Bipolar Disorder | OFFSIDES | ||
| 57 | Bipolar I disorder | OFFSIDES | ||
| 58 | Bladder pain | SIDER | ||
| 59 | Blast cells present | OFFSIDES | ||
| 60 | Blood Glucose | OFFSIDES | ||
| 61 | Blood albumin decreased | OFFSIDES | ||
| 62 | Blood alcohol increased | Canada Vigilance: 1 | Canada Vigilance | |
| 63 | Blood alkaline phosphatase increased | OFFSIDES | ||
| 64 | Blood amylase increased | OFFSIDES | ||
| 65 | Blood creatinine increased | Canada Vigilance: 1 | Canada Vigilance | |
| 66 | Blood sodium | OFFSIDES | ||
| 67 | Blood thyroid stimulating hormone increased | OFFSIDES | ||
| 68 | Breast cancer recurrent | OFFSIDES | ||
| 69 | Breast engorgement | SIDER | ||
| 70 | Bronchiectasis | OFFSIDES | ||
| 71 | Bronchitis | SIDER | ||
| 72 | Bruxism | OFFSIDES | ||
| 73 | Bunion | OFFSIDES | ||
| 74 | Bursitis | SIDER | ||
| 75 | Cardiac discomfort | OFFSIDES | ||
| 76 | Catatonia | OFFSIDES | ||
| 77 | Cellulitis | SIDER | ||
| 78 | Cerebellar infarction | OFFSIDES | ||
| 79 | Chemical and Drug Induced Liver Injury | 18608866 | CTD | |
| 80 | Chest Pain | SIDER | ||
| 81 | Chest discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 82 | Chills | SIDER | ||
| 83 | Cholecystitis | OFFSIDES | ||
| 84 | Cholelithiasis | SIDER | ||
| 85 | Chronic Fatigue Syndrome | OFFSIDES | ||
| 86 | Clumsiness | Canada Vigilance: 1 | Canada Vigilance | |
| 87 | Colitis | SIDER | ||
| 88 | Compression fracture | OFFSIDES | ||
| 89 | Confabulation | OFFSIDES | ||
| 90 | Conjunctivitis | SIDER | ||
| 91 | Constipation | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 92 | Coronary artery insufficiency | OFFSIDES | ||
| 93 | Cramps of lower extremities | SIDER | ||
| 94 | Culture positive | OFFSIDES | ||
| 95 | Cystitis | SIDER | ||
| 96 | Dementia | Canada Vigilance: 1 | Canada Vigilance | |
| 97 | Demyelination | OFFSIDES | ||
| 98 | Depressed Level of Consciousness | Canada Vigilance: 5 | Canada Vigilance OFFSIDES SIDER | |
| 99 | Depressed mood | Canada Vigilance: 1 | Canada Vigilance | |
| 100 | Depression suicidal | OFFSIDES | ||
| 101 | Dermatitis | SIDER | ||
| 102 | Device dislocation | OFFSIDES | ||
| 103 | Diabetic Retinopathy | OFFSIDES | ||
| 104 | Diplopia | SIDER | ||
| 105 | Discomfort | SIDER | ||
| 106 | Disease recurrence | OFFSIDES | ||
| 107 | Disorientation | Canada Vigilance: 3 | Canada Vigilance | |
| 108 | Disturbance in sexual arousal | SIDER | ||
| 109 | Dizziness | Canada Vigilance: 5 | Canada Vigilance SIDER | |
| 110 | Dreamy state | Canada Vigilance: 1 | Canada Vigilance | |
| 111 | Drowsiness | OFFSIDES SIDER | ||
| 112 | Drug abuser | Canada Vigilance: 1 | Canada Vigilance | |
| 113 | Drug abuse | Canada Vigilance: 1 | Canada Vigilance | |
| 114 | Drug addict | OFFSIDES | ||
| 115 | Drug ineffective | Canada Vigilance: 32 | Canada Vigilance | |
| 116 | Drug withdrawal syndrome | Canada Vigilance: 3 | Canada Vigilance SIDER | |
| 117 | Dry skin | SIDER | ||
| 118 | Dysarthria | Canada Vigilance: 1 | Canada Vigilance | |
| 119 | Dysgeusia | Canada Vigilance: 8 | Canada Vigilance SIDER | |
| 120 | Dysosmia | SIDER | ||
| 121 | Dysthymic Disorder | OFFSIDES | ||
| 122 | Dysuria | Canada Vigilance: 1 | Canada Vigilance OFFSIDES SIDER | |
| 123 | Ear discomfort | Canada Vigilance: 1 | Canada Vigilance OFFSIDES | |
| 124 | Eczema | SIDER | ||
| 125 | Emotional distress | Canada Vigilance: 1 | Canada Vigilance | |
| 126 | Eosinophilic myocarditis | OFFSIDES | ||
| 127 | Epistaxis | SIDER | ||
| 128 | Erectile dysfunction | SIDER | ||
| 129 | Erythema Multiforme | SIDER | ||
| 130 | Escherichia infection | OFFSIDES | ||
| 131 | Esophageal Stenosis | OFFSIDES | ||
| 132 | Euphoric mood | OFFSIDES SIDER | ||
| 133 | Extra dose administered | Canada Vigilance: 1 | Canada Vigilance | |
| 134 | Facial Neuralgia | OFFSIDES | ||
| 135 | Fatigue | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 136 | Fatty Liver | OFFSIDES | ||
| 137 | Feeling Cold | Canada Vigilance: 1 | Canada Vigilance | |
| 138 | Feeling of body temperature change | Canada Vigilance: 1 | Canada Vigilance | |
| 139 | Flat affect | SIDER | ||
| 140 | Furunculosis | SIDER | ||
| 141 | Gait inability | Canada Vigilance: 1 | Canada Vigilance | |
| 142 | Gambling | OFFSIDES | ||
| 143 | Gastric ulcer | SIDER | ||
| 144 | Gastritis | SIDER | ||
| 145 | Gastrointestinal Pain | SIDER | ||
| 146 | General physical health deterioration | OFFSIDES | ||
| 147 | Genital swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 148 | Gingivitis | Canada Vigilance: 1 | Canada Vigilance | |
| 149 | Gout | SIDER | ||
| 150 | Headache | Canada Vigilance: 2 | 2884682 | CTD SIDER Canada Vigilance |
| 151 | Heart Block | 2353332 | CTD | |
| 152 | Heartburn | SIDER | ||
| 153 | Heat Stroke | SIDER | ||
| 154 | Hepatitis | SIDER | ||
| 155 | Hepatomegaly | SIDER | ||
| 156 | Hepatosplenomegaly | OFFSIDES | ||
| 157 | Hernia | SIDER | ||
| 158 | Hiccough | OFFSIDES | ||
| 159 | Hirsutism | SIDER | ||
| 160 | Hostility | SIDER | ||
| 161 | Hyperacusis | SIDER | ||
| 162 | Hyperkeratosis | OFFSIDES | ||
| 163 | Hypersensitivity | SIDER | ||
| 164 | Hypersomnia | Canada Vigilance: 1 | Canada Vigilance | |
| 165 | Hypokinesia | SIDER | ||
| 166 | Hyporeflexia | SIDER | ||
| 167 | Hypotension | Canada Vigilance: 1 | Canada Vigilance | |
| 168 | Hypoxia | Canada Vigilance: 2 | Canada Vigilance | |
| 169 | Impaired driving ability | Canada Vigilance: 6 | Canada Vigilance | |
| 170 | Incontinence | Canada Vigilance: 1 | Canada Vigilance | |
| 171 | Incorrect dose administered | Canada Vigilance: 2 | Canada Vigilance | |
| 172 | Incorrect product administration duration | Canada Vigilance: 2 | Canada Vigilance | |
| 173 | Infection | SIDER | ||
| 174 | Influenza | SIDER | ||
| 175 | Intentional misuse | OFFSIDES | ||
| 176 | Intentional product use issue | Canada Vigilance: 2 | Canada Vigilance | |
| 177 | Intercostal neuralgia | OFFSIDES | ||
| 178 | Intestinal Perforation | OFFSIDES | ||
| 179 | Iritis | SIDER | ||
| 180 | Large intestine perforation | OFFSIDES | ||
| 181 | Laryngitis | SIDER | ||
| 182 | Left Ventricular Hypertrophy | OFFSIDES | ||
| 183 | Lethargy | OFFSIDES | ||
| 184 | Leukopenia neonatal | OFFSIDES | ||
| 185 | Libido disorder | SIDER | ||
| 186 | Lightheadedness | SIDER | ||
| 187 | Limb discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 188 | Lip swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 189 | Liver palpable subcostal | OFFSIDES | ||
| 190 | Liver transplant rejection | OFFSIDES | ||
| 191 | Lung squamous cell carcinoma recurrent | OFFSIDES | ||
| 192 | Lymphadenopathy | SIDER | ||
| 193 | Malaise | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 194 | Mastitis | SIDER | ||
| 195 | Memory Disorders | 12756510 | CTD | |
| 196 | Memory Loss | SIDER | ||
| 197 | Menorrhagia | SIDER | ||
| 198 | Mental impairment | Canada Vigilance: 2 | Canada Vigilance | |
| 199 | Mental status changes | Canada Vigilance: 1 | Canada Vigilance | |
| 200 | Metrorrhagia | SIDER | ||
| 201 | Mood Disorders | 2884682 | CTD | |
| 202 | Mood disorder due to a general medical condition | OFFSIDES | ||
| 203 | Mood swings | SIDER | ||
| 204 | Motor retardation | OFFSIDES | ||
| 205 | Muscle Weakness | OFFSIDES | ||
| 206 | Muscle necrosis | OFFSIDES | ||
| 207 | Muscle relaxant therapy | SIDER | ||
| 208 | Muscle strain | OFFSIDES | ||
| 209 | Musculoskeletal discomfort | SIDER | ||
| 210 | Musculoskeletal stiffness | SIDER | ||
| 211 | Myalgia | SIDER | ||
| 212 | Mydriasis | SIDER | ||
| 213 | Myopathy | SIDER | ||
| 214 | Nausea | Canada Vigilance: 4 | Canada Vigilance SIDER | |
| 215 | Neck stiffness | SIDER | ||
| 216 | Nephritis, Interstitial | 12778435 | CTD | |
| 217 | Nephrolithiasis | SIDER | ||
| 218 | Nephrotic Syndrome | OFFSIDES | ||
| 219 | Nervousness | SIDER | ||
| 220 | Neuralgia | SIDER | ||
| 221 | Neuritis | SIDER | ||
| 222 | Neuropathy | SIDER | ||
| 223 | Nuchal Rigidity | OFFSIDES SIDER | ||
| 224 | Numbness | SIDER | ||
| 225 | Nystagmus | SIDER | ||
| 226 | Oculogyric crisis | OFFSIDES | ||
| 227 | Oculomucocutaneous syndrome | OFFSIDES | ||
| 228 | Oliguria | SIDER | ||
| 229 | Oral mucosal exfoliation | Canada Vigilance: 1 | Canada Vigilance | |
| 230 | Oropharyngeal pain | Canada Vigilance: 1 | Canada Vigilance | |
| 231 | Osteochondrosis | OFFSIDES | ||
| 232 | Otitis Externa | SIDER | ||
| 233 | Otitis Media | SIDER | ||
| 234 | Overdose | Canada Vigilance: 2 | Canada Vigilance | |
| 235 | Oxygen saturation abnormal | Canada Vigilance: 1 | Canada Vigilance | |
| 236 | Pain | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 237 | Pallor | Canada Vigilance: 1 | Canada Vigilance | |
| 238 | Palmar erythema | OFFSIDES | ||
| 239 | Palpitations | Canada Vigilance: 7 | Canada Vigilance SIDER | |
| 240 | Panic Disorder | OFFSIDES | ||
| 241 | Paranoia | Canada Vigilance: 1 | Canada Vigilance | |
| 242 | Pharyngitis | SIDER | ||
| 243 | Photophobia | SIDER | ||
| 244 | Pneumococcal sepsis | OFFSIDES | ||
| 245 | Polysubstance dependence | OFFSIDES | ||
| 246 | Polyuria | OFFSIDES | ||
| 247 | Poor dental condition | OFFSIDES | ||
| 248 | Poor quality sleep | Canada Vigilance: 1 | Canada Vigilance | |
| 249 | Postmenopausal bleeding | OFFSIDES | ||
| 250 | Precancerous cells present | OFFSIDES | ||
| 251 | Pregnancy | SIDER | ||
| 252 | Product complaint | Canada Vigilance: 3 | Canada Vigilance | |
| 253 | Product physical issue | Canada Vigilance: 1 | Canada Vigilance | |
| 254 | Product quality issue | Canada Vigilance: 2 | Canada Vigilance | |
| 255 | Product substitution issue | Canada Vigilance: 8 | Canada Vigilance | |
| 256 | Product taste abnormal | Canada Vigilance: 4 | Canada Vigilance | |
| 257 | Product use complaint | Canada Vigilance: 1 | Canada Vigilance | |
| 258 | Product use issue | Canada Vigilance: 1 | Canada Vigilance | |
| 259 | Prolonged menses | SIDER | ||
| 260 | Protein total decreased | OFFSIDES | ||
| 261 | Pruritus | Canada Vigilance: 2 | Canada Vigilance SIDER | |
| 262 | Psychomotor Disorders | 12756510 | CTD | |
| 263 | Pyelonephritis | SIDER | ||
| 264 | Renal cyst | OFFSIDES | ||
| 265 | Renal pain | SIDER | ||
| 266 | Respiratory Depression | Canada Vigilance: 2 | Canada Vigilance | |
| 267 | Restless Legs Syndrome | Canada Vigilance: 1 | Canada Vigilance | |
| 268 | Restlessness | Canada Vigilance: 5 | Canada Vigilance | |
| 269 | Retrograde amnesia | SIDER | ||
| 270 | Rhinitis | SIDER | ||
| 271 | Schizophrenia | 12095078 | CTD | |
| 272 | Sedation complication | Canada Vigilance: 1 | Canada Vigilance | |
| 273 | Sick Sinus Syndrome | OFFSIDES | ||
| 274 | Sinusitis | Canada Vigilance: 1 | Canada Vigilance | |
| 275 | Sjogren's Syndrome | OFFSIDES | ||
| 276 | Skin lesion | Canada Vigilance: 1 | Canada Vigilance | |
| 277 | Skin reaction | Canada Vigilance: 1 | Canada Vigilance | |
| 278 | Sleep Initiation and Maintenance Disorders | 2884682 10742886 16025317 | CTD | |
| 279 | Somatoform Disorder | OFFSIDES | ||
| 280 | Somnambulism | Canada Vigilance: 2 | Canada Vigilance SIDER | |
| 281 | Somnolence | Canada Vigilance: 11 | Canada Vigilance SIDER | |
| 282 | Sphincter of Oddi Dysfunction | OFFSIDES | ||
| 283 | Spinal column stenosis | OFFSIDES | ||
| 284 | Sputum retention | OFFSIDES | ||
| 285 | Staring | OFFSIDES | ||
| 286 | Stevens-Johnson Syndrome | OFFSIDES | ||
| 287 | Stiffness | SIDER | ||
| 288 | Stomatitis | SIDER | ||
| 289 | Stress | Canada Vigilance: 2 | Canada Vigilance | |
| 290 | Stupor | SIDER | ||
| 291 | Substance-Related Disorders | 10627964 | CTD | |
| 292 | Sudden death | OFFSIDES | ||
| 293 | Suicide attempt | Canada Vigilance: 2 | Canada Vigilance | |
| 294 | Superficial Thrombophlebitis | OFFSIDES | ||
| 295 | Suprapubic pain | OFFSIDES | ||
| 296 | Sweating | SIDER | ||
| 297 | Swelling | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 298 | Tachycardia | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 299 | Taste Disorders | 2884682 | CTD | |
| 300 | Tension | SIDER | ||
| 301 | Therapeutic product effect decreased | Canada Vigilance: 1 | Canada Vigilance | |
| 302 | Therapeutic product effect incomplete | Canada Vigilance: 1 | Canada Vigilance | |
| 303 | Therapeutic product ineffective | Canada Vigilance: 1 | Canada Vigilance | |
| 304 | Therapeutic response changed | Canada Vigilance: 1 | Canada Vigilance | |
| 305 | Therapeutic response unexpected | Canada Vigilance: 1 | Canada Vigilance | |
| 306 | Thirst | SIDER | ||
| 307 | Thoracic vertebral fracture | OFFSIDES | ||
| 308 | Throat irritation | Canada Vigilance: 1 | Canada Vigilance | |
| 309 | Thrombophlebitis | SIDER | ||
| 310 | Tingling of extremity | SIDER | ||
| 311 | Tinnitus | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 312 | Tooth Infection | OFFSIDES | ||
| 313 | Tremor | Canada Vigilance: 3 | Canada Vigilance SIDER | |
| 314 | Ulcerative stomatitis | SIDER | ||
| 315 | Unresponsive to pain stimuli | OFFSIDES | ||
| 316 | Unresponsive to stimuli | Canada Vigilance: 1 | Canada Vigilance | |
| 317 | Urethritis noninfective | SIDER | ||
| 318 | Urethritis | SIDER | ||
| 319 | Urinary Incontinence | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 320 | Urinary tract infection | SIDER | ||
| 321 | Urticaria | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 322 | Vena cava filter insertion | OFFSIDES | ||
| 323 | Venous thrombosis limb | OFFSIDES | ||
| 324 | Vertigo | SIDER | ||
| 325 | Vesiculobullous rash | SIDER | ||
| 326 | Vision Disorders | 2884682 | CTD | |
| 327 | Vomiting | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 328 | Weight Gain | OFFSIDES | ||
| 329 | Weight decreased | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 330 | White blood cell count abnormal | OFFSIDES | ||
| 331 | Wrong technique in product usage process | Canada Vigilance: 1 | Canada Vigilance | |
| 332 | furuncle | SIDER | ||
| 333 | jaundice | Canada Vigilance: 1 | Canada Vigilance | |
| 334 | nervous system disorder | Canada Vigilance: 1 | Canada Vigilance |
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