MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

cilnidipine

(KJEBULYHNRNJTE-DHZHZOJOSA-N)

Structure

SMILES: COCCOC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OC/C=C/c1ccccc1)C
Type(s): Investigational
ATC code(s): C08CA14
Molecular Formula:: C27H28N2O7
Molecular Weight:: 492.520
Log P:: 5.1278
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 1
TPSA:: 119.68
CAS Number(s):: 132203-70-4

Synonym(s)

cilnidipine

2-methoxyethyl-3-phenyl-2-propen-1-yl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

FRC 8653

FRC-8653

cilnidipine, (+)-isomer

cilnidipine, (-)-isomer

External Link(s)

MeSH	C065927
PubChem Compound	5282138
BindingDB	50370704 50101813
ChEBI	31399 91506
CHEMBL	CHEMBL452076
DrugBank	DB09232
DrugCentral	642
IUPHAR/BPS Guide to PHARMACOLOGY	7767
KEGG	dr:D01173
Therapeutic Target Database	D0N3SR

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Abdominal Compartment Syndrome		OFFSIDES
2	Abdominal adhesions		OFFSIDES
3	Acute myocardial infarction		OFFSIDES
4	Acute otitis media		OFFSIDES
5	Alanine Aminotransferase Increased		OFFSIDES
6	Alanine aminotransferase abnormal		OFFSIDES
7	Albumin globulin ratio decreased		OFFSIDES
8	Altered state of consciousness		OFFSIDES
9	Alveolitis		OFFSIDES
10	Anal Fissure		OFFSIDES
11	Anorexia		OFFSIDES
12	Antinuclear antibody increased		OFFSIDES
13	Aspartate aminotransferase abnormal		OFFSIDES
14	Atrial Fibrillation	15912307	CTD
15	Atrioventricular Block		OFFSIDES
16	Band neutrophil percentage increased		OFFSIDES
17	Blepharoptosis		OFFSIDES
18	Blood Glucose		OFFSIDES
19	Blood alkaline phosphatase increased		OFFSIDES
20	Blood amylase		OFFSIDES
21	Blood chloride abnormal		OFFSIDES
22	Blood creatine phosphokinase decreased		OFFSIDES
23	Blood creatine phosphokinase increased		OFFSIDES
24	Blood creatinine increased		OFFSIDES
25	Blood lactate dehydrogenase increased		OFFSIDES
26	Blood phosphorus		OFFSIDES
27	Blood potassium increased		OFFSIDES
28	Blood sodium increased		OFFSIDES
29	Blood triglycerides increased		OFFSIDES
30	Blood urea increased		OFFSIDES
31	Blood uric acid		OFFSIDES
32	Bradycardia	15912307	CTD OFFSIDES
33	Brain natriuretic peptide increased		OFFSIDES
34	Cardiomegaly	16333380	CTD
35	Cardiothoracic ratio increased		OFFSIDES
36	Carotid aneurysm rupture		OFFSIDES
37	Cell marker increased		OFFSIDES
38	Cerebral Thrombosis		OFFSIDES
39	Cytomegalovirus antibody positive		OFFSIDES
40	Cytomegalovirus enterocolitis		OFFSIDES
41	Depressed Level of Consciousness		OFFSIDES
42	Diabetes Insipidus		OFFSIDES
43	Diabetes mellitus inadequate control		OFFSIDES
44	Disease Progression		OFFSIDES
45	Disseminated Intravascular Coagulation		OFFSIDES
46	Dyslalia		OFFSIDES
47	Endophthalmitis		OFFSIDES
48	Endotoxic shock		OFFSIDES
49	Enteritis		OFFSIDES
50	Enterocolitis		OFFSIDES
51	Enzyme abnormality		OFFSIDES
52	Eosinophil percentage increased		OFFSIDES
53	Epiglottitis		OFFSIDES
54	Extremity necrosis		OFFSIDES
55	Eye Infection		OFFSIDES
56	Gamma-Glutamyltransferase Increased		OFFSIDES
57	Gastric mucosal lesion		OFFSIDES
58	Granulocyte count decreased		OFFSIDES
59	Hepatic congestion		OFFSIDES
60	Human herpes virus 6 serology positive		OFFSIDES
61	Hypercholesterolemia	19338138	CTD
62	Hypertriglyceridemia	19338138	CTD
63	Hypotension	10480159	CTD
64	Hysterotomy		OFFSIDES
65	Immunosuppressant drug level		OFFSIDES
66	Injury asphyxiation		OFFSIDES
67	Intestinal Obstruction		OFFSIDES
68	Lipoprotein (a) abnormal		OFFSIDES
69	Liver Abscess		OFFSIDES
70	Lung infection pseudomonal		OFFSIDES
71	Lymphocyte percentage decreased		OFFSIDES
72	Lymphocyte stimulation test positive		OFFSIDES
73	Malabsorption		OFFSIDES
74	Metabolic acidosis		OFFSIDES
75	Monocyte percentage decreased		OFFSIDES
76	Monoplegia		OFFSIDES
77	Nephrotic Syndrome		OFFSIDES
78	Neutrophil count decreased		OFFSIDES
79	Oliguria		OFFSIDES
80	Oral pruritus		OFFSIDES
81	Oropharyngeal discomfort		OFFSIDES
82	PO2 decreased		OFFSIDES
83	Pneumocystis jiroveci pneumonia		OFFSIDES
84	Polymyalgia Rheumatica		OFFSIDES
85	Polyuria		OFFSIDES
86	Pre-Eclampsia		OFFSIDES
87	Proteinuria	19338138	CTD
88	Pulmonary function test increased		OFFSIDES
89	Reticulocyte count increased		OFFSIDES
90	Rhabdomyolysis		OFFSIDES
91	Rheumatoid factor increased		OFFSIDES
92	Rhinitis		OFFSIDES
93	Shunt malfunction		OFFSIDES
94	Sinus bradycardia		OFFSIDES
95	Subileus		OFFSIDES
96	Surgical vascular shunt		OFFSIDES
97	Tachycardia	10480159	CTD
98	Thrombophlebitis		OFFSIDES
99	Upper respiratory tract inflammation		OFFSIDES
100	Urine nitrogen		OFFSIDES

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