MetaADEDB 2.0 @ LMMD
tazarotene
(OGQICQVSFDPSEI-UHFFFAOYSA-N)
Structure
SMILES
CCOC(=O)c1ccc(nc1)C#Cc1ccc2c(c1)C(C)(C)CCS2
Type(s)
Approved; Investigational
ATC code(s)
D05AX05
Molecular Formula:
C21H21NO2S
Molecular Weight:
351.462
Log P:
4.4315
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
0
TPSA:
64.49
CAS Number(s):
118292-40-3
Synonym(s)
1.
tazarotene
2.
AGN 190168
3.
AGN-190168
4.
Tazorac
5.
ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate
External Link(s)
MeSHC086827
PubChem Compound5381
BindingDB50265951
ChEBI32184
CHEMBLCHEMBL1657
DrugBankDB00799
DrugCentral2571
IUPHAR/BPS Guide to PHARMACOLOGY6952
KEGGcpd:C12531
dr:D01132
Therapeutic Target DatabaseD0BM5G
ZINC1542199
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1ErythemaFAERS: 37OFFSIDES
SIDER
US FAERS
2Drug exposure during pregnancyFAERS: 29OFFSIDES
US FAERS
3PregnancyFAERS: 25US FAERS
4Drug ineffectiveFAERS: 17
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
US FAERS
5Application site erythemaFAERS: 16OFFSIDES
SIDER
US FAERS
6Burning sensationFAERS: 15OFFSIDES
SIDER
US FAERS
7PruritusFAERS: 14SIDER
US FAERS
8PainFAERS: 12OFFSIDES
SIDER
US FAERS
9AcneFAERS: 11OFFSIDES
SIDER
US FAERS
10Skin irritationFAERS: 11SIDER
US FAERS
11Application site painFAERS: 10SIDER
US FAERS
12HypersensitivityFAERS: 9US FAERS
13Dry skinFAERS: 8OFFSIDES
SIDER
US FAERS
14AnencephalyFAERS: 7OFFSIDES
US FAERS
15Application site exfoliationFAERS: 6SIDER
US FAERS
16Application site drynessFAERS: 5
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
17DizzinessFAERS: 5US FAERS
18HeadacheFAERS: 5US FAERS
19Application site vesiclesFAERS: 4US FAERS
20Drug dose omissionFAERS: 4US FAERS
21Inappropriate schedule of drug administrationFAERS: 4US FAERS
22ScabFAERS: 4US FAERS
23Single umbilical arteryFAERS: 4OFFSIDES
US FAERS
24AlopeciaFAERS: 3OFFSIDES
US FAERS
25Application site irritationFAERS: 3
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
26Application site rashFAERS: 3SIDER
US FAERS
27Expired product administeredFAERS: 3US FAERS
28Eye painFAERS: 3US FAERS
29Feeding disorder neonatalFAERS: 3OFFSIDES
US FAERS
30LaryngomalaciaFAERS: 3OFFSIDES
US FAERS
31Neonatal disorderFAERS: 3US FAERS
32Patent ductus arteriosusFAERS: 3US FAERS
33Rash erythematousFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
34Skin UlcerFAERS: 3US FAERS
35TracheomalaciaFAERS: 3US FAERS
36UrticariaFAERS: 3US FAERS
37Application site burnFAERS: 2US FAERS
38Application site pruritusFAERS: 2SIDER
US FAERS
39Blood folate decreasedFAERS: 2US FAERS
40Blood human chorionic gonadotropin increasedFAERS: 2OFFSIDES
US FAERS
41Chemical injuryFAERS: 2US FAERS
42Drug effect incompleteFAERS: 2US FAERS
43Expired drug administeredFAERS: 2OFFSIDES
US FAERS
44Facial PainFAERS: 2SIDER
US FAERS
45GlaucomaFAERS: 2US FAERS
46Lip swellingFAERS: 2US FAERS
47NasopharyngitisFAERS: 2OFFSIDES
US FAERS
48Neck PainFAERS: 2US FAERS
49Poor sucking reflexFAERS: 2US FAERS
50Product container issueFAERS: 2US FAERS
51Product formulation issueFAERS: 2US FAERS
52Product quality issueFAERS: 2US FAERS
53Skin texture abnormalFAERS: 2US FAERS
54Skin tightnessFAERS: 2US FAERS
55Ultrasound scan abnormalFAERS: 2OFFSIDES
US FAERS
56Abdominal PainFAERS: 1US FAERS
57Adverse eventFAERS: 1US FAERS
58Alopecia universalisFAERS: 1US FAERS
59Application site acneFAERS: 1US FAERS
60Application site hypersensitivityFAERS: 1US FAERS
61Application site papulesFAERS: 1US FAERS
62Application site swellingFAERS: 1US FAERS
63Application site urticariaFAERS: 1US FAERS
64Capillary FragilityFAERS: 1US FAERS
65Complication of deliveryFAERS: 1OFFSIDES
US FAERS
66CryingFAERS: 1US FAERS
67DermatitisFAERS: 1SIDER
US FAERS
68Drug exposure before pregnancyFAERS: 1US FAERS
69Drug ineffective for unapproved indicationFAERS: 1US FAERS
70Genital discomfortFAERS: 1US FAERS
71Joint Range of Motion DecreasedFAERS: 1US FAERS
72LymphomaFAERS: 1US FAERS
73Macular degenerationFAERS: 1US FAERS
74Maternal exposure before pregnancyFAERS: 1US FAERS
75Maternal exposure during pregnancyFAERS: 1US FAERS
76Mouth swellingFAERS: 1US FAERS
77No adverse eventFAERS: 1US FAERS
78Oropharyngeal painFAERS: 1US FAERS
79Pain of skinFAERS: 1OFFSIDES
SIDER
US FAERS
80Pilonidal cyst congenitalFAERS: 1US FAERS
81Poor quality product administeredFAERS: 1US FAERS
82Pre-EclampsiaFAERS: 1OFFSIDES
US FAERS
83Product administered at inappropriate siteFAERS: 1US FAERS
84Product contamination microbialFAERS: 1US FAERS
85Product dispensing errorFAERS: 1US FAERS
86Product intoleranceFAERS: 1US FAERS
87Product label confusionFAERS: 1US FAERS
88Product storage errorFAERS: 1US FAERS
89Product substitution issueFAERS: 1US FAERS
90PsoriasisFAERS: 115989518
16605289		CTD
OFFSIDES
US FAERS
91Secretion dischargeFAERS: 1US FAERS
92Sinus headacheFAERS: 1US FAERS
93Skin ErosionFAERS: 1US FAERS
94Skin WrinklingFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
95Skin lesionFAERS: 1US FAERS
96Skin reactionFAERS: 1US FAERS
97SunburnFAERS: 1US FAERS
98SwellingFAERS: 1SIDER
US FAERS
99Therapy non-responderFAERS: 1US FAERS
100TrichorrhexisFAERS: 1US FAERS
101VomitingFAERS: 1US FAERS
102Wrong technique in drug usage processFAERS: 1US FAERS
103AbasiaOFFSIDES
104Abdominal rigidityOFFSIDES
105AbscessOFFSIDES
106Actinic keratosisOFFSIDES
107AdenocarcinomaOFFSIDES
108AgraphiaOFFSIDES
109AmenorrheaOFFSIDES
110AmnesiaOFFSIDES
111Anal FissureOFFSIDES
112Aplasia Cutis CongenitaOFFSIDES
113ArteriosclerosisOFFSIDES
114ArthritisOFFSIDES
115ArthropathyOFFSIDES
116AstheniaOFFSIDES
117AtelectasisOFFSIDES
118AtherosclerosisOFFSIDES
119Basal cell carcinomaOFFSIDES
120Biopsy breast abnormalOFFSIDES
121Bladder spasmOFFSIDES
122BlepharospasmOFFSIDES
123Blood cholesterolOFFSIDES
124Blood count abnormalOFFSIDES
125Blood triglycerides increasedOFFSIDES
SIDER
126Breast tendernessOFFSIDES
127BronchiectasisOFFSIDES
128Cataract operationOFFSIDES
129CataractOFFSIDES
130Central venous catheter removalOFFSIDES
131Cerebral atrophyOFFSIDES
132CheilitisSIDER
133ChloasmaOFFSIDES
134Clostridium difficile colitisOFFSIDES
135ClumsinessOFFSIDES
136Completed SuicideOFFSIDES
137Congenital tracheomalaciaOFFSIDES
138Conjunctival depositOFFSIDES
139Contact DermatitisOFFSIDES
140CystOFFSIDES
141DebridementOFFSIDES
142DemyelinationOFFSIDES
143Dental cariesOFFSIDES
144Dependent Personality DisorderOFFSIDES
145Depressed moodOFFSIDES
146Dermoid CystOFFSIDES
147DiabetesOFFSIDES
148DiscomfortSIDER
149Double ureterOFFSIDES
150DysgeusiaOFFSIDES
151DysuriaOFFSIDES
152EczemaOFFSIDES
SIDER
153Emotional distressOFFSIDES
154Endodontic procedureOFFSIDES
155EpilepsyOFFSIDES
156FormicationOFFSIDES
157General physical health deteriorationOFFSIDES
158GoiterOFFSIDES
159HemiplegiaOFFSIDES
160Heparin-induced thrombocytopeniaOFFSIDES
161HyperkeratosisOFFSIDES
162HyperpigmentationOFFSIDES
163Impaired driving abilityOFFSIDES
164ImpetigoSIDER
165Incision site painOFFSIDES
166Incorrect dose administeredOFFSIDES
167InfectionOFFSIDES
168InflammationSIDER
169Instillation site painSIDER
170Intervertebral Disc DegenerationOFFSIDES
171Joint sprainOFFSIDES
172Joint stiffnessOFFSIDES
173LeukodermaSIDER
174Limb injuryOFFSIDES
175Lipodystrophy acquiredOFFSIDES
176Loose toothOFFSIDES
177Lumbar radiculopathyOFFSIDES
178Lung hyperinflationOFFSIDES
179Mass excisionOFFSIDES
180MastectomyOFFSIDES
181Metastatic NeoplasmOFFSIDES
182Micrographic skin surgeryOFFSIDES
183Musculoskeletal PainOFFSIDES
184MyelodysplasiaOFFSIDES
185OsteomyelitisOFFSIDES
186OsteopeniaOFFSIDES
187PhototoxicitySIDER
188Physical disabilityOFFSIDES
189Post procedural complicationOFFSIDES
190ProctitisOFFSIDES
191ProctocolitisOFFSIDES
192SpondylolisthesisOFFSIDES
193Squamous cell carcinoma of skinOFFSIDES
194Sudden onset of sleepOFFSIDES
195Therapeutic response unexpected with drug substitutionOFFSIDES
196Tooth ExtractionOFFSIDES
197UlcerOFFSIDES
198Vulvovaginal drynessOFFSIDES
199Weight GainOFFSIDES
200XerosisOFFSIDES
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