MetaADEDB 2.0 @ LMMD
Loperamide
(PGYPOBZJRVSMDS-UHFFFAOYSA-N)
Structure
SMILES
Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1.Cl
Molecular Formula:
C29H34Cl2N2O2
Molecular Weight:
513.498
Log P:
5.8279
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
2
TPSA:
43.78
CAS Number(s):
34552-83-5
Synonym(s)
1.
Loperamide
2.
Imodium
3.
Loperamide Hydrochloride
4.
Loperamide Monohydrochloride
5.
R-18553
6.
Hydrochloride, Loperamide
7.
Monohydrochloride, Loperamide
8.
R 18553
9.
R18553
External Link(s)
MeSHD008139
PubChem Compound71420
57516049
43833345
ChEBI6533
CHEMBLCHEMBL1707
KEGGdr:D00729
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 661
Canada Vigilance: 5
Canada Vigilance
US FAERS
2Incorrect dose administeredFAERS: 428US FAERS
3Expired product administeredFAERS: 268US FAERS
4Intentional product use issueFAERS: 267US FAERS
5OverdoseFAERS: 168US FAERS
6Inappropriate schedule of drug administrationFAERS: 159US FAERS
7Product use issueFAERS: 139US FAERS
8Incorrect drug administration durationFAERS: 135US FAERS
9ConstipationFAERS: 121
Canada Vigilance: 2
Canada Vigilance
US FAERS
10Product packaging issueFAERS: 106US FAERS
11Intentional product misuseFAERS: 103US FAERS
12Drug abuseFAERS: 102US FAERS
13Incorrect product administration durationFAERS: 76US FAERS
14Wrong technique in drug usage processFAERS: 65US FAERS
15VomitingFAERS: 55
Canada Vigilance: 1
Canada Vigilance
US FAERS
16Wrong technique in product usage processFAERS: 55US FAERS
17Product use complaintFAERS: 52
Canada Vigilance: 1
Canada Vigilance
US FAERS
18Product use in unapproved indicationFAERS: 47US FAERS
19NauseaFAERS: 43
Canada Vigilance: 2
Canada Vigilance
US FAERS
20Cardiac ArrestFAERS: 41US FAERS
21Therapeutic response unexpectedFAERS: 40US FAERS
22Product label issueFAERS: 37US FAERS
23Drug administration errorFAERS: 36US FAERS
24DysgeusiaFAERS: 35US FAERS
25SyncopeFAERS: 35US FAERS
26DizzinessFAERS: 31US FAERS
27Abdominal discomfortFAERS: 29
Canada Vigilance: 1
Canada Vigilance
US FAERS
28Product size issueFAERS: 29US FAERS
29Product quality issueFAERS: 27US FAERS
30Abdominal PainFAERS: 26
Canada Vigilance: 1
Canada Vigilance
US FAERS
31Drug ineffective for unapproved indicationFAERS: 26US FAERS
32No adverse eventFAERS: 26US FAERS
33MalaiseFAERS: 24US FAERS
34SomnolenceFAERS: 24
Canada Vigilance: 1
Canada Vigilance
US FAERS
35Adverse eventFAERS: 23US FAERS
36Product taste abnormalFAERS: 23US FAERS
37Drug prescribing errorFAERS: 22US FAERS
38FlatulenceFAERS: 22US FAERS
39Infrequent bowel movementsFAERS: 22US FAERS
40Product package associated injuryFAERS: 22US FAERS
41Intestinal ObstructionFAERS: 20US FAERS
42Product blister packaging issueFAERS: 20US FAERS
43Drug DependenceFAERS: 19
Canada Vigilance: 1
Canada Vigilance
US FAERS
44RetchingFAERS: 19US FAERS
45FatigueFAERS: 17US FAERS
46DehydrationFAERS: 16US FAERS
47Product difficult to swallowFAERS: 16US FAERS
48Toxicity to various agentsFAERS: 16US FAERS
49ChokingFAERS: 15
Canada Vigilance: 1
Canada Vigilance
US FAERS
50Medication ErrorFAERS: 15US FAERS
51Product physical issueFAERS: 15US FAERS
52Drug effect delayedFAERS: 14US FAERS
53PruritusFAERS: 14
Canada Vigilance: 1
Canada Vigilance
US FAERS
54Urinary RetentionFAERS: 14US FAERS
55Drug effect incompleteFAERS: 13US FAERS
56Therapeutic response delayedFAERS: 13US FAERS
57UrticariaFAERS: 13US FAERS
58Ventricular FibrillationFAERS: 13US FAERS
59BradycardiaFAERS: 12US FAERS
60Physical product label issueFAERS: 12US FAERS
61Throat irritationFAERS: 12US FAERS
62PainFAERS: 11US FAERS
63AstheniaFAERS: 10US FAERS
64DyspepsiaFAERS: 10US FAERS
65HypersensitivityFAERS: 10
Canada Vigilance: 2
Canada Vigilance
US FAERS
66Inappropriate schedule of product administrationFAERS: 10US FAERS
67Incorrect product storageFAERS: 10US FAERS
68Ventricular arrhythmiaFAERS: 10US FAERS
69CardiotoxicityFAERS: 9US FAERS
70Drug withdrawal syndromeFAERS: 9US FAERS
71HeadacheFAERS: 9US FAERS
72Intentional drug misuseFAERS: 9US FAERS
73Product availability issueFAERS: 9US FAERS
74Product outer packaging issueFAERS: 9US FAERS
75TachycardiaFAERS: 9US FAERS
76Accidental drug intake by childFAERS: 8US FAERS
77Accidental exposure to product by childFAERS: 8US FAERS
78Accidental overdoseFAERS: 8US FAERS
79Bowel movement irregularityFAERS: 8US FAERS
80Electrolyte imbalanceFAERS: 8US FAERS
81Product coating issueFAERS: 8US FAERS
82Product storage errorFAERS: 8US FAERS
83Blood glucose increasedFAERS: 7US FAERS
84Chest PainFAERS: 7US FAERS
85Contraindicated product administeredFAERS: 7US FAERS
86Drug exposure during pregnancyFAERS: 7US FAERS
87LethargyFAERS: 7US FAERS
88PalpitationsFAERS: 7US FAERS
89Respiratory DepressionFAERS: 7US FAERS
90AnxietyFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
91DependenceFAERS: 6US FAERS
92Depressed moodFAERS: 6US FAERS
93DysuriaFAERS: 6US FAERS
94Electrocardiogram abnormalFAERS: 6US FAERS
95HypotensionFAERS: 6US FAERS
96Peripheral swellingFAERS: 6US FAERS
97Product administration errorFAERS: 6US FAERS
98Product formulation issueFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
99Suicide attemptFAERS: 6US FAERS
100TremorFAERS: 6US FAERS
101Unresponsive to stimuliFAERS: 6US FAERS
102Wrong drug administeredFAERS: 6US FAERS
103Acute kidney injuryFAERS: 5US FAERS
104AmnesiaFAERS: 5US FAERS
105Anaphylactic shockFAERS: 5US FAERS
106ArthralgiaFAERS: 5
Canada Vigilance: 2
Canada Vigilance
US FAERS
107Blood potassium increasedFAERS: 5US FAERS
108Chest discomfortFAERS: 5US FAERS
109Drug effective for unapproved indicationFAERS: 5US FAERS
110DystoniaFAERS: 5US FAERS
111Feeling abnormalFAERS: 5US FAERS
112Gastrointestinal PainFAERS: 5US FAERS
113IleusFAERS: 5US FAERS
114Incorrect route of drug administrationFAERS: 5US FAERS
115LacerationFAERS: 5US FAERS
116OnychoclasisFAERS: 5US FAERS
117Product prescribing errorFAERS: 5US FAERS
118Respiratory arrestFAERS: 5US FAERS
119RhabdomyolysisFAERS: 5US FAERS
120Sinus bradycardiaFAERS: 5US FAERS
121Altered state of consciousnessFAERS: 4US FAERS
122Back PainFAERS: 4US FAERS
123Choking sensationFAERS: 4US FAERS
124ChromaturiaFAERS: 4US FAERS
125DementiaFAERS: 4US FAERS
126Depressed Level of ConsciousnessFAERS: 4US FAERS
127Drug ToleranceFAERS: 4US FAERS
128Drug level above therapeuticFAERS: 4US FAERS
129Euphoric moodFAERS: 4US FAERS
130Expired drug administeredFAERS: 4US FAERS
131Lip swellingFAERS: 4US FAERS
132Liquid product physical issueFAERS: 4US FAERS
133Long QT SyndromeFAERS: 4US FAERS
134MegacolonFAERS: 4US FAERS
135Myocardial InfarctionFAERS: 4US FAERS
136Product lot number issueFAERS: 4US FAERS
137Prostate examination abnormalFAERS: 4US FAERS
138SwellingFAERS: 4US FAERS
139Weight decreasedFAERS: 4US FAERS
140Accidental exposure to productFAERS: 3US FAERS
141AcidosisFAERS: 3US FAERS
142AgitationFAERS: 3US FAERS
143Angina PectorisFAERS: 3US FAERS
144AngioedemaFAERS: 3US FAERS
145CyanosisFAERS: 3US FAERS
146CytopeniaFAERS: 3US FAERS
147DiscomfortFAERS: 3US FAERS
148Drug abuserFAERS: 3US FAERS
149Drug administered to patient of inappropriate ageFAERS: 3US FAERS
150Drug screen positiveFAERS: 3US FAERS
151DysgraphiaFAERS: 3US FAERS
152Gait inabilityFAERS: 3US FAERS
153Gamma-Glutamyltransferase IncreasedFAERS: 3US FAERS
154HypokinesiaFAERS: 3US FAERS
155Intentional self-injuryFAERS: 3US FAERS
156Intestinal PerforationFAERS: 3US FAERS
157Joint swellingFAERS: 3US FAERS
158NocturiaFAERS: 3US FAERS
159PneumoniaFAERS: 3US FAERS
160Portal venous gasFAERS: 3US FAERS
161Prescribed overdoseFAERS: 3US FAERS
162Product complaintFAERS: 3US FAERS
163Product container issueFAERS: 3US FAERS
164Product packaging difficult to openFAERS: 3US FAERS
165SepsisFAERS: 3US FAERS
166Urine flow decreasedFAERS: 3US FAERS
167AlopeciaFAERS: 2US FAERS
168Anorectal discomfortFAERS: 2US FAERS
169Aspartate Aminotransferase IncreasedFAERS: 2US FAERS
170Blood potassium decreasedFAERS: 2US FAERS
171Blood urine presentFAERS: 2US FAERS
172CatatoniaFAERS: 2US FAERS
173Completed SuicideFAERS: 2US FAERS
174DisorientationFAERS: 2US FAERS
175Drug effect variableFAERS: 2US FAERS
176DysphoniaFAERS: 2US FAERS
177Ejection Fraction DecreasedFAERS: 2US FAERS
178Electrocardiogram ST-T changeFAERS: 2US FAERS
179EpilepsyFAERS: 2US FAERS
180Erectile dysfunctionFAERS: 2US FAERS
181EructationFAERS: 2US FAERS
182ErythemaFAERS: 2US FAERS
183Exposure to unspecified agentFAERS: 2US FAERS
184Extra dose administeredFAERS: 2US FAERS
185Foreign body in respiratory tractFAERS: 2US FAERS
186Foreign body traumaFAERS: 2US FAERS
187Gastrointestinal infectionFAERS: 2US FAERS
188Gastrointestinal motility disorderFAERS: 2US FAERS
189Histiocytosis haematophagicFAERS: 2US FAERS
190HypoxiaFAERS: 2US FAERS
191Impaired gastric emptyingFAERS: 2US FAERS
192Infectious peritonitisFAERS: 2US FAERS
193Intentional misuseFAERS: 2US FAERS
194Lactose IntoleranceFAERS: 2US FAERS
195Maternal exposure during pregnancyFAERS: 2US FAERS
196Mechanical urticariaFAERS: 2US FAERS
197Medication residue presentFAERS: 2US FAERS
198MyoclonusFAERS: 2US FAERS
199NasopharyngitisFAERS: 2US FAERS
200NephrolithiasisFAERS: 2US FAERS
201NeutropeniaFAERS: 2US FAERS
202Packaging design issueFAERS: 2US FAERS
203PallorFAERS: 2US FAERS
204PancreatitisFAERS: 2US FAERS
205Panic DisorderFAERS: 2US FAERS
206Poor quality drug administeredFAERS: 2US FAERS
207Post lumbar puncture syndromeFAERS: 2US FAERS
208Product expiration date issueFAERS: 2US FAERS
209Product packaging quantity issueFAERS: 2US FAERS
210Product solubility abnormalFAERS: 2US FAERS
211Product tamperingFAERS: 2US FAERS
212Protein-losing gastroenteropathyFAERS: 2US FAERS
213Reaction to drug excipientsFAERS: 2US FAERS
214Seizure like phenomenaFAERS: 2US FAERS
215Suspected product tamperingFAERS: 2US FAERS
216Transaminases increasedFAERS: 2US FAERS
217Unevaluable eventFAERS: 2US FAERS
218Unintentional use for unapproved indicationFAERS: 2US FAERS
219Vaginal DischargeFAERS: 2US FAERS
220YawningFAERS: 2US FAERS
221Accelerated Idioventricular RhythmFAERS: 1US FAERS
222Accidental exposureFAERS: 1US FAERS
223AcneFAERS: 1US FAERS
224Acute myocardial infarctionFAERS: 1US FAERS
225Alanine Aminotransferase IncreasedFAERS: 1US FAERS
226Amylase increasedFAERS: 1US FAERS
227Anal FissureFAERS: 1US FAERS
228Anal spasmFAERS: 1US FAERS
229Anoxic EncephalopathyFAERS: 1US FAERS
230AnuriaFAERS: 1US FAERS
231AphagiaFAERS: 1US FAERS
232ArthritisFAERS: 1US FAERS
233AsthmaFAERS: 1US FAERS
234Autonomic nervous system imbalanceFAERS: 1US FAERS
235AzoospermiaFAERS: 1US FAERS
236Blood albumin decreasedFAERS: 1US FAERS
237Blood elastase increasedFAERS: 1US FAERS
238Blood glucose decreasedFAERS: 1US FAERS
239Blood glucose fluctuationFAERS: 1US FAERS
240Blood phosphorus increasedFAERS: 1US FAERS
241Blood sodium increasedFAERS: 1US FAERS
242Bone painFAERS: 1US FAERS
243BruxismFAERS: 1US FAERS
244Burning sensationFAERS: 1US FAERS
245Cardiac DeathFAERS: 1US FAERS
246CardiomegalyFAERS: 1US FAERS
247CataractFAERS: 1US FAERS
248Catheter related complicationFAERS: 1US FAERS
249Catheter related infectionFAERS: 1US FAERS
250Cerebrovascular accidentFAERS: 1US FAERS
251ChillsFAERS: 1US FAERS
252CholangitisFAERS: 1US FAERS
253ChoreoathetosisFAERS: 1US FAERS
254Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
255Cold sweatFAERS: 1US FAERS
256Coma scale abnormalFAERS: 1US FAERS
257Congenital absence of cranial vaultFAERS: 1US FAERS
258ConjunctivitisFAERS: 1US FAERS
259Contraindicated drug administeredFAERS: 1US FAERS
260Decorticate postureFAERS: 1US FAERS
261DiverticulitisFAERS: 1US FAERS
262Drug administered in wrong deviceFAERS: 1US FAERS
263Drug dispensing errorFAERS: 1US FAERS
264Dry skinFAERS: 1US FAERS
265DysenteryFAERS: 1US FAERS
266DyslexiaFAERS: 1US FAERS
267Ear discomfortFAERS: 1US FAERS
268Electrocardiogram QT interval abnormalFAERS: 1US FAERS
269Electrocardiogram changeFAERS: 1US FAERS
270Emergency CareFAERS: 1US FAERS
271EmpyemaFAERS: 1US FAERS
272EnteritisFAERS: 1US FAERS
273EpistaxisFAERS: 1US FAERS
274Escherichia urinary tract infectionFAERS: 1US FAERS
275Exposure during breast feedingFAERS: 1US FAERS
276Eye irritationFAERS: 1US FAERS
277Facial ParesisFAERS: 1US FAERS
278Feeling ColdFAERS: 1US FAERS
279Feeling of body temperature changeFAERS: 1US FAERS
280Food PoisoningFAERS: 1US FAERS
281Gastric DilatationFAERS: 1US FAERS
282Gastric LavageFAERS: 1US FAERS
283Gastrointestinal carcinomaFAERS: 1US FAERS
284Gastrointestinal hypomotilityFAERS: 1US FAERS
285Gastrointestinal inflammationFAERS: 1US FAERS
286Gastrointestinal obstructionFAERS: 1US FAERS
287Genital painFAERS: 1US FAERS
288GingivitisFAERS: 1US FAERS
289GlaucomaFAERS: 1US FAERS
290HerniaFAERS: 1US FAERS
291HydronephrosisFAERS: 1US FAERS
292HyperreflexiaFAERS: 1US FAERS
293IncoherentFAERS: 1US FAERS
294InfectionFAERS: 1US FAERS
295Irritable Bowel SyndromeFAERS: 1US FAERS
296Joint injuryFAERS: 1US FAERS
297Large intestine perforationFAERS: 1US FAERS
298LazinessFAERS: 1US FAERS
299Leukocytoclastic vasculitisFAERS: 1US FAERS
300Ligament injuryFAERS: 1US FAERS
301Lipase increasedFAERS: 1US FAERS
302LymphadenopathyFAERS: 1US FAERS
303LymphomaFAERS: 1US FAERS
304LymphopeniaFAERS: 1US FAERS
305MastectomyFAERS: 1US FAERS
306Memory impairmentFAERS: 1US FAERS
307Mental status changesFAERS: 1US FAERS
308Mouth swellingFAERS: 1US FAERS
309Muscle RigidityFAERS: 1US FAERS
310Musculoskeletal chest painFAERS: 1US FAERS
311Musculoskeletal stiffnessFAERS: 1US FAERS
312MyalgiaFAERS: 1US FAERS
313Neck PainFAERS: 1US FAERS
314NervousnessFAERS: 1US FAERS
315Neuropsychiatric syndromeFAERS: 1US FAERS
316Nutritional condition abnormalFAERS: 1US FAERS
317Opiates positiveFAERS: 1US FAERS
318OpisthotonusFAERS: 1US FAERS
319Oral painFAERS: 1US FAERS
320Oropharyngeal painFAERS: 1US FAERS
321Oropharyngeal spasmFAERS: 1US FAERS
322Pancreatic enzymes increasedFAERS: 1US FAERS
323PancytopeniaFAERS: 1US FAERS
324Paroxysmal arrhythmiaFAERS: 1US FAERS
325Perianal erythemaFAERS: 1US FAERS
326Peripheral paralysisFAERS: 1US FAERS
327PeritonitisFAERS: 1US FAERS
328Pharmaceutical product complaintFAERS: 1US FAERS
329Pharmaceutical product counterfeitFAERS: 1US FAERS
330PiloerectionFAERS: 1US FAERS
331PoisoningFAERS: 1US FAERS
332Poor quality product administeredFAERS: 1US FAERS
333Product closure removal difficultFAERS: 1US FAERS
334Product comminglingFAERS: 1US FAERS
335Product contaminationFAERS: 1US FAERS
336Product contamination physicalFAERS: 1US FAERS
337Product dispensing errorFAERS: 1US FAERS
338Product physical consistency issueFAERS: 1US FAERS
339Product shape issueFAERS: 1US FAERS
340Pulmonary thrombosisFAERS: 1US FAERS
341PurpuraFAERS: 1US FAERS
342Rebound effectFAERS: 1US FAERS
343Rectal tenesmusFAERS: 1US FAERS
344Renal cystFAERS: 1US FAERS
345Respiratory FailureFAERS: 1US FAERS
346Respiratory distressFAERS: 1US FAERS
347Secretion dischargeFAERS: 1US FAERS
348Septic ShockFAERS: 1US FAERS
349ShockFAERS: 1US FAERS
350Skin irritationFAERS: 1US FAERS
351Skin lacerationFAERS: 1US FAERS
352Skin test positiveFAERS: 1US FAERS
353SneezingFAERS: 1US FAERS
354StressFAERS: 1US FAERS
355Suspected counterfeit productFAERS: 1US FAERS
356TachyarrhythmiaFAERS: 1US FAERS
357Thermal burnFAERS: 1US FAERS
358ThirstFAERS: 1US FAERS
359Tongue discomfortFAERS: 1US FAERS
360Tooth AvulsionFAERS: 1US FAERS
361Tooth LossFAERS: 1US FAERS
362UlcerFAERS: 1US FAERS
363Urinary IncontinenceFAERS: 1US FAERS
364Ventricular hypokinesiaFAERS: 1US FAERS
365VertigoFAERS: 1US FAERS
366Visual ImpairmentFAERS: 1US FAERS
367Visual disturbanceFAERS: 1US FAERS
368WheezingFAERS: 1US FAERS
369Wrong product administeredFAERS: 1US FAERS
370nervous system disorderFAERS: 1US FAERS
371treatment failureFAERS: 1US FAERS
372Joint stiffnessCanada Vigilance: 2Canada Vigilance
373Pre-EclampsiaCanada Vigilance: 1Canada Vigilance
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