MetaADEDB 2.0 @ LMMD
Aprepitant
(ATALOFNDEOCMKK-OITMNORJSA-N)
Structure
SMILES
Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1n[nH]c(=O)[nH]1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C
Type(s)
Approved; Investigational
ATC code(s)
A04AD12
Molecular Formula:
C23H21F7N4O3
Molecular Weight:
534.427
Log P:
4.8900
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
83.24
CAS Number(s):
170729-80-3; 321125-94-4
Synonym(s)
1.
Aprepitant
2.
(1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine
3.
(2R)-(1R)-3,5-bis(Trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine
4.
Emend
5.
L 754,030
6.
L 754030
7.
L-754,030
8.
L-754030
9.
MK 0517
10.
MK 0869
11.
MK 869
12.
MK-0517
13.
MK-0869
14.
MK-869
15.
MK0517
16.
L754,030
17.
L754030
18.
MK0869
19.
MK869
External Link(s)
MeSHD000077608
PubChem Compound6918365
135413536
BindingDB50220136
ChEBI499361
CHEMBLCHEMBL1471
DrugBankDB00673
DrugCentral230
IUPHAR/BPS Guide to PHARMACOLOGY3490
KEGGdr:D02968
cpd:C21555
Therapeutic Target DatabaseD0GU4K
ZINC27428713
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1No adverse eventFAERS: 99US FAERS
2Adverse eventFAERS: 95US FAERS
3FlushingFAERS: 71SIDER
US FAERS
4NauseaFAERS: 67

View details

CTD
OFFSIDES
SIDER
US FAERS
5Drug dose omissionFAERS: 50US FAERS
6HypersensitivityFAERS: 39SIDER
US FAERS
7Product quality issueFAERS: 35US FAERS
8ErythemaFAERS: 33OFFSIDES
SIDER
US FAERS
9VomitingFAERS: 32
Canada Vigilance: 2

View details

CTD
SIDER
Canada Vigilance
US FAERS
10Back PainFAERS: 31SIDER
US FAERS
11Infusion site painFAERS: 27SIDER
US FAERS
12Drug ineffectiveFAERS: 26US FAERS
13Product use issueFAERS: 25US FAERS
14Chest discomfortFAERS: 24SIDER
US FAERS
15Inappropriate schedule of drug administrationFAERS: 24US FAERS
16MalaiseFAERS: 24
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
17DizzinessFAERS: 17
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
18HeadacheFAERS: 16SIDER
US FAERS
19Chest PainFAERS: 15SIDER
US FAERS
20Product preparation errorFAERS: 15US FAERS
21Drug administration errorFAERS: 13US FAERS
22Wrong technique in drug usage processFAERS: 13US FAERS
23Product physical issueFAERS: 12US FAERS
24Product use in unapproved indicationFAERS: 12
Canada Vigilance: 1
Canada Vigilance
US FAERS
25AnxietyFAERS: 10SIDER
US FAERS
26ConstipationFAERS: 10SIDER
US FAERS
27ExtravasationFAERS: 10US FAERS
28Infusion site erythemaFAERS: 10SIDER
US FAERS
29PruritusFAERS: 10SIDER
US FAERS
30Burning sensationFAERS: 9US FAERS
31Disease ProgressionFAERS: 9US FAERS
32Product packaging quantity issueFAERS: 9US FAERS
33TremorFAERS: 9SIDER
US FAERS
34Abdominal PainFAERS: 8OFFSIDES
SIDER
US FAERS
35ChillsFAERS: 8SIDER
US FAERS
36Circumstance or information capable of leading to medication errorFAERS: 8OFFSIDES
US FAERS
37Infusion site irritationFAERS: 8US FAERS
38Malignant neoplasm progressionFAERS: 8US FAERS
39Medication ErrorFAERS: 8US FAERS
40PhlebitisFAERS: 8OFFSIDES
US FAERS
41Cerebrovascular accidentFAERS: 7
Canada Vigilance: 1
Canada Vigilance
US FAERS
42Injection site painFAERS: 7US FAERS
43PainFAERS: 7SIDER
US FAERS
44PalpitationsFAERS: 7SIDER
US FAERS
45Therapy cessationFAERS: 7US FAERS
46WheezingFAERS: 7SIDER
US FAERS
47AstheniaFAERS: 6
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
48White blood cell count decreasedFAERS: 6SIDER
US FAERS
49FatigueFAERS: 5
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
50Feeling abnormalFAERS: 5SIDER
US FAERS
51Hospice CareFAERS: 5US FAERS
52Incorrect product storageFAERS: 5US FAERS
53Incorrect route of drug administrationFAERS: 5US FAERS
54Infusion site swellingFAERS: 5US FAERS
55TachycardiaFAERS: 5SIDER
US FAERS
56Therapeutic response unexpectedFAERS: 5US FAERS
57Anaphylactic shockFAERS: 4SIDER
US FAERS
58Cardiac ArrestFAERS: 4US FAERS
59Drug ineffective for unapproved indicationFAERS: 4US FAERS
60HypotensionFAERS: 4SIDER
US FAERS
61Incorrect drug administration durationFAERS: 4US FAERS
62Infusion site reactionFAERS: 4US FAERS
63Injection site erythemaFAERS: 4US FAERS
64Injection site extravasationFAERS: 4US FAERS
65Intestinal ObstructionFAERS: 4US FAERS
66Myocardial InfarctionFAERS: 4
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
67OverdoseFAERS: 4US FAERS
68Product availability issueFAERS: 4US FAERS
69Product dose omissionFAERS: 4US FAERS
70ShockFAERS: 4SIDER
US FAERS
71ThrombophlebitisFAERS: 4OFFSIDES
SIDER
US FAERS
72Unevaluable eventFAERS: 4US FAERS
73UrticariaFAERS: 4SIDER
US FAERS
74Capsule physical issueFAERS: 3US FAERS
75CyanosisFAERS: 3US FAERS
76DehydrationFAERS: 3OFFSIDES
SIDER
US FAERS
77DiscomfortFAERS: 3SIDER
US FAERS
78DisorientationFAERS: 3SIDER
US FAERS
79DyspepsiaFAERS: 3SIDER
US FAERS
80Full blood count decreasedFAERS: 3US FAERS
81Infusion Site ExtravasationFAERS: 3US FAERS
82LymphomaFAERS: 3US FAERS
83NervousnessFAERS: 3US FAERS
84Peripheral swellingFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
85PneumoniaFAERS: 3SIDER
US FAERS
86SomnolenceFAERS: 3SIDER
US FAERS
87Supraventricular tachycardiaFAERS: 3US FAERS
88SyncopeFAERS: 3SIDER
US FAERS
89Unresponsive to stimuliFAERS: 3US FAERS
90Visual ImpairmentFAERS: 3US FAERS
91Weight decreasedFAERS: 3
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
92Acute kidney injuryFAERS: 2US FAERS
93Administration site reactionFAERS: 2US FAERS
94AmnesiaFAERS: 2US FAERS
95Atrial FibrillationFAERS: 2US FAERS
96Blood pressure immeasurableFAERS: 2US FAERS
97Breast cancer recurrentFAERS: 2US FAERS
98Drug effective for unapproved indicationFAERS: 2US FAERS
99Drug prescribing errorFAERS: 2US FAERS
100DysphoniaFAERS: 2US FAERS
101Flank PainFAERS: 2OFFSIDES
US FAERS
102Incorrect storage of drugFAERS: 2US FAERS
103InfectionFAERS: 2
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
104InflammationFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
105Infusion site phlebitisFAERS: 2US FAERS
106Infusion site urticariaFAERS: 2US FAERS
107Injection site irritationFAERS: 2US FAERS
108Injection site massFAERS: 2US FAERS
109Injection site vesiclesFAERS: 2US FAERS
110Lip swellingFAERS: 2US FAERS
111Maternal exposure during pregnancyFAERS: 2US FAERS
112NeutropeniaFAERS: 2SIDER
US FAERS
113Poor quality drug administeredFAERS: 2US FAERS
114Product packaging issueFAERS: 2US FAERS
115Product prescribing errorFAERS: 2US FAERS
116Product storage errorFAERS: 2US FAERS
117Rash erythematousFAERS: 2US FAERS
118Respiratory FailureFAERS: 2SIDER
US FAERS
119Skin irritationFAERS: 2US FAERS
120Therapeutic product effective for unapproved indicationFAERS: 2US FAERS
121Throat irritationFAERS: 2SIDER
US FAERS
122ThrombosisFAERS: 2US FAERS
123Wrong technique in product usage processFAERS: 2US FAERS
124Abdominal discomfortFAERS: 1OFFSIDES
SIDER
US FAERS
125Accidental exposure to productFAERS: 1US FAERS
126Accidental exposureFAERS: 1US FAERS
127Activities of daily living impairedFAERS: 1US FAERS
128Administration site erythemaFAERS: 1US FAERS
129AgitationFAERS: 1US FAERS
130AgranulocytosisFAERS: 1US FAERS
131Angina PectorisFAERS: 1US FAERS
132AngioedemaFAERS: 1OFFSIDES
SIDER
US FAERS
133ArthralgiaFAERS: 1SIDER
US FAERS
134ArthropathyFAERS: 1US FAERS
135Arthropod biteFAERS: 1US FAERS
136AscitesFAERS: 1US FAERS
137Bladder dysfunctionFAERS: 1US FAERS
138BlindnessFAERS: 1US FAERS
139Blood count abnormalFAERS: 1US FAERS
140Blood electrolytes decreasedFAERS: 1OFFSIDES
US FAERS
141Blood potassium decreasedFAERS: 1OFFSIDES
SIDER
US FAERS
142Bone painFAERS: 1OFFSIDES
US FAERS
143BradycardiaFAERS: 1SIDER
US FAERS
144Catheter site phlebitisFAERS: 1US FAERS
145Cerebral congestionFAERS: 1US FAERS
146Choking sensationFAERS: 1OFFSIDES
US FAERS
147ChokingFAERS: 1US FAERS
148CystitisFAERS: 1US FAERS
149Cytolytic hepatitisFAERS: 1OFFSIDES
US FAERS
150Drug dispensing errorFAERS: 1US FAERS
151Duodenal UlcerFAERS: 1SIDER
US FAERS
152DysarthriaFAERS: 1SIDER
US FAERS
153Ear discomfortFAERS: 1US FAERS
154EmbolismFAERS: 1SIDER
US FAERS
155EnteritisFAERS: 1OFFSIDES
US FAERS
156Euphoric moodFAERS: 1SIDER
US FAERS
157Exposure via skin contactFAERS: 1US FAERS
158Eye painFAERS: 1US FAERS
159Feeding tube userFAERS: 1US FAERS
160FibrosisFAERS: 1US FAERS
161FlatulenceFAERS: 1SIDER
US FAERS
162General physical health deteriorationFAERS: 1
Canada Vigilance: 2
Canada Vigilance
OFFSIDES
US FAERS
163General symptomFAERS: 1US FAERS
164GlioblastomaFAERS: 1US FAERS
165GoutFAERS: 1US FAERS
166Heart sounds abnormalFAERS: 1US FAERS
167HemiparesisFAERS: 1US FAERS
168Hepatic cancer metastaticFAERS: 1US FAERS
169HypersomniaFAERS: 1US FAERS
170IleusFAERS: 1US FAERS
171Implant site infectionFAERS: 1US FAERS
172Incorrect dose administeredFAERS: 1US FAERS
173Incorrect product formulation administeredFAERS: 1US FAERS
174InfluenzaFAERS: 1US FAERS
175Infusion site rashFAERS: 1US FAERS
176Injection related reactionFAERS: 1US FAERS
177Intentional dose omissionFAERS: 1US FAERS
178Intentional drug misuseFAERS: 1US FAERS
179Intentional product misuseFAERS: 1US FAERS
180Joint Range of Motion DecreasedFAERS: 1US FAERS
181Livedo ReticularisFAERS: 1US FAERS
182LymphadenopathyFAERS: 1US FAERS
183Medical device complicationFAERS: 1US FAERS
184Medication residue presentFAERS: 1US FAERS
185Metabolic acidosisFAERS: 1OFFSIDES
US FAERS
186Metastases to abdominal cavityFAERS: 1US FAERS
187Metastatic NeoplasmFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
188Musculoskeletal stiffnessFAERS: 1US FAERS
189MydriasisFAERS: 1US FAERS
190MyopathyFAERS: 1US FAERS
191Neck PainFAERS: 1US FAERS
192Neurostimulator implantationFAERS: 1US FAERS
193Oncologic complicationFAERS: 1US FAERS
194Oral candidiasisFAERS: 1SIDER
US FAERS
195Oropharyngeal painFAERS: 1SIDER
US FAERS
196Oropharyngeal surgeryFAERS: 1US FAERS
197Oropharyngeal swellingFAERS: 1OFFSIDES
US FAERS
198PallorFAERS: 1US FAERS
199Pancreatic carcinomaFAERS: 1US FAERS
200PancreatitisFAERS: 1US FAERS
201PancytopeniaFAERS: 1US FAERS
202Panic DisorderFAERS: 1US FAERS
203Pelvic PainFAERS: 1SIDER
US FAERS
204Poor quality product administeredFAERS: 1US FAERS
205Poor quality sleepFAERS: 1US FAERS
206Post procedural infectionFAERS: 1SIDER
US FAERS
207Pre-existing condition improvedFAERS: 1US FAERS
208PresyncopeFAERS: 1US FAERS
209Procedural nauseaFAERS: 1US FAERS
210Procedural vomitingFAERS: 1US FAERS
211Product administration errorFAERS: 1US FAERS
212Product container issueFAERS: 1US FAERS
213Product contamination physicalFAERS: 1US FAERS
214Product leakageFAERS: 1US FAERS
215Product reconstitution quality issueFAERS: 1US FAERS
216Product substitution issueFAERS: 1US FAERS
217Product supply issueFAERS: 1US FAERS
218Respiratory DepressionFAERS: 1SIDER
US FAERS
219Respiratory arrestFAERS: 1US FAERS
220Respiratory distressFAERS: 1US FAERS
221RestlessnessFAERS: 1US FAERS
222Secretion dischargeFAERS: 1US FAERS
223Skin lesionFAERS: 1SIDER
US FAERS
224Skin reactionFAERS: 1US FAERS
225Small cell lung cancer metastaticFAERS: 1US FAERS
226SneezingFAERS: 1SIDER
US FAERS
227Solvent sensitivityFAERS: 1US FAERS
228Stevens-Johnson SyndromeFAERS: 125811541CTD
SIDER
US FAERS
229StomatitisFAERS: 1SIDER
US FAERS
230Therapy changeFAERS: 1US FAERS
231Therapy responderFAERS: 1US FAERS
232ThrombocytopeniaFAERS: 1SIDER
US FAERS
233TinnitusFAERS: 1SIDER
US FAERS
234Tonic clonic movementsFAERS: 1US FAERS
235Tooth ExtractionFAERS: 1US FAERS
236ToothacheFAERS: 1US FAERS
237Toxicity to various agentsFAERS: 1US FAERS
238Tympanic Membrane PerforationFAERS: 1US FAERS
239Uterine CancerFAERS: 1US FAERS
240VasospasmFAERS: 1OFFSIDES
US FAERS
241VertigoFAERS: 1US FAERS
242Vocal Cord ParalysisFAERS: 1US FAERS
243White blood cell count abnormalFAERS: 1US FAERS
244leiomyosarcomaFAERS: 1US FAERS
245nervous system disorderFAERS: 1SIDER
US FAERS
246treatment failureFAERS: 1US FAERS
247Abdominal sepsisOFFSIDES
248Abnormal bowel soundsSIDER
249Acute Coronary SyndromeSIDER
250Acute psychosisOFFSIDES
251Adnexa uteri massOFFSIDES
252Alanine Aminotransferase IncreasedSIDER
253AlopeciaSIDER
254Altered state of consciousnessSIDER
255AlveolitisOFFSIDES
256Anal FissureOFFSIDES
257AnisocoriaOFFSIDES
258Anorexia30336258CTD
OFFSIDES
SIDER
259Anoxic EncephalopathyOFFSIDES
260Anticholinergic SyndromeOFFSIDES
261Aortic embolusOFFSIDES
262AphagiaOFFSIDES
263Arterial thrombosisOFFSIDES
264Aspartate Aminotransferase IncreasedSIDER
265Aspiration tracheal abnormalOFFSIDES
266AsterixisOFFSIDES
267AtelectasisOFFSIDES
268Atrial tachycardiaOFFSIDES
269Autoimmune thrombocytopeniaOFFSIDES
270Bacterial sepsisOFFSIDES
271Bile Duct StenosisOFFSIDES
272Bilirubin conjugated increasedOFFSIDES
273BlepharoptosisOFFSIDES
274BlepharospasmOFFSIDES
275Blood GlucoseOFFSIDES
276Blood albumin decreasedOFFSIDES
SIDER
277Blood alkaline phosphatase increasedOFFSIDES
SIDER
278Blood and lymphatic system disordersSIDER
279Blood chloride decreasedOFFSIDES
280Blood creatine increasedSIDER
281Blood creatinine increasedSIDER
282Blood electrolytes abnormalOFFSIDES
283Blood glucose increasedSIDER
284Blood magnesium decreasedOFFSIDES
285Blood sodiumOFFSIDES
286Blood urea increasedSIDER
287Blood urine presentSIDER
288Brain Diseases17389531CTD
289BronchitisOFFSIDES
290BronchopneumoniaOFFSIDES
291Cancer PainOFFSIDES
292Cardiac TamponadeOFFSIDES
293Catheter related infectionOFFSIDES
294Catheter site dischargeOFFSIDES
295Catheter site painOFFSIDES
296Cervical dysplasiaOFFSIDES
297Cervicitis human papilloma virusOFFSIDES
298Cervicobrachial syndromeOFFSIDES
299Chemotherapeutic drug level increasedOFFSIDES
300CholangiolitisOFFSIDES
301CholecystitisOFFSIDES
302Chronic sinusitisOFFSIDES
303ClonusOFFSIDES
304ColitisCanada Vigilance: 1Canada Vigilance
305ConjunctivitisSIDER
306Corneal UlcerOFFSIDES
307Creatine increasedSIDER
308Culture positiveOFFSIDES
309CystSIDER
310Deafness NeurosensoryOFFSIDES
311DebridementOFFSIDES
312Deep Vein ThrombosisSIDER
313Dental abscessOFFSIDES
314Depressed Level of ConsciousnessSIDER
315DermatitisSIDER
316Device occlusionOFFSIDES
317Diabetes MellitusSIDER
318DiarrheaOFFSIDES
319Disseminated Intravascular CoagulationOFFSIDES
320Diverticular perforationOFFSIDES
321Dry skinCanada Vigilance: 1Canada Vigilance
322Duodenal ulcer perforationOFFSIDES
SIDER
323DysgeusiaSIDER
324DystoniaOFFSIDES
325DysuriaSIDER
326Ear and labyrinth disordersSIDER
327Edema21466812CTD
328Embolic strokeOFFSIDES
329Endodontic procedureOFFSIDES
330EnterocolitisOFFSIDES
SIDER
331Epigastric discomfortSIDER
332EructationSIDER
333Erythema MultiformeSIDER
334Escherichia infectionOFFSIDES
335FastingSIDER
336Fatty LiverOFFSIDES
337Febrile NeutropeniaOFFSIDES
SIDER
338Febrile bone marrow aplasiaOFFSIDES
339Feeding tube complicationOFFSIDES
340FormicationOFFSIDES
341GastritisSIDER
342Gastrointestinal PainSIDER
343Gastrointestinal perforationOFFSIDES
344Gastrointestinal sounds abnormalSIDER
345GlycosuriaSIDER
346HeartburnSIDER
347Hepatitis B positiveOFFSIDES
348HepatosplenomegalyOFFSIDES
349HiccoughOFFSIDES
350HydronephrosisOFFSIDES
351HypophagiaOFFSIDES
352HyporeflexiaOFFSIDES
353HypoxiaOFFSIDES
354ImpetigoOFFSIDES
355InfestationSIDER
356Infusion site indurationSIDER
357Infusion site pruritusSIDER
358Infusion site thrombophlebitisSIDER
359Infusion site thrombosisSIDER
360Injection site dermatitisOFFSIDES
361Injection site phlebitisOFFSIDES
362Intestinal PerforationOFFSIDES
363Intraoperative HemorrhageSIDER
364Keratitis siccaOFFSIDES
365Kidney FailureOFFSIDES
366Laboratory test interferenceOFFSIDES
367Leriche SyndromeOFFSIDES
368LethargySIDER
369Leukopenia neonatalOFFSIDES
370LipaseOFFSIDES
371Lower respiratory tract infectionSIDER
372LymphedemaOFFSIDES
373MalnutritionSIDER
374Mental FatigueCanada Vigilance: 1Canada Vigilance
375Microscopic hematuriaSIDER
376Musculoskeletal PainSIDER
377Musculoskeletal chest painOFFSIDES
378Musculoskeletal discomfortSIDER
379MyalgiaSIDER
380Nephritic syndromeOFFSIDES
381Nephrotic SyndromeOFFSIDES
382Nerve Root CompressionOFFSIDES
383Neutropenic colitisSIDER
384Neutropenic sepsisOFFSIDES
SIDER
385Neutrophil count decreasedOFFSIDES
SIDER
386NoduleCanada Vigilance: 1Canada Vigilance
387ObstipationSIDER
388ObstructionOFFSIDES
389OsteoradionecrosisOFFSIDES
390OsteosclerosisOFFSIDES
391Pelvic fluid collectionOFFSIDES
392PeriarthritisOFFSIDES
393Perinephric collectionOFFSIDES
394PharyngitisSIDER
395Pharyngolaryngeal PainSIDER
396Pneumatosis Cystoides IntestinalisOFFSIDES
397PolydipsiaSIDER
398PolyuriaSIDER
399Portal Vein ThrombosisOFFSIDES
400Portal venous gasOFFSIDES
401Postoperative infectionSIDER
402PosturingOFFSIDES
403Protein total decreasedOFFSIDES
404Protein urine presentSIDER
405ProteinuriaSIDER
406PrurigoSIDER
407Pulmonary EmbolismSIDER
408Pulmonary HypertensionOFFSIDES
409Pulmonary function test decreasedSIDER
410Radiation mucositisOFFSIDES
411Radiation skin injuryOFFSIDES
412Renal cystOFFSIDES
413Respiratory InsufficiencySIDER
414RetrocollisOFFSIDES
415Retrograde amnesiaOFFSIDES
416SarcoidosisOFFSIDES
417Septic ShockOFFSIDES
SIDER
418SequestrectomyOFFSIDES
419Sinus TachycardiaSIDER
420Sinus bradycardiaOFFSIDES
421Subcutaneous AbscessOFFSIDES
422SubileusSIDER
423Sudden Cardiac DeathOFFSIDES
424Sudden deathOFFSIDES
425Superior Vena Cava SyndromeOFFSIDES
426Synovial CystOFFSIDES
427Thirst decreasedOFFSIDES
428ThirstSIDER
429TonsillitisOFFSIDES
430Tooth repairOFFSIDES
431Toxic Epidermal NecrolysisSIDER
432Transaminases increasedOFFSIDES
433Upper-airway cough syndromeSIDER
434Upset stomachSIDER
435Urinary tract infectionSIDER
436Urine output increasedSIDER
437Vagus Nerve DisorderOFFSIDES
438Viral sinusitisCanada Vigilance: 1Canada Vigilance
439Wound dehiscenceSIDER
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