MetaADEDB 2.0 @ LMMD
Glucovance
(HCEQQASHRRPQFE-UHFFFAOYSA-N)
Structure
SMILES
CN(C(=N)N=C(N)N)C.COc1ccc(cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1)Cl.Cl
Molecular Formula:
C27H40Cl2N8O5S
Molecular Weight:
659.628
Log P:
6.9537
Hydrogen Bond Acceptor:
13
Hydrogen Bond Donor:
7
TPSA:
213.47
CAS Number(s):
338752-31-1
Synonym(s)
1.
Glucovance
2.
Glyburide-metformin
External Link(s)
MeSHC417231
PubChem Compound200105
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Blood glucose increasedFAERS: 32US FAERS
2Drug ineffectiveFAERS: 26US FAERS
3Pharmaceutical product complaintFAERS: 13OFFSIDES
US FAERS
4Blood glucose decreasedFAERS: 12OFFSIDES
US FAERS
5DizzinessFAERS: 10OFFSIDES
US FAERS
6NauseaFAERS: 10OFFSIDES
US FAERS
7Product substitution issueFAERS: 6US FAERS
8Diabetes mellitus inadequate controlFAERS: 5OFFSIDES
US FAERS
9SyncopeFAERS: 5US FAERS
10TremorFAERS: 5US FAERS
11Abdominal PainFAERS: 4US FAERS
12Alanine Aminotransferase IncreasedFAERS: 4US FAERS
13ConstipationFAERS: 4US FAERS
14Feeling abnormalFAERS: 4US FAERS
15MalaiseFAERS: 4US FAERS
16Back PainFAERS: 3US FAERS
17Blood glucose abnormalFAERS: 3OFFSIDES
US FAERS
18HeadacheFAERS: 3US FAERS
19Incorrect dose administeredFAERS: 3OFFSIDES
US FAERS
20Medication ErrorFAERS: 3US FAERS
21PruritusFAERS: 3US FAERS
22SwellingFAERS: 3US FAERS
23UrticariaFAERS: 3US FAERS
24Wrong technique in product usage processFAERS: 3US FAERS
25Abdominal discomfortFAERS: 2OFFSIDES
US FAERS
26Adverse eventFAERS: 2US FAERS
27AstheniaFAERS: 2OFFSIDES
US FAERS
28Blood creatinine increasedFAERS: 2US FAERS
29Blood glucose fluctuationFAERS: 2OFFSIDES
US FAERS
30Blood pressure inadequately controlledFAERS: 2US FAERS
31Cytolytic hepatitisFAERS: 2US FAERS
32DysgeusiaFAERS: 2OFFSIDES
US FAERS
33ErythemaFAERS: 2US FAERS
34PainFAERS: 2US FAERS
35Weight decreasedFAERS: 2US FAERS
36Wrong technique in drug usage processFAERS: 2US FAERS
37Accidental exposureFAERS: 1US FAERS
38Altered state of consciousnessFAERS: 1US FAERS
39Anal discomfortFAERS: 1OFFSIDES
US FAERS
40AngerFAERS: 1US FAERS
41Anoxic EncephalopathyFAERS: 1US FAERS
42ArthritisFAERS: 1OFFSIDES
US FAERS
43Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
44Blood alkaline phosphatase increasedFAERS: 1US FAERS
45Blood creatinine decreasedFAERS: 1US FAERS
46Blood lactic acid abnormalFAERS: 1US FAERS
47BronchitisFAERS: 1US FAERS
48Cardiac ArrestFAERS: 1US FAERS
49Cerebrovascular accidentFAERS: 1US FAERS
50Chest discomfortFAERS: 1US FAERS
51Creatinine renal clearance increasedFAERS: 1US FAERS
52Death of relativeFAERS: 1US FAERS
53DermatitisFAERS: 1US FAERS
54Diabetes MellitusFAERS: 1US FAERS
55Drug administration errorFAERS: 1US FAERS
56Drug dispensing errorFAERS: 1OFFSIDES
US FAERS
57Dry skinFAERS: 1US FAERS
58DysarthriaFAERS: 1US FAERS
59DyspepsiaFAERS: 1OFFSIDES
US FAERS
60EpistaxisFAERS: 1US FAERS
61Extremity contractureFAERS: 1US FAERS
62FatigueFAERS: 1OFFSIDES
US FAERS
63Feeling jitteryFAERS: 1US FAERS
64Gastrointestinal PainFAERS: 1US FAERS
65Gastrointestinal motility disorderFAERS: 1US FAERS
66Genital rashFAERS: 1US FAERS
67GoutFAERS: 1OFFSIDES
US FAERS
68Hepatitis CFAERS: 1OFFSIDES
US FAERS
69HepatitisFAERS: 1US FAERS
70HungerFAERS: 1US FAERS
71HyperchlorhydriaFAERS: 1US FAERS
72HypersensitivityFAERS: 1US FAERS
73InfarctionFAERS: 1US FAERS
74Joint stiffnessFAERS: 1US FAERS
75LethargyFAERS: 1US FAERS
76Metabolic acidosisFAERS: 1US FAERS
77MetrorrhagiaFAERS: 1US FAERS
78Musculoskeletal PainFAERS: 1US FAERS
79Myocardial InfarctionFAERS: 1US FAERS
80NervousnessFAERS: 1US FAERS
81No adverse eventFAERS: 1US FAERS
82ObesityFAERS: 1US FAERS
83Oropharyngeal blisteringFAERS: 1US FAERS
84PalpitationsFAERS: 1US FAERS
85Penile swellingFAERS: 1US FAERS
86Pharmaceutical product counterfeitFAERS: 1US FAERS
87PregnancyFAERS: 1US FAERS
88Product formulation issueFAERS: 1US FAERS
89Product label issueFAERS: 1US FAERS
90Product quality issueFAERS: 1US FAERS
91Protein urine presentFAERS: 1US FAERS
92Respiratory distressFAERS: 1US FAERS
93Shoulder PainFAERS: 1US FAERS
94Skin UlcerFAERS: 1US FAERS
95SplenomegalyFAERS: 1US FAERS
96StressFAERS: 1OFFSIDES
US FAERS
97TachycardiaFAERS: 1US FAERS
98Therapeutic response unexpected with drug substitutionFAERS: 1US FAERS
99Unresponsive to stimuliFAERS: 1US FAERS
100White blood cell count decreasedFAERS: 1US FAERS
101jaundiceFAERS: 1US FAERS
102Accidental overdoseOFFSIDES
103AcidosisOFFSIDES
104Actinic keratosisOFFSIDES
105ActinomycosisOFFSIDES
106Acute Coronary SyndromeOFFSIDES
107Acute myocardial infarctionOFFSIDES
108Acute sinusitisOFFSIDES
109AdenocarcinomaOFFSIDES
110AdenomaOFFSIDES
111AgoraphobiaOFFSIDES
112AgraphiaOFFSIDES
113AlopeciaOFFSIDES
114Altered visual depth perceptionOFFSIDES
115AlveolitisOFFSIDES
116AlveoloplastyOFFSIDES
117AmyloidosisOFFSIDES
118Anal FissureOFFSIDES
119AnhidrosisOFFSIDES
120Ankle reconstructionOFFSIDES
121AnorexiaOFFSIDES
122Anticoagulation drug level below therapeuticOFFSIDES
123AnxietyOFFSIDES
124Aphthous StomatitisOFFSIDES
125ApneaOFFSIDES
126AppendectomyOFFSIDES
127Arteriovenous graft thrombosisOFFSIDES
128ArthropathyOFFSIDES
129Aspiration PneumoniaOFFSIDES
130AsthmaOFFSIDES
131AtelectasisOFFSIDES
132AtherosclerosisOFFSIDES
133Biopsy bone abnormalOFFSIDES
134Biopsy chest wall abnormalOFFSIDES
135Blood GlucoseOFFSIDES
136Blood cholesterol abnormalOFFSIDES
137Blood cholesterolOFFSIDES
138Blood magnesium decreasedOFFSIDES
139Blurred visionOFFSIDES
140Body fat disorderOFFSIDES
141Bowel movement irregularityOFFSIDES
142BruxismOFFSIDES
143Cardiac FlutterOFFSIDES
144Cardiac stress test abnormalOFFSIDES
145Carotid bruitOFFSIDES
146Cataract operationOFFSIDES
147CataractOFFSIDES
148CellulitisOFFSIDES
149Chest PainOFFSIDES
150Choking sensationOFFSIDES
151Chronic Obstructive Airway DiseaseOFFSIDES
152ClaustrophobiaOFFSIDES
153Cold sweatOFFSIDES
154Conjunctival depositOFFSIDES
155Cor pulmonaleOFFSIDES
156DebridementOFFSIDES
157Dental cariesOFFSIDES
158Dental discomfortOFFSIDES
159Dental prosthesis placementOFFSIDES
160DiabetesOFFSIDES
161Diabetic FootOFFSIDES
162Diabetic RetinopathyOFFSIDES
163DiarrheaOFFSIDES
164DiplopiaOFFSIDES
165DiverticulitisOFFSIDES
166DrowsinessOFFSIDES
167Drug withdrawal headacheOFFSIDES
168DysphasiaOFFSIDES
169Early satietyOFFSIDES
170Eating disorder symptomOFFSIDES
171Emotional distressOFFSIDES
172Endodontic procedureOFFSIDES
173Endometrial HyperplasiaOFFSIDES
174Erectile dysfunctionOFFSIDES
175EscharOFFSIDES
176Eustachian tube disorderOFFSIDES
177ExcoriationOFFSIDES
178Fatty LiverOFFSIDES
179Flank PainOFFSIDES
180FlatulenceOFFSIDES
181Fluid overloadOFFSIDES
182FormicationOFFSIDES
183GamblingOFFSIDES
184Gastric ulcerOFFSIDES
185GranulomaOFFSIDES
186HemiparesisOFFSIDES
187Hilar lymphadenopathyOFFSIDES
188HoarsenessOFFSIDES
189HypercapniaOFFSIDES
190HyperkeratosisOFFSIDES
191HysterectomyOFFSIDES
192Infusion site mobility decreasedOFFSIDES
193Injection site urticariaOFFSIDES
194Intention tremorOFFSIDES
195Intervertebral Disc DegenerationOFFSIDES
196Joint ligament ruptureOFFSIDES
197Joint sprainOFFSIDES
198Left Ventricular HypertrophyOFFSIDES
199Life expectancy shortenedOFFSIDES
200Ligament injuryOFFSIDES
201Loose toothOFFSIDES
202LymphedemaOFFSIDES
203Macular pseudoholeOFFSIDES
204Malignant tumour excisionOFFSIDES
205Mental status changesOFFSIDES
206Metastatic NeoplasmOFFSIDES
207Migraine with AuraOFFSIDES
208Muscle strainOFFSIDES
209Myeloma recurrenceOFFSIDES
210NephrolithiasisOFFSIDES
211Nervous tensionOFFSIDES
212NeurodermatitisOFFSIDES
213Neuropathic ulcerOFFSIDES
214NocturiaOFFSIDES
215Ocular vascular disorderOFFSIDES
216OligomenorrheaOFFSIDES
217Optic nerve infarctionOFFSIDES
218Oral infectionOFFSIDES
219Oral mucosal exfoliationOFFSIDES
220Oropharyngeal painOFFSIDES
221OsteomyelitisOFFSIDES
222OsteoporosisOFFSIDES
223Pancreatic NeoplasmOFFSIDES
224PancreatitisOFFSIDES
225Panic disorder with agoraphobiaOFFSIDES
226Pelvic Floor Muscle WeaknessOFFSIDES
227PeriarthritisOFFSIDES
228Pharyngolaryngeal PainOFFSIDES
229PneumothoraxOFFSIDES
230Polysubstance dependenceOFFSIDES
231Primary sequestrumOFFSIDES
232Productive CoughOFFSIDES
233Progesterone receptor assayOFFSIDES
234PterygiumOFFSIDES
235Pulmonary malformationOFFSIDES
236Renal ColicOFFSIDES
237Renal tubular necrosisOFFSIDES
238Respiratory FailureOFFSIDES
239SchizophreniaOFFSIDES
240Secondary sequestrumOFFSIDES
241SequestrectomyOFFSIDES
242Single vessel bypass graftOFFSIDES
243Skin lacerationOFFSIDES
244Skin lesionOFFSIDES
245Spontaneous penile erectionOFFSIDES
246TalipesOFFSIDES
247Tension HeadacheOFFSIDES
248Therapeutic response unexpectedOFFSIDES
249Tinea PedisOFFSIDES
250Tobacco userOFFSIDES
251Tooth ExtractionOFFSIDES
252Tooth LossOFFSIDES
253UlcerOFFSIDES
254UnemploymentOFFSIDES
255Unresponsive to pain stimuliOFFSIDES
256Urine ketone body presentOFFSIDES
257Venous angioma of brainOFFSIDES
258Viral pharyngitisOFFSIDES
259Walking aid userOFFSIDES
260Weight GainOFFSIDES
261Wound infection staphylococcalOFFSIDES
262XerosisOFFSIDES
263effusionOFFSIDES
264kyphosisOFFSIDES
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.