MetaADEDB 2.0 @ LMMD
metaxalone
(IMWZZHHPURKASS-UHFFFAOYSA-N)
Structure
SMILES
O=C1NCC(O1)COc1cc(C)cc(c1)C
Type(s)
Approved
Molecular Formula:
C12H15NO3
Molecular Weight:
221.252
Log P:
2.1194
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
1
TPSA:
47.56
CAS Number(s):
1665-48-1
Synonym(s)
1.
metaxalone
2.
AHR 438
3.
Skelaxin
External Link(s)
MeSHC011301
PubChem Compound15459
ChEBI6797
CHEMBLCHEMBL1079604
DrugBankDB00660
DrugCentral1722
IUPHAR/BPS Guide to PHARMACOLOGY7609
KEGGcpd:C07934
dr:D00773
Therapeutic Target DatabaseD0S5CH
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 76US FAERS
2NauseaFAERS: 44OFFSIDES
SIDER
US FAERS
3HeadacheFAERS: 29SIDER
US FAERS
4DizzinessFAERS: 27OFFSIDES
SIDER
US FAERS
5SomnolenceFAERS: 26
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
6PainFAERS: 25OFFSIDES
US FAERS
7UrticariaFAERS: 21US FAERS
8PruritusFAERS: 19SIDER
US FAERS
9Abdominal discomfortFAERS: 18OFFSIDES
SIDER
US FAERS
10Feeling abnormalFAERS: 16US FAERS
11MalaiseFAERS: 15US FAERS
12VomitingFAERS: 14SIDER
US FAERS
13TremorFAERS: 11US FAERS
14OverdoseFAERS: 10OFFSIDES
US FAERS
15ConstipationFAERS: 9US FAERS
16HypotensionFAERS: 9US FAERS
17Memory impairmentFAERS: 9US FAERS
18TachycardiaFAERS: 9US FAERS
19ErythemaFAERS: 8US FAERS
20FatigueFAERS: 8OFFSIDES
US FAERS
21HypersensitivityFAERS: 8SIDER
US FAERS
22Product use in unapproved indicationFAERS: 8US FAERS
23AstheniaFAERS: 7OFFSIDES
US FAERS
24ChillsFAERS: 7US FAERS
25Drug effect incompleteFAERS: 7US FAERS
26FlushingFAERS: 7US FAERS
27Muscle RigidityFAERS: 7US FAERS
28MydriasisFAERS: 7US FAERS
29PalpitationsFAERS: 7US FAERS
30Back PainFAERS: 6US FAERS
31Back disorderFAERS: 6US FAERS
32Feeling jitteryFAERS: 6US FAERS
33No adverse eventFAERS: 6US FAERS
34Abdominal PainFAERS: 5OFFSIDES
US FAERS
35ArthralgiaFAERS: 5US FAERS
36Burning sensationFAERS: 5OFFSIDES
US FAERS
37MyalgiaFAERS: 5US FAERS
38Product substitution issueFAERS: 5US FAERS
39Toxicity to various agentsFAERS: 5US FAERS
40Acute kidney injuryFAERS: 4US FAERS
41Adverse eventFAERS: 4US FAERS
42AngioedemaFAERS: 4OFFSIDES
US FAERS
43AnxietyFAERS: 4OFFSIDES
US FAERS
44Blood glucose increasedFAERS: 4US FAERS
45Bone painFAERS: 4OFFSIDES
US FAERS
46Chest discomfortFAERS: 4US FAERS
47DeliriumFAERS: 4US FAERS
48Depressed Level of ConsciousnessFAERS: 4US FAERS
49Drug ineffective for unapproved indicationFAERS: 4US FAERS
50Drug toxicityFAERS: 4US FAERS
51HyperreflexiaFAERS: 4US FAERS
52Impaired driving abilityFAERS: 4US FAERS
53Intentional product misuseFAERS: 4US FAERS
54Mental status changesFAERS: 4OFFSIDES
US FAERS
55Musculoskeletal stiffnessFAERS: 4OFFSIDES
US FAERS
56Neck PainFAERS: 4US FAERS
57Oropharyngeal painFAERS: 4OFFSIDES
US FAERS
58Product use issueFAERS: 4US FAERS
59Therapeutic response unexpectedFAERS: 4US FAERS
60AtaxiaFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
61Chest PainFAERS: 3OFFSIDES
US FAERS
62ClonusFAERS: 3US FAERS
63DysuriaFAERS: 3OFFSIDES
US FAERS
64Expired drug administeredFAERS: 3US FAERS
65FibromyalgiaFAERS: 3OFFSIDES
US FAERS
66Joint swellingFAERS: 3US FAERS
67Pre-existing condition improvedFAERS: 3US FAERS
68RestlessnessFAERS: 3US FAERS
69Stevens-Johnson SyndromeFAERS: 3OFFSIDES
US FAERS
70SwellingFAERS: 3US FAERS
71TrismusFAERS: 3US FAERS
72Urinary RetentionFAERS: 3US FAERS
73VertigoFAERS: 3US FAERS
74Activities of daily living impairedFAERS: 2OFFSIDES
US FAERS
75AlopeciaFAERS: 2US FAERS
76AnuriaFAERS: 2US FAERS
77BedriddenFAERS: 2US FAERS
78Blood creatine phosphokinase increasedFAERS: 2US FAERS
79CellulitisFAERS: 2US FAERS
80Choking sensationFAERS: 2OFFSIDES
US FAERS
81Completed SuicideFAERS: 2OFFSIDES
US FAERS
82ConjunctivitisFAERS: 2US FAERS
83Dental discomfortFAERS: 2OFFSIDES
US FAERS
84DiplopiaFAERS: 2US FAERS
85DiscomfortFAERS: 2US FAERS
86DisorientationFAERS: 2US FAERS
87Drug diversionFAERS: 2US FAERS
88DyspepsiaFAERS: 2OFFSIDES
US FAERS
89Feeling of body temperature changeFAERS: 2US FAERS
90FlatulenceFAERS: 2US FAERS
91InfluenzaFAERS: 2US FAERS
92Intervertebral Disc DegenerationFAERS: 2OFFSIDES
US FAERS
93LaryngitisFAERS: 2US FAERS
94LethargyFAERS: 2OFFSIDES
US FAERS
95Livedo ReticularisFAERS: 2OFFSIDES
US FAERS
96Musculoskeletal PainFAERS: 2OFFSIDES
US FAERS
97Musculoskeletal discomfortFAERS: 2US FAERS
98NervousnessFAERS: 2SIDER
US FAERS
99Oral painFAERS: 2US FAERS
100ParanoiaFAERS: 2US FAERS
101Peripheral swellingFAERS: 2US FAERS
102Pharmaceutical product complaintFAERS: 2US FAERS
103Skin reactionFAERS: 2US FAERS
104SyncopeFAERS: 2US FAERS
105Therapeutic product effect incompleteFAERS: 2US FAERS
106ThrombocytopeniaFAERS: 2US FAERS
107ThrombosisFAERS: 2US FAERS
108Unevaluable eventFAERS: 2OFFSIDES
US FAERS
109Weight decreasedFAERS: 2US FAERS
110AbasiaFAERS: 1US FAERS
111Abdominal tendernessFAERS: 1US FAERS
112AgeusiaFAERS: 1US FAERS
113AgitationFAERS: 1US FAERS
114Alanine Aminotransferase IncreasedFAERS: 1US FAERS
115Alcohol IntoleranceFAERS: 1US FAERS
116AphagiaFAERS: 1US FAERS
117AphoniaFAERS: 1US FAERS
118AppendicitisFAERS: 1OFFSIDES
US FAERS
119ArthropathyFAERS: 1OFFSIDES
US FAERS
120Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
121Atrial FibrillationFAERS: 1US FAERS
122Bladder painFAERS: 1US FAERS
123Bladder spasmFAERS: 1US FAERS
124Blood alkaline phosphatase increasedFAERS: 1US FAERS
125Blood chloride decreasedFAERS: 1US FAERS
126Blood glucose decreasedFAERS: 1US FAERS
127Blood osmolarity decreasedFAERS: 1US FAERS
128Blood potassium decreasedFAERS: 1US FAERS
129Blood sodium decreasedFAERS: 1US FAERS
130Blood urine presentFAERS: 1US FAERS
131BradyphreniaFAERS: 1US FAERS
132Brain DeathFAERS: 1OFFSIDES
US FAERS
133Breast CystFAERS: 1OFFSIDES
US FAERS
134Cardiac ArrestFAERS: 1US FAERS
135Cardiac discomfortFAERS: 1US FAERS
136Carpal Tunnel SyndromeFAERS: 1US FAERS
137Cerebrovascular accidentFAERS: 1US FAERS
138CholangitisFAERS: 1US FAERS
139CystitisFAERS: 1US FAERS
140DehydrationFAERS: 1OFFSIDES
US FAERS
141Drug dispensing errorFAERS: 1OFFSIDES
US FAERS
142Drug level above therapeuticFAERS: 1US FAERS
143Drug level increasedFAERS: 1US FAERS
144Drug screen false positiveFAERS: 1US FAERS
145Drug screen positiveFAERS: 1US FAERS
146DysgeusiaFAERS: 1OFFSIDES
US FAERS
147DysgraphiaFAERS: 1US FAERS
148DysphoniaFAERS: 1US FAERS
149DystoniaFAERS: 1OFFSIDES
US FAERS
150Ear discomfortFAERS: 1US FAERS
151EosinophiliaFAERS: 1US FAERS
152Expired product administeredFAERS: 1US FAERS
153Eye irritationFAERS: 1US FAERS
154Feeling ColdFAERS: 1US FAERS
155Flat affectFAERS: 1US FAERS
156HypokinesiaFAERS: 1US FAERS
157HypophagiaFAERS: 1OFFSIDES
US FAERS
158Impaired gastric emptyingFAERS: 1US FAERS
159Incorrect dose administeredFAERS: 1US FAERS
160InflammationFAERS: 1US FAERS
161Intentional drug misuseFAERS: 1US FAERS
162Irritable Bowel SyndromeFAERS: 1US FAERS
163LacerationFAERS: 1US FAERS
164Limb crushing injuryFAERS: 1US FAERS
165LymphomaFAERS: 1US FAERS
166Mental impairmentFAERS: 1US FAERS
167Mood swingsFAERS: 1US FAERS
168Multiple SclerosisFAERS: 1OFFSIDES
US FAERS
169Multiple sclerosis relapseFAERS: 1US FAERS
170Muscle strainFAERS: 1US FAERS
171Muscle tightnessFAERS: 1US FAERS
172Myocardial InfarctionFAERS: 1US FAERS
173NasopharyngitisFAERS: 1US FAERS
174Night sweatsFAERS: 1US FAERS
175Non-cardiac chest painFAERS: 1OFFSIDES
US FAERS
176Nonspecific reactionFAERS: 1US FAERS
177Oral administration complicationFAERS: 1US FAERS
178PeriodontitisFAERS: 1US FAERS
179PneumoniaFAERS: 1US FAERS
180Poor quality drug administeredFAERS: 1US FAERS
181PresyncopeFAERS: 1US FAERS
182Product quality issueFAERS: 1US FAERS
183ProteinuriaFAERS: 1US FAERS
184Pulmonary EmbolismFAERS: 1US FAERS
185Pulmonary FibrosisFAERS: 1US FAERS
186Reaction to drug excipientsFAERS: 1US FAERS
187Renin increasedFAERS: 1US FAERS
188Respiratory arrestFAERS: 1US FAERS
189RetchingFAERS: 1US FAERS
190Rheumatoid ArthritisFAERS: 1US FAERS
191ScotomaFAERS: 1US FAERS
192Sensitivity to weather changeFAERS: 1US FAERS
193Serotonin SyndromeFAERS: 1US FAERS
194Sinus TachycardiaFAERS: 1US FAERS
195SunburnFAERS: 1US FAERS
196Therapeutic response changedFAERS: 1US FAERS
197Therapy non-responderFAERS: 1US FAERS
198Throat irritationFAERS: 1US FAERS
199TinnitusFAERS: 1US FAERS
200Urine osmolarity decreasedFAERS: 1US FAERS
201Visual ImpairmentFAERS: 1US FAERS
202Vocal Cord DysfunctionFAERS: 1US FAERS
203Walking aid userFAERS: 1US FAERS
204Wheelchair userFAERS: 1US FAERS
205WheezingFAERS: 1US FAERS
206Wrong drug administeredFAERS: 1US FAERS
207jaundiceFAERS: 1SIDER
US FAERS
208Abnormal visionOFFSIDES
209AbscessOFFSIDES
210AbuseOFFSIDES
211Accidental deathOFFSIDES
212Acid refluxOFFSIDES
213ActinomycosisOFFSIDES
214Acute bronchitisOFFSIDES
215Acute myocardial infarctionOFFSIDES
216Acute sinusitisOFFSIDES
217AdenomaOFFSIDES
218Altered bowel functionOFFSIDES
219AlveolitisOFFSIDES
220AmblyopiaOFFSIDES
221AmnesiaOFFSIDES
222Anal candidiasisOFFSIDES
223AnalgesiaOFFSIDES
224Anaphylactic shockSIDER
225Anaphylactoid ReactionSIDER
226AngerOFFSIDES
227AnhedoniaOFFSIDES
228AnhidrosisOFFSIDES
229Ankle FractureOFFSIDES
230Anorectal discomfortOFFSIDES
231AnorexiaOFFSIDES
232AnorgasmiaOFFSIDES
233Anticonvulsant drug level above therapeuticOFFSIDES
234Antinuclear antibody increasedOFFSIDES
235Aortic valve calcificationOFFSIDES
236Aortic valve sclerosisOFFSIDES
237ApneaOFFSIDES
238AppendectomyOFFSIDES
239Application site drynessOFFSIDES
240Application site erythemaOFFSIDES
241Application site pruritusOFFSIDES
242ArthritisOFFSIDES
243AspergillosisOFFSIDES
244Aspiration PneumoniaOFFSIDES
245AstigmatismOFFSIDES
246AtelectasisOFFSIDES
247Atrial FlutterOFFSIDES
248Atrial thrombosisOFFSIDES
249AuraOFFSIDES
250BelligerenceOFFSIDES
251Benign Prostatic HyperplasiaOFFSIDES
252BereavementOFFSIDES
253Bile Duct StenosisOFFSIDES
254Biopsy breast abnormalOFFSIDES
255BlastomycosisOFFSIDES
256BlepharoptosisOFFSIDES
257Blood GlucoseOFFSIDES
258Blood cholesterolOFFSIDES
259Blurred visionOFFSIDES
260Bone callus excessiveOFFSIDES
261Bone density decreasedOFFSIDES
262Bone erosionOFFSIDES
263Bone fragmentationOFFSIDES
264Bone lesionOFFSIDES
265BradycardiaOFFSIDES
266Brain scan abnormalOFFSIDES
267Brief psychotic disorder with marked stressorsOFFSIDES
268BronchitisOFFSIDES
269Bronchoalveolar lavage abnormalOFFSIDES
270Bulbar palsyOFFSIDES
271CalcinosisOFFSIDES
272Cardioactive drug level below therapeuticOFFSIDES
273CataractOFFSIDES
274Cerebral ventricle dilatationOFFSIDES
275Cervicobrachial syndromeOFFSIDES
276CholangiolitisOFFSIDES
277ChondromalaciaOFFSIDES
278ChromaturiaOFFSIDES
279Chronic sinusitisOFFSIDES
280Circumstance or information capable of leading to medication errorOFFSIDES
281CirrhosisOFFSIDES
282Clostridium difficile colitisOFFSIDES
283Cold sweatOFFSIDES
284Colon adenomaOFFSIDES
285Compression fractureOFFSIDES
286Congenital HypothyroidismOFFSIDES
287Congenital heart diseaseOFFSIDES
288Congenital tricuspid valve incompetenceOFFSIDES
289CyanosisOFFSIDES
290DebridementOFFSIDES
291DemyelinationOFFSIDES
292Dental FistulaOFFSIDES
293Dental abscessOFFSIDES
294Dental cariesOFFSIDES
295Dentofacial anomalyOFFSIDES
296Depressed moodOFFSIDES
297DermatitisSIDER
298DermatomyositisOFFSIDES
299DiabetesOFFSIDES
300Diabetes mellitus inadequate controlOFFSIDES
301Diabetic FootOFFSIDES
302Diaphragmatic HerniaOFFSIDES
303DiarrheaOFFSIDES
304Diastolic dysfunctionOFFSIDES
305DiverticulosisOFFSIDES
306DiverticulumOFFSIDES
307DrowsinessOFFSIDES
SIDER
308Drug addictOFFSIDES
309Drug exposure during pregnancyOFFSIDES
310Drug withdrawal headacheOFFSIDES
311Dry skinOFFSIDES
312Economic problemOFFSIDES
313EczemaOFFSIDES
314Ejection Fraction DecreasedOFFSIDES
315Emergency CareOFFSIDES
316Emotional disorderOFFSIDES
317Emotional distressOFFSIDES
318Endocervical curettageOFFSIDES
319Endodontic procedureOFFSIDES
320Endometrial disorderOFFSIDES
321Endometrial hypertrophyOFFSIDES
322Erectile dysfunctionOFFSIDES
323Esophageal StenosisOFFSIDES
324Eyelid DiseasesOFFSIDES
325Failure to ThriveOFFSIDES
326Fatty LiverOFFSIDES
327Flank PainOFFSIDES
328Fluid overloadOFFSIDES
329FormicationOFFSIDES
330Full blood count decreasedOFFSIDES
331GamblingOFFSIDES
332Gastrointestinal arteriovenous malformationOFFSIDES
333General physical health deteriorationOFFSIDES
334Gingival erythemaOFFSIDES
335Gingival graftOFFSIDES
336GranulocytosisOFFSIDES
337Hallucinations15454584CTD
338Hepatitis COFFSIDES
339HepatitisOFFSIDES
340HepatotoxicityOFFSIDES
341High frequency ablationOFFSIDES
342HyperkeratosisOFFSIDES
343HypoxiaOFFSIDES
344HysteroscopyOFFSIDES
345Incision site complicationOFFSIDES
346Infusion site mobility decreasedOFFSIDES
347Intention tremorOFFSIDES
348Intervertebral disc disorderOFFSIDES
349Intestinal ObstructionOFFSIDES
350Joint sprainOFFSIDES
351Joint stiffnessOFFSIDES
352Kidney FailureOFFSIDES
353LaryngospasmOFFSIDES
354Left atrial dilatationOFFSIDES
355LeukopeniaSIDER
356Life expectancy shortenedOFFSIDES
357Loose toothOFFSIDES
358Lumbar radiculopathyOFFSIDES
359Lymphocyte count decreasedOFFSIDES
360Mastication disorderOFFSIDES
361Mechanical ventilationOFFSIDES
362Mitral valve sclerosisOFFSIDES
363Modified radical mastectomyOFFSIDES
364Monoclonal immunoglobulin presentOFFSIDES
365Multiple MyelomaOFFSIDES
366Muscle WeaknessOFFSIDES
367Muscle relaxant drug level above therapeuticOFFSIDES
368Musculoskeletal chest painOFFSIDES
369Myeloma recurrenceOFFSIDES
370MyofascitisOFFSIDES
371MyopiaOFFSIDES
372Nasal discomfortOFFSIDES
373Nephrogenic Fibrosing DermopathyOFFSIDES
374NephrolithiasisOFFSIDES
375Nervous tensionOFFSIDES
376Neurogenic BowelOFFSIDES
377NocturiaOFFSIDES
378Nodule on extremityOFFSIDES
379NoduleOFFSIDES
380NystagmusCanada Vigilance: 1Canada Vigilance
381Oral Cavity FistulaOFFSIDES
382Oral fungal infectionOFFSIDES
383Oral mucosa atrophyOFFSIDES
384Oral pustuleOFFSIDES
385Oral torusOFFSIDES
386OsteolysisOFFSIDES
387OsteomyelitisOFFSIDES
388OsteopeniaOFFSIDES
389Pancreatic Duct StenosisOFFSIDES
390PancreatitisOFFSIDES
391Panic DisorderOFFSIDES
392Personality ChangeOFFSIDES
393PlasmacytomaOFFSIDES
394PlasmacytosisOFFSIDES
395PolyuriaOFFSIDES
396Post procedural complicationOFFSIDES
397Postmenopausal bleedingOFFSIDES
398PresbyopiaOFFSIDES
399Prescribed overdoseOFFSIDES
400Progesterone receptor assayOFFSIDES
401Psychiatric symptomOFFSIDES
402Pulmonary HypertensionOFFSIDES
403Pulmonary Valve StenosisOFFSIDES
404Pulmonary artery stenosisOFFSIDES
405Purulent dischargeOFFSIDES
406PyelonephritisOFFSIDES
407QRS axis abnormalOFFSIDES
408Quality of life decreasedOFFSIDES
409Reaction to preservativesOFFSIDES
410Reflux gastritisOFFSIDES
411Reflux laryngitisOFFSIDES
412Renal cystOFFSIDES
413Reticulocyte count increasedOFFSIDES
414RhinorrheaOFFSIDES
415Right Ventricular DysfunctionOFFSIDES
416Right Ventricular HypertrophyOFFSIDES
417Schizoaffective DisorderOFFSIDES
418SequestrectomyOFFSIDES
419Shoulder PainOFFSIDES
420SinusitisOFFSIDES
421Skin ErosionOFFSIDES
422Skin IndurationOFFSIDES
423Skin hypertrophyOFFSIDES
424Skin neoplasm excisionOFFSIDES
425Sphincter of Oddi DysfunctionOFFSIDES
426Spinal column stenosisOFFSIDES
427Stem cell transplantOFFSIDES
428StressOFFSIDES
429Sudden Cardiac DeathOFFSIDES
430Synovial CystOFFSIDES
431Temperature intoleranceOFFSIDES
432TendinitisOFFSIDES
433TensionSIDER
434Tobacco userOFFSIDES
435Tooth ExtractionOFFSIDES
436Tooth InfectionOFFSIDES
437Tooth LossOFFSIDES
438Tooth repairOFFSIDES
439TracheobronchitisOFFSIDES
440Umbilical hernia perforationOFFSIDES
441Unresponsive to stimuliOFFSIDES
442Uterine PolypOFFSIDES
443VIIth nerve paralysisOFFSIDES
444Vascular insufficiencyOFFSIDES
445Venous InsufficiencyOFFSIDES
446Venous stasisOFFSIDES
447Weight GainOFFSIDES
448Wound dehiscenceOFFSIDES
449XerosisOFFSIDES
450colonoscopyOFFSIDES
451fibromaOFFSIDES
452muscle injuryOFFSIDES
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