MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Amiloride

(XSDQTOBWRPYKKA-UHFFFAOYSA-N)

Structure

SMILES: NC(=NC(=O)c1nc(Cl)c(nc1N)N)N
Type(s): Approved
ATC code(s): C03DB01
Molecular Formula:: C6H8ClN7O
Molecular Weight:: 229.627
Log P:: 1.2710
Hydrogen Bond Acceptor:: 8
Hydrogen Bond Donor:: 4
TPSA:: 159.29
CAS Number(s):: 2609-46-3; 137053-86-2

Synonym(s)

Amiloride

Amidal

Amiduret Trom

Amiloberag

Amiloride Hydrochloride

Amiloride Hydrochloride, Anhydrous

Kaluril

Midamor

Midoride

10.

Modamide

11.

Anhydrous Amiloride Hydrochloride

12.

Hydrochloride, Amiloride

13.

Hydrochloride, Anhydrous Amiloride

14.

Trom, Amiduret

External Link(s)

MeSH	D000584
PubChem Compound	137319713 16231
BindingDB	16173
ChEBI	2639
CHEMBL	CHEMBL945
DrugBank	DB00594
DrugCentral	158
IUPHAR/BPS Guide to PHARMACOLOGY	2421
KEGG	cpd:C06821 dr:D07447
Therapeutic Target Database	D0I0RJ
ZINC	4340269

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Dizziness	FAERS: 1		SIDER US FAERS
2	Dysgeusia	FAERS: 1		US FAERS
3	Palpitations	FAERS: 1		SIDER US FAERS
4	Product quality issue	FAERS: 1		US FAERS
5	Weight decreased	FAERS: 1		US FAERS
6	Abdominal Infection			OFFSIDES
7	Abdominal Pain			OFFSIDES SIDER
8	Abdominal tenderness			OFFSIDES
9	Acid reflux			OFFSIDES
10	Acidosis			OFFSIDES
11	Acute glomerulonephritis			OFFSIDES
12	Acute kidney injury		3861973	CTD
13	Adenocarcinoma			OFFSIDES
14	Alkalosis		12185466	CTD
15	Alopecia			SIDER
16	Anger			OFFSIDES
17	Angina Pectoris		8062500	CTD SIDER
18	Anorexia			SIDER
19	Antipsychotic drug level increased			OFFSIDES
20	Anxiety			OFFSIDES
21	Application site erythema			OFFSIDES
22	Application site pain			OFFSIDES
23	Application site pruritus			OFFSIDES
24	Arthralgia			SIDER
25	Arthritis			OFFSIDES
26	Arthropathy			OFFSIDES
27	Asthenia			SIDER
28	Atelectasis			OFFSIDES
29	Atrial tachycardia			OFFSIDES
30	Back Pain			SIDER
31	Biliary dilatation			OFFSIDES
32	Bladder tamponade			OFFSIDES
33	Blood Glucose			OFFSIDES
34	Blood albumin decreased			OFFSIDES
35	Blood chloride decreased			OFFSIDES
36	Blood creatinine decreased			OFFSIDES
37	Blood creatinine increased			OFFSIDES
38	Blood glucose decreased			OFFSIDES
39	Blood potassium decreased			OFFSIDES
40	Blood potassium increased			OFFSIDES SIDER
41	Blood pressure fluctuation			OFFSIDES
42	Blood sodium			OFFSIDES
43	Blood urea increased			OFFSIDES
44	Blood uric acid			OFFSIDES
45	Bone lesion			OFFSIDES
46	Bradycardia			OFFSIDES SIDER
47	Bronchial secretion retention			OFFSIDES
48	Bronchopneumonia			OFFSIDES
49	Cancer Pain			OFFSIDES
50	Carcinoma, Transitional Cell		14644129	CTD
51	Cardiac Tamponade			OFFSIDES
52	Cataract			OFFSIDES
53	Cauda Equina Syndrome			OFFSIDES
54	Cellulitis			OFFSIDES
55	Chemotherapeutic drug level increased			OFFSIDES
56	Chest Pain			SIDER
57	Choking sensation			OFFSIDES
58	Cholangiolitis			OFFSIDES
59	Chondromalacia			OFFSIDES
60	Chronic Obstructive Airway Disease			OFFSIDES
61	Chronic left ventricular failure			OFFSIDES
62	Clostridium difficile toxin test positive			OFFSIDES
63	Colitis		12065299	CTD
64	Confabulation			OFFSIDES
65	Constipation			SIDER
66	Contact Dermatitis			OFFSIDES
67	Culture positive			OFFSIDES
68	Dehydration			OFFSIDES
69	Demyelination			OFFSIDES
70	Depressed mood			OFFSIDES
71	Dermatitis			SIDER
72	Diabetes Insipidus		4000192 7453952 12680486	CTD
73	Diabetic Nephropathy			OFFSIDES
74	Disease Progression			OFFSIDES
75	Disturbance in sexual arousal			SIDER
76	Diuresis			SIDER
77	Drowsiness			OFFSIDES
78	Drug Eruptions		11792017	CTD
79	Drug dispensing error			OFFSIDES
80	Drug toxicity			OFFSIDES
81	Dyspepsia			SIDER
82	Dysuria			SIDER
83	Ejection Fraction Decreased			OFFSIDES
84	Electrocardiogram change			OFFSIDES
85	Electromechanical dissociation			OFFSIDES
86	Emotional distress			OFFSIDES
87	Enterococcal infection			OFFSIDES
88	Enthesopathy			OFFSIDES
89	Enuresis			OFFSIDES
90	Eosinophilic myocarditis			OFFSIDES
91	Epistaxis			OFFSIDES
92	Erectile dysfunction			SIDER
93	Erosive gastritis			OFFSIDES
94	Eye inflammation			OFFSIDES
95	Fatigability			SIDER
96	Fatigue			SIDER
97	Febrile Neutropenia			OFFSIDES
98	Feeling abnormal			SIDER
99	Flatulence			SIDER
100	Fluid overload			OFFSIDES
101	Fullness abdominal			SIDER
102	Gastroenteritis			OFFSIDES
103	Gastrointestinal Pain			SIDER
104	General physical health deterioration			OFFSIDES
105	Granuloma			OFFSIDES
106	Growth Disorders		19703807	CTD
107	Headache			SIDER
108	Heart failure		7018361	CTD
109	Heartburn			SIDER
110	Hepatic Encephalopathy			SIDER
111	Hepatomegaly		21356098	CTD
112	Hepatotoxicity			OFFSIDES
113	Hernial eventration			OFFSIDES
114	Hyperkalemia		2770099 3188359 7365313	CTD
115	Hypokalemia		View details 3045028 3290263 3296979 6478730 7018361 7334141 7357812 10669191 11418519	CTD
116	Hypokalemic periodic paralysis		19822448	CTD
117	Hypomagnesemia 2, renal		10669191	CTD
118	Hyponatremia		11999238	CTD
119	Immune reconstitution syndrome			OFFSIDES
120	Inappropriate schedule of drug administration			OFFSIDES
121	Infection			OFFSIDES
122	Inflammation		17237260 21356098	CTD
123	Infusion site mobility decreased			OFFSIDES
124	Injection site dermatitis			OFFSIDES
125	Intestinal resection			OFFSIDES
126	Investigation abnormal			OFFSIDES
127	Kidney Failure			OFFSIDES
128	Laceration			OFFSIDES
129	Left Ventricular Hypertrophy			OFFSIDES
130	Leukopenia neonatal			OFFSIDES
131	Liddle Syndrome		12185466 19344079	CTD
132	Lung Diseases, Obstructive		11150940	CTD
133	Lung consolidation			OFFSIDES
134	Lymphangiosis carcinomatosa			OFFSIDES
135	Lymphoma			OFFSIDES
136	Malabsorption			OFFSIDES
137	Malignant neoplasm progression			OFFSIDES
138	Meningioma			OFFSIDES
139	Mental status changes			OFFSIDES
140	Metabolic acidosis			OFFSIDES
141	Metastases to thorax			OFFSIDES
142	Monocyte percentage decreased			OFFSIDES
143	Muscle Fatigue			OFFSIDES
144	Musculoskeletal discomfort			OFFSIDES SIDER
145	Myelodysplasia			OFFSIDES
146	Nausea			OFFSIDES SIDER
147	Neck Pain			SIDER
148	Neoplasm Invasiveness		14644129	CTD
149	Nephrogenic Diabetes Insipidus			OFFSIDES
150	Nervousness			SIDER
151	Neurological infection			OFFSIDES
152	Neutropenia			SIDER
153	Neutropenic colitis			OFFSIDES
154	Neutropenic infection			OFFSIDES
155	Neutropenic sepsis			OFFSIDES
156	Non-cardiac chest pain			OFFSIDES
157	Oral pruritus			SIDER
158	Osteopenia			OFFSIDES
159	Osteoporosis			OFFSIDES
160	Osteosclerosis			OFFSIDES
161	Pain		19109946	CTD OFFSIDES SIDER
162	Peptic Ulcer			SIDER
163	Pericardial effusion			OFFSIDES
164	Physical disability			OFFSIDES
165	Polyuria		3538913 3969096 20344995	CTD OFFSIDES SIDER
166	Post procedural pain			OFFSIDES
167	Pruritus			SIDER
168	Pulmonary Hypertension			OFFSIDES
169	Pulmonary toxicity			OFFSIDES
170	Pustular psoriasis			OFFSIDES
171	Pyelonephritis			OFFSIDES
172	Rales			OFFSIDES
173	Renal Insufficiency		1115255	CTD
174	Reperfusion Injury		17356886	CTD
175	Respiratory Failure	Canada Vigilance: 1		Canada Vigilance OFFSIDES
176	Rheumatoid Nodule			OFFSIDES
177	Seizures		18572151	CTD
178	Serum potassium increased			SIDER
179	Shock			SIDER
180	Sinusitis			OFFSIDES
181	Smoker			OFFSIDES
182	Somnolence			SIDER
183	Splenic cyst			OFFSIDES
184	Status Epilepticus		18572151	CTD
185	Subileus			OFFSIDES
186	Superficial Thrombophlebitis			OFFSIDES
187	Superior Vena Cava Syndrome			OFFSIDES
188	Synovial Cyst			OFFSIDES
189	Tension			SIDER
190	Therapy non-responder			OFFSIDES
191	Thirst			SIDER
192	Tinnitus	Canada Vigilance: 1		Canada Vigilance SIDER
193	Transaminases increased			OFFSIDES
194	Tremor			SIDER
195	Urethral Obstruction			OFFSIDES
196	Urine ketone body present			OFFSIDES
197	Urine output increased			SIDER
198	Urticaria		11792017	CTD
199	Vasospasm			OFFSIDES
200	Venous occlusion			OFFSIDES
201	Vertigo			SIDER
202	Viral pharyngitis			OFFSIDES
203	Visual Impairment			SIDER
204	Visual disturbance			OFFSIDES SIDER
205	Vomiting			SIDER
206	Wound Infection			OFFSIDES
207	Wrong drug administered			OFFSIDES
208	effusion			OFFSIDES
209	jaundice			SIDER

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