MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Orphenadrine

(QVYRGXJJSLMXQH-UHFFFAOYSA-N)

Structure

SMILES: CN(CCOC(c1ccccc1C)c1ccccc1)C
Type(s): Approved
ATC code(s): M03BC01; M03BC51; N04AB02
Molecular Formula:: C18H23NO
Molecular Weight:: 269.381
Log P:: 3.6626
Hydrogen Bond Acceptor:: 2
Hydrogen Bond Donor:: 0
TPSA:: 12.47
CAS Number(s):: 83-98-7

Synonym(s)

Orphenadrine

Methyldiphenylhydramine

Disipal

Lysantin

Mefenamine

Mephenamine

Norflex

Norflex Orphenadrine Citrate

Orphenadrine Citrate

10.

Orphenadrine Hydrochloride

11.

Sodium Mefenamine

12.

Citrate, Norflex Orphenadrine

13.

Citrate, Orphenadrine

14.

Hydrochloride, Orphenadrine

15.

Mefenamine, Sodium

16.

Orphenadrine Citrate, Norflex

External Link(s)

MeSH	D009966
PubChem Compound	4601
BindingDB	50062614
ChEBI	7789
CHEMBL	CHEMBL900
DrugBank	DB01173
DrugCentral	1999
IUPHAR/BPS Guide to PHARMACOLOGY	7251
KEGG	cpd:C07935 dr:D08305
Therapeutic Target Database	D0D9FV

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Bradycardia	FAERS: 1		US FAERS
2	Chest Pain	FAERS: 1		OFFSIDES US FAERS
3	Dry skin	FAERS: 1		OFFSIDES US FAERS
4	Musculoskeletal Pain	FAERS: 1		OFFSIDES US FAERS
5	Nausea	FAERS: 1		OFFSIDES SIDER US FAERS
6	Product substitution issue	FAERS: 1		US FAERS
7	Radiculopathy	FAERS: 1		US FAERS
8	Rhabdomyolysis	FAERS: 1		US FAERS
9	Stupor	FAERS: 1		US FAERS
10	Suicide attempt	FAERS: 1		US FAERS
11	Syncope	FAERS: 1	16700864	CTD US FAERS
12	Abasia			OFFSIDES
13	Abdominal Pain			OFFSIDES
14	Abdominal discomfort			OFFSIDES
15	Abscess			OFFSIDES
16	Acanthoma			OFFSIDES
17	Accidental overdose			OFFSIDES
18	Acid reflux			OFFSIDES
19	Acne			OFFSIDES
20	Activities of daily living impaired			OFFSIDES
21	Acute Coronary Syndrome			OFFSIDES
22	Acute bronchitis			OFFSIDES
23	Acute myocardial infarction			OFFSIDES
24	Acute psychosis			OFFSIDES
25	Acute sinusitis			OFFSIDES
26	Adverse event			OFFSIDES
27	Agitation			SIDER
28	Alcohol consumption			OFFSIDES
29	Alopecia			OFFSIDES
30	Alveolitis			OFFSIDES
31	Amnesia			OFFSIDES
32	Analgesia			OFFSIDES
33	Anaphylactic shock			SIDER
34	Anger			OFFSIDES
35	Anhedonia			OFFSIDES
36	Anhidrosis			OFFSIDES
37	Ankle Fracture			OFFSIDES
38	Anoxic Encephalopathy			OFFSIDES
39	Anxiety			OFFSIDES
40	Apnea			OFFSIDES
41	Arteriosclerosis			OFFSIDES
42	Arteriovenous fistula thrombosis			OFFSIDES
43	Arthritis			OFFSIDES
44	Arthropathy			OFFSIDES
45	Arthropod bite			OFFSIDES
46	Aseptic Meningitis			OFFSIDES
47	Aspiration Pneumonia			OFFSIDES
48	Asthenia			OFFSIDES SIDER
49	Asthma			OFFSIDES
50	Atelectasis			OFFSIDES
51	Atrial Fibrillation		11599527	CTD
52	Atrial Flutter			OFFSIDES
53	Atrial tachycardia			OFFSIDES
54	Aura			OFFSIDES
55	Basal cell carcinoma			OFFSIDES
56	Bedridden			OFFSIDES
57	Biliary Dyskinesia			OFFSIDES
58	Biopsy site unspecified abnormal			OFFSIDES
59	Biopsy			OFFSIDES
60	Bipolar Disorder			OFFSIDES
61	Bipolar I disorder			OFFSIDES
62	Blepharospasm			OFFSIDES
63	Blood Glucose			OFFSIDES
64	Blood cholesterol			OFFSIDES
65	Blood immunoglobulin G increased			OFFSIDES
66	Blood iron increased			OFFSIDES
67	Blood magnesium decreased			OFFSIDES
68	Blood potassium decreased			OFFSIDES
69	Blood potassium increased			OFFSIDES
70	Blood pressure fluctuation			OFFSIDES
71	Blood sodium increased			OFFSIDES
72	Blood sodium			OFFSIDES
73	Blood triglycerides increased			OFFSIDES
74	Blurred vision			OFFSIDES
75	Bone density decreased			OFFSIDES
76	Brain natriuretic peptide increased			OFFSIDES
77	Breast Cyst			OFFSIDES
78	Breast cancer stage II			OFFSIDES
79	Breast fibroma			OFFSIDES
80	Bronchitis			OFFSIDES
81	Bruxism			OFFSIDES
82	Bursitis			OFFSIDES
83	Cardiac Tamponade			OFFSIDES
84	Cardioactive drug level increased			OFFSIDES
85	Cardiotoxicity			OFFSIDES
86	Carotid bruit			OFFSIDES
87	Cataract			OFFSIDES
88	Cellulitis			OFFSIDES
89	Cerebral atrophy			OFFSIDES
90	Cervical polyp			OFFSIDES
91	Cervicobrachial syndrome			OFFSIDES
92	Chemical and Drug Induced Liver Injury		22331495	CTD
93	Chest wall pain			OFFSIDES
94	Choking sensation			OFFSIDES
95	Chondroplasty			OFFSIDES
96	Chronic Fatigue Syndrome			OFFSIDES
97	Chronic Obstructive Airway Disease			OFFSIDES
98	Chronic sinusitis			OFFSIDES
99	Clostridium difficile colitis			OFFSIDES
100	Cognition Disorders		1220958	CTD
101	Completed Suicide			OFFSIDES
102	Confabulation			OFFSIDES
103	Confusion		1787292	CTD
104	Congenital tricuspid valve incompetence			OFFSIDES
105	Consciousness Disorders		216517	CTD
106	Constipation			SIDER
107	Contact Dermatitis			OFFSIDES
108	Conversion disorder			OFFSIDES
109	Corneal dystrophy			OFFSIDES
110	Crying			OFFSIDES
111	Cystocele			OFFSIDES
112	Cyst			OFFSIDES
113	Deafness			OFFSIDES
114	Debridement			OFFSIDES
115	Dehydration			OFFSIDES
116	Delusional disorder, unspecified type			OFFSIDES
117	Demyelination			OFFSIDES
118	Dependence			OFFSIDES
119	Depressive disorder		800383 1220958	CTD
120	Diabetes			OFFSIDES
121	Diabetes mellitus inadequate control			OFFSIDES
122	Diabetic Retinopathy			OFFSIDES
123	Diabetic ulcer			OFFSIDES
124	Diarrhea			OFFSIDES
125	Diplopia			OFFSIDES
126	Diverticulosis			OFFSIDES
127	Diverticulum			OFFSIDES
128	Dizziness			OFFSIDES SIDER
129	Drowsiness			OFFSIDES SIDER
130	Drug Tolerance			OFFSIDES
131	Drug abuser			OFFSIDES
132	Drug addict			OFFSIDES
133	Drug administration error			OFFSIDES
134	Drug ineffective			OFFSIDES
135	Drug screen positive			OFFSIDES
136	Drug toxicity			OFFSIDES
137	Drug withdrawal headache			OFFSIDES
138	Dysgraphia			OFFSIDES
139	Dyskinesia, Drug-Induced		216517 4155220	CTD
140	Dyspepsia			OFFSIDES
141	Dysphonia			OFFSIDES
142	Dyspnoea exacerbated			OFFSIDES
143	Dysthymic Disorder			OFFSIDES
144	Dystonia		11155505	CTD OFFSIDES
145	Ear discharge			OFFSIDES
146	Economic problem			OFFSIDES
147	Eczema			OFFSIDES
148	Ejection Fraction Decreased			OFFSIDES
149	Electromyogram abnormal			OFFSIDES
150	Emotional distress			OFFSIDES
151	Eosinophilic myocarditis			OFFSIDES
152	Epicondylitis			OFFSIDES
153	Epigastric discomfort			SIDER
154	Epistaxis			OFFSIDES
155	Erythema			OFFSIDES
156	Excoriation			OFFSIDES
157	Fat necrosis			OFFSIDES
158	Fatigue			OFFSIDES
159	Feeling abnormal			SIDER
160	Fibromyalgia			OFFSIDES
161	Flank Pain			OFFSIDES
162	Formication			OFFSIDES
163	Gambling			OFFSIDES
164	Gangrene			OFFSIDES
165	Gastric irritation			SIDER
166	Gastric ulcer			OFFSIDES
167	Gastrointestinal motility disorder			OFFSIDES
168	General physical health deterioration			OFFSIDES
169	Glaucoma			OFFSIDES
170	Goiter			OFFSIDES
171	Graft infection			OFFSIDES
172	Granulocytosis			OFFSIDES
173	Grip strength			OFFSIDES
174	Hallucinations		1220958	CTD
175	Headache		5964267	CTD SIDER
176	Hemiplegia			OFFSIDES
177	Hepatic necrosis			OFFSIDES
178	Hepatomegaly		23665940	CTD
179	Hilar lymphadenopathy			OFFSIDES
180	Hostility			OFFSIDES
181	Hyperalgesia		15553107 15991879	CTD
182	Hyperkeratosis			OFFSIDES
183	Hypersensitivity			SIDER
184	Hypophagia			OFFSIDES
185	Immobile			OFFSIDES
186	Impaired gastric emptying			OFFSIDES
187	Impaired work ability			OFFSIDES
188	Incontinence			OFFSIDES
189	Increased bronchial secretion			OFFSIDES
190	Infusion site mobility decreased			OFFSIDES
191	Injection site irritation			OFFSIDES
192	Injection site mass			OFFSIDES
193	Intention tremor			OFFSIDES
194	Intentional drug misuse			OFFSIDES
195	Intentional misuse			OFFSIDES
196	Intertrigo			OFFSIDES
197	Intervertebral Disc Degeneration			OFFSIDES
198	Intervertebral disc disorder			OFFSIDES
199	Intestinal Obstruction			OFFSIDES
200	Intestinal infarction			OFFSIDES
201	Iron Overload			OFFSIDES
202	Joint Range of Motion Decreased			OFFSIDES
203	Joint injury			OFFSIDES
204	Joint sprain			OFFSIDES
205	Joint stiffness			OFFSIDES
206	Laryngospasm			OFFSIDES
207	Left Ventricular Hypertrophy			OFFSIDES
208	Left atrial dilatation			OFFSIDES
209	Lethargy			OFFSIDES
210	Limb injury			OFFSIDES
211	Loose tooth			OFFSIDES
212	Lumbar radiculopathy			OFFSIDES
213	Lymphohistiocytosis			OFFSIDES
214	Markedly reduced dietary intake			OFFSIDES
215	Mastectomy			OFFSIDES
216	Mastoiditis			OFFSIDES
217	Mental impairment			OFFSIDES
218	Middle insomnia			OFFSIDES
219	Mitral Valve Stenosis			OFFSIDES
220	Multiple Sclerosis			OFFSIDES
221	Multiple drug overdose			OFFSIDES
222	Multiple drug overdose intentional			OFFSIDES
223	Multiple sclerosis relapse			OFFSIDES
224	Muscle Fatigue			OFFSIDES
225	Muscle Hypertonia		216517	CTD
226	Muscle Weakness			OFFSIDES
227	Muscle necrosis			OFFSIDES
228	Muscle strain			OFFSIDES
229	Muscle tightness			OFFSIDES
230	Musculoskeletal chest pain			OFFSIDES
231	Musculoskeletal stiffness			OFFSIDES
232	Mydriasis			SIDER
233	Myoclonus		7439114	CTD
234	Nasopharyngitis			OFFSIDES
235	Nephrolithiasis			OFFSIDES
236	Nerve Root Compression			OFFSIDES
237	Nervous tension			OFFSIDES
238	Neuralgia			OFFSIDES
239	Neuropsychological test abnormal			OFFSIDES
240	Oliguria			OFFSIDES
241	Onychalgia			OFFSIDES
242	Opiates positive			OFFSIDES
243	Oropharyngeal pain			OFFSIDES
244	Osteitis Deformans			OFFSIDES
245	Osteolysis			OFFSIDES
246	Osteopenia			OFFSIDES
247	Osteoporosis			OFFSIDES
248	Other dermatoses			SIDER
249	Overdose			OFFSIDES
250	PCO2 decreased			OFFSIDES
251	Pain			OFFSIDES
252	Palpitations			SIDER
253	Paranoia			OFFSIDES
254	Paraplegia			OFFSIDES
255	Parent-child problem			OFFSIDES
256	Parkinson Disease		3002197 11599527	CTD
257	Pathogen resistance			OFFSIDES
258	Pericardial effusion			OFFSIDES
259	Pharyngolaryngeal Pain			OFFSIDES
260	Pleurisy			OFFSIDES
261	Poisoning		7292637	CTD
262	Polyneuropathy			OFFSIDES
263	Polysubstance abuse			OFFSIDES
264	Poor peripheral circulation			OFFSIDES
265	Poor quality sleep			OFFSIDES
266	Post procedural fistula			OFFSIDES
267	Post procedural infection			OFFSIDES
268	Postoperative abscess			OFFSIDES
269	Prescribed overdose			OFFSIDES
270	Protein total increased			OFFSIDES
271	Pruritus			SIDER
272	Psychiatric symptom			OFFSIDES
273	Pulmonary Hypertension			OFFSIDES
274	Pulmonary congestion			OFFSIDES
275	Pulmonary toxicity			OFFSIDES
276	Purulent discharge			OFFSIDES
277	Pyoderma Gangrenosum			OFFSIDES
278	Radiation associated pain			OFFSIDES
279	Radiation skin injury			OFFSIDES
280	Regurgitation			OFFSIDES
281	Renal Colic			OFFSIDES
282	Respiratory Failure			OFFSIDES
283	Rheumatoid factor increased			OFFSIDES
284	Rhinorrhea			OFFSIDES
285	Right atrial dilatation			OFFSIDES
286	Scab			OFFSIDES
287	Schizophrenia			OFFSIDES
288	Septic Shock			OFFSIDES
289	Shoulder Pain			OFFSIDES
290	Sinus bradycardia			OFFSIDES
291	Sinusitis			OFFSIDES
292	Skin lesion			OFFSIDES
293	Skin necrosis			OFFSIDES
294	Somnolence			SIDER
295	Staphylococcal abscess			OFFSIDES
296	Stenotrophomonas infection			OFFSIDES
297	Stress			OFFSIDES
298	Subcutaneous Abscess			OFFSIDES
299	Supraventricular tachycardia			OFFSIDES
300	Synovitis			OFFSIDES
301	Tachycardia, Ventricular		1787292 11599527	CTD
302	Tachycardia			SIDER
303	Tendinitis			OFFSIDES
304	Tension			SIDER
305	Tetany			OFFSIDES
306	Thoracic vertebral fracture			OFFSIDES
307	Tinnitus			OFFSIDES
308	Tongue biting			OFFSIDES
309	Torsades de Pointes		16700864	CTD
310	Tremor			SIDER
311	Trigonitis			OFFSIDES
312	Ulcer			OFFSIDES
313	Ulnar Neuritis			OFFSIDES
314	Unresponsive to stimuli			OFFSIDES
315	Urinary hesitation			SIDER
316	Urticaria			SIDER
317	Uterine Cancer			OFFSIDES
318	Vascular calcification			OFFSIDES
319	Venous stasis			OFFSIDES
320	Venous thrombosis limb			OFFSIDES
321	Ventricular Fibrillation			OFFSIDES
322	Ventricular hypokinesia			OFFSIDES
323	Viral labyrinthitis			OFFSIDES
324	Viral myocarditis			OFFSIDES
325	Viral pharyngitis			OFFSIDES
326	Vomiting			SIDER
327	Wound infection pseudomonas			OFFSIDES
328	Wound necrosis			OFFSIDES
329	effusion			OFFSIDES
330	muscle injury			OFFSIDES
331	prostatitis			OFFSIDES

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120239