MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Desflurane

(DPYMFVXJLLWWEU-UHFFFAOYSA-N)

Structure

SMILES: FC(OC(C(F)(F)F)F)F
Type(s): Approved
ATC code(s): N01AB07
Molecular Formula:: C3H2F6O
Molecular Weight:: 168.038
Log P:: 2.0835
Hydrogen Bond Acceptor:: 1
Hydrogen Bond Donor:: 0
TPSA:: 9.23
CAS Number(s):: 57041-67-5

Synonym(s)

Desflurane

1,2,2,2-Tetrafluoroethyl difluoromethyl ether

I 653

I-653

I653

Suprane

External Link(s)

MeSH	D000077335
PubChem Compound	42113
ChEBI	4445
CHEMBL	CHEMBL1200733
DrugBank	DB01189
DrugCentral	811
IUPHAR/BPS Guide to PHARMACOLOGY	7156
KEGG	cpd:C07519 dr:D00546
Therapeutic Target Database	D0H4GN

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Bradycardia	FAERS: 26	7577293 8210002	CTD OFFSIDES SIDER US FAERS
2	Accidental exposure	FAERS: 11		OFFSIDES US FAERS
3	Hypotension	FAERS: 9	View details 1524238 2001030 8210002 12059896 12073197 12968239 16077295	CTD SIDER US FAERS
4	Post procedural complication	FAERS: 9		OFFSIDES US FAERS
5	Cardiac Arrest	FAERS: 8		SIDER US FAERS
6	Hepatitis	FAERS: 7		OFFSIDES SIDER US FAERS
7	Increased upper airway secretion	FAERS: 6		OFFSIDES US FAERS
8	Device malfunction	FAERS: 5		OFFSIDES US FAERS
9	Drug ineffective	FAERS: 5		US FAERS
10	Eye irritation	FAERS: 5		SIDER US FAERS
11	Post procedural pneumonia	FAERS: 5		US FAERS
12	Accidental exposure to product	FAERS: 4		US FAERS
13	Choking	FAERS: 4		US FAERS
14	Device Failure	FAERS: 4		OFFSIDES US FAERS
15	Asthma	FAERS: 3		SIDER US FAERS
16	Bronchospasm	FAERS: 3		SIDER US FAERS
17	Exposure via direct contact	FAERS: 3		US FAERS
18	Hepatotoxicity	FAERS: 3		OFFSIDES US FAERS
19	Incorrect dose administered by device	FAERS: 3		US FAERS
20	Occupational exposure to product	FAERS: 3		US FAERS
21	Overdose	FAERS: 3		OFFSIDES US FAERS
22	Pulmonary Embolism	FAERS: 3		US FAERS
23	Pulmonary granuloma	FAERS: 3		US FAERS
24	Respiratory Failure	FAERS: 3		OFFSIDES SIDER US FAERS
25	Tachycardia	FAERS: 3	View details 7577293 8210002 8363068 16037151	CTD SIDER US FAERS
26	Thrombosis	FAERS: 3		US FAERS
27	Agitation	FAERS: 2		SIDER US FAERS
28	Airway peak pressure increased	FAERS: 2		US FAERS
29	Carbon dioxide increased	FAERS: 2		SIDER US FAERS
30	Cardiac enzymes increased	FAERS: 2		OFFSIDES US FAERS
31	Cytolytic hepatitis	FAERS: 2		OFFSIDES SIDER US FAERS
32	Delirium	FAERS: 2		US FAERS
33	Device interaction	FAERS: 2		OFFSIDES US FAERS
34	Disease recurrence	FAERS: 2		US FAERS
35	Drug level decreased	FAERS: 2		US FAERS
36	Exposure via eye contact	FAERS: 2		US FAERS
37	Eye Burns	FAERS: 2		OFFSIDES SIDER US FAERS
38	Laryngospasm	FAERS: 2		OFFSIDES SIDER US FAERS
39	Mydriasis	FAERS: 2		US FAERS
40	No adverse event	FAERS: 2		US FAERS
41	Pneumothorax	FAERS: 2		US FAERS
42	Product deposit	FAERS: 2		US FAERS
43	Product quality issue	FAERS: 2		OFFSIDES US FAERS
44	Suture related complication	FAERS: 2		OFFSIDES US FAERS
45	Tachyarrhythmia	FAERS: 2		SIDER US FAERS
46	Visual Impairment	FAERS: 2		US FAERS
47	Blood pressure fluctuation	FAERS: 1		US FAERS
48	Bronchopulmonary Dysplasia	FAERS: 1		US FAERS
49	Chemical burns of eye	FAERS: 1		US FAERS
50	Chills	FAERS: 1		US FAERS
51	Conjunctival ulcer	FAERS: 1		US FAERS
52	Corneal irritation	FAERS: 1		US FAERS
53	Device alarm issue	FAERS: 1		US FAERS
54	Device breakage	FAERS: 1		US FAERS
55	Device connection issue	FAERS: 1		US FAERS
56	Dizziness	FAERS: 1		SIDER US FAERS
57	Electrocardiogram ST segment abnormal	FAERS: 1		US FAERS
58	Epilepsy	FAERS: 1		US FAERS
59	Eye pain	FAERS: 1		SIDER US FAERS
60	Fatigue	FAERS: 1		SIDER US FAERS
61	Flushing	FAERS: 1	8363068	CTD US FAERS
62	Headache	FAERS: 1		SIDER US FAERS
63	Hepatic necrosis	FAERS: 1		SIDER US FAERS
64	Hypersensitivity	FAERS: 1		US FAERS
65	Hypoventilation	FAERS: 1		US FAERS
66	Malaise	FAERS: 1		SIDER US FAERS
67	Medical device complication	FAERS: 1		OFFSIDES US FAERS
68	Memory impairment	FAERS: 1		US FAERS
69	Nausea	FAERS: 1		SIDER US FAERS
70	Occupational exposure to drug	FAERS: 1		US FAERS
71	Procedural nausea	FAERS: 1		US FAERS
72	Procedural vomiting	FAERS: 1		US FAERS
73	Punctate keratitis	FAERS: 1		US FAERS
74	Somnolence	FAERS: 1		US FAERS
75	Supraventricular tachycardia	FAERS: 1		US FAERS
76	Tympanic Membrane Perforation	FAERS: 1		US FAERS
77	Upper airway obstruction	FAERS: 1		US FAERS
78	Vascular occlusion	FAERS: 1		US FAERS
79	jaundice	FAERS: 1		SIDER US FAERS
80	Abdominal Pain			SIDER
81	Acidosis			OFFSIDES
82	Acute Coronary Syndrome			SIDER
83	Adenocarcinoma			OFFSIDES
84	Agraphia			OFFSIDES
85	Airway Obstruction		8363068	CTD
86	Alanine Aminotransferase Increased			OFFSIDES SIDER
87	Alveolitis			OFFSIDES
88	Ammonia increased			SIDER
89	Anticholinergic Syndrome			OFFSIDES
90	Anuria			OFFSIDES
91	Apathy			OFFSIDES
92	Apnea		16987347	CTD
93	Aspartate Aminotransferase Increased			SIDER
94	Asthenia			SIDER
95	Atrial Fibrillation			SIDER
96	Bladder spasm			OFFSIDES
97	Blood alkaline phosphatase increased			OFFSIDES
98	Blood and lymphatic system disorders			SIDER
99	Blood creatinine increased			SIDER
100	Blood glucose fluctuation			OFFSIDES
101	Blood phosphorus increased			OFFSIDES
102	Blood potassium			OFFSIDES
103	Breath Holding			SIDER
104	Carotid pulse decreased			OFFSIDES
105	Chemical and Drug Induced Liver Injury		11873055 12934853 17513640	CTD
106	Cholangiolitis			OFFSIDES
107	Cholestasis			SIDER
108	Chronic left ventricular failure			OFFSIDES
109	Cirrhosis			OFFSIDES
110	Coagulation test abnormal			SIDER
111	Cognition Disorders		20042477	CTD
112	Congenital pyelocaliectasis			OFFSIDES
113	Conjunctivitis			SIDER
114	Corneal Ulcer			OFFSIDES
115	Creatinine increased			SIDER
116	Creatinine renal clearance decreased			OFFSIDES
117	Cyanosis			SIDER
118	Cystostomy			OFFSIDES
119	Discomfort			SIDER
120	Drug administration error			SIDER
121	Dysmorphism	Canada Vigilance: 1		Canada Vigilance
122	Ejection Fraction Decreased			OFFSIDES
123	Electrocardiogram ST-T change			SIDER
124	Electrocardiogram abnormal			SIDER
125	Endophthalmitis			SIDER
126	Eosinophilic myocarditis			OFFSIDES
127	Erythema			SIDER
128	Fatty Liver			OFFSIDES
129	Feeling abnormal			SIDER
130	Fluid overload			SIDER
131	Gamma-Glutamyltransferase Increased			OFFSIDES
132	Gastrointestinal Pain			SIDER
133	Glycosuria		11149433	CTD
134	Grip strength			OFFSIDES
135	Heart Block		18323319	CTD
136	Heat exposure injury			OFFSIDES
137	Hepatic congestion			OFFSIDES
138	Hepatitis A			OFFSIDES
139	Hypercapnia			SIDER
140	Hypokinesia			OFFSIDES
141	Hypoxia			OFFSIDES SIDER
142	Infection			SIDER
143	Infestation			SIDER
144	Keratitis			SIDER
145	Liver Failure, Acute		18759731	CTD
146	Long QT Syndrome		18323319	CTD
147	Malignant Hypertension			SIDER
148	Malnutrition			SIDER
149	Metabolic acidosis			OFFSIDES SIDER
150	Mixed liver injury			OFFSIDES
151	Muscle Rigidity			SIDER
152	Muscle Weakness			OFFSIDES
153	Musculoskeletal discomfort			SIDER
154	Myalgia			SIDER
155	Myocardial Infarction			SIDER
156	Myocardial Ischemia		10051940 12968239	CTD
157	Ocular icterus			SIDER
158	Oliguria			OFFSIDES
159	Opisthotonus			OFFSIDES
160	Oropharyngeal spasm			OFFSIDES
161	Oxygen saturation abnormal			OFFSIDES
162	Palpitations			SIDER
163	Pharyngitis			SIDER
164	Polyuria			OFFSIDES
165	Post procedural discharge			OFFSIDES
166	Procedural hypotension			OFFSIDES
167	Proteinuria		11149433	CTD
168	Prothrombin time ratio decreased			OFFSIDES
169	Pruritus			SIDER
170	Pulmonary congestion			OFFSIDES
171	Pulmonary function test decreased			SIDER
172	Reperfusion Injury		15781515	CTD
173	Respiratory Depression			SIDER
174	Respiratory arrest			SIDER
175	Respiratory distress			SIDER
176	Rhabdomyolysis			OFFSIDES SIDER
177	Seizures		9768802	CTD
178	Serum Sickness			OFFSIDES
179	Shock			SIDER
180	Splenic Infarction			OFFSIDES
181	Sputum culture positive			OFFSIDES
182	Subileus			OFFSIDES
183	Toxoplasmosis			OFFSIDES
184	Transaminases increased			OFFSIDES SIDER
185	Urticaria			SIDER
186	Vasodilation procedure			SIDER
187	Vasodilation			SIDER
188	Ventricular bigeminy			SIDER
189	Ventricular failure			SIDER
190	Ventricular hypokinesia			SIDER
191	Vomiting			SIDER
192	nervous system disorder			SIDER

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