MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

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(JUVIOZPCNVVQFO-HBGVWJBISA-N)

Structure

SMILES: COc1cc2c(cc1OC)OC[C@@H]1[C@H]2C(=O)c2c(O1)c1C[C@@H](Oc1cc2)C(=C)C
Type(s): Vet_approved
Molecular Formula:: C23H22O6
Molecular Weight:: 394.417
Log P:: 3.7033
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 0
TPSA:: 63.22
CAS Number(s):: 83-79-4

Synonym(s)

Rotenone

External Link(s)

MeSH	D012402
PubChem Compound	6758
BindingDB	50135527
ChEBI	28201
CHEMBL	CHEMBL429023
DrugBank	DB11457
KEGG	cpd:C07593
Therapeutic Target Database	D0F7CS
ZINC	3860715

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Acute kidney injury	30099449	CTD
2	Agricultural Workers' Diseases	21269927 24120951	CTD
3	Anxiety Disorders	28238857	CTD
4	Blindness	20628600	CTD
5	Bone Diseases	28374803	CTD
6	Bone Resorption	19900598	CTD
7	Brain Injuries	View details 12504863 14645467 14766796 15635186 15854587 16118017 16219024 17459145 18197244 18289173 18803299 19385059 19626387	CTD
8	Catalepsy	View details 12385818 15635186 16118017 18308296 18817789 19616571 21807080 27016191 27252111	CTD
9	Cataract	24569607	CTD
10	Cerebrovascular Disorders	19276049	CTD
11	Chemical and Drug Induced Liver Injury	22331495 28110601	CTD
12	Chromosome Breakage	25428620	CTD
13	Depressive disorder	27866991	CTD
14	Dystonia	14766796 16219024	CTD
15	Encephalomalacia	30222980	CTD
16	Gastrointestinal Diseases	14766796	CTD
17	Gliosis	17367952 27252111 30222980	CTD
18	Hemorrhage	19276049	CTD
19	Hyperalgesia	16472913	CTD
20	Hypokinesia	View details 11100151 14766796 15635186 16219024 18289173 18308296 18817789 19385059 19616571 21736921	CTD
21	Inflammation	15720824 27317300	CTD
22	Lewy Body Disease	15280438	CTD
23	Liver Failure, Acute	24830863	CTD
24	Liver diseases	28374803	CTD
25	Memory Disorders	28238857	CTD
26	Mitochondrial Diseases	20414966 26075822	CTD
27	Motor Disorders	26770656 27016191	CTD
28	Motor Neuron Disease	17367952	CTD
29	Motor Skills Disorders	25446674 27425033 31251943	CTD
30	Movement Disorders	View details 15574749 17459145 17520785 18803299 25502462 27252111 27866991 30472438	CTD
31	Muscle Rigidity	View details 11100151 18817789 19385059 25446674	CTD
32	Necrosis	View details 7931358 10486581 16580092 25725130 27252111	CTD
33	Nerve Degeneration	View details 7824183 11826108 14766796 15280438 15574749 15790535 16490285 17356569 18206288 18619942 18804145 19580850 21807080 26446018 27585560 30222980	CTD
34	Neuralgia	16472913	CTD
35	Neurobehavioral Manifestations	23639798 25481089 30328585	CTD
36	Neuromuscular Manifestations	20371261	CTD
37	Neurotoxicity Syndromes	View details 14741061 19744517 22521218 23593274	CTD
38	Olfaction Disorders	27866991	CTD
39	Optic Atrophy, Hereditary, Leber	20628600 24569607	CTD
40	Parkinson Disease	View details 11445065 11535288 15280438 15451049 16140633 16412576 18191903 18619942 19114014 19232380 19276049 19385059 19681169 21269927 21807080 24120951 25461423 27473339	CTD
41	Parkinsonian Disorders	View details 12177198 15574749 15635186 15790535 15795934 15927086 16115015 16490285 18155613 18197244 18308296 18579341 20143419 21383081 21524431 21736921 22041943 23073839 23295396 23357119 23783886 24451142 24755484 25430725 25446015 26075822 26705857 26806867 27016191 27180985 27252111 28238857 28389404 30222980	CTD
42	Poisoning	9282833 27535828 30472438	CTD
43	Reperfusion Injury	15720824	CTD
44	Retinal Degeneration	19384599	CTD
45	Sialorrhea	21807080	CTD
46	Signs and Symptoms, Respiratory	21807080	CTD
47	Sleep Wake Disorders	15854587 17520785	CTD
48	Splenic Diseases	28374803	CTD
49	Striatonigral Degeneration	11100151 18155613	CTD
50	Tauopathies	16219024	CTD
51	Tremor	21736921	CTD
52	Vision Disorders	19384599	CTD

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