MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Silymarin

(SEBFKMXJBCUCAI-HKTJVKLFSA-N)

Structure

SMILES: OC[C@H]1Oc2ccc(cc2O[C@@H]1c1ccc(c(c1)OC)O)[C@H]1Oc2cc(O)cc(c2C(=O)[C@@H]1O)O
Type(s): Experimental; Investigational
Molecular Formula:: C25H22O10
Molecular Weight:: 482.436
Log P:: 2.3627
Hydrogen Bond Acceptor:: 10
Hydrogen Bond Donor:: 5
TPSA:: 155.14
CAS Number(s):: 22888-70-6; 36804-17-8; 802918-57-6

Synonym(s)

Silymarin

Carsil

Karsil

Legalon

Silimarin

External Link(s)

MeSH	D012838
PubChem Compound	31553
BindingDB	50084982
ChEBI	9144
CHEMBL	CHEMBL431701
DrugBank	DB09298
KEGG	dr:D08515
ZINC	2033589

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Acute kidney injury	10454517	CTD
2	Alanine Aminotransferase Increased		OFFSIDES
3	Anhidrosis		OFFSIDES
4	Anosmia		OFFSIDES
5	Application site necrosis		OFFSIDES
6	Ascites		OFFSIDES
7	Asterixis		OFFSIDES
8	Blood alkaline phosphatase increased		OFFSIDES
9	Blood amylase decreased		OFFSIDES
10	Blood chloride decreased		OFFSIDES
11	Blood iron increased		OFFSIDES
12	Blood potassium decreased		OFFSIDES
13	Blood sodium		OFFSIDES
14	Blood thyroid stimulating hormone increased		OFFSIDES
15	Blood urea increased		OFFSIDES
16	Brain Contusion		OFFSIDES
17	Cardiotoxicity	24062023 26335259	CTD
18	Chemical and Drug Induced Liver Injury	View details 3789688 14998559 17696131 18457366 18812229 20144634 22229868 22509279 24582681 25410024 25903262 26335259 27795452 28213291 28428136 28454924 29129047 31175915 31334637	CTD
19	Cholangiolitis		OFFSIDES
20	Diplopia		OFFSIDES
21	Drowsiness		OFFSIDES
22	Dyslipidemias	24062023	CTD
23	Edema	10753220 28422384	CTD
24	Endometrial Hyperplasia		OFFSIDES
25	Epistaxis		OFFSIDES
26	Erythema		OFFSIDES
27	Escherichia coli Infections	28454924	CTD
28	Escherichia sepsis		OFFSIDES
29	Failure of implant		OFFSIDES
30	Fatty Liver, Alcoholic	27795452	CTD
31	Fatty Liver	23348005 25410024	CTD
32	Febrile Neutropenia		OFFSIDES
33	Food Poisoning		OFFSIDES
34	Gamma-glutamyltransferase abnormal		OFFSIDES
35	Granuloma		OFFSIDES
36	Heart Diseases	18487002	CTD
37	Hemorrhage	20144634	CTD
38	Hepatitis		OFFSIDES
39	Hepatomegaly	View details 20144634 22705329 25656916 26115886	CTD
40	Hyperglycemia	22137898 29753610	CTD
41	Hypotension	26335259	CTD
42	Incontinence		OFFSIDES
43	Inflammation	17213517 25410024 28422384	CTD
44	Insulin Resistance	23348005	CTD
45	Intracranial Aneurysm		OFFSIDES
46	Kidney Diseases	View details 18487002 23070905 23339144 27616468	CTD
47	Liver Cirrhosis, Experimental	View details 9303494 15754394 15864749 16169303 17198567 18277467 25410024 26115886 29250925	CTD
48	Liver Cirrhosis	View details 17213517 21316382 22386810 22705329	CTD
49	Liver diseases	17213517	CTD
50	Liver neoplasms	19168119	CTD
51	Lung Neoplasms	16788158	CTD
52	Lymphocyte percentage decreased		OFFSIDES
53	Manganese Poisoning	22033861	CTD
54	Massive Hepatic Necrosis	28454924	CTD
55	Multiple Sclerosis		OFFSIDES
56	Mushroom Poisoning	17213517	CTD
57	Necrosis	View details 12849721 20144634 23810508 28428136 29250925	CTD
58	Neoplasm Invasiveness	25868784	CTD
59	Nerve Degeneration	20964710	CTD
60	Non-alcoholic Fatty Liver Disease	28454924 30713255	CTD
61	Obesity	30713255	CTD
62	Open wound		OFFSIDES
63	Pancreatitis		OFFSIDES
64	Parkinsonian Disorders	23963992	CTD
65	Prostatic Hyperplasia	23500659	CTD
66	Prostatic Neoplasms	16000596	CTD
67	Prothrombin time abnormal		OFFSIDES
68	Quadriparesis		OFFSIDES
69	Septic Shock		OFFSIDES
70	Skin Neoplasms	10753220	CTD
71	Stress		OFFSIDES
72	Supraventricular tachycardia		OFFSIDES
73	Tinnitus		OFFSIDES
74	Transfusion Reaction		OFFSIDES
75	Uterine Polyp		OFFSIDES
76	Varicocele	23659554	CTD
77	Ventricular Dysfunction, Left	26335259	CTD
78	Vulvovaginal pruritus		OFFSIDES
79	Weight Gain	22354081 31175915	CTD
80	leukemia	20932957	CTD

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