MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Buspirone

(QWCRAEMEVRGPNT-UHFFFAOYSA-N)

Structure

SMILES: O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Type(s): Approved; Investigational
ATC code(s): N05BE01
Molecular Formula:: C21H31N5O2
Molecular Weight:: 385.503
Log P:: 2.0290
Hydrogen Bond Acceptor:: 7
Hydrogen Bond Donor:: 0
TPSA:: 69.64
CAS Number(s):: 33386-08-2; 36505-84-7

Synonym(s)

Buspirone

Anxut

Apo-Buspirone

Bespar

Busp

Buspar

Buspirone Hydrochloride

Gen-Buspirone

Lin-Buspirone

10.

MJ-9022-1

11.

N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide

12.

Neurosine

13.

Novo-Buspirone

14.

Nu-Buspirone

15.

PMS-Buspirone

16.

Ratio-Buspirone

17.

Apo Buspirone

18.

Gen Buspirone

19.

Hydrochloride, Buspirone

20.

Lin Buspirone

21.

MJ 9022 1

22.

MJ90221

23.

Novo Buspirone

24.

Nu Buspirone

25.

PMS Buspirone

26.

Ratio Buspirone

External Link(s)

MeSH	D002065
PubChem Compound	2477
BindingDB	50001859
ChEBI	3223
CHEMBL	CHEMBL49
DrugBank	DB00490
DrugCentral	437
IUPHAR/BPS Guide to PHARMACOLOGY	36
KEGG	cpd:C06861 dr:D07593
Therapeutic Target Database	D0U2OO
ZINC	1530571

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 18 Canada Vigilance: 2		Canada Vigilance US FAERS
2	Anxiety	FAERS: 13 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
3	Product substitution issue	FAERS: 12		US FAERS
4	Dizziness	FAERS: 11 Canada Vigilance: 2	2870641 6130065 8666569	CTD OFFSIDES SIDER Canada Vigilance US FAERS
5	Headache	FAERS: 8 Canada Vigilance: 2	2870641 6130065 10901839	CTD SIDER Canada Vigilance US FAERS
6	Nausea	FAERS: 7	2870641 8666569 10901839	CTD OFFSIDES SIDER US FAERS
7	Feeling abnormal	FAERS: 6 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
8	Malaise	FAERS: 5 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
9	Somnolence	FAERS: 5		SIDER US FAERS
10	Abdominal discomfort	FAERS: 4		OFFSIDES US FAERS
11	Agitation	FAERS: 4 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
12	Arthralgia	FAERS: 4		SIDER US FAERS
13	Fatigue	FAERS: 4 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
14	Myalgia	FAERS: 3		SIDER US FAERS
15	Product use issue	FAERS: 3		US FAERS
16	Tinnitus	FAERS: 3		SIDER US FAERS
17	Albumin globulin ratio abnormal	FAERS: 2		US FAERS
18	Alopecia	FAERS: 2		SIDER US FAERS
19	Chest Pain	FAERS: 2		OFFSIDES SIDER US FAERS
20	Chest discomfort	FAERS: 2		US FAERS
21	Drug dispensing error	FAERS: 2		US FAERS
22	Emotional disorder	FAERS: 2		US FAERS
23	Flushing	FAERS: 2		SIDER US FAERS
24	Gluten sensitivity	FAERS: 2		US FAERS
25	Hypersensitivity	FAERS: 2		SIDER US FAERS
26	Incorrect dose administered	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
27	Influenza	FAERS: 2		US FAERS
28	Neck Pain	FAERS: 2		US FAERS
29	Overdose	FAERS: 2		OFFSIDES US FAERS
30	Product physical issue	FAERS: 2		US FAERS
31	Protein total increased	FAERS: 2		US FAERS
32	Unevaluable event	FAERS: 2		US FAERS
33	Urticaria	FAERS: 2		SIDER US FAERS
34	Acne	FAERS: 1		SIDER US FAERS
35	Akathisia	FAERS: 1		SIDER US FAERS
36	Alanine Aminotransferase Increased	FAERS: 1		US FAERS
37	Anhedonia	FAERS: 1		US FAERS
38	Arthritis	FAERS: 1		US FAERS
39	Aspartate Aminotransferase Increased	FAERS: 1		US FAERS
40	Asthenia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
41	Back Pain	FAERS: 1		US FAERS
42	Bone pain	FAERS: 1		US FAERS
43	Bulimia Nervosa	FAERS: 1		US FAERS
44	Coronary Artery Disease	FAERS: 1		US FAERS
45	Dehydration	FAERS: 1		US FAERS
46	Depressed mood	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
47	Dermatitis Herpetiformis	FAERS: 1		US FAERS
48	Dermatitis	FAERS: 1		SIDER US FAERS
49	Discomfort	FAERS: 1		SIDER US FAERS
50	Disorientation	FAERS: 1		US FAERS
51	Diverticulum	FAERS: 1		US FAERS
52	Drug ineffective for unapproved indication	FAERS: 1		US FAERS
53	Drug level decreased	FAERS: 1		US FAERS
54	Drug prescribing error	FAERS: 1		US FAERS
55	Drug withdrawal headache	FAERS: 1		OFFSIDES US FAERS
56	Dysarthria	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
57	Dysgeusia	FAERS: 1		SIDER US FAERS
58	Dystonia	FAERS: 1	8101969	CTD SIDER US FAERS
59	Emotional distress	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
60	Epistaxis	FAERS: 1		SIDER US FAERS
61	Erythema	FAERS: 1		SIDER US FAERS
62	False positive investigation result	FAERS: 1		US FAERS
63	Feeling jittery	FAERS: 1		US FAERS
64	Irritable Bowel Syndrome	FAERS: 1		SIDER US FAERS
65	Memory impairment	FAERS: 1		US FAERS
66	Mental impairment	FAERS: 1		US FAERS
67	Muscle tightness	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
68	Musculoskeletal stiffness	FAERS: 1		OFFSIDES SIDER US FAERS
69	Myocardial Infarction	FAERS: 1		SIDER US FAERS
70	Nerve injury	FAERS: 1		US FAERS
71	Nervousness	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
72	Palpitations	FAERS: 1		SIDER US FAERS
73	Pancreatitis	FAERS: 1		OFFSIDES US FAERS
74	Paranoia	FAERS: 1		US FAERS
75	Pneumonia	FAERS: 1		US FAERS
76	Presyncope	FAERS: 1		US FAERS
77	Product blister packaging issue	FAERS: 1		US FAERS
78	Product dispensing error	FAERS: 1		US FAERS
79	Product quality issue	FAERS: 1		US FAERS
80	Product solubility abnormal	FAERS: 1		US FAERS
81	Product storage error	FAERS: 1		US FAERS
82	Product taste abnormal	FAERS: 1		US FAERS
83	Product use complaint	FAERS: 1		US FAERS
84	Pruritus	FAERS: 1		SIDER US FAERS
85	Purging	FAERS: 1		US FAERS
86	Rash erythematous	FAERS: 1		US FAERS
87	Restlessness	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
88	Serotonin Syndrome	FAERS: 1	8681579 9179637	CTD SIDER US FAERS
89	Somnambulism	FAERS: 1		US FAERS
90	Syncope	FAERS: 1		SIDER US FAERS
91	Tardive Dyskinesia	FAERS: 1		OFFSIDES US FAERS
92	Therapeutic response unexpected with drug substitution	FAERS: 1		US FAERS
93	Therapy change	FAERS: 1		US FAERS
94	Ventricular hypokinesia	FAERS: 1		US FAERS
95	Vertigo	FAERS: 1		SIDER US FAERS
96	Vomiting	FAERS: 1		SIDER US FAERS
97	Abscess			OFFSIDES
98	Abuse			OFFSIDES
99	Ache			SIDER
100	Acid reflux			OFFSIDES
101	Activities of daily living impaired			OFFSIDES
102	Acute Coronary Syndrome			SIDER
103	Adnexa uteri mass			OFFSIDES
104	Adnexitis			OFFSIDES
105	Adverse event			OFFSIDES
106	Agraphia			OFFSIDES
107	Akathisia, Drug-Induced		3379031	CTD
108	Alcohol abuse			SIDER
109	Alcoholic Intoxication			OFFSIDES
110	Amnesia			OFFSIDES
111	Anger			SIDER
112	Angioedema			SIDER
113	Anorexia			SIDER
114	Anxiety Disorders		View details 1664741 2015445 2247245 2293776 2568095 2870641 3379031 3379150 8666569 10901839 12409990 12420156 12527476 12600694 15081793 16185722 17064759 17329302 19664757	CTD
115	Aphonia			SIDER
116	Apnea		10640309	CTD
117	Application site erythema			OFFSIDES
118	Application site pruritus			OFFSIDES
119	Application site vesicles			OFFSIDES
120	Arteriosclerosis			OFFSIDES
121	Asthma			OFFSIDES
122	Ataxia		11494197	CTD SIDER
123	Atelectasis			OFFSIDES
124	Aura			OFFSIDES
125	Autistic Disorder		18056831	CTD
126	Back disorder			OFFSIDES
127	Basal Ganglia Diseases		17351421	CTD
128	Bedridden			OFFSIDES
129	Biliary Dyskinesia			OFFSIDES
130	Bipolar Disorder		View details 2015445 2293776 2723135 3379150 11180215	CTD OFFSIDES
131	Blood Glucose			OFFSIDES
132	Blood chloride decreased			OFFSIDES
133	Blood cholesterol			OFFSIDES
134	Blood creatinine increased			OFFSIDES
135	Blood pH increased			OFFSIDES
136	Blood potassium decreased			OFFSIDES
137	Blood potassium			OFFSIDES
138	Blood testosterone decreased			OFFSIDES
139	Blood triglycerides increased			OFFSIDES
140	Blurred vision			OFFSIDES
141	Bone scan abnormal			OFFSIDES
142	Bradycardia		2207497	CTD SIDER
143	Brain scan abnormal			OFFSIDES
144	Breast Microcalcification			OFFSIDES
145	Breast tenderness			OFFSIDES
146	Bronchitis			OFFSIDES
147	Bruxism		19740153	CTD OFFSIDES
148	Burning tongue			SIDER
149	Catalepsy		View details 2250574 2907585 8386235 12398907	CTD
150	Cataract			OFFSIDES
151	Catatonia		8887967	CTD
152	Catheter related infection			OFFSIDES
153	Cellulitis			OFFSIDES
154	Cerebellar Ataxia		11096749	CTD
155	Cerebral atrophy			OFFSIDES
156	Cerebrovascular accident			SIDER
157	Cervicobrachial syndrome			OFFSIDES
158	Chills			SIDER
159	Choking sensation			OFFSIDES
160	Choking			OFFSIDES
161	Chronic Fatigue Syndrome			OFFSIDES
162	Chronic Obstructive Airway Disease			OFFSIDES
163	Circumstance or information capable of leading to medication error			OFFSIDES
164	Claustrophobia			SIDER
165	Clostridium colitis			OFFSIDES
166	Cocaine-Related Disorders		11777668	CTD
167	Cognitive deterioration			OFFSIDES
168	Cogwheel Rigidity			SIDER
169	Cold intolerance			SIDER
170	Cold sweat			SIDER
171	Confabulation			OFFSIDES
172	Confusion		10928399	CTD
173	Conjunctival abrasion			OFFSIDES
174	Conjunctival deposit			OFFSIDES
175	Conjunctivitis			SIDER
176	Constipation			SIDER
177	Contact Dermatitis			OFFSIDES
178	Deafness			OFFSIDES
179	Debridement			OFFSIDES
180	Decreased Libido			OFFSIDES
181	Demyelination			OFFSIDES
182	Depressed Level of Consciousness			SIDER
183	Depressive disorder		View details 1664741 3379031 8666569 9179637 11847943 12527476 20564960	CTD
184	Diabetes			OFFSIDES
185	Diabetes mellitus inadequate control			OFFSIDES
186	Diabetic Foot			OFFSIDES
187	Diabetic Retinopathy			OFFSIDES
188	Diabetic foot infection			OFFSIDES
189	Diarrhea		2870641 10928399	CTD OFFSIDES
190	Difficulty thinking			SIDER
191	Disorders of Excessive Somnolence		8666569	CTD
192	Dissociative disorder			SIDER
193	Distress			SIDER
194	Disturbance in sexual arousal			SIDER
195	Drowsiness			SIDER
196	Drug addict			OFFSIDES
197	Dry skin			SIDER
198	Dyskinesia, Drug-Induced		View details 8149361 15899244 16511872 17553556 19371586 20592420	CTD
199	Dysmenorrhea			OFFSIDES
200	Dysosmia			SIDER
201	Dyspepsia			OFFSIDES SIDER
202	Dysthymic Disorder			OFFSIDES
203	Dystonic reaction			SIDER
204	Dysuria			OFFSIDES SIDER
205	Ecchymosis			SIDER
206	Echocardiogram abnormal			OFFSIDES
207	Eczema			OFFSIDES
208	Edema		15748628	CTD
209	Electrocardiogram ST segment abnormal			OFFSIDES
210	Electrocardiogram change			SIDER
211	Endometriosis			OFFSIDES
212	Enteritis			OFFSIDES
213	Enuresis			SIDER
214	Eosinophilia			SIDER
215	Erectile dysfunction			OFFSIDES SIDER
216	Euphoric mood			OFFSIDES SIDER
217	Excoriation			OFFSIDES
218	Eye pain			SIDER
219	Fat necrosis			OFFSIDES
220	Feeling Cold			OFFSIDES
221	Fever		21990073	CTD
222	Fibromyalgia			OFFSIDES
223	Flatulence			OFFSIDES SIDER
224	Gambling		2723135	CTD
225	Gastric Lavage			OFFSIDES
226	Gastric pH decreased			OFFSIDES
227	Gastroenteritis			OFFSIDES
228	Hallucinations		8561216	CTD
229	Hemiplegia			OFFSIDES
230	Hepatitis B			OFFSIDES
231	Hip surgery			OFFSIDES
232	Histoplasmosis			OFFSIDES
233	Hostility			SIDER
234	Hyperventilation			SIDER
235	Hypogonadism			OFFSIDES
236	Hyponatremia		9179637	CTD
237	Hypotension			SIDER
238	Hysterectomy			OFFSIDES
239	Impetigo			OFFSIDES
240	Inappropriate schedule of drug administration			OFFSIDES
241	Incontinence			OFFSIDES
242	Increased tendency to bruise	Canada Vigilance: 1		Canada Vigilance SIDER
243	Influenza-like symptoms			SIDER
244	Injection site dermatitis			OFFSIDES
245	Intention tremor			OFFSIDES
246	Intermittent Claudication			OFFSIDES
247	Intermittent Explosive Disorder			OFFSIDES
248	Intervertebral disc disorder			OFFSIDES
249	Joint injury			OFFSIDES
250	Joint swelling	Canada Vigilance: 1		Canada Vigilance
251	Keratitis sicca			OFFSIDES
252	Lethargy			OFFSIDES
253	Leukopenia			SIDER
254	Lightheadedness			SIDER
255	Limb discomfort			OFFSIDES
256	Limb injury			OFFSIDES
257	Limb operation			OFFSIDES
258	Loose tooth			OFFSIDES
259	Lung consolidation			OFFSIDES
260	Lupus pneumonitis			OFFSIDES
261	Malignant neoplasm progression			OFFSIDES
262	Metrorrhagia			SIDER
263	Mononeuritis			OFFSIDES
264	Mood swings			SIDER
265	Movement Disorders		10928399 17306893 19283364	CTD
266	Multiple Sclerosis			OFFSIDES
267	Muscle Rigidity			SIDER
268	Muscle Weakness			OFFSIDES
269	Musculoskeletal Pain			OFFSIDES
270	Musculoskeletal discomfort			OFFSIDES SIDER
271	Mydriasis		7697953	CTD
272	Myoclonus		3379031 10928399	CTD
273	Neck stiffness			SIDER
274	Nephrolithiasis			OFFSIDES
275	Nicotine Dependence			OFFSIDES
276	Nocturia			SIDER
277	Nuchal Rigidity			SIDER
278	Numbness			SIDER
279	Obesity surgery			OFFSIDES
280	Obsessive-Compulsive Disorder		1552034 2258456	CTD
281	Optic Disc Edema			OFFSIDES
282	Optic Neuropathy			OFFSIDES
283	Oral fungal infection			OFFSIDES
284	Oropharyngeal discomfort			SIDER
285	Oropharyngeal pain			SIDER
286	Osteolysis			OFFSIDES
287	Osteopenia			OFFSIDES
288	PCO2 decreased			OFFSIDES
289	Pain			OFFSIDES SIDER
290	Pancreatic Insufficiency			OFFSIDES
291	Panic Disorder			OFFSIDES
292	Paresthesia		2870641	CTD
293	Parkinsonian Disorders		17553556	CTD
294	Pelvic Inflammatory Disease			SIDER
295	Pericarditis lupus			OFFSIDES
296	Pericarditis			OFFSIDES
297	Personality Disorders		9004110 9512081 11220492	CTD
298	Photophobia			SIDER
299	Pneumothorax			OFFSIDES
300	Post procedural complication			OFFSIDES
301	Prenatal Exposure Delayed Effects		12480124 20564960	CTD
302	Presbyopia			OFFSIDES
303	Pressure of speech			OFFSIDES
304	Proctitis			OFFSIDES
305	Psychotic Disorders		8561216	CTD
306	Pulmonary congestion			SIDER
307	Purulence			OFFSIDES
308	Redness			SIDER
309	Respiratory tract congestion			SIDER
310	Restless Legs Syndrome			SIDER
311	Rhonchi			OFFSIDES
312	Sarcoidosis			OFFSIDES
313	Schizoaffective Disorder			OFFSIDES
314	Schizophrenia			OFFSIDES
315	Seizures		View details 1552045 2376867 2906877 15582832 19800952	CTD
316	Semen volume decreased			OFFSIDES
317	Shock			SIDER
318	Sinus bradycardia			OFFSIDES
319	Sinusitis			OFFSIDES
320	Sleep Bruxism		11157444	CTD
321	Sleep Initiation and Maintenance Disorders		2723135	CTD
322	Slurred speech			SIDER
323	Sore eye			SIDER
324	Stress			OFFSIDES
325	Stupor			SIDER
326	Sweating			SIDER
327	Synovial Cyst			OFFSIDES
328	Tachycardia	Canada Vigilance: 2		Canada Vigilance SIDER
329	Temperature intolerance			SIDER
330	Tendinitis			OFFSIDES
331	Tension			SIDER
332	Thalamic infarction			OFFSIDES
333	Thrombocytopenia			SIDER
334	Tobacco withdrawal symptoms			OFFSIDES
335	Tremor		View details 2376867 8101969 10762688 11070179 16643965	CTD SIDER
336	Troponin increased			OFFSIDES
337	Ulcer			OFFSIDES
338	Unresponsive to stimuli			OFFSIDES
339	Urinary Retention			SIDER
340	Urinary hesitation			SIDER
341	Urinary tract inflammation			OFFSIDES
342	Urine flow decreased			OFFSIDES
343	Vascular calcification			OFFSIDES
344	Vasospasm			OFFSIDES
345	Viral upper respiratory tract infection			OFFSIDES
346	Visual disturbance			OFFSIDES
347	Weight Gain			OFFSIDES
348	Weight decreased			SIDER
349	Wrong technique in drug usage process			OFFSIDES
350	furuncle			OFFSIDES

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