MetaADEDB 2.0 @ LMMD
Tranexamic Acid
(GYDJEQRTZSCIOI-UHFFFAOYSA-N)
Structure
SMILES
NCC1CCC(CC1)C(=O)O
Type(s)
Approved
ATC code(s)
B02AA02
Molecular Formula:
C8H15NO2
Molecular Weight:
157.210
Log P:
1.5364
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
2
TPSA:
63.32
CAS Number(s):
701-54-2; 1197-17-7; 1197-18-8
Synonym(s)
1.
Tranexamic Acid
2.
AMCHA
3.
AMCA
4.
Amchafibrin
5.
Anvitoff
6.
Cyklokapron
7.
Exacyl
8.
KABI 2161
9.
Spotof
10.
Transamin
11.
Ugurol
12.
t-AMCHA
13.
trans-4-(Aminomethyl)cyclohexanecarboxylic Acid
External Link(s)
MeSHD014148
PubChem Compound5526
1549136
BindingDB50428067
ChEBI48669
94518
CHEMBLCHEMBL877
CHEMBL292500
DrugBankDB00302
DrugCentral2713
IUPHAR/BPS Guide to PHARMACOLOGY6573
KEGGcpd:C12535
dr:D01136
Therapeutic Target DatabaseD05HXX
ZINC1542907
100071256
100007011
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Pulmonary EmbolismFAERS: 28
Canada Vigilance: 1

View details

2611113
4083073
12144537
15826417
 		CTD
Canada Vigilance
US FAERS
2MyoclonusFAERS: 2212640092
19448237		CTD
US FAERS
3Cardiac ArrestFAERS: 17
Canada Vigilance: 2		Canada Vigilance
US FAERS
4Deep Vein ThrombosisFAERS: 17
Canada Vigilance: 2		Canada Vigilance
US FAERS
5HeadacheFAERS: 13
Canada Vigilance: 2		Canada Vigilance
US FAERS
6ThrombosisFAERS: 13
Canada Vigilance: 1		7376944
17667546		CTD
Canada Vigilance
US FAERS
7Product use in unapproved indicationFAERS: 11US FAERS
8Status EpilepticusFAERS: 1110525986CTD
US FAERS
9Drug ineffectiveFAERS: 10
Canada Vigilance: 4		Canada Vigilance
US FAERS
10Cerebrovascular accidentFAERS: 9
Canada Vigilance: 2		Canada Vigilance
US FAERS
11Back PainFAERS: 8
Canada Vigilance: 1		Canada Vigilance
US FAERS
12DizzinessFAERS: 8
Canada Vigilance: 4		Canada Vigilance
US FAERS
13Incorrect route of drug administrationFAERS: 8US FAERS
14Incorrect route of product administrationFAERS: 8US FAERS
15NauseaFAERS: 8
Canada Vigilance: 3		Canada Vigilance
US FAERS
16Wrong product administeredFAERS: 8US FAERS
17Chest PainFAERS: 7US FAERS
18Arterial thrombosisFAERS: 6US FAERS
19HypoxiaFAERS: 6OFFSIDES
US FAERS
20Medication ErrorFAERS: 6US FAERS
21Myoclonic EpilepsyFAERS: 6
Canada Vigilance: 8		Canada Vigilance
OFFSIDES
US FAERS
22TachycardiaFAERS: 6US FAERS
23Venous ThrombosisFAERS: 61782339
3373703
3385945		CTD
US FAERS
24Ventricular FibrillationFAERS: 6US FAERS
25Chest discomfortFAERS: 5
Canada Vigilance: 1		Canada Vigilance
US FAERS
26FatigueFAERS: 5
Canada Vigilance: 2		Canada Vigilance
US FAERS
27HypersomniaFAERS: 5US FAERS
28HypotensionFAERS: 5US FAERS
29Myocardial InfarctionFAERS: 512036532
15229393		CTD
US FAERS
30Post procedural complicationFAERS: 5US FAERS
31Abdominal PainFAERS: 4
Canada Vigilance: 1		Canada Vigilance
US FAERS
32Acute kidney injuryFAERS: 41961348CTD
US FAERS
33Peripheral artery thrombosisFAERS: 4US FAERS
34Posterior reversible encephalopathy syndromeFAERS: 4US FAERS
35Unresponsive to stimuliFAERS: 4US FAERS
36VomitingFAERS: 4US FAERS
37Accidental exposure to productFAERS: 3US FAERS
38Acute myocardial infarctionFAERS: 3OFFSIDES
US FAERS
39Adverse eventFAERS: 3US FAERS
40AgitationFAERS: 3US FAERS
41AngioedemaFAERS: 363691
7257742		CTD
US FAERS
42Ankle FractureFAERS: 3US FAERS
43ArthralgiaFAERS: 3US FAERS
44Cerebral InfarctionFAERS: 32407050
7104262		CTD
US FAERS
45EpilepsyFAERS: 3OFFSIDES
US FAERS
46HypersensitivityFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
47Incorrect dose administeredFAERS: 3US FAERS
48MyalgiaFAERS: 3US FAERS
49Procedural complicationFAERS: 3US FAERS
50PruritusFAERS: 3US FAERS
51Retinal Artery OcclusionFAERS: 39033905CTD
US FAERS
52Stevens-Johnson SyndromeFAERS: 3US FAERS
53SyncopeFAERS: 3US FAERS
54Visual ImpairmentFAERS: 3US FAERS
55Abdominal discomfortFAERS: 2US FAERS
56Accidental overdoseFAERS: 2US FAERS
57AstheniaFAERS: 2US FAERS
58Cerebral ThrombosisFAERS: 2US FAERS
59Chemical burns of eyeFAERS: 2US FAERS
60ChillsFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
61ChokingFAERS: 2US FAERS
62Drug administration errorFAERS: 2US FAERS
63Drug level increasedFAERS: 2US FAERS
64DysarthriaFAERS: 2US FAERS
65ExtravasationFAERS: 2US FAERS
66Eye painFAERS: 2US FAERS
67GangreneFAERS: 2US FAERS
68HemiparesisFAERS: 2US FAERS
69MalaiseFAERS: 2US FAERS
70Mental status changesFAERS: 2US FAERS
71Multi-organ disorderFAERS: 2US FAERS
72PainFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
73ParesisFAERS: 27000850CTD
US FAERS
74Peripheral swellingFAERS: 2US FAERS
75PhotophobiaFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
76Postoperative respiratory failureFAERS: 2US FAERS
77Product quality issueFAERS: 2US FAERS
78Product substitution issueFAERS: 2US FAERS
79RestlessnessFAERS: 2US FAERS
80SomnolenceFAERS: 2US FAERS
81Urinary tract obstructionFAERS: 2US FAERS
82Vascular stent stenosisFAERS: 2US FAERS
83VasculitisFAERS: 2US FAERS
84Wrong drug administeredFAERS: 2US FAERS
85Accidental exposureFAERS: 1US FAERS
86AlopeciaFAERS: 1US FAERS
87AnoxiaFAERS: 1US FAERS
88AnuriaFAERS: 1US FAERS
89AphasiaFAERS: 1US FAERS
90ArteritisFAERS: 1US FAERS
91Atrial FibrillationFAERS: 1US FAERS
92Atrial thrombosisFAERS: 1US FAERS
93BlindnessFAERS: 114712363CTD
US FAERS
94Blood creatinine increasedFAERS: 1OFFSIDES
US FAERS
95Blood urine presentFAERS: 1US FAERS
96Brain stem syndromeFAERS: 1OFFSIDES
US FAERS
97BronchospasmFAERS: 1US FAERS
98Burning sensationFAERS: 1US FAERS
99Carotid Artery ThrombosisFAERS: 163691
7104262		CTD
OFFSIDES
US FAERS
100Carotid artery aneurysmFAERS: 1US FAERS
101Cerebellar infarctionFAERS: 1US FAERS
102Cerebral atrophyFAERS: 1OFFSIDES
US FAERS
103Cerebral hypoperfusionFAERS: 1US FAERS
104Cold sweatFAERS: 1US FAERS
105Coma scale abnormalFAERS: 1US FAERS
106CryingFAERS: 1US FAERS
107DeliriumFAERS: 1US FAERS
108Device computer issueFAERS: 1US FAERS
109DiscomfortFAERS: 1US FAERS
110DisorientationFAERS: 1US FAERS
111Disseminated Intravascular CoagulationFAERS: 11961348
2670794		CTD
OFFSIDES
US FAERS
112Drug dispensing errorFAERS: 1US FAERS
113Drug screen false positiveFAERS: 1US FAERS
114DyspepsiaFAERS: 1US FAERS
115Economic problemFAERS: 1US FAERS
116Electrocardiogram QT interval abnormalFAERS: 1US FAERS
117Electrocardiogram ST-T segment abnormalFAERS: 1US FAERS
118Embolic cerebral infarctionFAERS: 1US FAERS
119Embolic strokeFAERS: 1US FAERS
120EmbolismFAERS: 1US FAERS
121EndometriosisFAERS: 1US FAERS
122Endotracheal intubation complicationFAERS: 1US FAERS
123Eye irritationFAERS: 1US FAERS
124Facial paralysisFAERS: 1US FAERS
125False negative investigation resultFAERS: 1US FAERS
126Feeling abnormalFAERS: 1US FAERS
127FibromyalgiaFAERS: 1US FAERS
128Hip surgeryFAERS: 1US FAERS
129HydronephrosisFAERS: 1OFFSIDES
US FAERS
130HypercapniaFAERS: 1OFFSIDES
US FAERS
131Impaired work abilityFAERS: 1US FAERS
132Incorrect drug administration durationFAERS: 1OFFSIDES
US FAERS
133Incorrect drug administration rateFAERS: 1US FAERS
134Infusion Site ExtravasationFAERS: 1US FAERS
135Intentional product use issueFAERS: 1US FAERS
136Intercepted drug prescribing errorFAERS: 1US FAERS
137Joint swellingFAERS: 1US FAERS
138LazinessFAERS: 1US FAERS
139Ligament ruptureFAERS: 1US FAERS
140Ligneous conjunctivitisFAERS: 1US FAERS
141Limb discomfortFAERS: 1US FAERS
142Maternal exposure during pregnancyFAERS: 1US FAERS
143Maternal exposure timing unspecifiedFAERS: 1US FAERS
144Memory impairmentFAERS: 1US FAERS
145MenorrhagiaFAERS: 1
Canada Vigilance: 1

View details

2236942
11943936
15229393
19016686
19236375
 		CTD
Canada Vigilance
US FAERS
146Metabolic acidosisFAERS: 1US FAERS
147MetrorrhagiaFAERS: 1US FAERS
148Middle insomniaFAERS: 1US FAERS
149Muscle RigidityFAERS: 1US FAERS
150Muscle tightnessFAERS: 1US FAERS
151Musculoskeletal PainFAERS: 1US FAERS
152Musculoskeletal stiffnessFAERS: 1US FAERS
153MydriasisFAERS: 1US FAERS
154No adverse eventFAERS: 1US FAERS
155OverdoseFAERS: 1US FAERS
156PalpitationsFAERS: 1US FAERS
157PetechiaeFAERS: 1US FAERS
158Plasminogen decreasedFAERS: 1US FAERS
159Platelet count abnormalFAERS: 1US FAERS
160PneumoniaFAERS: 1US FAERS
161Portal Vein ThrombosisFAERS: 1US FAERS
162Product appearance confusionFAERS: 1US FAERS
163Product outer packaging issueFAERS: 1US FAERS
164Product packaging confusionFAERS: 1US FAERS
165Product packaging issueFAERS: 1US FAERS
166Product preparation errorFAERS: 1US FAERS
167Product preparation issueFAERS: 1US FAERS
168Product taste abnormalFAERS: 1US FAERS
169Product use complaintFAERS: 1US FAERS
170Product use issueFAERS: 1US FAERS
171Pulmonary InfarctionFAERS: 1OFFSIDES
US FAERS
172Pulmonary artery thrombosisFAERS: 1US FAERS
173Rash erythematousFAERS: 1US FAERS
174Renal painFAERS: 1US FAERS
175Respiratory FailureFAERS: 1OFFSIDES
US FAERS
176Respiratory distressFAERS: 1US FAERS
177Retinal Vein OcclusionFAERS: 12236942CTD
US FAERS
178RhabdomyolysisFAERS: 1OFFSIDES
US FAERS
179SepsisFAERS: 1US FAERS
180Skin lacerationFAERS: 1OFFSIDES
US FAERS
181SneezingFAERS: 1US FAERS
182Sudden deathFAERS: 1US FAERS
183TetanyFAERS: 1US FAERS
184Therapy cessationFAERS: 1US FAERS
185ThrombocytopeniaFAERS: 1US FAERS
186Thyroid NeoplasmFAERS: 1US FAERS
187ToothacheFAERS: 1US FAERS
188Toxic Epidermal NecrolysisFAERS: 1US FAERS
189Toxicity to various agentsFAERS: 1US FAERS
190UrticariaFAERS: 1US FAERS
191Vascular stent thrombosisFAERS: 1US FAERS
192Vasculitic rashFAERS: 1US FAERS
193Weight decreasedFAERS: 1US FAERS
194WheezingFAERS: 1US FAERS
195White matter lesionFAERS: 1US FAERS
196Wound InfectionFAERS: 1US FAERS
197nervous system disorderFAERS: 1US FAERS
198Abdominal InfectionOFFSIDES
199Abdominal tendernessOFFSIDES
200Acute left ventricular failureOFFSIDES
201AdenocarcinomaOFFSIDES
202Alanine Aminotransferase IncreasedOFFSIDES
203Alanine aminotransferase abnormalOFFSIDES
204Alcoholic IntoxicationOFFSIDES
205Altered state of consciousnessOFFSIDES
206Angioedemas, Hereditary19477491CTD
207Anorectal operationOFFSIDES
208Antibody test abnormalOFFSIDES
209Anticholinergic SyndromeOFFSIDES
210AscitesOFFSIDES
211Aspartate aminotransferase abnormalOFFSIDES
212AsphyxiaOFFSIDES
213AuraOFFSIDES
214AutomatismOFFSIDES
215Biliary Tract Diseases24633426CTD
216Blast cells presentOFFSIDES
217Blood albumin decreasedOFFSIDES
218Blood alkaline phosphatase increasedOFFSIDES
219Blood beta-D-glucan increasedOFFSIDES
220Blood chloride decreasedOFFSIDES
221Blood creatine phosphokinase increasedOFFSIDES
222Blood electrolytes abnormalOFFSIDES
223Blood fibrinogen increasedOFFSIDES
224Blood glucose decreasedOFFSIDES
225Blood lactate dehydrogenase increasedOFFSIDES
226Blood potassium increasedCanada Vigilance: 1Canada Vigilance
OFFSIDES
227Blood smear test abnormalOFFSIDES
228Blood sodiumOFFSIDES
229Blood urea increasedOFFSIDES
230Blood uric acidOFFSIDES
231Brain DeathOFFSIDES
232Brain Edema21127298CTD
233Brain Ischemia7000850CTD
234Bronchoalveolar LavageOFFSIDES
235BruxismOFFSIDES
236CataractCanada Vigilance: 1Canada Vigilance
237Chemical and Drug Induced Liver Injury22507835
24633426		CTD
238Chemotherapeutic drug level increasedOFFSIDES
239CholangiolitisOFFSIDES
240Clostridium colitisOFFSIDES
241Coagulation factor IX level decreasedOFFSIDES
242Coagulation factor increasedOFFSIDES
243Consciousness Disorders7000850CTD
244Contracted bladderOFFSIDES
245Corneal UlcerOFFSIDES
246DeafnessOFFSIDES
247DehydrationCanada Vigilance: 1Canada Vigilance
248Depressed Level of ConsciousnessOFFSIDES
249Depression suicidalOFFSIDES
250Device ineffectiveOFFSIDES
251Diabetes InsipidusOFFSIDES
252Diabetes mellitus inadequate controlOFFSIDES
253Diastolic dysfunctionOFFSIDES
254Disease ProgressionOFFSIDES
255Disease recurrenceOFFSIDES
256Drug Overdose12640092CTD
257Dry skinOFFSIDES
258Duodenal UlcerOFFSIDES
259DuodenitisOFFSIDES
260DystoniaOFFSIDES
261EncephalomalaciaOFFSIDES
262EnterocolitisOFFSIDES
263Eosinophilic PneumoniaOFFSIDES
264EpiglottitisOFFSIDES
265EpistaxisOFFSIDES
266Erythema InduratumOFFSIDES
267Erythema MultiformeOFFSIDES
268Factor IX inhibitionOFFSIDES
269Factor VIII inhibitionOFFSIDES
270FractureCanada Vigilance: 1Canada Vigilance
271Gamma-Glutamyltransferase IncreasedOFFSIDES
272Gastric pH decreasedOFFSIDES
273Gastrointestinal toxicityOFFSIDES
274Gaze palsyOFFSIDES
275GlossitisOFFSIDES
276GlossoptosisOFFSIDES
277Granulocyte count decreasedOFFSIDES
278GranulocytosisOFFSIDES
279Hemiplegia7104262CTD
280Hemophilia A11209027
12144537		CTD
281Hemorrhage877527
8035603
12144537		CTD
282Hepatitis B positiveOFFSIDES
283Hepatitis B surface antigen positiveOFFSIDES
284Hepatitis C RNA increasedOFFSIDES
285HiccoughOFFSIDES
286Hippocampal sclerosisOFFSIDES
287HydrocephalusOFFSIDES
288HyperventilationOFFSIDES
289Inappropriate schedule of drug administrationOFFSIDES
290InfarctionCanada Vigilance: 317667546CTD
Canada Vigilance
291InfectionOFFSIDES
292Injection site infectionOFFSIDES
293Intestinal infarctionOFFSIDES
294Intracranial Aneurysm7000850CTD
OFFSIDES
295Intracranial Thrombosis59118CTD
296Joint stiffnessOFFSIDES
297Kidney Cortex Necrosis10193833
11209027		CTD
298Klebsiella sepsisOFFSIDES
299LentigoOFFSIDES
300Leukopenia neonatalOFFSIDES
301Limb massCanada Vigilance: 1Canada Vigilance
302Lung consolidationOFFSIDES
303Lymph Node TuberculosisOFFSIDES
304Malignant neoplasm progressionOFFSIDES
305Metastases to abdominal cavityOFFSIDES
306Multiple MyelomaOFFSIDES
307Musculoskeletal chest painCanada Vigilance: 1Canada Vigilance
308Myocardial ruptureOFFSIDES
309NasopharyngitisOFFSIDES
310Neck PainCanada Vigilance: 1Canada Vigilance
311Necrosis of bronchioliOFFSIDES
312Necrosis2524618
24633426		CTD
313Neuropathic painOFFSIDES
314Neutropenic sepsisOFFSIDES
315Neutrophil count decreasedOFFSIDES
316ObstructionOFFSIDES
317Oculomucocutaneous syndromeOFFSIDES
318OliguriaOFFSIDES
319PallorOFFSIDES
320PeritonitisOFFSIDES
321Pharyngolaryngeal PainOFFSIDES
322PhlebitisCanada Vigilance: 1Canada Vigilance
323Pneumocystis jiroveci pneumoniaOFFSIDES
324Postoperative Complications877527
20719731		CTD
325Postoperative renal failureOFFSIDES
326Potentiating drug interactionCanada Vigilance: 1Canada Vigilance
327PregnancyCanada Vigilance: 1Canada Vigilance
328Product lot number issueCanada Vigilance: 1Canada Vigilance
329Protein total decreasedOFFSIDES
330Prothrombin level decreasedOFFSIDES
331Radiation PneumonitisOFFSIDES
332RalesOFFSIDES
333Refusal of treatment by relativeOFFSIDES
334Renal Insufficiency19020118CTD
335Renal tubular disorderOFFSIDES
336RhinitisOFFSIDES
337ScreamingOFFSIDES
338Seizures

View details

11126922
11807648
19020118
19996135
20719731
24588023
 		CTD
339Septic ShockOFFSIDES
340Serum SicknessOFFSIDES
341Sinus Thrombosis, Intracranial3590072CTD
342Sputum culture positiveOFFSIDES
343Stenotrophomonas infectionOFFSIDES
344Subarachnoid Hemorrhage7000850CTD
345Thromboembolism7206930
8035603
8652924		CTD
346Tinea PedisOFFSIDES
347Tongue bitingOFFSIDES
348Tooth AvulsionOFFSIDES
349Transfusion ReactionOFFSIDES
350TremorCanada Vigilance: 2Canada Vigilance
351Trigeminal palsyOFFSIDES
352Ulcer15229393CTD
353Upper airway obstructionOFFSIDES
354Urge IncontinenceOFFSIDES
355Urinary sediment abnormalOFFSIDES
356Uterine Neoplasms17667546CTD
357Uterine PolypOFFSIDES
358Uterine hemorrhage7104262CTD
359Viral mutation identifiedOFFSIDES
360Water IntoxicationOFFSIDES
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