MetaADEDB 2.0 @ LMMD
Dextropropoxyphene
(XLMALTXPSGQGBX-GCJKJVERSA-N)
Structure
SMILES
CCC(=O)O[C@](c1ccccc1)([C@@H](CN(C)C)C)Cc1ccccc1
Type(s)
Approved; Illicit; Investigational; Withdrawn
ATC code(s)
N02AC04; N02AC54; N02AC74
Molecular Formula:
C22H29NO2
Molecular Weight:
339.471
Log P:
4.2755
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
0
TPSA:
29.54
CAS Number(s):
469-62-5; 2621-61-6
Synonym(s)
1.
Dextropropoxyphene
2.
D-Propoxyphene
3.
Darvon
4.
Propoxyphene
5.
Propoxyphene Hydrochloride
6.
Propoxyphene Hydrochloride, (R*,R*)-(+-)-Isomer
7.
Propoxyphene Hydrochloride, (R-(R*,R*))-Isomer
8.
Propoxyphene Hydrochloride, (R-(R*,S*))-Isomer
9.
Propoxyphene Hydrochloride, (S-(R*,R*))-Isomer
10.
Propoxyphene Maleate, (+)-Isomer
11.
Propoxyphene Phosphate, (S-(R*,S*))-Isomer
12.
Propoxyphene Sulfate, (S-(R*,S*))-Isomer
13.
D Propoxyphene
14.
Hydrochloride, Propoxyphene
External Link(s)
MeSHD011431
PubChem Compound10100
BindingDB82269
ChEBI51173
CHEMBLCHEMBL1213351
DrugBankDB00647
DrugCentral844
IUPHAR/BPS Guide to PHARMACOLOGY7593
KEGGcpd:C07406
dr:D07809
Therapeutic Target DatabaseD0D4PB
ZINC1530769
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Pharmaceutical product complaintFAERS: 2OFFSIDES
US FAERS
2Completed SuicideFAERS: 1SIDER
US FAERS
3DizzinessFAERS: 1OFFSIDES
SIDER
US FAERS
4Drug ineffectiveFAERS: 1OFFSIDES
SIDER
US FAERS
5OverdoseFAERS: 1US FAERS
6PalpitationsFAERS: 1US FAERS
7TremorFAERS: 1US FAERS
8AbasiaOFFSIDES
9Abdominal AbscessOFFSIDES
10Abdominal PainCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
11Abdominal discomfortOFFSIDES
12Abdominal massOFFSIDES
13Abdominal symptomOFFSIDES
14Abnormal visionOFFSIDES
15AbscessOFFSIDES
16Acid fast bacilli infectionOFFSIDES
17Acid refluxOFFSIDES
18Activities of daily living impairedOFFSIDES
19Acute Coronary SyndromeSIDER
20Acute kidney injury7100020CTD
21Acute sinusitisOFFSIDES
22AdenocarcinomaOFFSIDES
23AdenomaOFFSIDES
24Adverse eventOFFSIDES
25AgeusiaOFFSIDES
26AgitationSIDER
27Alcohol poisoningOFFSIDES
28AlopeciaOFFSIDES
29AlveolitisOFFSIDES
30AmnesiaOFFSIDES
31AnalgesiaOFFSIDES
32Anemia, Hemolytic2716023CTD
33AngerOFFSIDES
34AnhedoniaOFFSIDES
35Anorexia7100020CTD
36AnosmiaOFFSIDES
37Anoxic EncephalopathyOFFSIDES
38Anticonvulsant drug level decreasedOFFSIDES
39Anticonvulsant drug level increasedOFFSIDES
40AnxietyOFFSIDES
41ApathyOFFSIDES
42AphagiaOFFSIDES
43AphoniaOFFSIDES
44Application site burnOFFSIDES
45Application site erythemaOFFSIDES
46Application site scabOFFSIDES
47ArthritisOFFSIDES
48ArthropathyOFFSIDES
49Artificial crown procedureOFFSIDES
50AscitesOFFSIDES
51AstheniaOFFSIDES
SIDER
52AsthmaOFFSIDES
53AtaxiaSIDER
54AtelectasisOFFSIDES
55Atrial Fibrillation16513452CTD
56Atrial FlutterOFFSIDES
57Atrial tachycardiaOFFSIDES
58Atrioventricular BlockOFFSIDES
59AuraOFFSIDES
60Autoimmune hepatitisOFFSIDES
61Back disorderOFFSIDES
62Bed restOFFSIDES
63Biliary DyskinesiaOFFSIDES
64Bipolar DisorderOFFSIDES
65Blood GlucoseOFFSIDES
66Blood alkaline phosphatase increasedOFFSIDES
67Blood cholesterolOFFSIDES
68Blood glucose abnormalOFFSIDES
69Blood glucose decreasedOFFSIDES
70Blood magnesium decreasedOFFSIDES
71Blood potassium decreasedOFFSIDES
72Blood potassium increasedOFFSIDES
73Blood sodiumOFFSIDES
74Blood thyroid stimulating hormoneOFFSIDES
75Blood triglycerides increasedOFFSIDES
76Blood uric acidOFFSIDES
77Bradycardia16513452CTD
OFFSIDES
SIDER
78BronchiolitisOFFSIDES
79BronchitisOFFSIDES
80Bronchoalveolar lavage abnormalOFFSIDES
81BruxismOFFSIDES
82Bundle-Branch Block6650949CTD
83Burning sensationOFFSIDES
84Cardiac ArrestSIDER
85Cardiac TamponadeOFFSIDES
86Cardioactive drug level increasedOFFSIDES
87Cardiovascular insufficiencyOFFSIDES
88Carotid artery aneurysmOFFSIDES
89CellulitisOFFSIDES
90Central nervous system lesionOFFSIDES
91Cerebral atrophyOFFSIDES
92Cerebral ventricle dilatationOFFSIDES
93Chest PainOFFSIDES
94Choking sensationOFFSIDES
95ChromaturiaOFFSIDES
96Chronic Obstructive Airway DiseaseOFFSIDES
97Chronic active hepatitisOFFSIDES
98Circumstance or information capable of leading to medication errorOFFSIDES
99CirrhosisOFFSIDES
100Clostridium difficile toxin test positiveOFFSIDES
101Colon adenomaOFFSIDES
102Compression fractureOFFSIDES
103ConfabulationOFFSIDES
104Congenital tricuspid valve incompetenceOFFSIDES
105ConstipationSIDER
106Contact DermatitisOFFSIDES
107Cor pulmonaleOFFSIDES
108Cubital Tunnel SyndromeOFFSIDES
109Culture positiveOFFSIDES
110Culture wound positiveOFFSIDES
111Deafness10881270CTD
112DehydrationOFFSIDES
113DemyelinationOFFSIDES
114Depressed moodOFFSIDES
115DermatitisSIDER
116Device FailureOFFSIDES
117Device breakageOFFSIDES
118Device dislocationOFFSIDES
119Device related infectionOFFSIDES
120DiabetesOFFSIDES
121Diabetes mellitus inadequate controlOFFSIDES
122Diabetic FootOFFSIDES
123DiarrheaOFFSIDES
124DiplopiaOFFSIDES
125DiscomfortSIDER
126DiverticulitisOFFSIDES
127DiverticulumOFFSIDES
128DrowsinessOFFSIDES
SIDER
129Drug Overdose7114696CTD
130Drug ToleranceSIDER
131Drug administration errorOFFSIDES
132Drug dose omissionOFFSIDES
133Drug screen positiveOFFSIDES
134Drug toxicityOFFSIDES
135Drug withdrawal convulsionsOFFSIDES
136Drug withdrawal headacheOFFSIDES
137Drug withdrawal syndromeSIDER
138Dry gangreneOFFSIDES
139Dry skinOFFSIDES
140Duodenal ObstructionOFFSIDES
141DysgeusiaOFFSIDES
142DysmenorrheaOFFSIDES
143DyspareuniaOFFSIDES
144DyspepsiaOFFSIDES
SIDER
145DysphoniaOFFSIDES
146Economic problemOFFSIDES
147Ejection Fraction DecreasedOFFSIDES
148Electrocardiogram ST-T changeOFFSIDES
149Emotional disorderOFFSIDES
150Emotional distressOFFSIDES
151Empty Sella SyndromeOFFSIDES
152EndocarditisOFFSIDES
153Endometrial HyperplasiaOFFSIDES
154EnuresisOFFSIDES
155Erosive gastritisOFFSIDES
156ErythemaOFFSIDES
157Euphoric moodOFFSIDES
SIDER
158ExcoriationOFFSIDES
159Factor VIII DeficiencyOFFSIDES
160FatigueOFFSIDES
161Febrile NeutropeniaOFFSIDES
162Feeling ColdOFFSIDES
163Feeling abnormalOFFSIDES
SIDER
164Fibromuscular DysplasiaOFFSIDES
165FibromyalgiaOFFSIDES
166Fibrosis8478886CTD
167Flank PainOFFSIDES
168FormicationOFFSIDES
169FrustrationOFFSIDES
170GamblingOFFSIDES
171Gastrointestinal PainSIDER
172Gastrointestinal arteriovenous malformationOFFSIDES
173Gastrointestinal inflammationOFFSIDES
174Gastrointestinal perforationOFFSIDES
175General physical health deteriorationOFFSIDES
176GlaucomaOFFSIDES
177GoutOFFSIDES
178Graft infectionOFFSIDES
179GranulocytosisOFFSIDES
180Hallucinations, mixedOFFSIDES
181Hay feverOFFSIDES
182HeadacheSIDER
183Heart Diseases17078595CTD
184Heart sounds abnormalOFFSIDES
185HemiparesisOFFSIDES
186HepatomegalySIDER
187HepatosplenomegalyOFFSIDES
188HerniaOFFSIDES
189High frequency ablationOFFSIDES
190Hormone level abnormalOFFSIDES
191HyperkeratosisOFFSIDES
192HyperparathyroidismOFFSIDES
193HypersensitivitySIDER
194Hypertensive heart diseaseOFFSIDES
195HypomaniaOFFSIDES
196HypotensionSIDER
197IleitisOFFSIDES
198Impaired self-careOFFSIDES
199IncontinenceOFFSIDES
200Incorrect drug dosage form administeredOFFSIDES
201Increased upper airway secretionOFFSIDES
202InfectionOFFSIDES
203Injection site thrombosisOFFSIDES
204Intention tremorOFFSIDES
205Intentional drug misuseOFFSIDES
206Intestinal PerforationOFFSIDES
207Joint fluid drainageOFFSIDES
208Joint injuryOFFSIDES
209Kidney FailureOFFSIDES
210LightheadednessSIDER
211MalnutritionSIDER
212Mediastinal massOFFSIDES
213Mental disorder due to a general medical conditionOFFSIDES
214Mental impairmentOFFSIDES
215Mental status changesOFFSIDES
216Metabolic acidosisSIDER
217Mitral Valve StenosisOFFSIDES
218Mitral valve sclerosisOFFSIDES
219MononeuritisOFFSIDES
220Multiple drug overdoseOFFSIDES
221MumpsOFFSIDES
222Muscle WeaknessOFFSIDES
223Muscle strainOFFSIDES
224Muscle tightnessOFFSIDES
225Musculoskeletal PainOFFSIDES
226Musculoskeletal chest painOFFSIDES
227Musculoskeletal discomfortOFFSIDES
228Musculoskeletal stiffnessOFFSIDES
229Myocardial InfarctionSIDER
230Myoglobin blood increasedOFFSIDES
231MyopathySIDER
232Nausea7100020CTD
OFFSIDES
SIDER
233Nephritis, Interstitial7100020CTD
234Nephrogenic Fibrosing DermopathyOFFSIDES
235NephrolithiasisOFFSIDES
236Nervous tensionOFFSIDES
237NeuralgiaOFFSIDES
238Nicotine DependenceOFFSIDES
239Nodal osteoarthritisOFFSIDES
240NoduleOFFSIDES
241Non-cardiac chest painOFFSIDES
242Occult blood positiveOFFSIDES
243Ocular icterusOFFSIDES
244Oliguria7100020CTD
245Optic Atrophy7114696CTD
246Oral fungal infectionOFFSIDES
247Oral mucosal erythemaOFFSIDES
248Oropharyngeal candidiasisOFFSIDES
249Oropharyngeal plaqueOFFSIDES
250OrthopneaOFFSIDES
251OsteomyelitisOFFSIDES
252OsteopeniaOFFSIDES
253OsteoporosisOFFSIDES
254Ovarian adhesionOFFSIDES
255Pain, Postoperative7357809CTD
256Pain79851
7562497
11124199		CTD
OFFSIDES
257Pancreatic PseudocystOFFSIDES
258Pancytopenia4723831CTD
259Panic DisorderOFFSIDES
260Panic disorder with agoraphobiaOFFSIDES
261Papilledema7114696CTD
262Pericardial effusionOFFSIDES
263PericarditisOFFSIDES
264PeriodontitisOFFSIDES
265Pharyngeal polypOFFSIDES
266PleurisyOFFSIDES
267Polymyalgia RheumaticaOFFSIDES
268Polyuria5852703CTD
269Post procedural bile leakOFFSIDES
270Post procedural complicationOFFSIDES
271Post procedural discomfortOFFSIDES
272Postictal headacheOFFSIDES
273Procedural complicationOFFSIDES
274PsoriasisOFFSIDES
275Pulmonary HypertensionOFFSIDES
276Pulmonary arterial hypertensionOFFSIDES
277Pulmonary congestionOFFSIDES
278Pulmonary function test decreasedSIDER
279RalesOFFSIDES
280Recall phenomenonOFFSIDES
281Reflux gastritisOFFSIDES
282Renal Insufficiency8554694CTD
283Renal cystOFFSIDES
284Respiratory DepressionSIDER
285Respiratory FailureOFFSIDES
286Respiratory arrestSIDER
287Restless Legs Syndrome19317385CTD
288Rheumatoid factor increasedOFFSIDES
289RhinorrheaOFFSIDES
290Ruptured cerebral aneurysmOFFSIDES
291SarcoidosisOFFSIDES
292Schizoaffective DisorderOFFSIDES
293SclerodermaOFFSIDES
294Secretion dischargeOFFSIDES
295ShockSIDER
296Sinus headacheOFFSIDES
297SinusitisOFFSIDES
298Skeletal injuryOFFSIDES
299Skin lacerationOFFSIDES
300Sleep TalkingOFFSIDES
301SmokerOFFSIDES
302SomnolenceSIDER
303SpondylolisthesisOFFSIDES
304Spondylosis4712825CTD
305Staphylococcal abscessOFFSIDES
306Stasis dermatitisOFFSIDES
307StressOFFSIDES
308StridorOFFSIDES
309Substance Withdrawal Syndrome3804694
6794076		CTD
310Substance-Related Disorders6167247CTD
311SyncopeSIDER
312TachycardiaSIDER
313ThrombophlebitisOFFSIDES
314Tobacco userOFFSIDES
315UlcerOFFSIDES
316Umbilical herniaOFFSIDES
317Urinary tract infection staphylococcalOFFSIDES
318Varicose vein operationOFFSIDES
319Violence-related symptomOFFSIDES
320Visual ImpairmentSIDER
321Visual disturbanceSIDER
322Vitamin B 12 DeficiencyOFFSIDES
323VomitingSIDER
324Vulvovaginal burning sensationOFFSIDES
325Waist circumference increasedOFFSIDES
326Walking aid userOFFSIDES
327Weight GainOFFSIDES
328White blood cell count abnormalOFFSIDES
329effusionOFFSIDES
330jaundiceSIDER
331nervous system disorderSIDER
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