MetaADEDB 2.0 @ LMMD
Darunavir
(CJBJHOAVZSMMDJ-HEXNFIEUSA-N)
Structure
SMILES
CC(CN(S(=O)(=O)c1ccc(cc1)N)C[C@H]([C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@@H]2[C@H]1CCO2)O)C
Type(s)
Approved
ATC code(s)
G01AE10; J05AE10; J05AR14; J05AR22
Molecular Formula:
C27H37N3O7S
Molecular Weight:
547.664
Log P:
4.4282
Hydrogen Bond Acceptor:
10
Hydrogen Bond Donor:
3
TPSA:
148.8
CAS Number(s):
206361-99-1
Synonym(s)
1.
Darunavir
2.
Darunavir Ethanolate
3.
Prezista
4.
TMC 114
5.
TMC-114
6.
TMC114
7.
UIC-94017
8.
UIC94017
9.
114, TMC
10.
Ethanolate, Darunavir
11.
UIC 94017
External Link(s)
MeSHD000069454
PubChem Compound213039
BindingDB8125
ChEBI367163
CHEMBLCHEMBL1323
DrugBankDB01264
DrugCentral4143
KEGGdr:D03656
Therapeutic Target DatabaseD03IGH
D01WFC
ZINC3955219
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug dose omissionFAERS: 58US FAERS
2Wrong technique in drug usage processFAERS: 22US FAERS
3Adverse eventFAERS: 20US FAERS
4Incorrect product storageFAERS: 20US FAERS
5Drug ineffectiveFAERS: 16
Canada Vigilance: 1		Canada Vigilance
US FAERS
6NephrolithiasisFAERS: 15OFFSIDES
SIDER
US FAERS
7NauseaFAERS: 13SIDER
US FAERS
8OverdoseFAERS: 11US FAERS
9Drug dispensing errorFAERS: 10OFFSIDES
US FAERS
10MalaiseFAERS: 10SIDER
US FAERS
11Drug administration errorFAERS: 9US FAERS
12Product packaging quantity issueFAERS: 9US FAERS
13Low density lipoprotein increasedFAERS: 8SIDER
US FAERS
14Maternal exposure during pregnancyFAERS: 8US FAERS
15PruritusFAERS: 7SIDER
US FAERS
16VomitingFAERS: 7SIDER
US FAERS
17Poor quality drug administeredFAERS: 6US FAERS
18Product physical issueFAERS: 6US FAERS
19Product size issueFAERS: 6US FAERS
20Wrong technique in product usage processFAERS: 6US FAERS
21Drug prescribing errorFAERS: 5US FAERS
22HepatotoxicityFAERS: 5OFFSIDES
SIDER
US FAERS
23Incorrect dose administeredFAERS: 5US FAERS
24Medication ErrorFAERS: 5US FAERS
25Product dose omissionFAERS: 5US FAERS
26Product quality issueFAERS: 5
Canada Vigilance: 1		Canada Vigilance
US FAERS
27AmnesiaFAERS: 4US FAERS
28Blood creatine phosphokinase increasedFAERS: 4OFFSIDES
SIDER
US FAERS
29Cerebrovascular accidentFAERS: 4
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
30DehydrationFAERS: 4US FAERS
31Drug resistanceFAERS: 4OFFSIDES
US FAERS
32HeadacheFAERS: 4SIDER
US FAERS
33Inappropriate schedule of drug administrationFAERS: 4US FAERS
34Lipodystrophy acquiredFAERS: 4OFFSIDES
SIDER
US FAERS
35Myocardial InfarctionFAERS: 4SIDER
US FAERS
36PancreatitisFAERS: 4OFFSIDES
SIDER
US FAERS
37Stevens-Johnson SyndromeFAERS: 425811541CTD
OFFSIDES
SIDER
US FAERS
38Alanine Aminotransferase IncreasedFAERS: 3OFFSIDES
SIDER
US FAERS
39AnxietyFAERS: 3SIDER
US FAERS
40AscitesFAERS: 3US FAERS
41Blood creatine increasedFAERS: 3US FAERS
42Gastric BypassFAERS: 3US FAERS
43GastrostomyFAERS: 3US FAERS
44Immune reconstitution syndromeFAERS: 3OFFSIDES
US FAERS
45Incorrect route of drug administrationFAERS: 3US FAERS
46MyositisFAERS: 3SIDER
US FAERS
47Product container issueFAERS: 3US FAERS
48Product difficult to swallowFAERS: 3US FAERS
49Product packaging issueFAERS: 3US FAERS
50Product storage errorFAERS: 3US FAERS
51Product use complaintFAERS: 3US FAERS
52Product use issueFAERS: 3US FAERS
53TachycardiaFAERS: 3
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
54Therapy cessationFAERS: 3US FAERS
55TinnitusFAERS: 3US FAERS
56VasculitisFAERS: 3US FAERS
57Viral load increasedFAERS: 3US FAERS
58Virologic failureFAERS: 3US FAERS
59Abdominal PainFAERS: 2SIDER
US FAERS
60Abdominal discomfortFAERS: 2SIDER
US FAERS
61Accidental overdoseFAERS: 2US FAERS
62Acute myocardial infarctionFAERS: 2SIDER
US FAERS
63AlopeciaFAERS: 2SIDER
US FAERS
64AngioedemaFAERS: 2SIDER
US FAERS
65ArthropathyFAERS: 2US FAERS
66Blood HIV RNA increasedFAERS: 2US FAERS
67Blood cholesterol increasedFAERS: 2US FAERS
68Completed SuicideFAERS: 2SIDER
US FAERS
69Diabetes MellitusFAERS: 2SIDER
US FAERS
70DizzinessFAERS: 2SIDER
US FAERS
71Drug exposure during pregnancyFAERS: 2OFFSIDES
US FAERS
72DysgeusiaFAERS: 2SIDER
US FAERS
73FatigueFAERS: 2SIDER
US FAERS
74InfarctionFAERS: 2US FAERS
75InfluenzaFAERS: 2US FAERS
76Lip swellingFAERS: 2US FAERS
77Medication residue presentFAERS: 2US FAERS
78Pneumocystis jiroveci pneumoniaFAERS: 2OFFSIDES
US FAERS
79Product container seal issueFAERS: 2US FAERS
80Rash erythematousFAERS: 2US FAERS
81Renal ColicFAERS: 2US FAERS
82Septic ShockFAERS: 2US FAERS
83SwellingFAERS: 2US FAERS
84Toxic Epidermal NecrolysisFAERS: 2SIDER
US FAERS
85Transaminases increasedFAERS: 2OFFSIDES
US FAERS
86Urinary RetentionFAERS: 2US FAERS
87Weight decreasedFAERS: 2SIDER
US FAERS
88treatment failureFAERS: 2US FAERS
89AcneFAERS: 1US FAERS
90Acute Coronary SyndromeFAERS: 1OFFSIDES
SIDER
US FAERS
91Acute hepatitis CFAERS: 1US FAERS
92Adrenogenital SyndromeFAERS: 1OFFSIDES
US FAERS
93AgitationFAERS: 1SIDER
US FAERS
94AphagiaFAERS: 1US FAERS
95Aphthous StomatitisFAERS: 1SIDER
US FAERS
96ArthralgiaFAERS: 1SIDER
US FAERS
97ArthritisFAERS: 1SIDER
US FAERS
98Aspartate Aminotransferase IncreasedFAERS: 1SIDER
US FAERS
99Autoimmune nephritisFAERS: 1US FAERS
100Blood alkaline phosphatase increasedFAERS: 1OFFSIDES
SIDER
US FAERS
101Blood amylase increasedFAERS: 1OFFSIDES
SIDER
US FAERS
102Blood creatine phosphokinase MB increasedFAERS: 1US FAERS
103Blood glucose abnormalFAERS: 1US FAERS
104Blood triglycerides increasedFAERS: 1OFFSIDES
SIDER
US FAERS
105Body fat disorderFAERS: 1US FAERS
106Bulimia NervosaFAERS: 1US FAERS
107CD4 Lymphocytes DecreasedFAERS: 1OFFSIDES
US FAERS
108Cardiac FlutterFAERS: 1US FAERS
109Carpal Tunnel SyndromeFAERS: 1US FAERS
110ChromaturiaFAERS: 1US FAERS
111Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
112ConstipationFAERS: 1SIDER
US FAERS
113Cytomegalovirus chorioretinitisFAERS: 1OFFSIDES
US FAERS
114Diffuse Large B-Cell LymphomaFAERS: 1OFFSIDES
US FAERS
115Disease ProgressionFAERS: 1US FAERS
116Drug diversionFAERS: 1US FAERS
117Drug level increasedFAERS: 1US FAERS
118Drug screen positiveFAERS: 1US FAERS
119Economic problemFAERS: 1US FAERS
120EmbolismFAERS: 1US FAERS
121EncephalomyelitisFAERS: 1US FAERS
122EosinophiliaFAERS: 1SIDER
US FAERS
123EpilepsyFAERS: 1US FAERS
124EructationFAERS: 1SIDER
US FAERS
125Extra dose administeredFAERS: 1US FAERS
126Eye irritationFAERS: 1US FAERS
127Fanconi SyndromeFAERS: 1OFFSIDES
US FAERS
128Feeling abnormalFAERS: 1SIDER
US FAERS
129Foreign body in respiratory tractFAERS: 1US FAERS
130FrustrationFAERS: 1US FAERS
131GastritisFAERS: 1SIDER
US FAERS
132Gastrointestinal carcinomaFAERS: 1US FAERS
133Gastrointestinal ulcerFAERS: 1US FAERS
134Gene MutationFAERS: 1US FAERS
135General physical health deteriorationFAERS: 1US FAERS
136GoutFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
137Hepatitis CFAERS: 1OFFSIDES
SIDER
US FAERS
138HepatitisFAERS: 1OFFSIDES
SIDER
US FAERS
139Hyperosmolar stateFAERS: 1US FAERS
140HyperoxaluriaFAERS: 1US FAERS
141HypersensitivityFAERS: 1SIDER
US FAERS
142HypotensionFAERS: 1US FAERS
143Inability to afford medicationFAERS: 1US FAERS
144InfectionFAERS: 1US FAERS
145Intentional product misuseFAERS: 1US FAERS
146Intentional self-injuryFAERS: 1US FAERS
147Intercepted drug prescribing errorFAERS: 1US FAERS
148LymphomaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
149MastitisFAERS: 1US FAERS
150MenorrhagiaFAERS: 1US FAERS
151Mental impairmentFAERS: 1US FAERS
152Mental status changesFAERS: 1US FAERS
153MetamorphopsiaFAERS: 1US FAERS
154MyalgiaFAERS: 1SIDER
US FAERS
155Nephrotic SyndromeFAERS: 1US FAERS
156NervousnessFAERS: 1US FAERS
157Obesity surgeryFAERS: 1US FAERS
158OsteoporosisFAERS: 1OFFSIDES
SIDER
US FAERS
159PericarditisFAERS: 1US FAERS
160PetechiaeFAERS: 1US FAERS
161Pharyngeal lesionFAERS: 1SIDER
US FAERS
162PneumoniaFAERS: 1US FAERS
163PolydipsiaFAERS: 1SIDER
US FAERS
164PolyneuropathyFAERS: 1US FAERS
165Pre-EclampsiaFAERS: 1OFFSIDES
US FAERS
166Product label confusionFAERS: 1US FAERS
167Product tamperingFAERS: 1US FAERS
168Product taste abnormalFAERS: 1US FAERS
169Product use in unapproved indicationFAERS: 1US FAERS
170Renal tubular necrosisFAERS: 1OFFSIDES
SIDER
US FAERS
171RetchingFAERS: 1SIDER
US FAERS
172RetinitisFAERS: 1US FAERS
173RhabdomyolysisFAERS: 1OFFSIDES
SIDER
US FAERS
174SomnolenceFAERS: 1SIDER
US FAERS
175SoporFAERS: 1US FAERS
176Sudden infant death syndromeFAERS: 1OFFSIDES
US FAERS
177Suicide attemptFAERS: 1US FAERS
178Suppressed lactationFAERS: 1OFFSIDES
US FAERS
179SyphilisFAERS: 1OFFSIDES
US FAERS
180Systemic lupus erythematosus rashFAERS: 1US FAERS
181Therapeutic response unexpectedFAERS: 1US FAERS
182Therapy changeFAERS: 1US FAERS
183Throat cancerFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
184Toxicity to various agentsFAERS: 1US FAERS
185ToxoplasmosisFAERS: 1US FAERS
186Transcription medication errorFAERS: 1US FAERS
187Trisomy 21FAERS: 1OFFSIDES
US FAERS
188Unresponsive to stimuliFAERS: 1US FAERS
189Urinary tract infectionFAERS: 1US FAERS
190UrticariaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
191Vagus Nerve DisorderFAERS: 1US FAERS
192Ventricular hypertrophyFAERS: 1US FAERS
193Vitreous floatersFAERS: 1US FAERS
194Waist circumference increasedFAERS: 1OFFSIDES
US FAERS
195WheezingFAERS: 1US FAERS
196White blood cell count decreasedFAERS: 1US FAERS
197intensive careFAERS: 1US FAERS
198jaundiceFAERS: 1SIDER
US FAERS
199AcidosisOFFSIDES
200Acute psychosisOFFSIDES
201AgeusiaSIDER
202Altered state of consciousnessSIDER
203Amylase increasedSIDER
204Angina PectorisSIDER
205Anorectal agenesisOFFSIDES
206AnorexiaSIDER
207Anti-HBc antibodyOFFSIDES
208Aortic valve sclerosisOFFSIDES
209AortitisOFFSIDES
210ApneaOFFSIDES
211Application site noduleOFFSIDES
212ArteriosclerosisOFFSIDES
213Aseptic MeningitisOFFSIDES
214AsphyxiaOFFSIDES
215AstheniaSIDER
216Autoimmune thyroiditisOFFSIDES
217Bacterial EndocarditisOFFSIDES
218Basal cell carcinomaOFFSIDES
219BicytopeniaOFFSIDES
220Biliary dilatationOFFSIDES
221Biopsy liver abnormalCanada Vigilance: 1Canada Vigilance
222BlepharoptosisOFFSIDES
223Blighted ovumOFFSIDES
224Blood and lymphatic system disordersSIDER
225Blood cholesterolOFFSIDES
226Blood corticotrophinOFFSIDES
227Blood cortisol decreasedOFFSIDES
228Blood creatinine decreasedSIDER
229Blood creatinine increasedSIDER
230Blood iron decreasedOFFSIDES
231Blood thyroid stimulating hormone increasedSIDER
232Bone infarctionOFFSIDES
233BradycardiaSIDER
234Buffalo humpSIDER
235Burning Mouth SyndromeSIDER
236CD4 lymphocytes increasedOFFSIDES
237Cardiac TamponadeOFFSIDES
238Cardiac valve replacement complicationOFFSIDES
239Caudal Regression SyndromeOFFSIDES
240Cerebral atrophyOFFSIDES
241Cervical dysplasiaOFFSIDES
242CheilitisSIDER
243Chest PainSIDER
244ChillsSIDER
245CholangiolitisOFFSIDES
246CholestasisSIDER
247Cholestatic liver injuryOFFSIDES
248ChorioamnionitisOFFSIDES
249Chronic left ventricular failureOFFSIDES
250CirrhosisOFFSIDES
251Congenital anomaly in offspringOFFSIDES
252Congenital heart diseaseOFFSIDES
253Congenital heart valve disorderOFFSIDES
254Creatinine lowSIDER
255CryptosporidiosisOFFSIDES
256Cytolytic hepatitisOFFSIDES
SIDER
257Cytomegalovirus myocarditisOFFSIDES
258DermatitisSIDER
259DiplopiaOFFSIDES
260DiscomfortSIDER
261DisorientationSIDER
262Disturbance in sexual arousalSIDER
263Dry skinSIDER
264DyspepsiaSIDER
265DysphasiaOFFSIDES
266DysuriaSIDER
267Ear and labyrinth disordersSIDER
268EczemaSIDER
269Electrocardiogram abnormalSIDER
270Eosinophilic myocarditisOFFSIDES
271EpistaxisSIDER
272Erectile dysfunctionSIDER
273ErysipelasOFFSIDES
274Erythema MultiformeSIDER
275ErythemaSIDER
276EscharOFFSIDES
277Facial paralysisSIDER
278Facial wastingOFFSIDES
279Fat redistributionSIDER
280FlatulenceSIDER
281FlushingSIDER
282FolliculitisSIDER
283Gamma-Glutamyltransferase IncreasedSIDER
284Gastric ulcerOFFSIDES
285Gastrointestinal PainSIDER
286Gastrointestinal disorder congenitalOFFSIDES
287Gastrointestinal mucosal disorderOFFSIDES
288Gastrointestinal obstructionOFFSIDES
289Genital painOFFSIDES
290Gestational DiabetesOFFSIDES
291GiardiasisOFFSIDES
292HIV Wasting SyndromeOFFSIDES
293Hepatic necrosisOFFSIDES
294Hepatitis B positiveOFFSIDES
295Hepatitis BOFFSIDES
SIDER
296Hepatitis EOFFSIDES
297HepatomegalySIDER
298HepatosplenomegalyOFFSIDES
299Hypertrophy of BreastSIDER
300Hypocoagulable stateOFFSIDES
301Hypothalamo-pituitary disorderOFFSIDES
302HypothyroidismSIDER
303Idiopathic urticariaOFFSIDES
304IleitisOFFSIDES
305Iliac artery stenosisOFFSIDES
306Imminent abortionOFFSIDES
307InfestationSIDER
308InflammationSIDER
309Insulin ResistanceSIDER
310Intermittent ClaudicationOFFSIDES
311Joint stiffnessSIDER
312Kidney FailureOFFSIDES
313Leriche SyndromeOFFSIDES
314LethargySIDER
315LeukopeniaSIDER
316Lipase increasedSIDER
317LipaseOFFSIDES
318Lipids abnormalOFFSIDES
319LipoatrophySIDER
320LipodystrophySIDER
321LipohypertrophyOFFSIDES
SIDER
322Live BirthOFFSIDES
323Lower respiratory tract infection bacterialOFFSIDES
324Lupus-like syndromeOFFSIDES
325LymphangitisOFFSIDES
326MalnutritionSIDER
327Medication residueOFFSIDES
328Memory impairmentSIDER
329MeningoceleOFFSIDES
330Metabolic acidosisOFFSIDES
SIDER
331Mitochondrial toxicityOFFSIDES
332Molluscum ContagiosumOFFSIDES
333Mood swingsSIDER
334Mucocutaneous rashOFFSIDES
335Multiple drug overdoseOFFSIDES
336Musculoskeletal DeformityOFFSIDES
337Musculoskeletal discomfortSIDER
338Musculoskeletal stiffnessSIDER
339Mycobacterium avium complex immune restoration diseaseOFFSIDES
340MyelitisOFFSIDES
341MyelocytosisOFFSIDES
342MyocarditisSIDER
343Nail pigmentationSIDER
344NasopharyngitisSIDER
345Neonatal respiratory arrestOFFSIDES
346NeutropeniaSIDER
347Night sweatsSIDER
348NocturiaSIDER
349ObesitySIDER
350OligohydramniosOFFSIDES
351OphthalmoplegiaOFFSIDES
352OsteopeniaSIDER
353Oxygen consumption decreasedOFFSIDES
354PainSIDER
355PalpitationsSIDER
356Pancreatic InsufficiencyOFFSIDES
357PancytopeniaSIDER
358ParotitisOFFSIDES
359Penis carcinomaOFFSIDES
360PeriostitisOFFSIDES
361Plasmablastic lymphomaOFFSIDES
362Pneumococcal sepsisOFFSIDES
363PneumothoraxSIDER
364PolydactylyOFFSIDES
365PolyhydramniosOFFSIDES
366PolyuriaSIDER
367Portal HypertensionOFFSIDES
368Product dispensing errorCanada Vigilance: 1Canada Vigilance
369Protein urine presentSIDER
370ProteinuriaSIDER
371PrurigoSIDER
372Pseudomyxoma PeritoneiOFFSIDES
373Pulmonary valve sclerosisOFFSIDES
374Renal tubular disorderOFFSIDES
375Respiratory FailureSIDER
376SepsisSIDER
377ShockSIDER
378Sinus bradycardiaSIDER
379Skin lesionSIDER
380Staphylococcal abscessOFFSIDES
381StomatitisSIDER
382Subcutaneous EmphysemaOFFSIDES
383SyncopeSIDER
384Tethered Cord SyndromeOFFSIDES
385Throat irritationSIDER
386ThrombocytopeniaSIDER
387Ultrasound antenatal screenOFFSIDES
388Ultrasound scan abnormalOFFSIDES
389UnderweightOFFSIDES
390Urinary Tract PainOFFSIDES
391Urine amphetamine positiveOFFSIDES
392Urine output increasedSIDER
393Uterine contractions during pregnancyOFFSIDES
394VIIth nerve paralysisSIDER
395Vascular procedure complicationOFFSIDES
396VertigoSIDER
397Victim of spousal abuseOFFSIDES
398Viral mutation identifiedOFFSIDES
399Visual ImpairmentSIDER
400Visual disturbanceSIDER
401Wolff-Parkinson-White SyndromeOFFSIDES
402XerodermaSIDER
403XerosisSIDER
404nervous system disorderSIDER
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