MetaADEDB 2.0 @ LMMD
etravirine
(PYGWGZALEOIKDF-UHFFFAOYSA-N)
Structure
SMILES
N#Cc1ccc(cc1)Nc1nc(N)c(c(n1)Oc1c(C)cc(cc1C)C#N)Br
Type(s)
Approved
ATC code(s)
J05AG04
Molecular Formula:
C20H15BrN6O
Molecular Weight:
435.277
Log P:
5.3716
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
2
TPSA:
120.64
CAS Number(s):
269055-15-4; 394729-17-0
Synonym(s)
1.
etravirine
2.
4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-benzonitrile
3.
Intelence
4.
R165335
5.
TMC 125
6.
TMC-125
7.
TMC125 cpd
8.
benzonitrile, 4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-
External Link(s)
MeSHC451734
PubChem Compound193962
BindingDB50103642
ChEBI63589
CHEMBLCHEMBL308954
DrugBankDB06414
DrugCentral1115
KEGGdr:D04112
Therapeutic Target DatabaseD0BP9C
ZINC602632
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1ChokingFAERS: 18
Canada Vigilance: 1		Canada Vigilance
US FAERS
2Drug dose omissionFAERS: 16US FAERS
3Product solubility abnormalFAERS: 10US FAERS
4Drug dispensing errorFAERS: 9US FAERS
5Incorrect product storageFAERS: 9US FAERS
6NauseaFAERS: 9SIDER
US FAERS
7Poor quality drug administeredFAERS: 9US FAERS
8Product physical issueFAERS: 9US FAERS
9Product formulation issueFAERS: 8US FAERS
10Product quality issueFAERS: 7US FAERS
11Drug ineffectiveFAERS: 5US FAERS
12DysgeusiaFAERS: 5US FAERS
13Incorrect dose administeredFAERS: 5OFFSIDES
US FAERS
14Product packaging quantity issueFAERS: 5US FAERS
15VomitingFAERS: 5SIDER
US FAERS
16Adverse eventFAERS: 4US FAERS
17FatigueFAERS: 4SIDER
US FAERS
18Product packaging issueFAERS: 4US FAERS
19Product size issueFAERS: 4US FAERS
20Product storage errorFAERS: 4US FAERS
21Product use in unapproved indicationFAERS: 4US FAERS
22Product use issueFAERS: 4US FAERS
23Stevens-Johnson SyndromeFAERS: 425811541CTD
OFFSIDES
SIDER
US FAERS
24Wrong technique in drug usage processFAERS: 4OFFSIDES
US FAERS
25Wrong technique in product usage processFAERS: 4
Canada Vigilance: 2		Canada Vigilance
US FAERS
26ArthralgiaFAERS: 3US FAERS
27HeadacheFAERS: 3
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
28Medication ErrorFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
29Oropharyngeal painFAERS: 3
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
30Product coating issueFAERS: 3US FAERS
31Product difficult to swallowFAERS: 3US FAERS
32Product dose omissionFAERS: 3US FAERS
33SyncopeFAERS: 3SIDER
US FAERS
34UrticariaFAERS: 3US FAERS
35Accidental overdoseFAERS: 2US FAERS
36Aphthous StomatitisFAERS: 2OFFSIDES
US FAERS
37AstheniaFAERS: 2SIDER
US FAERS
38Blood HIV RNA increasedFAERS: 2US FAERS
39CD4 Lymphocytes DecreasedFAERS: 2US FAERS
40CD8 lymphocytes decreasedFAERS: 2US FAERS
41DehydrationFAERS: 2US FAERS
42Drug screen false positiveFAERS: 2US FAERS
43LethargyFAERS: 2US FAERS
44MyalgiaFAERS: 2US FAERS
45Myocardial InfarctionFAERS: 2SIDER
US FAERS
46MyopathyFAERS: 2US FAERS
47PainFAERS: 2SIDER
US FAERS
48Physical product label issueFAERS: 2US FAERS
49Product counterfeitFAERS: 2US FAERS
50Product dispensing errorFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
51PruritusFAERS: 2US FAERS
52RetchingFAERS: 2SIDER
US FAERS
53TremorFAERS: 2SIDER
US FAERS
54treatment failureFAERS: 2US FAERS
55AbasiaFAERS: 1US FAERS
56Abdominal discomfortFAERS: 1US FAERS
57Accidental exposure to productFAERS: 1US FAERS
58Acute myocardial infarctionFAERS: 1US FAERS
59AmnesiaFAERS: 1SIDER
US FAERS
60Angina PectorisFAERS: 1SIDER
US FAERS
61AnxietyFAERS: 1SIDER
US FAERS
62AphagiaFAERS: 1US FAERS
63AsthmaFAERS: 1US FAERS
64Back PainFAERS: 1US FAERS
65Cerebral InfarctionFAERS: 1US FAERS
66Cerebrovascular accidentFAERS: 1US FAERS
67ChillsFAERS: 1US FAERS
68ConstipationFAERS: 1SIDER
US FAERS
69Contraindicated drug administeredFAERS: 1US FAERS
70DiscomfortFAERS: 1SIDER
US FAERS
71Drug administration errorFAERS: 1US FAERS
72Drug resistanceFAERS: 1US FAERS
73EpistaxisFAERS: 1OFFSIDES
US FAERS
74Erythema MultiformeFAERS: 1SIDER
US FAERS
75ErythemaFAERS: 1OFFSIDES
US FAERS
76Extra dose administeredFAERS: 1US FAERS
77Fat redistributionFAERS: 1US FAERS
78Feeling abnormalFAERS: 1SIDER
US FAERS
79FlatulenceFAERS: 1SIDER
US FAERS
80Foreign body traumaFAERS: 1US FAERS
81Gastric BypassFAERS: 1US FAERS
82Gastrointestinal PainFAERS: 1SIDER
US FAERS
83GastrostomyFAERS: 1US FAERS
84General physical health deteriorationFAERS: 1US FAERS
85Grip strength decreasedFAERS: 1US FAERS
86HepatitisFAERS: 1SIDER
US FAERS
87HypersomniaFAERS: 1SIDER
US FAERS
88Inappropriate schedule of drug administrationFAERS: 1US FAERS
89Infrequent bowel movementsFAERS: 1US FAERS
90Intervertebral disc injuryFAERS: 1US FAERS
91Lichen PlanusFAERS: 1US FAERS
92MalaiseFAERS: 1SIDER
US FAERS
93Medication residue presentFAERS: 1US FAERS
94Memory impairmentFAERS: 1US FAERS
95Musculoskeletal PainFAERS: 1US FAERS
96NasopharyngitisFAERS: 1US FAERS
97OsteochondrosisFAERS: 1US FAERS
98OverdoseFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
99PalpitationsFAERS: 1US FAERS
100Pancreatic CystFAERS: 1US FAERS
101PancreatitisFAERS: 1OFFSIDES
SIDER
US FAERS
102PoisoningFAERS: 1US FAERS
103Product administration errorFAERS: 1US FAERS
104Product packaging counterfeitFAERS: 1US FAERS
105Product taste abnormalFAERS: 1US FAERS
106Product use complaintFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
107Psychiatric symptomFAERS: 1US FAERS
108RegurgitationFAERS: 1US FAERS
109Renal ColicFAERS: 1US FAERS
110Sensorimotor disorderFAERS: 1US FAERS
111SomnolenceFAERS: 1SIDER
US FAERS
112StressFAERS: 1US FAERS
113Sudden deathFAERS: 1US FAERS
114Superficial siderosis of central nervous systemFAERS: 1US FAERS
115TachyphreniaFAERS: 1US FAERS
116Throat irritationFAERS: 1US FAERS
117Toxic Epidermal NecrolysisFAERS: 1SIDER
US FAERS
118Urinary IncontinenceFAERS: 1US FAERS
119Viral load increasedFAERS: 1US FAERS
120nervous system disorderFAERS: 1SIDER
US FAERS
121Abdominal PainSIDER
122Abnormal visionOFFSIDES
123AcheSIDER
124Acute Coronary SyndromeSIDER
125AdenocarcinomaOFFSIDES
126Adrenogenital SyndromeOFFSIDES
127Alanine Aminotransferase IncreasedOFFSIDES
128Alanine aminotransferase abnormalOFFSIDES
129AlveolitisOFFSIDES
130Anal cancer stage IIOFFSIDES
131AngioedemaSIDER
132Ankylosing spondylitisOFFSIDES
133Anorectal agenesisOFFSIDES
134AnorexiaSIDER
135ArteriosclerosisOFFSIDES
136Aspartate aminotransferase abnormalOFFSIDES
137Aspiration tracheal abnormalOFFSIDES
138Atrial FibrillationSIDER
139Autoimmune thyroiditisOFFSIDES
140Basal cell carcinomaOFFSIDES
141BlepharoptosisOFFSIDES
142Blood and lymphatic system disordersSIDER
143Blood creatine phosphokinase increasedOFFSIDES
144Blood iron decreasedOFFSIDES
145Blood testosterone decreasedOFFSIDES
146Blood triglycerides increasedSIDER
147Body temperature fluctuationOFFSIDES
148Bone infarctionOFFSIDES
149Brain AbscessOFFSIDES
150BronchitisOFFSIDES
151Bronchoalveolar LavageOFFSIDES
152Bronchoalveolar lavage abnormalOFFSIDES
153BronchospasmSIDER
154Buffalo humpSIDER
155Cardiac TamponadeOFFSIDES
156Caudal Regression SyndromeOFFSIDES
157Cell DeathOFFSIDES
158CellulitisOFFSIDES
159Cerebellar AtaxiaOFFSIDES
160CheilitisOFFSIDES
161ChorioamnionitisOFFSIDES
162Chronic left ventricular failureOFFSIDES
163Clostridium difficile colitisOFFSIDES
164ConjunctivitisSIDER
165Conversion disorderOFFSIDES
166Cytolytic hepatitisSIDER
167DermatitisSIDER
168Diabetes MellitusSIDER
169DiplopiaOFFSIDES
170DisorientationSIDER
171DizzinessSIDER
172Dry skinSIDER
173DysphasiaOFFSIDES
174Ear and labyrinth disordersSIDER
175Enterococcal infectionOFFSIDES
176EosinophiliaSIDER
177FormicationOFFSIDES
178Gastric ulcerOFFSIDES
179GastritisSIDER
180Gastrointestinal disorder congenitalOFFSIDES
181Gastrointestinal mucosal disorderOFFSIDES
182Genotype drug resistance testOFFSIDES
183Genotype drug resistance test positiveOFFSIDES
184GlobulinuriaOFFSIDES
185HIV Infections18195053CTD
186Hepatitis BOFFSIDES
SIDER
187Hepatitis COFFSIDES
SIDER
188HepatomegalySIDER
189HistoplasmosisOFFSIDES
190HypersensitivitySIDER
191Hypertrophy of BreastSIDER
192Hypothalamo-pituitary disorderOFFSIDES
193HypoxiaOFFSIDES
194Immune reconstitution syndromeOFFSIDES
195Immunosuppressant drug levelOFFSIDES
196InfectionSIDER
197InflammationSIDER
198Injection site massOFFSIDES
199Injection site noduleOFFSIDES
200Injection site urticariaOFFSIDES
201Intermittent ClaudicationOFFSIDES
202Intestinal PerforationOFFSIDES
203IridocyclitisOFFSIDES
204Kidney FailureOFFSIDES
205Laboratory test interferenceOFFSIDES
206Lipodystrophy acquiredOFFSIDES
SIDER
207LipodystrophySIDER
208LipohypertrophyOFFSIDES
SIDER
209MalnutritionSIDER
210MeningoceleOFFSIDES
211Mitochondrial toxicityOFFSIDES
212Mucocutaneous rashOFFSIDES
213Musculoskeletal DeformityOFFSIDES
214Mycobacterium avium complex immune restoration diseaseOFFSIDES
215MyelitisOFFSIDES
216MyelodysplasiaOFFSIDES
217MyopericarditisOFFSIDES
218NervousnessSIDER
219Night sweatsSIDER
220OphthalmoplegiaOFFSIDES
221Oral lesionSIDER
222OsteoporosisOFFSIDES
223ParaparesisOFFSIDES
224PenicilliosisOFFSIDES
225Penis carcinomaOFFSIDES
226PeriostitisOFFSIDES
227Pneumococcal sepsisOFFSIDES
228PolyhydramniosOFFSIDES
229Product label issueCanada Vigilance: 1Canada Vigilance
230PrurigoSIDER
231RhabdomyolysisOFFSIDES
SIDER
232ShockSIDER
233Skin IndurationOFFSIDES
234SluggishnessSIDER
235Squamous cell carcinoma of skinOFFSIDES
236StomatitisSIDER
237Subacute combined cord degenerationOFFSIDES
238Subcutaneous noduleOFFSIDES
239TensionSIDER
240Tethered Cord SyndromeOFFSIDES
241ThrombocytopeniaSIDER
242Uterine contractions during pregnancyOFFSIDES
243VertigoSIDER
244Vitamin B 12 DeficiencyOFFSIDES
245Vulvovaginal mycotic infectionOFFSIDES
246Weight GainOFFSIDES
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