MetaADEDB 2.0 @ LMMD
Dacarbazine
(FDKXTQMXEQVLRF-ZHACJKMWSA-N)
Structure
SMILES
CN(/N=N/c1nc[nH]c1C(=O)N)C
Type(s)
Approved; Investigational
ATC code(s)
L01AX04
Molecular Formula:
C6H10N6O
Molecular Weight:
182.183
Log P:
0.7692
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
2
TPSA:
99.73
CAS Number(s):
4342-03-4; 891986
Synonym(s)
1.
Dacarbazine
2.
DTIC
3.
5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
4.
Biocarbazine
5.
DIC
6.
DTIC-Dome
7.
Decarbazine
8.
Deticene
9.
Dimethyl Imidazole Carboxamide
10.
Dimethyl Triazeno Imidazole Carboxamide
11.
ICDT
12.
NSC-45388
13.
Carboxamide, Dimethyl Imidazole
14.
DTIC Dome
15.
DTICDome
16.
Imidazole Carboxamide, Dimethyl
17.
NSC 45388
18.
NSC45388
External Link(s)
MeSHD003606
PubChem Compound135398738
5351166
BindingDB233149
ChEBI94587
4305
CHEMBLCHEMBL476
DrugBankDB00851
DrugCentral773
KEGGcpd:C06936
dr:D00288
Therapeutic Target DatabaseD0Y7ZU
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Disease ProgressionFAERS: 16US FAERS
2Back PainFAERS: 9US FAERS
3DiverticulitisFAERS: 7OFFSIDES
US FAERS
4Malignant neoplasm progressionFAERS: 7US FAERS
5NephrolithiasisFAERS: 7OFFSIDES
US FAERS
6OverdoseFAERS: 6US FAERS
7Abdominal PainFAERS: 5OFFSIDES
US FAERS
8PneumoniaFAERS: 5US FAERS
9IleusFAERS: 4US FAERS
10Medication ErrorFAERS: 4US FAERS
11Pulmonary toxicityFAERS: 4OFFSIDES
US FAERS
12Renal cystFAERS: 4OFFSIDES
US FAERS
13TachycardiaFAERS: 4US FAERS
14Abdominal AbscessFAERS: 3OFFSIDES
US FAERS
15Atrial FibrillationFAERS: 3US FAERS
16FatigueFAERS: 3
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
17Gastrointestinal perforationFAERS: 3US FAERS
18Intestinal PerforationFAERS: 3US FAERS
19NauseaFAERS: 36704980
17692730
CTD
SIDER
US FAERS
20ChillsFAERS: 2US FAERS
21Colonic fistulaFAERS: 2OFFSIDES
US FAERS
22ConstipationFAERS: 2US FAERS
23Diverticular perforationFAERS: 2OFFSIDES
US FAERS
24General physical health deteriorationFAERS: 2US FAERS
25HypotensionFAERS: 26704980
7916039
8262729
CTD
SIDER
US FAERS
26Intestinal FistulaFAERS: 2OFFSIDES
US FAERS
27NeutropeniaFAERS: 29221855
12494480
CTD
US FAERS
28Pulmonary EmbolismFAERS: 2US FAERS
29ThrombocytopeniaFAERS: 212494480CTD
SIDER
US FAERS
30TremorFAERS: 2US FAERS
31jaundiceFAERS: 2US FAERS
32AbscessFAERS: 1US FAERS
33Alanine aminotransferase abnormalFAERS: 1US FAERS
34AnorexiaFAERS: 1SIDER
US FAERS
35AnxietyFAERS: 1US FAERS
36Autoimmune dermatitisFAERS: 1US FAERS
37Autoimmune hepatitisFAERS: 1OFFSIDES
US FAERS
38Blood alkaline phosphatase abnormalFAERS: 1US FAERS
39Bulbar palsyFAERS: 1US FAERS
40ChromaturiaFAERS: 1US FAERS
41Clostridium difficile colitisFAERS: 1US FAERS
42ColitisFAERS: 1US FAERS
43DehydrationFAERS: 1US FAERS
44Depressed moodFAERS: 1US FAERS
45DiplopiaFAERS: 1US FAERS
46Disease recurrenceFAERS: 1OFFSIDES
US FAERS
47Drug effect variableFAERS: 1US FAERS
48Drug toxicityFAERS: 1OFFSIDES
US FAERS
49EpilepsyFAERS: 1US FAERS
50Febrile NeutropeniaFAERS: 1SIDER
US FAERS
51Fungating woundFAERS: 1US FAERS
52GastritisFAERS: 1US FAERS
53Gastrointestinal toxicityFAERS: 1US FAERS
54General physical condition abnormalFAERS: 1US FAERS
55HepatotoxicityFAERS: 1SIDER
US FAERS
56HypersensitivityFAERS: 1SIDER
US FAERS
57HypersomniaFAERS: 1US FAERS
58HypophagiaFAERS: 1US FAERS
59IleitisFAERS: 1US FAERS
60InfectionFAERS: 1US FAERS
61Infusion site painFAERS: 1US FAERS
62Large intestine perforationFAERS: 1US FAERS
63LeukocytosisFAERS: 1US FAERS
64LeukopeniaFAERS: 17960606CTD
SIDER
US FAERS
65MalaiseFAERS: 1SIDER
US FAERS
66Malignant melanoma in situFAERS: 1US FAERS
67Mental status changesFAERS: 1US FAERS
68Metastases to stomachFAERS: 1OFFSIDES
US FAERS
69Micturition frequency decreasedFAERS: 1US FAERS
70Neutrophil count decreasedFAERS: 1US FAERS
71PainFAERS: 1SIDER
US FAERS
72Pancreatic enzymes increasedFAERS: 1US FAERS
73PancreatitisFAERS: 1OFFSIDES
US FAERS
74PancytopeniaFAERS: 1SIDER
US FAERS
75Pelvic Inflammatory DiseaseFAERS: 1US FAERS
76Peridiverticular abscessFAERS: 1US FAERS
77Peripheral nerve palsyFAERS: 1US FAERS
78Peripheral swellingFAERS: 1US FAERS
79Pneumatosis intestinalisFAERS: 1US FAERS
80PneumothoraxFAERS: 1OFFSIDES
US FAERS
81Product storage errorFAERS: 1US FAERS
82PruritusFAERS: 1US FAERS
83Restrictive pulmonary diseaseFAERS: 1OFFSIDES
US FAERS
84SepsisFAERS: 1US FAERS
85Shoulder PainFAERS: 1US FAERS
86SinusitisFAERS: 1OFFSIDES
US FAERS
87ThrombocytosisFAERS: 1US FAERS
88Toxicity to various agentsFAERS: 1US FAERS
89Urinary tract infectionFAERS: 1US FAERS
90WheezingFAERS: 1US FAERS
91White blood cell count decreasedFAERS: 1US FAERS
92leiomyosarcomaFAERS: 111330370CTD
US FAERS
93nervous system disorderFAERS: 1US FAERS
94Abdominal discomfortOFFSIDES
95Acute Coronary SyndromeOFFSIDES
96Acute myocardial infarctionOFFSIDES
97Adenocarcinoma1127724
6340628
CTD
98Adnexa uteri massOFFSIDES
99AgranulocytosisSIDER
100Alanine Aminotransferase IncreasedOFFSIDES
101AlopeciaSIDER
102Anaphylactic shockSIDER
103Anaplastic astrocytomaOFFSIDES
104AnosmiaOFFSIDES
105AnuriaOFFSIDES
106Anus Neoplasms12170190CTD
107AppendectomyOFFSIDES
108Arterial insufficiencyOFFSIDES
109Aspiration PneumoniaOFFSIDES
110AstheniaSIDER
111AsthmaOFFSIDES
112Atrial FlutterOFFSIDES
113Atrial tachycardiaOFFSIDES
114Bacteria body fluid identifiedOFFSIDES
115Bacteria stool identifiedOFFSIDES
116Bacterial sepsisOFFSIDES
117Band neutrophil count increasedOFFSIDES
118Blood amylase increasedOFFSIDES
119Blood count abnormalOFFSIDES
120Blood fibrinogen increasedOFFSIDES
121Blood parathyroid hormone increasedOFFSIDES
122Blood pressure immeasurableOFFSIDES
123Blood urea increasedOFFSIDES
124Body TemperatureOFFSIDES
125Bone marrow depressionSIDER
126Bone painOFFSIDES
127BronchiectasisOFFSIDES
128Budd-Chiari Syndrome

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CTD
OFFSIDES
SIDER
129Burning sensationOFFSIDES
130Carcinoid Tumor16051944CTD
131Cardiomyopathies597823CTD
132Carotid Artery Thrombosis11330370CTD
OFFSIDES
133CellulitisOFFSIDES
SIDER
134Chemical and Drug Induced Liver Injury

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CTD
135Chemotherapeutic drug level increasedOFFSIDES
136Chest PainOFFSIDES
137Choking sensationOFFSIDES
138CholecystitisOFFSIDES
139ChondrosarcomaOFFSIDES
140Circumstance or information capable of leading to medication errorOFFSIDES
141Colorectal Neoplasms7960606
15273666
CTD
142Contact DermatitisOFFSIDES
143Cystitis17692730CTD
144Cytolytic hepatitisOFFSIDES
145Dental abscessOFFSIDES
146DermatitisSIDER
147Desmoid disease, hereditary9221855CTD
148Diarrhea6704980CTD
149Diffuse Large B-Cell LymphomaOFFSIDES
150DiscomfortSIDER
151Disseminated Intravascular CoagulationOFFSIDES
152DiverticulumOFFSIDES
153Drug exposure during pregnancyOFFSIDES
154Drug ineffectiveCanada Vigilance: 1Canada Vigilance
155Duodenal UlcerOFFSIDES
156DuodenitisOFFSIDES
157DysmenorrheaOFFSIDES
158DysphoniaOFFSIDES
159Dysuria17692730CTD
OFFSIDES
160EczemaOFFSIDES
161Edema17692730CTD
162EnterocolitisOFFSIDES
163Eosinophilia4093126CTD
SIDER
164Epistaxis9221855CTD
165Escherichia sepsisOFFSIDES
166ExtravasationSIDER
167Eye painOFFSIDES
168Facial paresthesiaSIDER
169Fanconi SyndromeOFFSIDES
170Fatty LiverOFFSIDES
171Feeling abnormalSIDER
172Fibromatosis, Aggressive19069698CTD
173Fixed drug eruptionSIDER
174FlushingSIDER
175Gamma-Glutamyltransferase IncreasedOFFSIDES
176GastroenteritisOFFSIDES
177Gastrointestinal Diseases7960606CTD
178Gastrointestinal infectionOFFSIDES
179Gene MutationOFFSIDES
180Glioblastoma12592361
12853885
CTD
181GranulocytosisOFFSIDES
182Granulomatous liver diseaseSIDER
183Groin infectionOFFSIDES
184Headache6704980CTD
SIDER
185Hematuria17692730CTD
186Hemorrhage17692730CTD
187Hepatic Vein ThrombosisOFFSIDES
SIDER
188Hepatic Veno-Occlusive Disease

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CTD
189Hepatic necrosisOFFSIDES
SIDER
190Hepatic vein occlusionSIDER
191HistoplasmosisOFFSIDES
192Hodgkin Disease

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CTD
193HyperpigmentationOFFSIDES
194HypersplenismOFFSIDES
195Hypocalcemia7916039CTD
196HypoxiaOFFSIDES
197ImmunosuppressionOFFSIDES
198ImpetigoOFFSIDES
199Incision site infectionOFFSIDES
200InfluenzaSIDER
201Injection site painSIDER
202Intervertebral Disc DegenerationOFFSIDES
203Joint sprainOFFSIDES
204Keratitis siccaOFFSIDES
205LethargySIDER
206Leukopenia neonatalOFFSIDES
207LipaseOFFSIDES
208Liver Failure528568
11901312
CTD
209Liver diseases2707742
3802121
CTD
210Local reactionSIDER
211Lymphocyte count decreasedOFFSIDES
212Lymphocyte stimulation test positiveOFFSIDES
213Lymphoma, Non-Hodgkin1127724CTD
214Malignant neoplasm of spinal cordOFFSIDES
215Melanoma, Amelanotic15990972CTD
216MelanosisOFFSIDES
217Mesothelioma malignant advancedOFFSIDES
218Metastatic NeoplasmOFFSIDES
219MicrophthalmosOFFSIDES
220Migraine with AuraOFFSIDES
221Muscle tightnessOFFSIDES
222Musculoskeletal discomfortSIDER
223Musculoskeletal stiffnessOFFSIDES
224MyalgiaSIDER
225MyelodysplasiaOFFSIDES
226Myeloid maturation arrestOFFSIDES
227MyelosuppressionSIDER
228Neoplasm Metastasis7960606CTD
229Neuroblastoma recurrentOFFSIDES
230Neuroblastoma857581
3688893
CTD
231Neutropenic sepsisOFFSIDES
232NystagmusOFFSIDES
233ObstructionOFFSIDES
234OligohydramniosOFFSIDES
235OliguriaOFFSIDES
236OsteolysisOFFSIDES
237PallorOFFSIDES
238Pelvic venous thrombosisOFFSIDES
239Peripheral Nervous System Diseases3028665CTD
240PhototoxicitySIDER
241Phyllodes Tumor17983394CTD
242Portal HypertensionOFFSIDES
243Portal Vein ThrombosisOFFSIDES
244Post procedural complicationOFFSIDES
245Post procedural hypothyroidismOFFSIDES
246Post procedural nauseaOFFSIDES
247Postoperative abscessOFFSIDES
248Prostatic Neoplasms6340628CTD
249Pulmonary function test decreasedOFFSIDES
250Purulent dischargeOFFSIDES
251Pyoderma GangrenosumOFFSIDES
252Restrictive cardiomyopathyOFFSIDES
253Rhabdomyosarcoma857581CTD
254SarcoidosisOFFSIDES
255Sarcoma

View details

CTD
256SclerodermaOFFSIDES
257Senile dementiaOFFSIDES
258Shock2278422CTD
259Sinus polypOFFSIDES
260Skin Neoplasms7218735CTD
261Stent occlusionOFFSIDES
262StomatitisSIDER
263Supraventricular tachyarrhythmiaOFFSIDES
264Synovial CystOFFSIDES
265Thoracic cavity drainageOFFSIDES
266Thromboembolism7960606CTD
267Thymus Neoplasms1127724CTD
268Treatment related secondary malignancyOFFSIDES
269UlcerOFFSIDES
270UrticariaSIDER
271Vaginal Neoplasms15577323CTD
272Vascular occlusionSIDER
273Venoocclusive diseaseSIDER
274Venous Thrombosis9221855
11330370
CTD
275Vertebral column massOFFSIDES
276Vomiting6704980
17692730
CTD
SIDER
277Whole blood transfusionOFFSIDES
278Wound InfectionOFFSIDES
279kyphosisOFFSIDES
280melanoma

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CTD
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