MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

tibolone

(WZDGZWOAQTVYBX-XOINTXKNSA-N)

Structure

SMILES: C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](C)CC2=C1CCC(=O)C2
Type(s): Approved; Investigational
ATC code(s): G03CX01
Molecular Formula:: C21H28O2
Molecular Weight:: 312.446
Log P:: 3.8826
Hydrogen Bond Acceptor:: 2
Hydrogen Bond Donor:: 1
TPSA:: 37.3
CAS Number(s):: 5630-53-5

Synonym(s)

tibolone

Boltin

Livial

Liviella

Org OD 14

Org OD14

tibilone

External Link(s)

MeSH	C027385
PubChem Compound	444008
ChEBI	32223
CHEMBL	CHEMBL2103774
DrugBank	DB09070
DrugCentral	2655
IUPHAR/BPS Guide to PHARMACOLOGY	9711
KEGG	dr:D01639
Therapeutic Target Database	D0W3OS
ZINC	3812889

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Abdominal Pain		OFFSIDES
2	Abdominal discomfort		SIDER
3	Abdominal tenderness		OFFSIDES
4	Acne		SIDER
5	Acute Coronary Syndrome		SIDER
6	Ageusia		OFFSIDES
7	Alopecia		OFFSIDES
8	Amnesia		OFFSIDES
9	Amphetamines		OFFSIDES
10	Apathy		OFFSIDES
11	Aphthous Stomatitis		OFFSIDES
12	Arteriosclerosis	11256880	CTD
13	Arthralgia		SIDER
14	Ascites		OFFSIDES
15	Atherosclerosis	15780535	CTD
16	Blood creatine phosphokinase increased		OFFSIDES
17	Bone pain		OFFSIDES
18	Breast discomfort		SIDER
19	Breast tenderness		SIDER
20	Bronchopneumonia		OFFSIDES
21	Candidiasis of vagina		OFFSIDES
22	Catheter related infection		OFFSIDES
23	Cerebrovascular accident		SIDER
24	Cervical dysplasia		SIDER
25	Cervix carcinoma		SIDER
26	Chloasma		SIDER
27	Cholangiolitis		OFFSIDES
28	Chromaturia		OFFSIDES
29	Chronic Obstructive Airway Disease		OFFSIDES
30	Confabulation		OFFSIDES
31	Decreased immune responsiveness		OFFSIDES
32	Dementia		SIDER
33	Demyelination		OFFSIDES
34	Dengue Fever		OFFSIDES
35	Depressed mood		OFFSIDES
36	Dermatitis		SIDER
37	Diverticulitis		OFFSIDES
38	Dizziness		OFFSIDES SIDER
39	Drug withdrawal headache		OFFSIDES
40	Dysgeusia		OFFSIDES
41	Endometriosis	25673440	CTD OFFSIDES
42	Eosinophilic myocarditis		OFFSIDES
43	Erythema Multiforme		SIDER
44	Erythema Nodosum		SIDER
45	Fatigue		OFFSIDES
46	Febrile bone marrow aplasia		OFFSIDES
47	Formication		OFFSIDES
48	Gamma-Glutamyltransferase Increased		OFFSIDES
49	Genital discharge		SIDER
50	Globulinuria		OFFSIDES
51	Headache		SIDER
52	Hepatitis		OFFSIDES
53	Hypoaesthesia facial		OFFSIDES
54	Hypophagia		OFFSIDES
55	Hypoxia		OFFSIDES
56	Iatrogenic injury		OFFSIDES
57	Infusion site mobility decreased		OFFSIDES
58	Intestinal Perforation		OFFSIDES
59	Lethargy		OFFSIDES
60	Medical device complication		OFFSIDES
61	Micturition frequency decreased		OFFSIDES
62	Multiple Myeloma		OFFSIDES
63	Musculoskeletal discomfort		SIDER
64	Myalgia		SIDER
65	Myocardial Infarction		SIDER
66	Myocardial Ischemia	11791085	CTD
67	Nausea		OFFSIDES
68	Nipple pain		SIDER
69	Obsessive thoughts		OFFSIDES
70	Ocular vascular disorder		OFFSIDES
71	Oropharyngeal pain		OFFSIDES
72	Ossicle disorder		OFFSIDES
73	Osteoporosis, Postmenopausal	11991445	CTD
74	Osteoporosis	11791085	CTD
75	Pain		OFFSIDES
76	Pelvic Pain		SIDER
77	Pelvic venous thrombosis		SIDER
78	Pericardial effusion		OFFSIDES
79	Porphyria non-acute		OFFSIDES
80	Post procedural pain		OFFSIDES
81	Pruritus		SIDER
82	Pseudoporphyria		OFFSIDES
83	Pulmonary Embolism		SIDER
84	Salpingitis		OFFSIDES
85	Septic arthritis staphylococcal		OFFSIDES
86	Sleep-related eating disorder		OFFSIDES
87	Staphylococcal osteomyelitis		OFFSIDES
88	Tinea Pedis		OFFSIDES
89	Tympanosclerosis		OFFSIDES
90	Vaginal Discharge		SIDER
91	Vaginal mycosis		SIDER
92	Vascular purpura		SIDER
93	Venous Thromboembolism		SIDER
94	Viral myocarditis		OFFSIDES
95	Visual Impairment		SIDER
96	Visual disturbance		OFFSIDES SIDER
97	Vulvovaginal mycotic infection		SIDER
98	Vulvovaginitis		SIDER
99	Weight Gain	11991445	CTD OFFSIDES
100	Wound Infection		OFFSIDES

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