Ospemifene
(LUMKNAVTFCDUIE-VHXPQNKSSA-N)
Structure
- SMILES
- ClCC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCO)/c1ccccc1
- Type(s)
- Approved; Investigational
- ATC code(s)
- G03XC05
- Molecular Formula:
- C24H23ClO2
- Molecular Weight:
- 378.891
- Log P:
- 5.6457
- Hydrogen Bond Acceptor:
- 2
- Hydrogen Bond Donor:
- 1
- TPSA:
- 29.46
- CAS Number(s):
- 128607-22-7
Synonym(s)
1.
Ospemifene
2.
FC-1271a
3.
Osphena
4.
Z-2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Headache | FAERS: 118 | US FAERS | |
| 2 | No adverse event | FAERS: 118 | US FAERS | |
| 3 | Vaginal Discharge | FAERS: 65 | SIDER US FAERS | |
| 4 | Drug ineffective | FAERS: 50 | US FAERS | |
| 5 | Nausea | FAERS: 45 | US FAERS | |
| 6 | Dizziness | FAERS: 39 | US FAERS | |
| 7 | Therapeutic response unexpected | FAERS: 33 | US FAERS | |
| 8 | Pruritus | FAERS: 27 | US FAERS | |
| 9 | Alopecia | FAERS: 24 | US FAERS | |
| 10 | Drug prescribing error | FAERS: 24 | US FAERS | |
| 11 | Hypersensitivity | FAERS: 23 | US FAERS | |
| 12 | Fatigue | FAERS: 22 | US FAERS | |
| 13 | Night sweats | FAERS: 22 | US FAERS | |
| 14 | Urticaria | FAERS: 21 | US FAERS | |
| 15 | Deep Vein Thrombosis | FAERS: 19 | SIDER US FAERS | |
| 16 | Abdominal discomfort | FAERS: 18 | US FAERS | |
| 17 | Palpitations | FAERS: 18 | US FAERS | |
| 18 | Vulvovaginal burning sensation | FAERS: 18 | US FAERS | |
| 19 | Breast tenderness | FAERS: 16 | US FAERS | |
| 20 | Chest Pain | FAERS: 16 | US FAERS | |
| 21 | Vulvovaginal pruritus | FAERS: 16 | US FAERS | |
| 22 | Abdominal Pain | FAERS: 15 | US FAERS | |
| 23 | Arthralgia | FAERS: 15 | US FAERS | |
| 24 | Feeling abnormal | FAERS: 15 | US FAERS | |
| 25 | Unevaluable event | FAERS: 15 | US FAERS | |
| 26 | Anxiety | FAERS: 14 | US FAERS | |
| 27 | Dyspareunia | FAERS: 14 | US FAERS | |
| 28 | Inappropriate schedule of drug administration | FAERS: 14 | US FAERS | |
| 29 | Poor quality sleep | FAERS: 14 | US FAERS | |
| 30 | Endometrial thickening | FAERS: 13 | US FAERS | |
| 31 | Therapy cessation | FAERS: 13 | US FAERS | |
| 32 | Inability to afford medication | FAERS: 12 | US FAERS | |
| 33 | Mood swings | FAERS: 12 | US FAERS | |
| 34 | Product use in unapproved indication | FAERS: 12 | US FAERS | |
| 35 | Vulvovaginal discomfort | FAERS: 12 | US FAERS | |
| 36 | Myalgia | FAERS: 11 | US FAERS | |
| 37 | Peripheral swelling | FAERS: 11 | US FAERS | |
| 38 | Thrombosis | FAERS: 11 | US FAERS | |
| 39 | Urinary tract infection | FAERS: 11 | US FAERS | |
| 40 | Asthenia | FAERS: 10 | US FAERS | |
| 41 | Burning sensation | FAERS: 10 | US FAERS | |
| 42 | Prescribed underdose | FAERS: 10 | US FAERS | |
| 43 | Cerebrovascular accident | FAERS: 9 | US FAERS | |
| 44 | Pain | FAERS: 9 | US FAERS | |
| 45 | Vulvovaginal dryness | FAERS: 9 | US FAERS | |
| 46 | Chills | FAERS: 8 | US FAERS | |
| 47 | Constipation | FAERS: 8 | US FAERS | |
| 48 | Dyspepsia | FAERS: 8 | US FAERS | |
| 49 | Erythema | FAERS: 8 | US FAERS | |
| 50 | Vulvovaginal pain | FAERS: 8 | US FAERS | |
| 51 | Acne | FAERS: 7 | US FAERS | |
| 52 | Malaise | FAERS: 7 | US FAERS | |
| 53 | Tremor | FAERS: 7 | US FAERS | |
| 54 | Uterine Polyp | FAERS: 7 | US FAERS | |
| 55 | Vomiting | FAERS: 7 | US FAERS | |
| 56 | Vulvovaginal erythema | FAERS: 7 | US FAERS | |
| 57 | Vulvovaginal swelling | FAERS: 7 | US FAERS | |
| 58 | Lip swelling | FAERS: 6 | US FAERS | |
| 59 | Memory impairment | FAERS: 6 | US FAERS | |
| 60 | Pulmonary Embolism | FAERS: 6 | US FAERS | |
| 61 | Vertigo | FAERS: 6 | US FAERS | |
| 62 | Back Pain | FAERS: 5 | US FAERS | |
| 63 | Dry skin | FAERS: 5 | US FAERS | |
| 64 | Arthritis | FAERS: 4 | US FAERS | |
| 65 | Drug ineffective for unapproved indication | FAERS: 4 | US FAERS | |
| 66 | Dysgeusia | FAERS: 4 | US FAERS | |
| 67 | Endometrial Hyperplasia | FAERS: 4 | US FAERS | |
| 68 | Therapeutic response changed | FAERS: 4 | US FAERS | |
| 69 | Accidental overdose | FAERS: 3 | US FAERS | |
| 70 | Amnesia | FAERS: 3 | US FAERS | |
| 71 | Bacterial Vaginosis | FAERS: 3 | US FAERS | |
| 72 | Coital bleeding | FAERS: 3 | US FAERS | |
| 73 | Crying | FAERS: 3 | US FAERS | |
| 74 | Depressed mood | FAERS: 3 | US FAERS | |
| 75 | Disorientation | FAERS: 3 | US FAERS | |
| 76 | Drug dose omission | FAERS: 3 | US FAERS | |
| 77 | Dysuria | FAERS: 3 | US FAERS | |
| 78 | Emotional disorder | FAERS: 3 | US FAERS | |
| 79 | Expired product administered | FAERS: 3 | US FAERS | |
| 80 | Genital erythema | FAERS: 3 | US FAERS | |
| 81 | Intentional product misuse | FAERS: 3 | US FAERS | |
| 82 | Medication Error | FAERS: 3 | US FAERS | |
| 83 | Metrorrhagia | FAERS: 3 | US FAERS | |
| 84 | Nervousness | FAERS: 3 | US FAERS | |
| 85 | Oropharyngeal pain | FAERS: 3 | US FAERS | |
| 86 | Pelvic Pain | FAERS: 3 | US FAERS | |
| 87 | Somnolence | FAERS: 3 | US FAERS | |
| 88 | Swelling | FAERS: 3 | US FAERS | |
| 89 | Throat irritation | FAERS: 3 | US FAERS | |
| 90 | Visual Impairment | FAERS: 3 | US FAERS | |
| 91 | Vulvovaginal mycotic infection | FAERS: 3 | US FAERS | |
| 92 | Wrong technique in product usage process | FAERS: 3 | US FAERS | |
| 93 | Accidental exposure to product | FAERS: 2 | US FAERS | |
| 94 | Adverse event | FAERS: 2 | US FAERS | |
| 95 | Anorgasmia | FAERS: 2 | US FAERS | |
| 96 | Bladder spasm | FAERS: 2 | US FAERS | |
| 97 | Blood cholesterol increased | FAERS: 2 | US FAERS | |
| 98 | Bone pain | FAERS: 2 | US FAERS | |
| 99 | Bronchitis | FAERS: 2 | US FAERS | |
| 100 | Chest discomfort | FAERS: 2 | US FAERS | |
| 101 | Cystitis | FAERS: 2 | US FAERS | |
| 102 | Eczema | FAERS: 2 | US FAERS | |
| 103 | Endometrial disorder | FAERS: 2 | US FAERS | |
| 104 | Endometrial hypertrophy | FAERS: 2 | US FAERS | |
| 105 | Epistaxis | FAERS: 2 | US FAERS | |
| 106 | Exertional headache | FAERS: 2 | US FAERS | |
| 107 | Exposure during breast feeding | FAERS: 2 | US FAERS | |
| 108 | Flank Pain | FAERS: 2 | US FAERS | |
| 109 | Flatulence | FAERS: 2 | US FAERS | |
| 110 | Gastrointestinal Pain | FAERS: 2 | US FAERS | |
| 111 | Genital discharge | FAERS: 2 | SIDER US FAERS | |
| 112 | Hysterectomy | FAERS: 2 | US FAERS | |
| 113 | Intentional product use issue | FAERS: 2 | US FAERS | |
| 114 | Joint swelling | FAERS: 2 | US FAERS | |
| 115 | Lethargy | FAERS: 2 | US FAERS | |
| 116 | Middle insomnia | FAERS: 2 | US FAERS | |
| 117 | Nasopharyngitis | FAERS: 2 | US FAERS | |
| 118 | Neck Pain | FAERS: 2 | US FAERS | |
| 119 | Ocular discomfort | FAERS: 2 | US FAERS | |
| 120 | Pain of skin | FAERS: 2 | US FAERS | |
| 121 | Product package associated injury | FAERS: 2 | US FAERS | |
| 122 | Pulmonary thrombosis | FAERS: 2 | US FAERS | |
| 123 | Tachycardia | FAERS: 2 | US FAERS | |
| 124 | Thyroid hormones increased | FAERS: 2 | US FAERS | |
| 125 | Urinary Incontinence | FAERS: 2 | US FAERS | |
| 126 | Urine flow decreased | FAERS: 2 | US FAERS | |
| 127 | Uterine Prolapse | FAERS: 2 | US FAERS | |
| 128 | Vulvovaginal rash | FAERS: 2 | US FAERS | |
| 129 | Vulvovaginitis | FAERS: 2 | US FAERS | |
| 130 | White blood cell count decreased | FAERS: 2 | US FAERS | |
| 131 | Accidental underdose | FAERS: 1 | US FAERS | |
| 132 | Adnexa uteri pain | FAERS: 1 | US FAERS | |
| 133 | Agitation | FAERS: 1 | US FAERS | |
| 134 | Allergic respiratory symptom | FAERS: 1 | US FAERS | |
| 135 | Anger | FAERS: 1 | US FAERS | |
| 136 | Angioedema | FAERS: 1 | US FAERS | |
| 137 | Anorectal discomfort | FAERS: 1 | US FAERS | |
| 138 | Arthropathy | FAERS: 1 | US FAERS | |
| 139 | Asthma | FAERS: 1 | US FAERS | |
| 140 | Atrophic vulvovaginitis | FAERS: 1 | US FAERS | |
| 141 | Autonomic nervous system imbalance | FAERS: 1 | US FAERS | |
| 142 | Back disorder | FAERS: 1 | US FAERS | |
| 143 | Blepharospasm | FAERS: 1 | US FAERS | |
| 144 | Blood prolactin increased | FAERS: 1 | US FAERS | |
| 145 | Blood triglycerides increased | FAERS: 1 | US FAERS | |
| 146 | Bone density abnormal | FAERS: 1 | US FAERS | |
| 147 | Capillary Fragility | FAERS: 1 | US FAERS | |
| 148 | Cardiac discomfort | FAERS: 1 | US FAERS | |
| 149 | Choking | FAERS: 1 | US FAERS | |
| 150 | Cold sweat | FAERS: 1 | US FAERS | |
| 151 | Colitis | FAERS: 1 | US FAERS | |
| 152 | Contraindicated drug prescribed | FAERS: 1 | US FAERS | |
| 153 | Cortisol increased | FAERS: 1 | US FAERS | |
| 154 | Craniectomy | FAERS: 1 | US FAERS | |
| 155 | Cyst | FAERS: 1 | US FAERS | |
| 156 | Dementia | FAERS: 1 | US FAERS | |
| 157 | Discomfort | FAERS: 1 | US FAERS | |
| 158 | Drug effective for unapproved indication | FAERS: 1 | US FAERS | |
| 159 | Drug screen positive | FAERS: 1 | US FAERS | |
| 160 | Dysarthria | FAERS: 1 | US FAERS | |
| 161 | Endometrial adenocarcinoma | FAERS: 1 | US FAERS | |
| 162 | Endometriosis | FAERS: 1 | US FAERS | |
| 163 | Excoriation | FAERS: 1 | US FAERS | |
| 164 | Exposure via partner | FAERS: 1 | US FAERS | |
| 165 | Eye pain | FAERS: 1 | US FAERS | |
| 166 | Eyelid infection | FAERS: 1 | US FAERS | |
| 167 | Feeling jittery | FAERS: 1 | US FAERS | |
| 168 | Feeling of body temperature change | FAERS: 1 | US FAERS | |
| 169 | Gait inability | FAERS: 1 | US FAERS | |
| 170 | Genital Herpes | FAERS: 1 | US FAERS | |
| 171 | Genital burning sensation | FAERS: 1 | US FAERS | |
| 172 | Genital rash | FAERS: 1 | US FAERS | |
| 173 | Hemiparesis | FAERS: 1 | US FAERS | |
| 174 | Hirsutism | FAERS: 1 | US FAERS | |
| 175 | Hydrometra | FAERS: 1 | US FAERS | |
| 176 | Hypersomnia | FAERS: 1 | US FAERS | |
| 177 | Inadequate lubrication | FAERS: 1 | US FAERS | |
| 178 | Inappropriate schedule of product administration | FAERS: 1 | US FAERS | |
| 179 | Incontinence | FAERS: 1 | US FAERS | |
| 180 | Incorrect dose administered | FAERS: 1 | US FAERS | |
| 181 | Inflammation | FAERS: 1 | US FAERS | |
| 182 | Initial insomnia | FAERS: 1 | US FAERS | |
| 183 | Intracranial Aneurysm | FAERS: 1 | US FAERS | |
| 184 | Intraductal papilloma of breast | FAERS: 1 | US FAERS | |
| 185 | Limb discomfort | FAERS: 1 | US FAERS | |
| 186 | Medication monitoring error | FAERS: 1 | US FAERS | |
| 187 | Migraine with Aura | FAERS: 1 | US FAERS | |
| 188 | Mouth swelling | FAERS: 1 | US FAERS | |
| 189 | Musculoskeletal chest pain | FAERS: 1 | US FAERS | |
| 190 | Musculoskeletal discomfort | FAERS: 1 | US FAERS | |
| 191 | Noninfective encephalitis | FAERS: 1 | US FAERS | |
| 192 | Onychoclasis | FAERS: 1 | US FAERS | |
| 193 | Orgasmic sensation decreased | FAERS: 1 | US FAERS | |
| 194 | Osteopenia | FAERS: 1 | US FAERS | |
| 195 | Paranoia | FAERS: 1 | US FAERS | |
| 196 | Pelvic discomfort | FAERS: 1 | US FAERS | |
| 197 | Peripheral embolism | FAERS: 1 | US FAERS | |
| 198 | Personality Change | FAERS: 1 | US FAERS | |
| 199 | Portal Vein Thrombosis | FAERS: 1 | US FAERS | |
| 200 | Post procedural complication | FAERS: 1 | US FAERS | |
| 201 | Premature Menopause | FAERS: 1 | US FAERS | |
| 202 | Premenstrual pain | FAERS: 1 | US FAERS | |
| 203 | Product use issue | FAERS: 1 | US FAERS | |
| 204 | Rosacea | FAERS: 1 | US FAERS | |
| 205 | Screaming | FAERS: 1 | US FAERS | |
| 206 | Sepsis | FAERS: 1 | US FAERS | |
| 207 | Sinusitis | FAERS: 1 | US FAERS | |
| 208 | Skin Papilloma | FAERS: 1 | US FAERS | |
| 209 | Skin texture abnormal | FAERS: 1 | US FAERS | |
| 210 | Skin tightness | FAERS: 1 | US FAERS | |
| 211 | Spontaneous ejaculation | FAERS: 1 | US FAERS | |
| 212 | Stomatitis | FAERS: 1 | US FAERS | |
| 213 | Tardive Dyskinesia | FAERS: 1 | US FAERS | |
| 214 | Tension | FAERS: 1 | US FAERS | |
| 215 | Thrombophlebitis | FAERS: 1 | US FAERS | |
| 216 | Thyroid hormones decreased | FAERS: 1 | US FAERS | |
| 217 | Tinnitus | FAERS: 1 | US FAERS | |
| 218 | Tongue discomfort | FAERS: 1 | US FAERS | |
| 219 | Urinary Retention | FAERS: 1 | US FAERS | |
| 220 | Urinary tract discomfort | FAERS: 1 | US FAERS | |
| 221 | Uterine spasm | FAERS: 1 | US FAERS | |
| 222 | Vaginal lesion | FAERS: 1 | US FAERS | |
| 223 | Viral upper respiratory tract infection | FAERS: 1 | US FAERS | |
| 224 | Weight decreased | FAERS: 1 | US FAERS | |
| 225 | Wrong drug administered | FAERS: 1 | US FAERS | |
| 226 | Embolic stroke | SIDER | ||
| 227 | Mammary Neoplasms, Experimental | 16153821 | CTD | |
| 228 | Osteoporosis, Postmenopausal | 16816926 | CTD | |
| 229 | Thromboembolic stroke | SIDER |
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