MetaADEDB 2.0 @ LMMD
Tapentadol
(KWTWDQCKEHXFFR-SMDDNHRTSA-N)
Structure
SMILES
CC[C@@H](c1cccc(c1)O)[C@H](CN(C)C)C
Type(s)
Approved
ATC code(s)
N02AX06
Molecular Formula:
C14H23NO
Molecular Weight:
221.339
Log P:
3.0835
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
1
TPSA:
23.47
CAS Number(s):
175591-23-8
Synonym(s)
1.
Tapentadol
2.
3-((1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl)phenol
3.
Nucynta
4.
Tapentadol Hydrochloride
External Link(s)
MeSHD000077432
PubChem Compound9838022
BindingDB50386381
ChEBI135935
CHEMBLCHEMBL1201776
DrugBankDB06204
DrugCentral4283
IUPHAR/BPS Guide to PHARMACOLOGY7477
KEGGdr:D06007
Therapeutic Target DatabaseD0K4MH
ZINC20783
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 81US FAERS
2NauseaFAERS: 63
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
3PainFAERS: 6117656655
28499616
CTD
US FAERS
4DizzinessFAERS: 54SIDER
US FAERS
5Drug dose omissionFAERS: 53US FAERS
6Adverse eventFAERS: 43US FAERS
7Feeling abnormalFAERS: 36SIDER
US FAERS
8SomnolenceFAERS: 36
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
9HeadacheFAERS: 34SIDER
US FAERS
10VomitingFAERS: 34SIDER
US FAERS
11Product use in unapproved indicationFAERS: 31US FAERS
12MalaiseFAERS: 28US FAERS
13TremorFAERS: 27SIDER
US FAERS
14PalpitationsFAERS: 26SIDER
US FAERS
15AmnesiaFAERS: 24US FAERS
16PruritusFAERS: 24SIDER
US FAERS
17DisorientationFAERS: 22SIDER
US FAERS
18AnxietyFAERS: 21SIDER
US FAERS
19Serotonin SyndromeFAERS: 21SIDER
US FAERS
20OverdoseFAERS: 20US FAERS
21Product quality issueFAERS: 20US FAERS
22Drug abuseFAERS: 16SIDER
US FAERS
23Product use issueFAERS: 16US FAERS
24ConstipationFAERS: 15SIDER
US FAERS
25FatigueFAERS: 15SIDER
US FAERS
26Urinary RetentionFAERS: 15US FAERS
27UrticariaFAERS: 15SIDER
US FAERS
28AgitationFAERS: 13SIDER
US FAERS
29Mental status changesFAERS: 13US FAERS
30TachycardiaFAERS: 13SIDER
US FAERS
31Chest discomfortFAERS: 12US FAERS
32DeliriumFAERS: 12US FAERS
33Drug diversionFAERS: 12US FAERS
34Drug screen positiveFAERS: 12US FAERS
35HypersensitivityFAERS: 12SIDER
US FAERS
36Suicide attemptFAERS: 12US FAERS
37Drug withdrawal syndromeFAERS: 11SIDER
US FAERS
38DysarthriaFAERS: 11SIDER
US FAERS
39Respiratory DepressionFAERS: 11SIDER
US FAERS
40Toxicity to various agentsFAERS: 11US FAERS
41AstheniaFAERS: 10SIDER
US FAERS
42AsthmaFAERS: 10US FAERS
43Drug prescribing errorFAERS: 10US FAERS
44HypotensionFAERS: 9SIDER
US FAERS
45Memory impairmentFAERS: 9SIDER
US FAERS
46Unresponsive to stimuliFAERS: 9US FAERS
47VertigoFAERS: 9SIDER
US FAERS
48AlopeciaFAERS: 8US FAERS
49CryingFAERS: 8US FAERS
50Drug DependenceFAERS: 8US FAERS
51Medication ErrorFAERS: 8US FAERS
52NervousnessFAERS: 8SIDER
US FAERS
53Visual ImpairmentFAERS: 8SIDER
US FAERS
54Wrong technique in product usage processFAERS: 8US FAERS
55Chest PainFAERS: 7US FAERS
56Drug dose titration not performedFAERS: 7US FAERS
57Incorrect route of drug administrationFAERS: 7US FAERS
58Intentional drug misuseFAERS: 7US FAERS
59Product distribution issueFAERS: 7US FAERS
60AkathisiaFAERS: 6US FAERS
61Cerebrovascular accidentFAERS: 6US FAERS
62ChillsFAERS: 6SIDER
US FAERS
63Depressed Level of ConsciousnessFAERS: 6SIDER
US FAERS
64Depressed moodFAERS: 6US FAERS
65Euphoric moodFAERS: 6SIDER
US FAERS
66Impaired driving abilityFAERS: 6US FAERS
67LethargyFAERS: 6SIDER
US FAERS
68Mental impairmentFAERS: 6US FAERS
69PancreatitisFAERS: 6US FAERS
70PneumoniaFAERS: 6US FAERS
71PresyncopeFAERS: 6SIDER
US FAERS
72Unevaluable eventFAERS: 6US FAERS
73Wrong drug administeredFAERS: 6US FAERS
74AbasiaFAERS: 5US FAERS
75Activities of daily living impairedFAERS: 5US FAERS
76AphasiaFAERS: 5US FAERS
77Back PainFAERS: 5US FAERS
78Drug ineffective for unapproved indicationFAERS: 5US FAERS
79Drug screen negativeFAERS: 5US FAERS
80DysphoniaFAERS: 5US FAERS
81ErythemaFAERS: 5US FAERS
82FibromyalgiaFAERS: 5US FAERS
83Inappropriate schedule of drug administrationFAERS: 5US FAERS
84Intentional product misuseFAERS: 5US FAERS
85Myocardial InfarctionFAERS: 5US FAERS
86NasopharyngitisFAERS: 5SIDER
US FAERS
87Weight decreasedFAERS: 5SIDER
US FAERS
88Wrong technique in drug usage processFAERS: 5US FAERS
89Abdominal PainFAERS: 4US FAERS
90Abdominal discomfortFAERS: 4SIDER
US FAERS
91Cardiac ArrestFAERS: 4US FAERS
92Completed SuicideFAERS: 4US FAERS
93DehydrationFAERS: 4US FAERS
94Drug dispensing errorFAERS: 4US FAERS
95DysuriaFAERS: 4US FAERS
96FlushingFAERS: 4US FAERS
97Impaired work abilityFAERS: 4US FAERS
98Incorrect dose administeredFAERS: 4US FAERS
99LymphadenopathyFAERS: 4US FAERS
100MyalgiaFAERS: 4US FAERS
101ParanoiaFAERS: 4US FAERS
102Renal painFAERS: 4US FAERS
103ScreamingFAERS: 4US FAERS
104SyncopeFAERS: 4
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
105Therapeutic response unexpectedFAERS: 4US FAERS
106Accidental exposure to productFAERS: 3US FAERS
107Accidental exposure to product by childFAERS: 3US FAERS
108Accidental overdoseFAERS: 3US FAERS
109AgeusiaFAERS: 3US FAERS
110AngioedemaFAERS: 3SIDER
US FAERS
111ArthralgiaFAERS: 3SIDER
US FAERS
112Back disorderFAERS: 3US FAERS
113BlindnessFAERS: 3US FAERS
114Blood glucose increasedFAERS: 3US FAERS
115BradycardiaFAERS: 3SIDER
US FAERS
116ChromaturiaFAERS: 3US FAERS
117Cold sweatFAERS: 3US FAERS
118Drug ToleranceFAERS: 3US FAERS
119DystoniaFAERS: 3US FAERS
120Electrocardiogram changeFAERS: 3US FAERS
121Feeling jitteryFAERS: 3US FAERS
122Intestinal ObstructionFAERS: 3US FAERS
123Joint injuryFAERS: 3US FAERS
124Limb injuryFAERS: 3US FAERS
125No adverse eventFAERS: 3US FAERS
126Opiates negativeFAERS: 3US FAERS
127Panic DisorderFAERS: 3US FAERS
128Product dose omissionFAERS: 3US FAERS
129RestlessnessFAERS: 3US FAERS
130Sinus TachycardiaFAERS: 3US FAERS
131SwellingFAERS: 3US FAERS
132Urinary tract infectionFAERS: 3SIDER
US FAERS
133WheezingFAERS: 3US FAERS
134AtaxiaFAERS: 2SIDER
US FAERS
135Bipolar DisorderFAERS: 2US FAERS
136Bladder painFAERS: 2US FAERS
137BlepharospasmFAERS: 2US FAERS
138Blood potassium decreasedFAERS: 2US FAERS
139BradyphreniaFAERS: 2US FAERS
140Burning sensationFAERS: 2US FAERS
141Circumstance or information capable of leading to medication errorFAERS: 2US FAERS
142CystFAERS: 2US FAERS
143Dental cariesFAERS: 2US FAERS
144DependenceFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
145Diabetes MellitusFAERS: 2US FAERS
146DisabilityFAERS: 2US FAERS
147DiscomfortFAERS: 2US FAERS
148DissociationFAERS: 2US FAERS
149Drug screen false positiveFAERS: 2US FAERS
150DysgeusiaFAERS: 2US FAERS
151Electrocardiogram abnormalFAERS: 2US FAERS
152Expired product administeredFAERS: 2US FAERS
153Gait inabilityFAERS: 2US FAERS
154GamblingFAERS: 2US FAERS
155Gamma-Glutamyltransferase IncreasedFAERS: 2SIDER
US FAERS
156GoutFAERS: 2US FAERS
157HemiplegiaFAERS: 2US FAERS
158HysterectomyFAERS: 2US FAERS
159IleusFAERS: 2US FAERS
160LacerationFAERS: 2US FAERS
161LaryngitisFAERS: 2US FAERS
162Neck PainFAERS: 2US FAERS
163Nerve injuryFAERS: 2US FAERS
164NeuralgiaFAERS: 2US FAERS
165NystagmusFAERS: 2US FAERS
166Obsessive-Compulsive DisorderFAERS: 2US FAERS
167Opiates positiveFAERS: 2US FAERS
168Personality ChangeFAERS: 2US FAERS
169PetechiaeFAERS: 2US FAERS
170Product taste abnormalFAERS: 2US FAERS
171Restless Legs SyndromeFAERS: 2US FAERS
172RhabdomyolysisFAERS: 2US FAERS
173Rotator cuff syndromeFAERS: 2US FAERS
174Sinus bradycardiaFAERS: 2US FAERS
175StuporFAERS: 2US FAERS
176Sudden deathFAERS: 2US FAERS
177TachyphreniaFAERS: 2US FAERS
178Therapeutic response delayedFAERS: 2US FAERS
179Therapy cessationFAERS: 2US FAERS
180Tooth LossFAERS: 2US FAERS
181Transaminases increasedFAERS: 2US FAERS
182Violence-related symptomFAERS: 2US FAERS
183Vitreous DetachmentFAERS: 2US FAERS
184nervous system disorderFAERS: 2SIDER
US FAERS
185Acute Lung InjuryFAERS: 1US FAERS
186Acute myocardial infarctionFAERS: 1US FAERS
187Acute psychosisFAERS: 1US FAERS
188Anaphylactic shockFAERS: 1SIDER
US FAERS
189Androgenetic AlopeciaFAERS: 1US FAERS
190AngerFAERS: 1US FAERS
191AnhedoniaFAERS: 1US FAERS
192Ankle FractureFAERS: 1US FAERS
193AnosmiaFAERS: 1US FAERS
194AnuriaFAERS: 1US FAERS
195ArachnoiditisFAERS: 1US FAERS
196AscitesFAERS: 1US FAERS
197Atrial FibrillationFAERS: 1US FAERS
198Blood alkaline phosphatase increasedFAERS: 1US FAERS
199Blood cholesterol increasedFAERS: 1US FAERS
200Blood creatine phosphokinase increasedFAERS: 1US FAERS
201Blood glucose decreasedFAERS: 1US FAERS
202Blood sodium decreasedFAERS: 1US FAERS
203Bone painFAERS: 1US FAERS
204Breakthrough PainFAERS: 1US FAERS
205BronchitisFAERS: 1US FAERS
206BronchospasmFAERS: 1US FAERS
207BruxismFAERS: 1US FAERS
208Carpal Tunnel SyndromeFAERS: 1US FAERS
209CystitisFAERS: 1US FAERS
210DeafnessFAERS: 1US FAERS
211DementiaFAERS: 1US FAERS
212DiplopiaFAERS: 1US FAERS
213Dreamy stateFAERS: 1US FAERS
214DroolingFAERS: 1US FAERS
215Drug administered to patient of inappropriate ageFAERS: 1US FAERS
216Drug effect variableFAERS: 1US FAERS
217DysgraphiaFAERS: 1US FAERS
218DyspepsiaFAERS: 1SIDER
US FAERS
219DysphemiaFAERS: 1US FAERS
220Economic problemFAERS: 1US FAERS
221Emotional disorderFAERS: 1US FAERS
222EpistaxisFAERS: 1US FAERS
223Erectile dysfunctionFAERS: 1SIDER
US FAERS
224Escherichia test positiveFAERS: 1US FAERS
225Exposure during breast feedingFAERS: 1US FAERS
226Eye irritationFAERS: 1US FAERS
227Eye painFAERS: 1US FAERS
228Feeling ColdFAERS: 1US FAERS
229Feeling of body temperature changeFAERS: 1US FAERS
230Flat affectFAERS: 1US FAERS
231FormicationFAERS: 1US FAERS
232Gastrointestinal motility disorderFAERS: 1US FAERS
233General physical health deteriorationFAERS: 1US FAERS
234GlossitisFAERS: 1US FAERS
235Grip strength decreasedFAERS: 1US FAERS
236Hallucinations, mixedFAERS: 1US FAERS
237HepatotoxicityFAERS: 1US FAERS
238Histamine abnormalFAERS: 1US FAERS
239HypercreatininaemiaFAERS: 1US FAERS
240HypersomniaFAERS: 1US FAERS
241HyperventilationFAERS: 1US FAERS
242HypoxiaFAERS: 1US FAERS
243ImmobileFAERS: 1US FAERS
244Impaired gastric emptyingFAERS: 1SIDER
US FAERS
245Inadequate analgesiaFAERS: 1US FAERS
246Inappropriate schedule of product administrationFAERS: 1US FAERS
247IncoherentFAERS: 1US FAERS
248IncontinenceFAERS: 1US FAERS
249InfluenzaFAERS: 1US FAERS
250Infrequent bowel movementsFAERS: 1US FAERS
251Intentional product use issueFAERS: 1US FAERS
252Intentional self-injuryFAERS: 1US FAERS
253Intercepted drug dispensing errorFAERS: 1US FAERS
254Intervertebral Disc DegenerationFAERS: 1US FAERS
255Intervertebral disc injuryFAERS: 1US FAERS
256Irritable Bowel SyndromeFAERS: 1US FAERS
257LeukocytosisFAERS: 1US FAERS
258Lip swellingFAERS: 1US FAERS
259Loose toothFAERS: 1US FAERS
260Lyme DiseaseFAERS: 1US FAERS
261Mechanical urticariaFAERS: 1US FAERS
262MenorrhagiaFAERS: 1US FAERS
263Middle insomniaFAERS: 1US FAERS
264MonoplegiaFAERS: 1US FAERS
265Mood swingsFAERS: 1US FAERS
266Mouth swellingFAERS: 1US FAERS
267Musculoskeletal stiffnessFAERS: 1US FAERS
268MydriasisFAERS: 1US FAERS
269Myoclonic EpilepsyFAERS: 1US FAERS
270MyoclonusFAERS: 1US FAERS
271NephrolithiasisFAERS: 1US FAERS
272NeutropeniaFAERS: 1US FAERS
273ObesityFAERS: 1US FAERS
274Obsessive thoughtsFAERS: 1US FAERS
275Ocular discomfortFAERS: 1US FAERS
276Oropharyngeal painFAERS: 1US FAERS
277PallorFAERS: 1US FAERS
278Performance status decreasedFAERS: 1US FAERS
279PeriodontitisFAERS: 1US FAERS
280PeritonitisFAERS: 1US FAERS
281Peritonsillar AbscessFAERS: 1US FAERS
282Poor quality sleepFAERS: 1US FAERS
283Post procedural sepsisFAERS: 1US FAERS
284Product administered to patient of inappropriate ageFAERS: 1US FAERS
285Product packaging quantity issueFAERS: 1US FAERS
286Product physical issueFAERS: 1US FAERS
287Product prescribing errorFAERS: 1US FAERS
288Product selection errorFAERS: 1US FAERS
289Product used for unknown indicationFAERS: 1US FAERS
290PsoriasisFAERS: 1US FAERS
291Pulmonary EmbolismFAERS: 1US FAERS
292Pulmonary FibrosisFAERS: 1US FAERS
293Pulmonary HypertensionFAERS: 1US FAERS
294ScabFAERS: 1US FAERS
295SchizophreniaFAERS: 1US FAERS
296SepsisFAERS: 1US FAERS
297ShockFAERS: 1SIDER
US FAERS
298Sick Sinus SyndromeFAERS: 1US FAERS
299Sinus headacheFAERS: 1US FAERS
300Skin lacerationFAERS: 1US FAERS
301Sleep disorder due to general medical condition, insomnia typeFAERS: 1US FAERS
302SoporFAERS: 1US FAERS
303Splenic InfarctionFAERS: 1US FAERS
304StaringFAERS: 1US FAERS
305StressFAERS: 1US FAERS
306Suspected counterfeit productFAERS: 1US FAERS
307Tardive DyskinesiaFAERS: 1US FAERS
308Temperature regulation disorderFAERS: 1US FAERS
309ThrombosisFAERS: 1US FAERS
310TonsillitisFAERS: 1US FAERS
311Upper airway obstructionFAERS: 1US FAERS
312Urinary hesitationFAERS: 1SIDER
US FAERS
313Vein painFAERS: 1US FAERS
314jaundiceFAERS: 1US FAERS
315Alanine Aminotransferase IncreasedSIDER
316Altered state of consciousnessSIDER
317Aspartate Aminotransferase IncreasedSIDER
318Brain Injuries28499616CTD
319Chemical and Drug Induced Liver Injury28689766CTD
320DermatitisSIDER
321Fatty Liver28689766CTD
322Heart Diseases28499616CTD
323Hemorrhage28499616CTD
324HypotensiveSIDER
325InfectionSIDER
326InfestationSIDER
327Lung Injury28499616CTD
328MalnutritionSIDER
329Mental RetardationSIDER
330Musculoskeletal discomfortSIDER
331Necrosis27317026CTD
332Nerve Degeneration28499616CTD
333Perceptual disturbanceSIDER
334Proteinuria28689766CTD
335Pulmonary function test decreasedSIDER
336Sexual DysfunctionSIDER
337TensionSIDER
338Visual disturbanceSIDER
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