MetaADEDB 2.0 @ LMMD
Ropivacaine
(ZKMNUMMKYBVTFN-HNNXBMFYSA-N)
Structure
SMILES
CCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C
Type(s)
Approved
ATC code(s)
N01BB09
Molecular Formula:
C17H26N2O
Molecular Weight:
274.401
Log P:
3.5173
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
1
TPSA:
32.34
CAS Number(s):
84057-95-4; 98717-15-8
Synonym(s)
1.
Ropivacaine
2.
1-Propyl-2',6'-pipecoloxylidide
3.
AL 381
4.
AL-381
5.
LEA 103
6.
LEA-103
7.
Naropeine
8.
Naropin
9.
Ropivacaine Hydrochloride
10.
Ropivacaine Monohydrochloride
11.
Ropivacaine Monohydrochloride, (S)-isomer
12.
1 Propyl 2',6' pipecoloxylidide
13.
AL381
14.
LEA103
External Link(s)
MeSHD000077212
PubChem Compound175805
ChEBI8890
CHEMBLCHEMBL1077896
DrugBankDB00296
DrugCentral2403
IUPHAR/BPS Guide to PHARMACOLOGY7602
KEGGcpd:C07532
dr:D08490
Therapeutic Target DatabaseD09RHQ
ZINC897002
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 58US FAERS
2Cardiac ArrestFAERS: 28SIDER
US FAERS
3OverdoseFAERS: 19OFFSIDES
US FAERS
4Medication ErrorFAERS: 15
Canada Vigilance: 1		Canada Vigilance
US FAERS
5Respiratory arrestFAERS: 13SIDER
US FAERS
6Drug toxicityFAERS: 11OFFSIDES
US FAERS
7HypotensionFAERS: 11

View details

1897763
2511782
11133597
12859315
19412143
 		CTD
SIDER
US FAERS
8Post procedural complicationFAERS: 11OFFSIDES
SIDER
US FAERS
9PainFAERS: 910522581
16012418		CTD
OFFSIDES
SIDER
US FAERS
10FatigueFAERS: 8US FAERS
11BradycardiaFAERS: 712025250CTD
SIDER
US FAERS
12Toxicity to various agentsFAERS: 7US FAERS
13Anaphylactic shockFAERS: 6SIDER
US FAERS
14Incorrect route of drug administrationFAERS: 6OFFSIDES
US FAERS
15ParaplegiaFAERS: 6OFFSIDES
US FAERS
16SomnolenceFAERS: 6SIDER
US FAERS
17TremorFAERS: 612694015CTD
SIDER
US FAERS
18Accidental overdoseFAERS: 5US FAERS
19AstheniaFAERS: 5SIDER
US FAERS
20Drug exposure during pregnancyFAERS: 5OFFSIDES
US FAERS
21VomitingFAERS: 5SIDER
US FAERS
22Cauda Equina SyndromeFAERS: 4
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
23Depressed Level of ConsciousnessFAERS: 4OFFSIDES
SIDER
US FAERS
24Drug effect delayedFAERS: 4US FAERS
25HeadacheFAERS: 4SIDER
US FAERS
26Incorrect dose administeredFAERS: 4US FAERS
27InfectionFAERS: 4OFFSIDES
SIDER
US FAERS
28MyoclonusFAERS: 419837813CTD
US FAERS
29ParaparesisFAERS: 4OFFSIDES
US FAERS
30Respiratory FailureFAERS: 4SIDER
US FAERS
31Sensorimotor disorderFAERS: 4OFFSIDES
US FAERS
32Supraventricular tachycardiaFAERS: 4US FAERS
33AbasiaFAERS: 3US FAERS
34AgitationFAERS: 3SIDER
US FAERS
35Atrial tachycardiaFAERS: 3OFFSIDES
US FAERS
36Axonal neuropathyFAERS: 3OFFSIDES
US FAERS
37BlindnessFAERS: 3US FAERS
38Brain DeathFAERS: 3US FAERS
39Brain stem syndromeFAERS: 3OFFSIDES
US FAERS
40Denervation atrophyFAERS: 3OFFSIDES
US FAERS
41DisorientationFAERS: 3US FAERS
42Drug administration errorFAERS: 3US FAERS
43Inadequate analgesiaFAERS: 3US FAERS
44MonoplegiaFAERS: 3OFFSIDES
US FAERS
45MydriasisFAERS: 3US FAERS
46Nerve injuryFAERS: 3US FAERS
47NystagmusFAERS: 3US FAERS
48Phrenic nerve paralysisFAERS: 3OFFSIDES
US FAERS
49Procedural complicationFAERS: 3OFFSIDES
US FAERS
50Product quality issueFAERS: 3OFFSIDES
US FAERS
51ShockFAERS: 3SIDER
US FAERS
52Spinal cord paralysisFAERS: 3OFFSIDES
US FAERS
53SwellingFAERS: 3US FAERS
54Therapeutic product effect prolongedFAERS: 3US FAERS
55AkathisiaFAERS: 2US FAERS
56Altered state of consciousnessFAERS: 2OFFSIDES
US FAERS
57Apallic syndromeFAERS: 2US FAERS
58ArthropathyFAERS: 2US FAERS
59AtelectasisFAERS: 2OFFSIDES
SIDER
US FAERS
60Chest discomfortFAERS: 2US FAERS
61Circumstance or information capable of leading to medication errorFAERS: 2OFFSIDES
US FAERS
62Diffuse Axonal InjuryFAERS: 2
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
63DizzinessFAERS: 29175963CTD
SIDER
US FAERS
64DysgeusiaFAERS: 2US FAERS
65DysphoniaFAERS: 2US FAERS
66Erectile dysfunctionFAERS: 2US FAERS
67ErythemaFAERS: 2SIDER
US FAERS
68FlushingFAERS: 2US FAERS
69HypersensitivityFAERS: 2SIDER
US FAERS
70HypokinesiaFAERS: 2SIDER
US FAERS
71MonoparesisFAERS: 2US FAERS
72Musculoskeletal PainFAERS: 2OFFSIDES
US FAERS
73Pharmaceutical product complaintFAERS: 2US FAERS
74Posterior reversible encephalopathy syndromeFAERS: 2US FAERS
75Postoperative infectionFAERS: 2OFFSIDES
US FAERS
76PresyncopeFAERS: 2US FAERS
77PruritusFAERS: 212694015
16816394		CTD
SIDER
US FAERS
78QuadriplegiaFAERS: 2OFFSIDES
US FAERS
79RadiculopathyFAERS: 2US FAERS
80Respiratory distressFAERS: 2US FAERS
81Retinal Artery OcclusionFAERS: 2US FAERS
82Sciatic Nerve PalsyFAERS: 2OFFSIDES
US FAERS
83SepsisFAERS: 2US FAERS
84Sudden infant death syndromeFAERS: 2OFFSIDES
US FAERS
85TachycardiaFAERS: 21897763
12027861		CTD
SIDER
US FAERS
86TinnitusFAERS: 2
Canada Vigilance: 1		18522937CTD
SIDER
Canada Vigilance
US FAERS
87Tongue bitingFAERS: 2US FAERS
88Unresponsive to stimuliFAERS: 2US FAERS
89Visual ImpairmentFAERS: 2US FAERS
90Abdominal discomfortFAERS: 1US FAERS
91Acquired diaphragmatic eventrationFAERS: 1US FAERS
92AkinesiaFAERS: 1OFFSIDES
US FAERS
93AmaurosisFAERS: 1US FAERS
94AmnesiaFAERS: 1SIDER
US FAERS
95Amylase increasedFAERS: 1US FAERS
96Anal sphincter atonyFAERS: 1US FAERS
97Anaphylactoid ReactionFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
98Anterior Spinal Artery SyndromeFAERS: 1OFFSIDES
SIDER
US FAERS
99AnuriaFAERS: 1US FAERS
100AnxietyFAERS: 1SIDER
US FAERS
101AphasiaFAERS: 112694015CTD
US FAERS
102AphoniaFAERS: 1US FAERS
103AsphyxiaFAERS: 1US FAERS
104Back PainFAERS: 1SIDER
US FAERS
105Bipolar I disorderFAERS: 1US FAERS
106BlepharospasmFAERS: 1US FAERS
107Blood pressure immeasurableFAERS: 1US FAERS
108Bone painFAERS: 1US FAERS
109Catheter related complicationFAERS: 1US FAERS
110CellulitisFAERS: 1US FAERS
111Cerebrovascular accidentFAERS: 1US FAERS
112Chest PainFAERS: 1SIDER
US FAERS
113Circumstance or information capable of leading to device use errorFAERS: 1US FAERS
114ClonusFAERS: 1OFFSIDES
US FAERS
115CyanosisFAERS: 1OFFSIDES
US FAERS
116DemyelinationFAERS: 1OFFSIDES
US FAERS
117DermatitisFAERS: 1SIDER
US FAERS
118Device FailureFAERS: 1US FAERS
119Device malfunctionFAERS: 1US FAERS
120DiplopiaFAERS: 1US FAERS
121Drug dose omissionFAERS: 1US FAERS
122Drug level increasedFAERS: 1US FAERS
123DysphemiaFAERS: 1US FAERS
124DysuriaFAERS: 1OFFSIDES
SIDER
US FAERS
125Ear discomfortFAERS: 1US FAERS
126EmbolismFAERS: 1US FAERS
127EnuresisFAERS: 1US FAERS
128EpilepsyFAERS: 1OFFSIDES
US FAERS
129Eye operation complicationFAERS: 1US FAERS
130Eye painFAERS: 1US FAERS
131Feeling ColdFAERS: 1US FAERS
132Gastrointestinal motility disorderFAERS: 1US FAERS
133Grip strength decreasedFAERS: 1US FAERS
134HypercapniaFAERS: 1SIDER
US FAERS
135Hypertensive crisisFAERS: 1US FAERS
136Hypoaesthesia facialFAERS: 1US FAERS
137HypopyonFAERS: 1US FAERS
138HyporeflexiaFAERS: 1US FAERS
139Hyporesponsive to stimuliFAERS: 1US FAERS
140HypoventilationFAERS: 1US FAERS
141IncoherentFAERS: 1US FAERS
142IncontinenceFAERS: 1US FAERS
143Incorrect dose administered by deviceFAERS: 1US FAERS
144InflammationFAERS: 120014599CTD
US FAERS
145Injection site infectionFAERS: 1OFFSIDES
US FAERS
146Injection site painFAERS: 1SIDER
US FAERS
147Intentional drug misuseFAERS: 1US FAERS
148Jugular vein distensionFAERS: 1US FAERS
149LaryngospasmFAERS: 1SIDER
US FAERS
150Lesion of Sciatic NerveFAERS: 1OFFSIDES
US FAERS
151Limb injuryFAERS: 1US FAERS
152Lip swellingFAERS: 1US FAERS
153Lipase increasedFAERS: 1US FAERS
154MalaiseFAERS: 1SIDER
US FAERS
155Maternal exposure during deliveryFAERS: 1US FAERS
156Mechanical ventilationFAERS: 1US FAERS
157Metabolic acidosisFAERS: 1OFFSIDES
US FAERS
158Muscle RigidityFAERS: 19175963CTD
SIDER
US FAERS
159Musculoskeletal stiffnessFAERS: 1US FAERS
160NauseaFAERS: 1SIDER
US FAERS
161Neck PainFAERS: 1US FAERS
162NeuralgiaFAERS: 1US FAERS
163OpisthotonusFAERS: 1US FAERS
164Peripheral nerve lesionFAERS: 1US FAERS
165Postoperative adhesionFAERS: 1US FAERS
166Procedural site reactionFAERS: 1US FAERS
167Product leakageFAERS: 1US FAERS
168QuadriparesisFAERS: 1US FAERS
169Respiratory DepressionFAERS: 1SIDER
US FAERS
170SciaticaFAERS: 1US FAERS
171Serratia test positiveFAERS: 1US FAERS
172Sick Sinus SyndromeFAERS: 1OFFSIDES
US FAERS
173Sinus TachycardiaFAERS: 1US FAERS
174StridorFAERS: 1US FAERS
175StuporFAERS: 1SIDER
US FAERS
176Systemic toxicityFAERS: 1US FAERS
177TachyarrhythmiaFAERS: 1US FAERS
178Therapy non-responderFAERS: 1OFFSIDES
US FAERS
179Tonic clonic movementsFAERS: 1US FAERS
180Troponin I increasedFAERS: 1US FAERS
181Urinary IncontinenceFAERS: 1SIDER
US FAERS
182UrticariaFAERS: 1SIDER
US FAERS
183Ventricular FibrillationFAERS: 111049891
12933426		CTD
SIDER
US FAERS
184Ventricular FlutterFAERS: 1US FAERS
185Vital functions abnormalFAERS: 1US FAERS
186Vitreous floatersFAERS: 1US FAERS
187WheezingFAERS: 1US FAERS
188White blood cell count decreasedFAERS: 1US FAERS
189Winged scapulaFAERS: 1US FAERS
190Wound infection staphylococcalFAERS: 1OFFSIDES
US FAERS
191Wrong technique in device usage processFAERS: 1US FAERS
192Wrong technique in drug usage processFAERS: 1US FAERS
193nervous system disorderFAERS: 1US FAERS
194Abdominal PainSIDER
195Abdominal cavity drainageOFFSIDES
196AcidosisOFFSIDES
SIDER
197Acute Coronary SyndromeSIDER
198Adams-Stokes SyndromeOFFSIDES
199Alanine Aminotransferase IncreasedSIDER
200AlbuminuriaSIDER
201AngioedemaSIDER
202Anorectal discomfortSIDER
203Application site reactionSIDER
204ArachnoiditisOFFSIDES
SIDER
205ArthralgiaSIDER
206Aspartate Aminotransferase IncreasedSIDER
207Atrial FibrillationSIDER
208Atrioventricular BlockOFFSIDES
SIDER
209AutomatismOFFSIDES
210Blood alkaline phosphatase increasedSIDER
211Blood alkaline phosphataseOFFSIDES
212Blood creatine phosphokinase increasedSIDER
213Blood glucose fluctuationOFFSIDES
214Blood pH increasedOFFSIDES
215Blood pressure fluctuationOFFSIDES
216Breast FeedingSIDER
217BronchospasmSIDER
218Bulbar palsyOFFSIDES
219CNS toxicitySIDER
220Carbon dioxide increasedSIDER
221Cardiac DeathOFFSIDES
222CatatoniaOFFSIDES
223Cervicobrachial syndromeOFFSIDES
224ChillsSIDER
225Chronic left ventricular failureOFFSIDES
226Coagulation factor increasedOFFSIDES
227Congenital pyelocaliectasisOFFSIDES
228ConstipationSIDER
229Creatine Phosphokinase IncreasedSIDER
230CryingOFFSIDES
231Cystitis viralOFFSIDES
232Deafness NeurosensoryOFFSIDES
233Deep Vein ThrombosisSIDER
234Demyelinating Diseases20014599CTD
235Dental PlaqueOFFSIDES
236Dependence on enabling machine or deviceOFFSIDES
237DiscomfortSIDER
238DrowsinessSIDER
239Duodenal perforationOFFSIDES
240Dysarthria9175963CTD
SIDER
241DyslaliaOFFSIDES
242DyspepsiaSIDER
243Electrocardiogram T wave amplitude increasedOFFSIDES
244Electrocardiogram repolarisation abnormalityOFFSIDES
245Electromechanical dissociationOFFSIDES
246Electromyogram abnormalOFFSIDES
247Enlargement abdomenSIDER
248Eosinophil percentage abnormalOFFSIDES
249Eosinophilic myocarditisOFFSIDES
250Epidural AbscessOFFSIDES
251Excitation cerebralSIDER
252Feeling abnormalSIDER
253Femoral Neuropathy17065901CTD
254Flail ChestOFFSIDES
255Gas GangreneOFFSIDES
256Gastrointestinal PainSIDER
257GlossoptosisOFFSIDES
258Hepatic congestionOFFSIDES
259Horner Syndrome19470147CTD
260Hypoglossal Nerve DisorderOFFSIDES
261HypoxiaSIDER
262Iatrogenic injuryOFFSIDES
263IleusSIDER
264Impaired work abilityOFFSIDES
265Injection Site ReactionSIDER
266Injection site inflammationSIDER
267Injection site movement impairmentOFFSIDES
268Injection site thrombosisOFFSIDES
269Injury associated with deviceSIDER
270Intraoperative Complications15595588CTD
271Joint Range of Motion DecreasedOFFSIDES
272Joint injuryOFFSIDES
273Labor Pain

View details

11412729
12712868
16430561
18326251
 		CTD
274LaparotomyOFFSIDES
275LeukocytosisSIDER
276Low Cardiac Output SyndromeOFFSIDES
277Lung consolidationOFFSIDES
278Lymphocyte count abnormalOFFSIDES
279MeningismSIDER
280MeningitisSIDER
281MononeuritisOFFSIDES
282Mood swingsSIDER
283Muscle WeaknessOFFSIDES
284Muscle necrosisOFFSIDES
285Muscle relaxant therapySIDER
286Musculoskeletal discomfortOFFSIDES
SIDER
287MyalgiaSIDER
288MyelitisOFFSIDES
289Myocardial InfarctionSIDER
290Needle injurySIDER
291Neonatal infectionSIDER
292Neonatal respiratory failureOFFSIDES
293Nerve BlockOFFSIDES
294Nerve DegenerationOFFSIDES
295Nerve root injuryOFFSIDES
296NervousnessSIDER
297Neuralgic AmyotrophyOFFSIDES
298Neurologic reactionSIDER
299NeuropathySIDER
300Neurotoxicity Syndromes15620167
20014599		CTD
301Oculomucocutaneous syndromeOFFSIDES
302OliguriaOFFSIDES
SIDER
303Oral mucosal erythemaOFFSIDES
304Oxygen supplementationOFFSIDES
305PCO2 decreasedOFFSIDES
306Pain, Postoperative

View details

10447906
11133631
15160664
15595588
17006078
19452582
19572930
 		CTD
307PanniculitisOFFSIDES
308ParesisSIDER
309Paresthesia9175963CTD
310Peripartum cardiomyopathyOFFSIDES
311Peripheral nerve palsyOFFSIDES
312Peripheral paralysisOFFSIDES
313Phantom painOFFSIDES
314PhlebitisSIDER
315PleurisyOFFSIDES
316PneumopericardiumOFFSIDES
317PneumothoraxSIDER
318PolyuriaOFFSIDES
319Post procedural bile leakOFFSIDES
320Post procedural painOFFSIDES
321Postoperative Nausea and Vomiting16816394CTD
322Prothrombin level decreasedSIDER
323Pulmonary EmbolismSIDER
324Pulmonary InfarctionOFFSIDES
325Pulmonary function test decreasedSIDER
326PurpuraSIDER
327PyuriaSIDER
328RalesSIDER
329Rectal tenesmusSIDER
330Renal tubular necrosisOFFSIDES
331Respiratory InsufficiencySIDER
332Respiratory ParalysisSIDER
333Retroperitoneal lymphadenopathyOFFSIDES
334RhinitisSIDER
335Scrotal InfectionOFFSIDES
336Seizures

View details

1897763
2511782
9356113
10492405
11261529
11524350
11989048
12027861
12461832
12471790
15620167
18522937
18936039
20137580
 		CTD
337Sinoatrial BlockOFFSIDES
338SneezingSIDER
339Spinal Cord Diseases20014599CTD
340Splenic InfarctionOFFSIDES
341Sputum culture positiveOFFSIDES
342Subdural EffusionOFFSIDES
343Superficial ThrombophlebitisOFFSIDES
344SyncopeSIDER
345Tachycardia, Ventricular18420879CTD
346TensionSIDER
347Therapeutic product effect decreasedCanada Vigilance: 1Canada Vigilance
348Therapeutic response unexpectedSIDER
349ThrombocytopeniaSIDER
350ThrombocytosisSIDER
351Unexpected therapeutic effectSIDER
352Urinary RetentionSIDER
353Urinary tract infection staphylococcalOFFSIDES
354Urinary tract infectionSIDER
355Urination Disorders16816394CTD
356Vascular purpuraSIDER
357Vascular resistance systemic decreasedOFFSIDES
358VasospasmSIDER
359Ventricular arrhythmiaSIDER
360VertigoSIDER
361Vision Disorders9175963CTD
362Wound ComplicationOFFSIDES
363jaundiceSIDER
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