MetaADEDB 2.0 @ LMMD
Lubiprostone
(WGFOBBZOWHGYQH-MXHNKVEKSA-N)
Structure
SMILES
CCCCC([C@@]1(O)CC[C@H]2[C@H](O1)CC(=O)[C@@H]2CCCCCCC(=O)O)(F)F
Type(s)
Approved; Investigational
ATC code(s)
A06AX03
Molecular Formula:
C20H32F2O5
Molecular Weight:
390.462
Log P:
4.3099
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
83.83
CAS Number(s):
136790-76-6; 333963-40-9
Synonym(s)
1.
Lubiprostone
2.
Amitiza
3.
Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11alpha)-
4.
RU 0211
5.
RU-0211
6.
RU0211
7.
SPI 0211
8.
SPI-0211
9.
SPI0211
10.
0211, RU
11.
0211, SPI
External Link(s)
MeSHD000068238
PubChem Compound157920
CHEMBLCHEMBL1201134
DrugBankDB01046
DrugCentral4123
IUPHAR/BPS Guide to PHARMACOLOGY4242
KEGGcpd:C13707
dr:D04790
Therapeutic Target DatabaseD00CTS
ZINC4217732
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NauseaFAERS: 80OFFSIDES
SIDER
US FAERS
2Chest discomfortFAERS: 69SIDER
US FAERS
3Chest PainFAERS: 46OFFSIDES
SIDER
US FAERS
4DizzinessFAERS: 40OFFSIDES
SIDER
US FAERS
5Drug ineffectiveFAERS: 32US FAERS
6HeadacheFAERS: 29SIDER
US FAERS
7Abdominal PainFAERS: 21OFFSIDES
SIDER
US FAERS
8VomitingFAERS: 18SIDER
US FAERS
9MalaiseFAERS: 17SIDER
US FAERS
10PalpitationsFAERS: 15SIDER
US FAERS
11AstheniaFAERS: 14OFFSIDES
SIDER
US FAERS
12ConstipationFAERS: 14SIDER
US FAERS
13FatigueFAERS: 13OFFSIDES
SIDER
US FAERS
14Feeling abnormalFAERS: 12OFFSIDES
SIDER
US FAERS
15AnxietyFAERS: 11OFFSIDES
SIDER
US FAERS
16DehydrationFAERS: 11OFFSIDES
US FAERS
17SyncopeFAERS: 11SIDER
US FAERS
18FlatulenceFAERS: 10SIDER
US FAERS
19PancreatitisFAERS: 10US FAERS
20Maternal exposure during pregnancyFAERS: 9US FAERS
21HypersensitivityFAERS: 8SIDER
US FAERS
22PregnancyFAERS: 8US FAERS
23FlushingFAERS: 7US FAERS
24Weight decreasedFAERS: 7US FAERS
25ArthralgiaFAERS: 5US FAERS
26Back PainFAERS: 5US FAERS
27Cold sweatFAERS: 5SIDER
US FAERS
28Drug exposure during pregnancyFAERS: 5OFFSIDES
US FAERS
29No adverse eventFAERS: 5US FAERS
30PainFAERS: 5OFFSIDES
SIDER
US FAERS
31Abdominal discomfortFAERS: 4OFFSIDES
SIDER
US FAERS
32Adverse eventFAERS: 4US FAERS
33AlopeciaFAERS: 4US FAERS
34Choking sensationFAERS: 4OFFSIDES
US FAERS
35ColitisFAERS: 4OFFSIDES
US FAERS
36Depressed Level of ConsciousnessFAERS: 4US FAERS
37DiscomfortFAERS: 4SIDER
US FAERS
38DyspepsiaFAERS: 4SIDER
US FAERS
39IleusFAERS: 4US FAERS
40Activities of daily living impairedFAERS: 3OFFSIDES
US FAERS
41Altered state of consciousnessFAERS: 3OFFSIDES
US FAERS
42AsthmaFAERS: 3OFFSIDES
US FAERS
43Atrial FibrillationFAERS: 3US FAERS
44Blood creatine phosphokinase increasedFAERS: 3US FAERS
45ChromaturiaFAERS: 3US FAERS
46Drug administration errorFAERS: 3OFFSIDES
US FAERS
47ErythemaFAERS: 3SIDER
US FAERS
48Intestinal ObstructionFAERS: 3US FAERS
49PresyncopeFAERS: 3US FAERS
50PruritusFAERS: 3US FAERS
51SomnolenceFAERS: 3US FAERS
52TachycardiaFAERS: 3SIDER
US FAERS
53Throat irritationFAERS: 3US FAERS
54WheezingFAERS: 3US FAERS
55Alanine Aminotransferase IncreasedFAERS: 2SIDER
US FAERS
56Anaphylactic shockFAERS: 2US FAERS
57Anaphylactoid ReactionFAERS: 2US FAERS
58AnorexiaFAERS: 2OFFSIDES
SIDER
US FAERS
59Aspartate Aminotransferase IncreasedFAERS: 2SIDER
US FAERS
60Blood glucose decreasedFAERS: 2US FAERS
61Blood urine presentFAERS: 2US FAERS
62Cerebrovascular accidentFAERS: 2US FAERS
63ChillsFAERS: 2US FAERS
64ChokingFAERS: 2US FAERS
65DiverticulumFAERS: 2OFFSIDES
US FAERS
66Electrocardiogram ST segment abnormalFAERS: 2US FAERS
67Gastrointestinal PainFAERS: 2SIDER
US FAERS
68GastrostomyFAERS: 2US FAERS
69HerniaFAERS: 2US FAERS
70Incorrect dose administeredFAERS: 2US FAERS
71Intestinal PerforationFAERS: 2US FAERS
72Irritable Bowel SyndromeFAERS: 223330973CTD
US FAERS
73Metabolic alkalosisFAERS: 2US FAERS
74Musculoskeletal PainFAERS: 2US FAERS
75NephrolithiasisFAERS: 2OFFSIDES
US FAERS
76Peripheral swellingFAERS: 2US FAERS
77Post procedural complicationFAERS: 2OFFSIDES
US FAERS
78Product quality issueFAERS: 2US FAERS
79Pulmonary EmbolismFAERS: 2US FAERS
80Rectal tenesmusFAERS: 2US FAERS
81RhabdomyolysisFAERS: 2US FAERS
82Stevens-Johnson SyndromeFAERS: 2US FAERS
83ThrombocytopeniaFAERS: 2US FAERS
84TremorFAERS: 2SIDER
US FAERS
85UrticariaFAERS: 2US FAERS
86VertigoFAERS: 2US FAERS
87Wrong technique in product usage processFAERS: 2US FAERS
88AbasiaFAERS: 1US FAERS
89Accidental overdoseFAERS: 1US FAERS
90Alcohol interactionFAERS: 1US FAERS
91AmnesiaFAERS: 1OFFSIDES
US FAERS
92Anorectal discomfortFAERS: 1US FAERS
93AphasiaFAERS: 1US FAERS
94Apparent deathFAERS: 1US FAERS
95ArthritisFAERS: 1OFFSIDES
US FAERS
96AsphyxiaFAERS: 1US FAERS
97Atrioventricular BlockFAERS: 1US FAERS
98Back disorderFAERS: 1US FAERS
99BedriddenFAERS: 1OFFSIDES
US FAERS
100Blood creatine phosphokinase abnormalFAERS: 1US FAERS
101Blood creatinine increasedFAERS: 1US FAERS
102Blood lactate dehydrogenase increasedFAERS: 1US FAERS
103BradycardiaFAERS: 1US FAERS
104BronchospasmFAERS: 1US FAERS
105Cardiac ArrestFAERS: 1US FAERS
106Cardiac enzymes increasedFAERS: 1OFFSIDES
US FAERS
107CholelithiasisFAERS: 1US FAERS
108Clostridium difficile colitisFAERS: 1US FAERS
109ClubbingFAERS: 1US FAERS
110Contraindicated product administeredFAERS: 1US FAERS
111Crystal deposit intestineFAERS: 1US FAERS
112CyanosisFAERS: 1US FAERS
113CystFAERS: 1OFFSIDES
US FAERS
114Diabetes InsipidusFAERS: 1US FAERS
115DiplopiaFAERS: 1OFFSIDES
US FAERS
116DiverticulitisFAERS: 1US FAERS
117Drug ToleranceFAERS: 1OFFSIDES
US FAERS
118Drug dispensing errorFAERS: 1US FAERS
119Drug dose omissionFAERS: 1US FAERS
120DysuriaFAERS: 1US FAERS
121Ear discomfortFAERS: 1US FAERS
122Economic problemFAERS: 1OFFSIDES
US FAERS
123EndometriosisFAERS: 1US FAERS
124EpistaxisFAERS: 1OFFSIDES
US FAERS
125ExcoriationFAERS: 1US FAERS
126Feeling ColdFAERS: 1US FAERS
127Feeling of body temperature changeFAERS: 1US FAERS
128Gamma-Glutamyltransferase IncreasedFAERS: 1US FAERS
129Gastric FistulaFAERS: 1US FAERS
130Gastrointestinal carcinomaFAERS: 1US FAERS
131Gastrointestinal hypomotilityFAERS: 1US FAERS
132Gastrointestinal sounds abnormalFAERS: 1OFFSIDES
US FAERS
133General physical health deteriorationFAERS: 1US FAERS
134GlaucomaFAERS: 1US FAERS
135Head discomfortFAERS: 1US FAERS
136Hormone level abnormalFAERS: 1US FAERS
137HyperventilationFAERS: 1US FAERS
138HypophagiaFAERS: 1OFFSIDES
US FAERS
139HypotensionFAERS: 1US FAERS
140HysterectomyFAERS: 1US FAERS
141Idiosyncratic drug reactionFAERS: 1US FAERS
142ImmobileFAERS: 1US FAERS
143Inappropriate schedule of drug administrationFAERS: 1US FAERS
144Inappropriate schedule of product administrationFAERS: 1US FAERS
145IncoherentFAERS: 1US FAERS
146Incorrect route of drug administrationFAERS: 1OFFSIDES
US FAERS
147Infective pulmonary exacerbation of cystic fibrosisFAERS: 1US FAERS
148IntussusceptionFAERS: 1US FAERS
149Joint swellingFAERS: 1SIDER
US FAERS
150Large intestine perforationFAERS: 1US FAERS
151LethargyFAERS: 1SIDER
US FAERS
152Limb discomfortFAERS: 1US FAERS
153Macular ruptureFAERS: 1US FAERS
154MalnutritionFAERS: 1SIDER
US FAERS
155Mastication disorderFAERS: 1US FAERS
156Mechanical ileusFAERS: 1US FAERS
157Medication ErrorFAERS: 1US FAERS
158MenorrhagiaFAERS: 1US FAERS
159Mental status changesFAERS: 1US FAERS
160Middle insomniaFAERS: 1US FAERS
161Mucosal excoriationFAERS: 1US FAERS
162Muscle tightnessFAERS: 1US FAERS
163Musculoskeletal chest painFAERS: 1OFFSIDES
US FAERS
164MyalgiaFAERS: 1SIDER
US FAERS
165Myocardial InfarctionFAERS: 1US FAERS
166Nasogastric output highFAERS: 1US FAERS
167NasopharyngitisFAERS: 1US FAERS
168Neck PainFAERS: 1US FAERS
169No reaction on previous exposure to drugFAERS: 1US FAERS
170Non-cardiac chest painFAERS: 1US FAERS
171Occult blood positiveFAERS: 1US FAERS
172OverdoseFAERS: 1OFFSIDES
US FAERS
173PallorFAERS: 1US FAERS
174Pelvic PainFAERS: 1US FAERS
175Pharmaceutical product complaintFAERS: 1US FAERS
176PharyngitisFAERS: 1US FAERS
177PhotophobiaFAERS: 1US FAERS
178PneumoniaFAERS: 1US FAERS
179Positron emission tomogram abnormalFAERS: 1US FAERS
180Pregnancy on contraceptiveFAERS: 1US FAERS
181Product formulation issueFAERS: 1US FAERS
182Product packaging confusionFAERS: 1US FAERS
183Product packaging issueFAERS: 1US FAERS
184Productive CoughFAERS: 1US FAERS
185Pseudo-Bartter syndromeFAERS: 1US FAERS
186Pulmonary thrombosisFAERS: 1US FAERS
187Reaction to drug excipientsFAERS: 1US FAERS
188Rectal fissureFAERS: 1US FAERS
189Respiratory FailureFAERS: 1OFFSIDES
US FAERS
190Respiratory distressFAERS: 1US FAERS
191RetchingFAERS: 1US FAERS
192Salpingo-oophorectomyFAERS: 1US FAERS
193ShockFAERS: 1SIDER
US FAERS
194SinusitisFAERS: 1US FAERS
195SwellingFAERS: 1SIDER
US FAERS
196Tension HeadacheFAERS: 1US FAERS
197ThrombosisFAERS: 1US FAERS
198ToothacheFAERS: 1US FAERS
199Unresponsive to stimuliFAERS: 1OFFSIDES
US FAERS
200Upper-airway cough syndromeFAERS: 1US FAERS
201Urinary RetentionFAERS: 1US FAERS
202Uterine CancerFAERS: 1US FAERS
203Ventricular FibrillationFAERS: 1US FAERS
204Vulvovaginal burning sensationFAERS: 1US FAERS
205Walking aid userFAERS: 1US FAERS
206Wrong drug administeredFAERS: 1US FAERS
207Wrong technique in drug usage processFAERS: 1US FAERS
208Abdominal adhesionsOFFSIDES
209Abdominal rigiditySIDER
210Abdominal tendernessSIDER
211AcantholysisOFFSIDES
212Acid refluxOFFSIDES
213ActinomycosisOFFSIDES
214AdnexitisOFFSIDES
215Adrenal massOFFSIDES
216AgraphiaOFFSIDES
217Altered bowel functionOFFSIDES
218AlveoloplastyOFFSIDES
219AnhedoniaOFFSIDES
220AnhidrosisOFFSIDES
221Anticonvulsant drug level decreasedOFFSIDES
222Application site erythemaOFFSIDES
223Application site noduleOFFSIDES
224Atrial tachycardiaOFFSIDES
225AuraOFFSIDES
226Biopsy liver abnormalOFFSIDES
227Blood cholesterolOFFSIDES
228Blood chromogranin A increasedOFFSIDES
229Blood parathyroid hormone increasedOFFSIDES
230Blood potassium decreasedOFFSIDES
SIDER
231Blood prolactin increasedOFFSIDES
232Blurred visionOFFSIDES
233Bone density decreasedOFFSIDES
234Bone erosionOFFSIDES
235Bone fragmentationOFFSIDES
236Bone lesionOFFSIDES
237Bone painOFFSIDES
238Bone scan abnormalOFFSIDES
239Bowel movement irregularityOFFSIDES
240Breast cancer recurrentOFFSIDES
241BronchitisOFFSIDES
242Cardiac valve vegetationOFFSIDES
243CellulitisOFFSIDES
244Central venous catheter removalOFFSIDES
245Cerebral artery occlusionOFFSIDES
246Cerebral atrophyOFFSIDES
247Chronic idiopathic constipationSIDER
248Chronic sinusitisOFFSIDES
249ClumsinessOFFSIDES
250Dental FistulaOFFSIDES
251Dental abscessOFFSIDES
252Dental prosthesis placementOFFSIDES
253DermatitisSIDER
254Device related infectionOFFSIDES
255DiarrheaOFFSIDES
256Drug withdrawal headacheOFFSIDES
257Duodenal UlcerOFFSIDES
258DysgeusiaSIDER
259Early satietyOFFSIDES
260EczemaOFFSIDES
261Ejection Fraction DecreasedOFFSIDES
262Electrocardiogram changeOFFSIDES
263Electrolyte imbalanceSIDER
264Embolic strokeOFFSIDES
265Emotional disorderOFFSIDES
266Emotional distressOFFSIDES
267EndocarditisOFFSIDES
268Endodontic procedureOFFSIDES
269EructationSIDER
270Essential HypertensionOFFSIDES
271Eye painOFFSIDES
272Facial NeuralgiaOFFSIDES
273FibromyalgiaSIDER
274Fluid overloadOFFSIDES
275FormicationOFFSIDES
276Gastric BypassOFFSIDES
277Gastric DilatationOFFSIDES
278Gastric ulcerOFFSIDES
279GastritisSIDER
280Gastrointestinal discomfortSIDER
281Gastrointestinal infectionOFFSIDES
282Genital painOFFSIDES
283Gingival graftOFFSIDES
284GranulomaOFFSIDES
285High frequency ablationOFFSIDES
286HydronephrosisOFFSIDES
287HyperkeratosisOFFSIDES
288HyperparathyroidismOFFSIDES
289Hypoaesthesia facialOFFSIDES
290Impaired gastric emptyingOFFSIDES
291ImpetigoOFFSIDES
292IndurationOFFSIDES
293InfluenzaSIDER
294Initial insomniaOFFSIDES
295Injection site erythemaOFFSIDES
296Injection site pruritusOFFSIDES
297Intention tremorOFFSIDES
298Intermittent ClaudicationOFFSIDES
299Intracranial HypotensionOFFSIDES
300Joint sprainOFFSIDES
301Kidney FailureOFFSIDES
302Liver scan abnormalOFFSIDES
303Loose toothOFFSIDES
304Lymphocyte count decreasedOFFSIDES
305Medication residueOFFSIDES
306Metastases to adrenalsOFFSIDES
307Metastatic painOFFSIDES
308Multiple MyelomaOFFSIDES
309Multiple SclerosisOFFSIDES
310Multiple sclerosis relapseOFFSIDES
311Muscle WeaknessOFFSIDES
312Musculoskeletal discomfortSIDER
313Nodule on extremityOFFSIDES
314Optic NeuritisOFFSIDES
315Oral Cavity FistulaOFFSIDES
316Oral dischargeOFFSIDES
317Oral infectionOFFSIDES
318Oral mucosa atrophyOFFSIDES
319Oropharyngeal painOFFSIDES
320OsteolysisOFFSIDES
321OsteomyelitisOFFSIDES
322OsteopeniaOFFSIDES
323OsteoporosisOFFSIDES
324OsteosclerosisOFFSIDES
325ParacentesisOFFSIDES
326ParaplegiaOFFSIDES
327ParathyroidectomyOFFSIDES
328Perivascular dermatitisOFFSIDES
329Pharyngolaryngeal PainSIDER
330PlasmacytosisOFFSIDES
331PolyuriaOFFSIDES
332Postmenopausal bleedingOFFSIDES
333Pregnancy on oral contraceptiveOFFSIDES
334Primary sequestrumOFFSIDES
335Procedural complicationOFFSIDES
336Prostate cancer recurrentOFFSIDES
337Protein total decreasedOFFSIDES
338Purulent dischargeOFFSIDES
339RegurgitationOFFSIDES
340Retinal vascular occlusionOFFSIDES
341Retroperitoneal lymphadenopathyOFFSIDES
342RhinorrheaOFFSIDES
343RhonchiOFFSIDES
344Risus sardonicusOFFSIDES
345Skin neoplasm excisionOFFSIDES
346Spinal column stenosisOFFSIDES
347StaringOFFSIDES
348Stem cell transplantOFFSIDES
349Temperature intoleranceOFFSIDES
350Therapy regimen changedOFFSIDES
351ThyroidectomyOFFSIDES
352Tooth ExtractionOFFSIDES
353Tooth InfectionOFFSIDES
354Tooth LossOFFSIDES
355Tooth repairOFFSIDES
356UlcerOFFSIDES
357Unevaluable eventOFFSIDES
358Upset stomachSIDER
359Urethral caruncleOFFSIDES
360Urinary tract infectionSIDER
361VIIth nerve paralysisOFFSIDES
362Wound dehiscenceOFFSIDES
363fibromaOFFSIDES
364nervous system disorderSIDER
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