ramelteon
(YLXDSYKOBKBWJQ-LBPRGKRZSA-N)
Structure
- SMILES
- CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2
- Type(s)
- Approved; Investigational
- ATC code(s)
- N05CH02
- Molecular Formula:
- C16H21NO2
- Molecular Weight:
- 259.343
- Log P:
- 2.9585
- Hydrogen Bond Acceptor:
- 3
- Hydrogen Bond Donor:
- 1
- TPSA:
- 38.33
- CAS Number(s):
- 196597-26-9
Synonym(s)
1.
ramelteon
2.
(S)-N-(2-(1,6,7,8-tetrahydro-2H-indeno-(5,4)furan-8-yl)ethyl)propionamide
3.
Rozerem
4.
TAK-375
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Drug ineffective | FAERS: 335 | OFFSIDES US FAERS | |
| 2 | Initial insomnia | FAERS: 138 | OFFSIDES US FAERS | |
| 3 | Middle insomnia | FAERS: 131 | OFFSIDES US FAERS | |
| 4 | Somnolence | FAERS: 125 | SIDER US FAERS | |
| 5 | Poor quality sleep | FAERS: 74 | OFFSIDES US FAERS | |
| 6 | Fatigue | FAERS: 71 | OFFSIDES SIDER US FAERS | |
| 7 | Feeling abnormal | FAERS: 68 | OFFSIDES US FAERS | |
| 8 | Dizziness | FAERS: 52 | OFFSIDES SIDER US FAERS | |
| 9 | Headache | FAERS: 49 | SIDER US FAERS | |
| 10 | Nausea | FAERS: 47 | SIDER US FAERS | |
| 11 | Overdose | FAERS: 30 | US FAERS | |
| 12 | No adverse event | FAERS: 28 | US FAERS | |
| 13 | Anxiety | FAERS: 27 | US FAERS | |
| 14 | Toxicity to various agents | FAERS: 26 | US FAERS | |
| 15 | Feeling jittery | FAERS: 25 | US FAERS | |
| 16 | Palpitations | FAERS: 19 | US FAERS | |
| 17 | Agitation | FAERS: 16 | US FAERS | |
| 18 | Hypersomnia | FAERS: 16 | US FAERS | |
| 19 | Restlessness | FAERS: 16 | US FAERS | |
| 20 | Vomiting | FAERS: 16 | US FAERS | |
| 21 | Malaise | FAERS: 14 | US FAERS | |
| 22 | Wrong technique in product usage process | FAERS: 14 | US FAERS | |
| 23 | Pruritus | FAERS: 12 | US FAERS | |
| 24 | Drug prescribing error | FAERS: 11 | US FAERS | |
| 25 | Nervousness | FAERS: 11 | US FAERS | |
| 26 | Incorrect dose administered | FAERS: 10 | OFFSIDES US FAERS | |
| 27 | Paradoxical drug reaction | FAERS: 10 | US FAERS | |
| 28 | Prescribed overdose | FAERS: 10 | OFFSIDES US FAERS | |
| 29 | Asthenia | FAERS: 9 | SIDER US FAERS | |
| 30 | Dysgeusia | FAERS: 9 | SIDER US FAERS | |
| 31 | Suicide attempt | FAERS: 9 | US FAERS | |
| 32 | No adverse reaction | FAERS: 8 | US FAERS | |
| 33 | Pain | FAERS: 8 | US FAERS | |
| 34 | Disorientation | FAERS: 7 | US FAERS | |
| 35 | Night sweats | FAERS: 7 | US FAERS | |
| 36 | Tremor | FAERS: 7 | US FAERS | |
| 37 | Unevaluable event | FAERS: 7 | OFFSIDES US FAERS | |
| 38 | Arthralgia | FAERS: 6 | SIDER US FAERS | |
| 39 | Amnesia | FAERS: 5 | US FAERS | |
| 40 | Blood prolactin increased | FAERS: 5 | OFFSIDES US FAERS | |
| 41 | Completed Suicide | FAERS: 5 | US FAERS | |
| 42 | Drug administered to patient of inappropriate age | FAERS: 5 | US FAERS | |
| 43 | Drug screen positive | FAERS: 5 | OFFSIDES US FAERS | |
| 44 | Dyspepsia | FAERS: 5 | US FAERS | |
| 45 | Excitability | FAERS: 5 | US FAERS | |
| 46 | Myalgia | FAERS: 5 | SIDER US FAERS | |
| 47 | Sluggishness | FAERS: 5 | US FAERS | |
| 48 | Abasia | FAERS: 4 | US FAERS | |
| 49 | Chest Pain | FAERS: 4 | US FAERS | |
| 50 | No adverse effect | FAERS: 4 | OFFSIDES US FAERS | |
| 51 | Paranoia | FAERS: 4 | US FAERS | |
| 52 | Restless Legs Syndrome | FAERS: 4 | US FAERS | |
| 53 | Somnambulism | FAERS: 4 | US FAERS | |
| 54 | Tinnitus | FAERS: 4 | US FAERS | |
| 55 | Urticaria | FAERS: 4 | US FAERS | |
| 56 | Abdominal Pain | FAERS: 3 | US FAERS | |
| 57 | Abnormal sleep-related event | FAERS: 3 | US FAERS | |
| 58 | Activities of daily living impaired | FAERS: 3 | US FAERS | |
| 59 | Anger | FAERS: 3 | US FAERS | |
| 60 | Back Pain | FAERS: 3 | US FAERS | |
| 61 | Crying | FAERS: 3 | US FAERS | |
| 62 | Delirium | FAERS: 3 | US FAERS | |
| 63 | Dissociation | FAERS: 3 | US FAERS | |
| 64 | Dysarthria | FAERS: 3 | US FAERS | |
| 65 | Dysuria | FAERS: 3 | US FAERS | |
| 66 | Epilepsy | FAERS: 3 | US FAERS | |
| 67 | Erectile dysfunction | FAERS: 3 | OFFSIDES US FAERS | |
| 68 | Hypersensitivity | FAERS: 3 | US FAERS | |
| 69 | Impaired driving ability | FAERS: 3 | US FAERS | |
| 70 | Impaired work ability | FAERS: 3 | US FAERS | |
| 71 | Lethargy | FAERS: 3 | OFFSIDES US FAERS | |
| 72 | Medication Error | FAERS: 3 | US FAERS | |
| 73 | Nocturia | FAERS: 3 | US FAERS | |
| 74 | Product administered to patient of inappropriate age | FAERS: 3 | US FAERS | |
| 75 | Respiratory Depression | FAERS: 3 | US FAERS | |
| 76 | Visual disturbance | FAERS: 3 | US FAERS | |
| 77 | Abdominal discomfort | FAERS: 2 | US FAERS | |
| 78 | Acne | FAERS: 2 | OFFSIDES US FAERS | |
| 79 | Acute kidney injury | FAERS: 2 | US FAERS | |
| 80 | Alopecia | FAERS: 2 | US FAERS | |
| 81 | Ammonia increased | FAERS: 2 | US FAERS | |
| 82 | Bipolar Disorder | FAERS: 2 | US FAERS | |
| 83 | Blood glucose increased | FAERS: 2 | US FAERS | |
| 84 | Breast tenderness | FAERS: 2 | OFFSIDES US FAERS | |
| 85 | Burning sensation | FAERS: 2 | US FAERS | |
| 86 | Chest discomfort | FAERS: 2 | US FAERS | |
| 87 | Cholelithiasis | FAERS: 2 | US FAERS | |
| 88 | Chromaturia | FAERS: 2 | OFFSIDES US FAERS | |
| 89 | Dependence | FAERS: 2 | US FAERS | |
| 90 | Diplopia | FAERS: 2 | US FAERS | |
| 91 | Discomfort | FAERS: 2 | US FAERS | |
| 92 | Drug dispensing error | FAERS: 2 | OFFSIDES US FAERS | |
| 93 | Ear discomfort | FAERS: 2 | US FAERS | |
| 94 | Emotional disorder | FAERS: 2 | US FAERS | |
| 95 | Erection increased | FAERS: 2 | US FAERS | |
| 96 | Euphoric mood | FAERS: 2 | US FAERS | |
| 97 | Excoriation | FAERS: 2 | US FAERS | |
| 98 | Flight of ideas | FAERS: 2 | US FAERS | |
| 99 | Hypokinesia | FAERS: 2 | US FAERS | |
| 100 | Intentional product misuse | FAERS: 2 | US FAERS | |
| 101 | Intentional self-injury | FAERS: 2 | US FAERS | |
| 102 | Joint swelling | FAERS: 2 | US FAERS | |
| 103 | Loss of personal independence in daily activities | FAERS: 2 | US FAERS | |
| 104 | Memory impairment | FAERS: 2 | US FAERS | |
| 105 | Myoclonus | FAERS: 2 | US FAERS | |
| 106 | Neck Pain | FAERS: 2 | US FAERS | |
| 107 | Oropharyngeal pain | FAERS: 2 | US FAERS | |
| 108 | Pneumonia | FAERS: 2 | US FAERS | |
| 109 | Post-Traumatic Stress Disorder | FAERS: 2 | US FAERS | |
| 110 | Pre-existing condition improved | FAERS: 2 | OFFSIDES US FAERS | |
| 111 | Pregnancy | FAERS: 2 | US FAERS | |
| 112 | Priapism | FAERS: 2 | US FAERS | |
| 113 | Screaming | FAERS: 2 | US FAERS | |
| 114 | Serotonin Syndrome | FAERS: 2 | US FAERS | |
| 115 | Sleep Talking | FAERS: 2 | US FAERS | |
| 116 | Stress | FAERS: 2 | US FAERS | |
| 117 | Therapeutic response delayed | FAERS: 2 | US FAERS | |
| 118 | Therapy non-responder | FAERS: 2 | US FAERS | |
| 119 | Visual Impairment | FAERS: 2 | US FAERS | |
| 120 | Wrong drug administered | FAERS: 2 | OFFSIDES US FAERS | |
| 121 | Adverse event | FAERS: 1 | OFFSIDES US FAERS | |
| 122 | Alcohol interaction | FAERS: 1 | US FAERS | |
| 123 | Anaphylactoid Reaction | FAERS: 1 | SIDER US FAERS | |
| 124 | Arthritis | FAERS: 1 | US FAERS | |
| 125 | Asphyxia | FAERS: 1 | US FAERS | |
| 126 | Asthma | FAERS: 1 | US FAERS | |
| 127 | Blindness | FAERS: 1 | US FAERS | |
| 128 | Blood corticotrophin increased | FAERS: 1 | OFFSIDES US FAERS | |
| 129 | Blood creatine phosphokinase increased | FAERS: 1 | US FAERS | |
| 130 | Blood creatinine increased | FAERS: 1 | US FAERS | |
| 131 | Blood pressure fluctuation | FAERS: 1 | US FAERS | |
| 132 | Blood testosterone decreased | FAERS: 1 | OFFSIDES US FAERS | |
| 133 | Bone pain | FAERS: 1 | US FAERS | |
| 134 | Breast engorgement | FAERS: 1 | US FAERS | |
| 135 | Chills | FAERS: 1 | US FAERS | |
| 136 | Dehydration | FAERS: 1 | US FAERS | |
| 137 | Delusional perception | FAERS: 1 | OFFSIDES US FAERS | |
| 138 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 139 | Diabetes Mellitus | FAERS: 1 | US FAERS | |
| 140 | Disease recurrence | FAERS: 1 | US FAERS | |
| 141 | Dreamy state | FAERS: 1 | OFFSIDES US FAERS | |
| 142 | Drug Dependence | FAERS: 1 | US FAERS | |
| 143 | Drug Tolerance | FAERS: 1 | US FAERS | |
| 144 | Drug screen false positive | FAERS: 1 | US FAERS | |
| 145 | Drug therapy changed | FAERS: 1 | US FAERS | |
| 146 | Ecchymosis | FAERS: 1 | US FAERS | |
| 147 | Electroencephalogram abnormal | FAERS: 1 | US FAERS | |
| 148 | Embolic stroke | FAERS: 1 | US FAERS | |
| 149 | Eructation | FAERS: 1 | US FAERS | |
| 150 | Erythema | FAERS: 1 | US FAERS | |
| 151 | Extra dose administered | FAERS: 1 | US FAERS | |
| 152 | Eye irritation | FAERS: 1 | US FAERS | |
| 153 | Eye pain | FAERS: 1 | US FAERS | |
| 154 | Fasciitis | FAERS: 1 | US FAERS | |
| 155 | Female Orgasmic Disorder | FAERS: 1 | US FAERS | |
| 156 | Flushing | FAERS: 1 | US FAERS | |
| 157 | Food craving | FAERS: 1 | US FAERS | |
| 158 | Gait inability | FAERS: 1 | US FAERS | |
| 159 | Glaucoma | FAERS: 1 | US FAERS | |
| 160 | Hallucinations, mixed | FAERS: 1 | OFFSIDES US FAERS | |
| 161 | Head discomfort | FAERS: 1 | US FAERS | |
| 162 | Hostility | FAERS: 1 | US FAERS | |
| 163 | Hyperacusis | FAERS: 1 | US FAERS | |
| 164 | Hyperchlorhydria | FAERS: 1 | US FAERS | |
| 165 | Hypervigilance | FAERS: 1 | US FAERS | |
| 166 | Hypoaesthesia facial | FAERS: 1 | US FAERS | |
| 167 | Hypogonadism | FAERS: 1 | US FAERS | |
| 168 | Idiosyncratic drug reaction | FAERS: 1 | US FAERS | |
| 169 | Incorrect drug administration duration | FAERS: 1 | US FAERS | |
| 170 | Influenza | FAERS: 1 | SIDER US FAERS | |
| 171 | Intentional drug misuse | FAERS: 1 | US FAERS | |
| 172 | Intercepted drug dispensing error | FAERS: 1 | US FAERS | |
| 173 | Intercepted drug prescribing error | FAERS: 1 | US FAERS | |
| 174 | Intercepted medication error | FAERS: 1 | US FAERS | |
| 175 | Joint injury | FAERS: 1 | US FAERS | |
| 176 | Joint sprain | FAERS: 1 | US FAERS | |
| 177 | Joint stiffness | FAERS: 1 | US FAERS | |
| 178 | Laceration | FAERS: 1 | US FAERS | |
| 179 | Lactation Disorder | FAERS: 1 | OFFSIDES US FAERS | |
| 180 | Laziness | FAERS: 1 | US FAERS | |
| 181 | Lip swelling | FAERS: 1 | US FAERS | |
| 182 | Malignant genitourinary tract neoplasm | FAERS: 1 | US FAERS | |
| 183 | Mental impairment | FAERS: 1 | US FAERS | |
| 184 | Migraine with Aura | FAERS: 1 | US FAERS | |
| 185 | Mood swings | FAERS: 1 | US FAERS | |
| 186 | Muscle tightness | FAERS: 1 | US FAERS | |
| 187 | Musculoskeletal Pain | FAERS: 1 | US FAERS | |
| 188 | Musculoskeletal stiffness | FAERS: 1 | US FAERS | |
| 189 | Nasal discomfort | FAERS: 1 | US FAERS | |
| 190 | Ocular discomfort | FAERS: 1 | US FAERS | |
| 191 | Opiates positive | FAERS: 1 | US FAERS | |
| 192 | Partner stress | FAERS: 1 | US FAERS | |
| 193 | Personality Change | FAERS: 1 | US FAERS | |
| 194 | Pharmaceutical product complaint | FAERS: 1 | US FAERS | |
| 195 | Phobia of driving | FAERS: 1 | OFFSIDES US FAERS | |
| 196 | Photophobia | FAERS: 1 | US FAERS | |
| 197 | Poor quality drug administered | FAERS: 1 | US FAERS | |
| 198 | Product formulation issue | FAERS: 1 | US FAERS | |
| 199 | Product prescribing error | FAERS: 1 | US FAERS | |
| 200 | Product quality issue | FAERS: 1 | US FAERS | |
| 201 | Product use issue | FAERS: 1 | US FAERS | |
| 202 | Rebound effect | FAERS: 1 | US FAERS | |
| 203 | Rhabdomyolysis | FAERS: 1 | US FAERS | |
| 204 | Skin laceration | FAERS: 1 | US FAERS | |
| 205 | Sleep Paralysis | FAERS: 1 | OFFSIDES US FAERS | |
| 206 | Spontaneous penile erection | FAERS: 1 | OFFSIDES US FAERS | |
| 207 | Stevens-Johnson Syndrome | FAERS: 1 | US FAERS | |
| 208 | Swelling | FAERS: 1 | US FAERS | |
| 209 | Tachycardia | FAERS: 1 | US FAERS | |
| 210 | Tachyphrenia | FAERS: 1 | US FAERS | |
| 211 | Tension | FAERS: 1 | US FAERS | |
| 212 | Therapeutic response unexpected | FAERS: 1 | US FAERS | |
| 213 | Therapy regimen changed | FAERS: 1 | US FAERS | |
| 214 | Transaminases increased | FAERS: 1 | US FAERS | |
| 215 | Urinary tract infection | FAERS: 1 | US FAERS | |
| 216 | Vertigo | FAERS: 1 | US FAERS | |
| 217 | Wrong technique in drug usage process | FAERS: 1 | US FAERS | |
| 218 | jaundice | FAERS: 1 | US FAERS | |
| 219 | Accidental death | OFFSIDES | ||
| 220 | Acidosis | OFFSIDES | ||
| 221 | Amenorrhea | OFFSIDES | ||
| 222 | Anaphylactic shock | SIDER | ||
| 223 | Anhedonia | OFFSIDES | ||
| 224 | Arteritis | OFFSIDES | ||
| 225 | Atelectasis | OFFSIDES | ||
| 226 | Atrophic vulvovaginitis | OFFSIDES | ||
| 227 | Autonomic neuropathy | OFFSIDES | ||
| 228 | Aversion | OFFSIDES | ||
| 229 | Bilirubin conjugated increased | OFFSIDES | ||
| 230 | Biopsy breast abnormal | OFFSIDES | ||
| 231 | Biopsy lymph gland abnormal | OFFSIDES | ||
| 232 | Blood cortisol decreased | SIDER | ||
| 233 | Bone density decreased | OFFSIDES | ||
| 234 | Bone lesion | OFFSIDES | ||
| 235 | Brain natriuretic peptide increased | OFFSIDES | ||
| 236 | Breast hyperplasia | OFFSIDES | ||
| 237 | Bursitis | OFFSIDES | ||
| 238 | Cancer Pain | OFFSIDES | ||
| 239 | Cardiac enzymes increased | OFFSIDES | ||
| 240 | Cardioactive drug level increased | OFFSIDES | ||
| 241 | Cartilage injury | OFFSIDES | ||
| 242 | Catheter site infection | OFFSIDES | ||
| 243 | Causalgia | OFFSIDES | ||
| 244 | Cerebral artery stenosis | OFFSIDES | ||
| 245 | Cervical myelopathy | OFFSIDES | ||
| 246 | Chronic Insomnia | SIDER | ||
| 247 | Chronic active hepatitis | OFFSIDES | ||
| 248 | Circumstance or information capable of leading to medication error | OFFSIDES | ||
| 249 | Conjunctival abrasion | OFFSIDES | ||
| 250 | Cutaneous Candidiasis | OFFSIDES | ||
| 251 | Device related infection | OFFSIDES | ||
| 252 | Drowsiness | OFFSIDES | ||
| 253 | Drug toxicity | OFFSIDES | ||
| 254 | Drug withdrawal headache | OFFSIDES | ||
| 255 | Economic problem | OFFSIDES | ||
| 256 | Endodontic procedure | OFFSIDES | ||
| 257 | Endometrial hypertrophy | OFFSIDES | ||
| 258 | Enteritis | OFFSIDES | ||
| 259 | Excessive eye blinking | OFFSIDES | ||
| 260 | Eyelid pain | OFFSIDES | ||
| 261 | Fear of falling | OFFSIDES | ||
| 262 | Frustration | OFFSIDES | ||
| 263 | Galactorrhea | OFFSIDES | ||
| 264 | General physical condition | OFFSIDES | ||
| 265 | Glioblastoma Multiforme | OFFSIDES | ||
| 266 | Hemicephalalgia | OFFSIDES | ||
| 267 | Hemiparesis | OFFSIDES | ||
| 268 | Infective exacerbation of chronic obstructive airways disease | OFFSIDES | ||
| 269 | Insomnia exacerbated | SIDER | ||
| 270 | Libido disorder | OFFSIDES | ||
| 271 | Lymphedema | OFFSIDES | ||
| 272 | Lymphocyte count decreased | OFFSIDES | ||
| 273 | Macrocytosis | OFFSIDES | ||
| 274 | Malocclusion | OFFSIDES | ||
| 275 | Mastectomy | OFFSIDES | ||
| 276 | Metaplasia | OFFSIDES | ||
| 277 | Musculoskeletal chest pain | OFFSIDES | ||
| 278 | Musculoskeletal discomfort | SIDER | ||
| 279 | Nervous tension | OFFSIDES | ||
| 280 | Optic Neuritis | OFFSIDES | ||
| 281 | Orthopnea | OFFSIDES | ||
| 282 | Osteolysis | OFFSIDES | ||
| 283 | Osteosclerosis | OFFSIDES | ||
| 284 | Pancreatic enzymes increased | OFFSIDES | ||
| 285 | Postmenopausal bleeding | OFFSIDES | ||
| 286 | Presbyopia | OFFSIDES | ||
| 287 | Proctitis | OFFSIDES | ||
| 288 | Prostate cancer recurrent | OFFSIDES | ||
| 289 | Prostate examination abnormal | OFFSIDES | ||
| 290 | Pulmonary congestion | OFFSIDES | ||
| 291 | Pulmonary thrombosis | OFFSIDES | ||
| 292 | Rectal tenesmus | OFFSIDES | ||
| 293 | Reflux gastritis | OFFSIDES | ||
| 294 | Retroperitoneal lymphadenopathy | OFFSIDES | ||
| 295 | Rhinorrhea | OFFSIDES | ||
| 296 | Right atrial dilatation | OFFSIDES | ||
| 297 | Schizoaffective Disorder | OFFSIDES | ||
| 298 | Secretion discharge | OFFSIDES | ||
| 299 | Sensation of blood flow | OFFSIDES | ||
| 300 | Seroma | OFFSIDES | ||
| 301 | Shoulder Pain | OFFSIDES | ||
| 302 | Sigmoiditis | OFFSIDES | ||
| 303 | Sinus headache | OFFSIDES | ||
| 304 | Skin Induration | OFFSIDES | ||
| 305 | Skin hypertrophy | OFFSIDES | ||
| 306 | Sleep Initiation and Maintenance Disorders | CTD | ||
| 307 | Synovial Cyst | OFFSIDES | ||
| 308 | Temporal Arteritis | OFFSIDES | ||
| 309 | Thymoma | OFFSIDES | ||
| 310 | Tooth Loss | OFFSIDES | ||
| 311 | Upper respiratory tract inflammation | OFFSIDES | ||
| 312 | Venous thrombosis limb | OFFSIDES | ||
| 313 | Visual acuity tests abnormal | OFFSIDES | ||
| 314 | Vitreous Detachment | OFFSIDES | ||
| 315 | Weight Gain | 20633116 | CTD | |
| 316 | colonoscopy | OFFSIDES | ||
| 317 | furuncle | OFFSIDES | ||
| 318 | muscle injury | OFFSIDES |
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