MetaADEDB 2.0 @ LMMD
Propafenone
(JWHAUXFOSRPERK-UHFFFAOYSA-N)
Structure
SMILES
CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O
Type(s)
Approved
ATC code(s)
C01BC03
Molecular Formula:
C21H27NO3
Molecular Weight:
341.444
Log P:
3.6323
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
2
TPSA:
58.56
CAS Number(s):
54063-53-5; 107300-59-4
Synonym(s)
1.
Propafenone
2.
Apo-Propafenone
3.
Arythmol
4.
Baxarytmon
5.
Cuxafenon
6.
Fenoprain
7.
Jutanorm
8.
Nistaken
9.
Norfenon
10.
Pintoform
11.
Prolecofen
12.
Propafenon AL
13.
Propafenon Hexal
14.
Propafenon Minden
15.
Propafenone Hydrochloride
16.
Propafenone Hydrochloride, (R)-Isomer
17.
Propafenone Hydrochloride, (S)-Isomer
18.
Propafenone, (+-)-Isomer
19.
Propafenone, (R)-Isomer
20.
Propafenone, (S)-Isomer
21.
Propamerck
22.
Rythmol
23.
Rytmo-Puren
24.
Rytmogenat
25.
Rytmonorm
26.
SA-79
27.
Hydrochloride, Propafenone
28.
SA 79
29.
SA79
External Link(s)
MeSHD011405
PubChem Compound4932
BindingDB50067133
ChEBI63619
CHEMBLCHEMBL631
DrugBankDB01182
DrugCentral2291
IUPHAR/BPS Guide to PHARMACOLOGY2561
KEGGcpd:C07381
dr:D08435
Therapeutic Target DatabaseD0J2KV
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Toxicity to various agentsFAERS: 60
Canada Vigilance: 1		Canada Vigilance
US FAERS
2Cardiac ArrestFAERS: 53SIDER
US FAERS
3Atrial FibrillationFAERS: 29
Canada Vigilance: 6

View details

1721143
2399896
3692070
7663030
8298383
8330477
8752188
8772625
8842506
9052343
10496451
10517649
11599527
11757212
12552163
15312873
16180181
16615278
 		CTD
SIDER
Canada Vigilance
US FAERS
4Drug ineffectiveFAERS: 29
Canada Vigilance: 6		Canada Vigilance
US FAERS
5OverdoseFAERS: 22US FAERS
6Suicide attemptFAERS: 20
Canada Vigilance: 3		Canada Vigilance
US FAERS
7BradycardiaFAERS: 183682985CTD
OFFSIDES
SIDER
US FAERS
8HypotensionFAERS: 1819105102
20548984		CTD
SIDER
US FAERS
9VomitingFAERS: 12
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
10Metabolic acidosisFAERS: 11US FAERS
11Electrocardiogram abnormalFAERS: 10
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
12SyncopeFAERS: 10SIDER
US FAERS
13MalaiseFAERS: 9SIDER
US FAERS
14DizzinessFAERS: 8
Canada Vigilance: 5		18675768CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
15Product substitution issueFAERS: 8
Canada Vigilance: 5		Canada Vigilance
US FAERS
16PalpitationsFAERS: 7
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
17TachycardiaFAERS: 7
Canada Vigilance: 1

View details

1712954
3122689
6141285
10709239
19105102
19934146
 		CTD
SIDER
Canada Vigilance
US FAERS
18Accidental overdoseFAERS: 6US FAERS
19AnxietyFAERS: 6
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
20Chest PainFAERS: 6
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
21Completed SuicideFAERS: 6US FAERS
22PoisoningFAERS: 6US FAERS
23ShockFAERS: 6SIDER
US FAERS
24AstheniaFAERS: 5
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
25Drug toxicityFAERS: 5US FAERS
26FatigueFAERS: 5
Canada Vigilance: 5		Canada Vigilance
SIDER
US FAERS
27LethargyFAERS: 5US FAERS
28NauseaFAERS: 5
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
29Sinus ArrhythmiaFAERS: 5SIDER
US FAERS
30Sinus bradycardiaFAERS: 5OFFSIDES
SIDER
US FAERS
31Abdominal PainFAERS: 4
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
32Accidental exposure to product by childFAERS: 4US FAERS
33Atrioventricular BlockFAERS: 4OFFSIDES
SIDER
US FAERS
34ConstipationFAERS: 4
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
35CyanosisFAERS: 414976857CTD
OFFSIDES
US FAERS
36Medication ErrorFAERS: 4
Canada Vigilance: 1		Canada Vigilance
US FAERS
37MydriasisFAERS: 4US FAERS
38PresyncopeFAERS: 4SIDER
US FAERS
39TremorFAERS: 4
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
40Accidental exposure to productFAERS: 3US FAERS
41Adverse eventFAERS: 3US FAERS
42Atrial FlutterFAERS: 3

View details

2399896
3692070
8072758
8752188
9793099
15312873
15546305
 		CTD
OFFSIDES
SIDER
US FAERS
43Drug dose omissionFAERS: 3US FAERS
44Drug screen false positiveFAERS: 3US FAERS
45HepatitisFAERS: 311320851CTD
SIDER
US FAERS
46Pharmaceutical product complaintFAERS: 3US FAERS
47Respiratory FailureFAERS: 3OFFSIDES
SIDER
US FAERS
48jaundiceFAERS: 3SIDER
US FAERS
49treatment failureFAERS: 3US FAERS
50Altered state of consciousnessFAERS: 2US FAERS
51ArthralgiaFAERS: 2US FAERS
52Cardiac ablationFAERS: 2US FAERS
53Cardiac stress test abnormalFAERS: 2US FAERS
54CardiotoxicityFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
55Depressed Level of ConsciousnessFAERS: 2US FAERS
56DiscomfortFAERS: 2SIDER
US FAERS
57Disease recurrenceFAERS: 2US FAERS
58Drug administered to patient of inappropriate ageFAERS: 2US FAERS
59Drug level increasedFAERS: 2US FAERS
60DysphoniaFAERS: 2US FAERS
61Electromechanical dissociationFAERS: 2OFFSIDES
US FAERS
62ErythemaFAERS: 2SIDER
US FAERS
63HepatotoxicityFAERS: 2US FAERS
64Incorrect dose administeredFAERS: 2US FAERS
65Intentional product misuseFAERS: 2US FAERS
66LeukocytosisFAERS: 2US FAERS
67Myocardial InfarctionFAERS: 2US FAERS
68NervousnessFAERS: 2SIDER
US FAERS
69Pericardial effusionFAERS: 2OFFSIDES
US FAERS
70Respiratory arrestFAERS: 2US FAERS
71SomnolenceFAERS: 2SIDER
US FAERS
72Tonic clonic movementsFAERS: 2US FAERS
73Trifascicular blockFAERS: 2OFFSIDES
US FAERS
74Type III immune complex mediated reactionFAERS: 2US FAERS
75nervous system disorderFAERS: 2SIDER
US FAERS
76Abdominal discomfortFAERS: 1OFFSIDES
US FAERS
77Accelerated Idioventricular RhythmFAERS: 1US FAERS
78Accidental exposureFAERS: 1US FAERS
79Acquired porphyriaFAERS: 1US FAERS
80Acute respiratory failureFAERS: 1US FAERS
81Alcohol interactionFAERS: 1US FAERS
82Back PainFAERS: 1US FAERS
83Basal cell carcinomaFAERS: 1US FAERS
84Blood gases abnormalFAERS: 1OFFSIDES
US FAERS
85Blood iron decreasedFAERS: 1US FAERS
86Blood pressure fluctuationFAERS: 1OFFSIDES
US FAERS
87Cardiac FlutterFAERS: 1SIDER
US FAERS
88CardiomegalyFAERS: 1US FAERS
89Cerebrovascular accidentFAERS: 1SIDER
US FAERS
90Chest discomfortFAERS: 1US FAERS
91ChillsFAERS: 1US FAERS
92ChromaturiaFAERS: 1US FAERS
93Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
94Cold sweatFAERS: 1US FAERS
95DementiaFAERS: 1SIDER
US FAERS
96Drug administration errorFAERS: 1US FAERS
97Drug dispensing errorFAERS: 1US FAERS
98Drug effect incompleteFAERS: 1US FAERS
99Electrocardiogram repolarisation abnormalityFAERS: 1US FAERS
100EpilepsyFAERS: 1US FAERS
101Exposure during breast feedingFAERS: 1US FAERS
102Extra dose administeredFAERS: 1US FAERS
103FlatulenceFAERS: 1SIDER
US FAERS
104General physical health deteriorationFAERS: 1US FAERS
105General symptomFAERS: 1US FAERS
106GlaucomaFAERS: 1OFFSIDES
US FAERS
107HeadacheFAERS: 1
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
108HypersensitivityFAERS: 1SIDER
US FAERS
109Hypertrophic CardiomyopathyFAERS: 1US FAERS
110HypothyroidismFAERS: 1US FAERS
111HypoventilationFAERS: 1US FAERS
112Inability to afford medicationFAERS: 1US FAERS
113Inappropriate device signal detectionFAERS: 1US FAERS
114Incorrect drug dosage form administeredFAERS: 1US FAERS
115Intentional drug misuseFAERS: 1US FAERS
116Joint swellingFAERS: 1US FAERS
117LacerationFAERS: 1US FAERS
118LazinessFAERS: 1US FAERS
119Limb injuryFAERS: 1US FAERS
120Memory impairmentFAERS: 1US FAERS
121Mental status changesFAERS: 1US FAERS
122Musculoskeletal chest painFAERS: 1US FAERS
123Musculoskeletal discomfortFAERS: 1SIDER
US FAERS
124Neck PainFAERS: 1SIDER
US FAERS
125NeuralgiaFAERS: 1US FAERS
126No adverse eventFAERS: 1US FAERS
127Pacemaker generated arrhythmiaFAERS: 1US FAERS
128PainFAERS: 1SIDER
US FAERS
129PallorFAERS: 1SIDER
US FAERS
130Polymyalgia RheumaticaFAERS: 1US FAERS
131PolyneuropathyFAERS: 1US FAERS
132Product appearance confusionFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
133Product dose omissionFAERS: 1US FAERS
134Product physical issueFAERS: 1US FAERS
135Product quality issueFAERS: 1OFFSIDES
US FAERS
136Product storage errorFAERS: 1US FAERS
137Product use issueFAERS: 1US FAERS
138PruritusFAERS: 1SIDER
US FAERS
139Pulse waveform abnormalFAERS: 1US FAERS
140Pupillary light reflex tests abnormalFAERS: 1US FAERS
141QRS axis abnormalFAERS: 1US FAERS
142Quality of life decreasedFAERS: 1US FAERS
143Refusal of treatment by relativeFAERS: 1US FAERS
144RestlessnessFAERS: 1US FAERS
145Status EpilepticusFAERS: 1US FAERS
146StuporFAERS: 1US FAERS
147Supraventricular tachycardiaFAERS: 1OFFSIDES
SIDER
US FAERS
148Suspected counterfeit productFAERS: 1US FAERS
149Therapeutic response unexpected with drug substitutionFAERS: 1US FAERS
150Therapy cessationFAERS: 1US FAERS
151ThrombosisFAERS: 1SIDER
US FAERS
152Ventricular FibrillationFAERS: 11869328CTD
SIDER
US FAERS
153VertigoFAERS: 1SIDER
US FAERS
154Visual ImpairmentFAERS: 1SIDER
US FAERS
155Vitreous floatersFAERS: 1US FAERS
156Weight decreasedFAERS: 1SIDER
US FAERS
157Wrong technique in product usage processFAERS: 1US FAERS
158Abdominal adhesionsOFFSIDES
159Abnormal visionSIDER
160AbscessOFFSIDES
161AgranulocytosisSIDER
162Alanine Aminotransferase IncreasedSIDER
163AlopeciaOFFSIDES
SIDER
164Amnesia, Transient Global7663030CTD
165AmnesiaCanada Vigilance: 1Canada Vigilance
SIDER
166Angina PectorisSIDER
167AnorexiaSIDER
168AnuriaOFFSIDES
169AppendectomyOFFSIDES
170Arteriogram coronary abnormalOFFSIDES
171Arteriovenous fistulaOFFSIDES
172ArthritisSIDER
173ArthropathySIDER
174Aspartate Aminotransferase IncreasedSIDER
175AsthmaOFFSIDES
176Ataxia10981493CTD
SIDER
177AtelectasisOFFSIDES
SIDER
178Atrial arrhythmiaSIDER
179Atrial hypertrophySIDER
180Autonomic neuropathyOFFSIDES
181Back disorderOFFSIDES
182Biliary adenomaOFFSIDES
183Blood albumin decreasedOFFSIDES
184Blood alkaline phosphatase increasedSIDER
185Blood and lymphatic system disordersSIDER
186Blood chloride decreasedOFFSIDES
187Blood creatinine increasedOFFSIDES
SIDER
188Blood electrolytes abnormalOFFSIDES
189Blood glucose decreasedOFFSIDES
190Blood glucose increasedSIDER
191Blood pH increasedOFFSIDES
192Blood parathyroid hormone increasedOFFSIDES
193Blood phosphorus increasedOFFSIDES
194Blood potassium decreasedOFFSIDES
195Blood potassium increasedOFFSIDES
196Blood pressure immeasurableCanada Vigilance: 1Canada Vigilance
OFFSIDES
197Blood prolactin increasedSIDER
198Blood sodiumOFFSIDES
199Blood triglycerides increasedSIDER
200Blood urea increasedOFFSIDES
201Bone abscessOFFSIDES
202Bronchial HyperreactivitySIDER
203BronchiectasisOFFSIDES
204BronchospasmCanada Vigilance: 1Canada Vigilance
205BruxismOFFSIDES
206Bundle-Branch Block14696640
16321708		CTD
207BursitisSIDER
208Cardioactive drug level above therapeuticSIDER
209Carotid Artery ThrombosisOFFSIDES
210Carotid bruitSIDER
211Cataract operationOFFSIDES
212CellulitisOFFSIDES
213Cervical myelopathyOFFSIDES
214Chemical and Drug Induced Liver Injury

View details

8482464
11320851
12189974
27485346
 		CTD
215Chemotherapeutic drug level increasedOFFSIDES
216Choking sensationOFFSIDES
217CholangiolitisOFFSIDES
218Cholestasis8482464
11320851
12189974		CTD
SIDER
219ClonusOFFSIDES
220Collagen-vascular diseaseSIDER
221Consciousness Disorders20548984CTD
222Coronary Artery DiseaseSIDER
223Culture wound positiveOFFSIDES
224Cytolytic hepatitisOFFSIDES
225DeafnessSIDER
226DehydrationCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
227Delirium1927831CTD
228DemyelinationOFFSIDES
229DermatitisSIDER
230Device capturing issueSIDER
231Diabetes MellitusSIDER
232DiarrheaOFFSIDES
233Disturbance in sexual arousalSIDER
234DiuresisSIDER
235DiverticulumOFFSIDES
236DrowsinessOFFSIDES
SIDER
237Dry skinSIDER
238DuodenitisSIDER
239DysgeusiaSIDER
240DyspepsiaCanada Vigilance: 1Canada Vigilance
SIDER
241DysuriaSIDER
242Ear and labyrinth disordersSIDER
243Early satietyOFFSIDES
244EcchymosisSIDER
245Electrocardiogram QRS complexSIDER
246Electrocardiogram changeOFFSIDES
247Embolism arterial (limb)SIDER
248Emotional disorderSIDER
249EndophthalmitisSIDER
250EosinophiliaSIDER
251EpistaxisSIDER
252Erectile dysfunctionSIDER
253EructationSIDER
254Escherichia infectionOFFSIDES
255Eye irritationSIDER
256Fatty LiverOFFSIDES
257Febrile bone marrow aplasiaOFFSIDES
258Feeling abnormalOFFSIDES
SIDER
259Fluid overloadOFFSIDES
260FlushingSIDER
261Gait Apraxia8298383CTD
262Gamma-Glutamyltransferase IncreasedOFFSIDES
SIDER
263Gastric DilatationOFFSIDES
264GastritisSIDER
265Gastroenteritis norovirusOFFSIDES
266GastroenteritisSIDER
267Gastrointestinal PainSIDER
268GlobulinuriaOFFSIDES
269GlossitisSIDER
270Glucose increasedSIDER
271GlycosuriaSIDER
272GoutSIDER
273GranulocytosisOFFSIDES
274HaematotoxicityOFFSIDES
275Heart Block3682985CTD
276Heart failure2305684
2509529		CTD
277Heart sounds abnormalSIDER
278HepatomegalySIDER
279Hypertensive crisisSIDER
280Hypoxia14976857CTD
281ImmunosuppressionOFFSIDES
282Impaired gastric emptyingOFFSIDES
283Incision site complicationOFFSIDES
284IncontinenceOFFSIDES
285Increased upper airway secretionOFFSIDES
286InfectionOFFSIDES
SIDER
287InfestationSIDER
288InfluenzaSIDER
289Injection site urticariaOFFSIDES
290Intestinal ObstructionSIDER
291Joint injuryOFFSIDES
292KetonuriaSIDER
293Labile blood pressureSIDER
294LeukopeniaSIDER
295Limb discomfortOFFSIDES
296Long QT Syndrome24052561CTD
297Lupus-like syndromeSIDER
298LymphadenopathySIDER
299Malaria, Falciparum16882315CTD
300MalnutritionSIDER
301Memory LossSIDER
302MoaningOFFSIDES
303Monocyte count increasedSIDER
304Multiple MyelomaOFFSIDES
305Muscle WeaknessOFFSIDES
306MyalgiaSIDER
307Myasthenia Gravis2056335CTD
308Myocardial Stunning16180181CTD
309Myoclonus8298383CTD
310Nephrotic SyndromeOFFSIDES
SIDER
311Neuropathic painOFFSIDES
312NocturiaSIDER
313NumbnessSIDER
314OliguriaSIDER
315Oropharyngeal blisteringOFFSIDES
316Oropharyngeal discomfortSIDER
317Oropharyngeal painOFFSIDES
SIDER
318OsteolysisOFFSIDES
319OsteomyelitisOFFSIDES
320OsteopeniaOFFSIDES
321OsteoporosisOFFSIDES
322OsteosclerosisOFFSIDES
323Pancreatic NeoplasmOFFSIDES
324Pancreatic PseudocystOFFSIDES
325PancreatitisSIDER
326PanophthalmitisSIDER
327Paroxysmal atrial fibrillationSIDER
328Peptic UlcerSIDER
329PericarditisSIDER
330PeriodontitisOFFSIDES
331Peripheral Nervous System Diseases7731257CTD
332Peripheral embolismSIDER
333PetechiaeSIDER
334Physical disabilityOFFSIDES
335PlasmacytosisOFFSIDES
336PneumothoraxSIDER
337PolyuriaSIDER
338PovertyOFFSIDES
339Primary sequestrumOFFSIDES
340ProarrhythmiaSIDER
341Productive CoughCanada Vigilance: 1Canada Vigilance
OFFSIDES
342Prostatic AdenomaOFFSIDES
343ProstatismSIDER
344Protein urine presentSIDER
345ProteinuriaSIDER
346Prothrombin level decreasedOFFSIDES
347Psychoses, Substance-Induced11949740CTD
348Pulmonary Edema14696640CTD
349Pulmonary HypertensionOFFSIDES
350Pulmonary congestionSIDER
351Pulmonary vascular disorderOFFSIDES
352PurpuraSIDER
353PyuriaSIDER
354Radicular painOFFSIDES
355RalesSIDER
356Respiratory tract congestionSIDER
357Retinal Vascular DisorderOFFSIDES
358RhinitisSIDER
359SciaticaSIDER
360SequestrectomyOFFSIDES
361Sick Sinus Syndrome3414526CTD
OFFSIDES
SIDER
362Sinoatrial BlockSIDER
363Sperm concentration decreasedSIDER
364Sperm count decreasedSIDER
365Sphincter of Oddi DysfunctionOFFSIDES
366Spinal haemangiomaOFFSIDES
367SpondylolysisOFFSIDES
368StomatitisSIDER
369Sudden deathOFFSIDES
370Tachycardia, Atrioventricular Nodal Reentry3584724CTD
371Tachycardia, Paroxysmal3584724CTD
372Tachycardia, Ventricular

View details

1712954
1869328
3499736
8316922
8364947
11599527
 		CTD
373TensionSIDER
374ThrombocytopeniaSIDER
375Thyroid cancer metastaticOFFSIDES
376TinnitusSIDER
377Tooth ExtractionOFFSIDES
378Torsades de Pointes

View details

1721143
3607590
6137140
17467628
 		CTD
379Unresponsive to stimuliOFFSIDES
380Urinary IncontinenceSIDER
381Urinary RetentionSIDER
382UrticariaSIDER
383Vascular purpuraSIDER
384Venous ThrombosisSIDER
385Ventricular Dysfunction, Left14696640CTD
386Ventricular Dysfunction14976857CTD
387Ventricular hypertrophySIDER
388Vestibular NeuronitisOFFSIDES
389WheezingSIDER
390Wide complex tachycardiaSIDER
391Wolff-Parkinson-White Syndrome3584724
17547624		CTD
OFFSIDES
392Wound infection bacterialOFFSIDES
393muscle injuryOFFSIDES
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