MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Zalcitabine

(WREGKURFCTUGRC-POYBYMJQSA-N)

Structure

SMILES: Nc1ccn(c(=O)n1)[C@H]1CC[C@H](O1)CO
Type(s): Approved; Investigational
ATC code(s): J05AF03
Molecular Formula:: C9H13N3O3
Molecular Weight:: 211.218
Log P:: 0.0766
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 2
TPSA:: 90.37
CAS Number(s):: 7481-89-2

Synonym(s)

Zalcitabine

2',3'-Dideoxycytidine

Dideoxycytidine

ddC (Antiviral)

HIVID Roche

Hivid

NSC-606170

2',3' Dideoxycytidine

NSC 606170

10.

NSC606170

External Link(s)

MeSH	D016047
PubChem Compound	24066
BindingDB	50145605
ChEBI	10101
CHEMBL	CHEMBL853
DrugBank	DB00943
DrugCentral	2856
IUPHAR/BPS Guide to PHARMACOLOGY	4828
KEGG	cpd:C07207 dr:D00412
Therapeutic Target Database	D0DC7N D0M1YO D0Z9QR
ZINC	39906

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Abasia		OFFSIDES
2	Abdominal Pain		SIDER
3	Abdominal bloating		SIDER
4	Abnormal vision		SIDER
5	Ache		SIDER
6	Acidosis		OFFSIDES
7	Acquired Immunodeficiency Syndrome	2558314 8094279 8382349	CTD
8	Ageusia		SIDER
9	Agitation		SIDER
10	Agraphia		OFFSIDES
11	Albuminuria		SIDER
12	Alopecia		SIDER
13	Amnesia		SIDER
14	Anemia	12403023	CTD
15	Anorexia		SIDER
16	Anticonvulsant drug level increased		OFFSIDES
17	Anxiety		SIDER
18	Aphasia		SIDER
19	Arthralgia		SIDER
20	Arthritis		SIDER
21	Arthropathy		SIDER
22	Asthenia		OFFSIDES SIDER
23	Ataxia		OFFSIDES SIDER
24	Atrial Fibrillation		SIDER
25	Back Pain		SIDER
26	Bladder pain		SIDER
27	Blood alkaline phosphatase increased		OFFSIDES SIDER
28	Blood cholesterol		OFFSIDES
29	Blood creatine increased		OFFSIDES
30	Blood creatinine increased		SIDER
31	Blood triglycerides increased		OFFSIDES
32	Blood urea increased		SIDER
33	Blood uric acid		OFFSIDES
34	Bone pain		OFFSIDES
35	Bruxism		OFFSIDES
36	Bullous eruption		SIDER
37	Bursitis		SIDER
38	Cachexia		SIDER
39	Cardiomyopathies	10591146	CTD
40	Cell Death		OFFSIDES
41	Cellulitis		SIDER
42	Chemical and Drug Induced Liver Injury	17187420 28437613	CTD
43	Chest discomfort		SIDER
44	Chest tightness		SIDER
45	Chills		SIDER
46	Cholangiolitis		OFFSIDES
47	Cholecystitis		SIDER
48	Chronic ulcerative colitis		OFFSIDES
49	Colitis		SIDER
50	Common Cold		SIDER
51	Congenital neurological disorder		OFFSIDES
52	Congenital pulmonary hypertension		OFFSIDES
53	Cramps of lower extremities		SIDER
54	Creatinine increased		SIDER
55	Crying		OFFSIDES
56	Cyanosis		SIDER
57	Deafness		SIDER
58	Dementia		SIDER
59	Demyelinating Diseases	View details 1309930 1309931 7515130 11706061	CTD
60	Depressed Level of Consciousness		SIDER
61	Dermatitis		SIDER
62	Developmental Coordination Disorder		OFFSIDES
63	Diabetes		OFFSIDES
64	Diabetes Mellitus		SIDER
65	Diabetic Nephropathy		OFFSIDES
66	Diaphragmatic Hernia		OFFSIDES
67	Diarrhea	12403023	CTD OFFSIDES
68	Discomfort		SIDER
69	Disease complication		OFFSIDES
70	Disturbance in sexual arousal		SIDER
71	Dizziness		SIDER
72	Drug exposure during pregnancy		OFFSIDES
73	Drug resistance		OFFSIDES
74	Dry skin		SIDER
75	Dysgeusia		SIDER
76	Dyspepsia		SIDER
77	Dysphonia		SIDER
78	Dysuria		SIDER
79	Ejection fraction abnormal		OFFSIDES
80	Endocarditis		OFFSIDES
81	Endophthalmitis		SIDER
82	Enlargement abdomen		SIDER
83	Eosinophilia		SIDER
84	Epigastric pain		SIDER
85	Epistaxis		SIDER
86	Eructation		SIDER
87	Euphoric mood		SIDER
88	Eye Redness		SIDER
89	Eye irritation		SIDER
90	Eye pain		SIDER
91	Facial Pain		SIDER
92	Fat redistribution		SIDER
93	Fatigue		OFFSIDES SIDER
94	Fatty Liver	9562777 17187420 18299183	CTD OFFSIDES
95	Feeling abnormal		SIDER
96	Fibrosarcoma		OFFSIDES
97	Flank Pain		SIDER
98	Flatulence		OFFSIDES SIDER
99	Flushing		SIDER
100	Gagging		SIDER
101	Gastritis		SIDER
102	Gastrointestinal Pain		SIDER
103	Gingivitis		SIDER
104	Glossitis		SIDER
105	Glycosuria		SIDER
106	Gout		SIDER
107	Granulocytosis		SIDER
108	Granuloma		OFFSIDES
109	HIV Infections	9562777 12403023 17457083	CTD
110	HIV Wasting Syndrome		OFFSIDES
111	Headache		SIDER
112	Hearing Loss, Bilateral	1970411 9089033	CTD
113	Heartburn		SIDER
114	Hemiparesis		OFFSIDES
115	Hepatitis C		OFFSIDES
116	Hepatitis		SIDER
117	Hepatomegaly		SIDER
118	Hepatosplenomegaly		OFFSIDES
119	Herpes Labialis		SIDER
120	Hyperalgesia	View details 16472913 16632831 17319957 17558434 17761732 17888573 18234883 20726883	CTD
121	Hypercreatininaemia		OFFSIDES
122	Hyperkinesia		SIDER
123	Hypersensitivity		SIDER
124	Hypogeusia		SIDER
125	Hypokinesia		OFFSIDES SIDER
126	Hyporeflexia		OFFSIDES
127	Impetigo		SIDER
128	Infection		SIDER
129	Inflammation		SIDER
130	Influenza-like symptoms		SIDER
131	Intention tremor		OFFSIDES
132	Joint swelling		SIDER
133	Kidney Failure		OFFSIDES
134	Late developer		OFFSIDES
135	Legionella		OFFSIDES
136	Lethargy		OFFSIDES
137	Leukopenia		SIDER
138	Lipodystrophy acquired		OFFSIDES
139	Lipohypertrophy		OFFSIDES
140	Lymphadenopathy		SIDER
141	Lymphoma, AIDS-Related	8697399	CTD
142	Lymphoma	View details 8764131 8840982 9205081 9488045 11980663 17941976 18798262	CTD
143	Malaise		SIDER
144	Manic psychosis		SIDER
145	Memory Loss		SIDER
146	Mental retardation severity unspecified		OFFSIDES
147	Mental status changes		OFFSIDES
148	Mitochondrial Diseases	View details 7515130 8232219 11706061 17187420	CTD
149	Mitochondrial encephalopathy	20032772	CTD
150	Mitochondrial toxicity		OFFSIDES
151	Mood swings		SIDER
152	Multiple Myeloma		OFFSIDES
153	Musculoskeletal chest pain		SIDER
154	Musculoskeletal discomfort		SIDER
155	Musculoskeletal stiffness		SIDER
156	Myalgia		SIDER
157	Myasthenia Gravis		OFFSIDES
158	Myelodysplasia		OFFSIDES
159	Myopathy		SIDER
160	Myositis		SIDER
161	Nasopharyngitis		SIDER
162	Nausea		OFFSIDES
163	Neck Pain		SIDER
164	Neck stiffness		SIDER
165	Neoplasms, Experimental	8764131 9205081 9488045	CTD
166	Nephrolithiasis		SIDER
167	Nerve Degeneration	1309930 7515130 11706061	CTD
168	Nervousness		SIDER
169	Neuralgia	16472913 17292584	CTD SIDER
170	Neuritis		SIDER
171	Neurotoxicity Syndromes	1309930 1970411	CTD
172	Neutropenia		SIDER
173	Night sweats		SIDER
174	Nocturia		SIDER
175	Nodular regenerative hyperplasia		OFFSIDES
176	Nuchal Rigidity		SIDER
177	Nystagmus		OFFSIDES
178	Ocular icterus		SIDER
179	Optic Atrophy		OFFSIDES
180	Oral lesion		SIDER
181	Oropharyngeal discomfort		SIDER
182	Oropharyngeal pain		SIDER
183	Pain	8780079	CTD SIDER
184	Palpitations		SIDER
185	Pancreatitis		SIDER
186	Pancytopenia	12403023	CTD
187	Panophthalmitis		SIDER
188	Paranoia		SIDER
189	Paranoid state		SIDER
190	Paresis	1309930	CTD
191	Paresthesia	7853984 9089033	CTD
192	Periodontitis		OFFSIDES
193	Peripheral Nervous System Diseases	View details 1309930 1849990 2558314 7552481 7853984 8094279 8382349 8780079 9030365 10463516 11706061 12403023 17319957 18505180 18606552 20032772 20726883 22891239	CTD
194	Pharyngitis		SIDER
195	Pharyngolaryngeal Pain		OFFSIDES
196	Photophobia		SIDER
197	Polyneuropathy		OFFSIDES
198	Polyuria		SIDER
199	Prurigo		SIDER
200	Pruritus		SIDER
201	Pulmonary Hypertension		OFFSIDES
202	Pulmonary congestion		SIDER
203	Purpura		SIDER
204	Pyuria		OFFSIDES
205	Rales		SIDER
206	Rash erythematous		SIDER
207	Rash follicular		SIDER
208	Rectal mass		SIDER
209	Renal cyst		SIDER
210	Respiratory Failure		OFFSIDES
211	Respiratory distress		SIDER
212	Respiratory tract congestion		SIDER
213	Retching		SIDER
214	Rhabdomyolysis		OFFSIDES
215	Rhinitis		SIDER
216	Rhinorrhea		OFFSIDES
217	Rhonchi		SIDER
218	Rib pain		SIDER
219	Scleral icterus		SIDER
220	Shock		SIDER
221	Sinus headache		SIDER
222	Sinus pain		SIDER
223	Sinusitis		SIDER
224	Skin Ulcer		SIDER
225	Somnolence		SIDER
226	Status Epilepticus		SIDER
227	Stupor		SIDER
228	Sudden death		OFFSIDES
229	Suicide attempt		SIDER
230	Swelling		SIDER
231	Syncope		SIDER
232	Tachycardia		SIDER
233	Tension		SIDER
234	Therapy non-responder		OFFSIDES
235	Thrombocytopenia		SIDER
236	Thymus Neoplasms	8840982	CTD
237	Tinnitus	9089033	CTD SIDER
238	Toothache		SIDER
239	Toxoplasmosis		OFFSIDES
240	Transaminases increased		OFFSIDES
241	Tremor		SIDER
242	Ulcer		SIDER
243	Urinary Retention		SIDER
244	Urinary sediment abnormal		OFFSIDES
245	Urine output increased		SIDER
246	Urticaria		SIDER
247	VIIth nerve paralysis		SIDER
248	Vaginal Discharge		SIDER
249	Vaginal pain		SIDER
250	Vascular purpura		SIDER
251	Vertigo	9089033	CTD SIDER
252	Visual Impairment		SIDER
253	Visual tracking test abnormal		OFFSIDES
254	Vomiting		SIDER
255	Vulvovaginal pain		SIDER
256	Vulvovaginal pruritus		SIDER
257	Weight decreased		SIDER
258	Wheezing		SIDER
259	Xerophthalmia		SIDER
260	carbuncle		SIDER
261	furuncle		SIDER
262	jaundice		SIDER

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