Phenylbutazone
(VYMDGNCVAMGZFE-UHFFFAOYSA-N)
Structure
- SMILES
- CCCCC1C(=O)N(N(C1=O)c1ccccc1)c1ccccc1
- Type(s)
- Approved; Vet_approved
- ATC code(s)
- M01AA01; M01BA01; M02AA01
- Molecular Formula:
- C19H20N2O2
- Molecular Weight:
- 308.374
- Log P:
- 3.9178
- Hydrogen Bond Acceptor:
- 4
- Hydrogen Bond Donor:
- 0
- TPSA:
- 40.62
- CAS Number(s):
- 50-33-9; 4297-92-1
Synonym(s)
1.
Phenylbutazone
2.
Diphenylbutazone
3.
Fenilbutazon
4.
Butacote
5.
Butadion
6.
Butadione
7.
Butapirazol
8.
Butapyrazole
9.
Butazolidin
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Agranulocytosis | FAERS: 1 Canada Vigilance: 6 | 3747087 | CTD Canada Vigilance US FAERS |
| 2 | Arteriosclerosis | FAERS: 1 | US FAERS | |
| 3 | Asthenia | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 4 | Chills | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 5 | Cyanosis | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 6 | Disease susceptibility | FAERS: 1 | US FAERS | |
| 7 | Dry gangrene | FAERS: 1 | US FAERS | |
| 8 | Erythema Multiforme | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 9 | Erythema | FAERS: 1 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 10 | Extremity necrosis | FAERS: 1 | US FAERS | |
| 11 | Eye pain | FAERS: 1 | US FAERS | |
| 12 | General physical health deterioration | FAERS: 1 | US FAERS | |
| 13 | Leukocytosis | FAERS: 1 | US FAERS | |
| 14 | Pain of skin | FAERS: 1 | US FAERS | |
| 15 | Pneumonia | FAERS: 1 | US FAERS | |
| 16 | Purpura | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 17 | Rash erythematous | FAERS: 1 Canada Vigilance: 11 | Canada Vigilance US FAERS | |
| 18 | Scab | FAERS: 1 | US FAERS | |
| 19 | Skin Induration | FAERS: 1 | US FAERS | |
| 20 | Skin Ulcer | FAERS: 1 | US FAERS | |
| 21 | Skin graft detachment | FAERS: 1 | US FAERS | |
| 22 | Skin lesion | FAERS: 1 | US FAERS | |
| 23 | Skin necrosis | FAERS: 1 | US FAERS | |
| 24 | Stevens-Johnson Syndrome | FAERS: 1 | US FAERS | |
| 25 | Tonsillitis | FAERS: 1 | US FAERS | |
| 26 | Abdominal Pain | Canada Vigilance: 5 | 1065802 4351955 | CTD Canada Vigilance |
| 27 | Abdominal discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 28 | Accidental overdose | Canada Vigilance: 1 | Canada Vigilance | |
| 29 | Acute kidney injury | Canada Vigilance: 1 | CTD Canada Vigilance | |
| 30 | Ageusia | Canada Vigilance: 1 | Canada Vigilance | |
| 31 | Agitation | Canada Vigilance: 1 | Canada Vigilance | |
| 32 | Anaphylactoid Reaction | Canada Vigilance: 1 | Canada Vigilance | |
| 33 | Anemia | 7257098 | CTD | |
| 34 | Angioedema | Canada Vigilance: 2 | Canada Vigilance | |
| 35 | Anuria | Canada Vigilance: 1 | 5569932 6060746 6668168 | CTD Canada Vigilance |
| 36 | Anxiety | Canada Vigilance: 1 | Canada Vigilance | |
| 37 | Arthralgia | Canada Vigilance: 1 | Canada Vigilance | |
| 38 | Arthritis, Gouty | 5655316 | CTD | |
| 39 | Arthritis | 316351 | CTD | |
| 40 | Aspartate Aminotransferase Increased | Canada Vigilance: 1 | Canada Vigilance | |
| 41 | Atelectasis | Canada Vigilance: 1 | Canada Vigilance | |
| 42 | Back Pain | Canada Vigilance: 1 | Canada Vigilance | |
| 43 | Blindness | Canada Vigilance: 1 | Canada Vigilance | |
| 44 | Blood alkaline phosphatase increased | Canada Vigilance: 1 | Canada Vigilance | |
| 45 | Blood creatine phosphokinase increased | Canada Vigilance: 1 | Canada Vigilance | |
| 46 | Blood creatinine increased | Canada Vigilance: 1 | Canada Vigilance | |
| 47 | Blood urea increased | Canada Vigilance: 1 | Canada Vigilance | |
| 48 | Carcinoma | 7744695 | CTD | |
| 49 | Cardiac Arrest | Canada Vigilance: 1 | Canada Vigilance | |
| 50 | Cardiomegaly | Canada Vigilance: 1 | Canada Vigilance | |
| 51 | Cardiomyopathies | 5546848 | CTD | |
| 52 | Chemical and Drug Induced Liver Injury | CTD | ||
| 53 | Chest Pain | Canada Vigilance: 3 | Canada Vigilance | |
| 54 | Chest discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 55 | Cholestasis | 879127 | CTD | |
| 56 | Conjunctivitis | 6214246 | CTD | |
| 57 | Coronary Artery Disease | Canada Vigilance: 1 | Canada Vigilance | |
| 58 | Dermatitis | Canada Vigilance: 6 | Canada Vigilance | |
| 59 | Dermatomyositis | 3599016 | CTD | |
| 60 | Diplopia | 2573801 | CTD | |
| 61 | Dissociative disorder | Canada Vigilance: 1 | Canada Vigilance | |
| 62 | Dizziness | Canada Vigilance: 5 | 2573801 | CTD Canada Vigilance |
| 63 | Drug ineffective | Canada Vigilance: 1 | Canada Vigilance | |
| 64 | Dyspepsia | Canada Vigilance: 2 | Canada Vigilance | |
| 65 | Dysuria | Canada Vigilance: 1 | Canada Vigilance | |
| 66 | Ecchymosis | 989582 | CTD | |
| 67 | Eczema | Canada Vigilance: 1 | Canada Vigilance | |
| 68 | Edema | CTD | ||
| 69 | Eosinophilia | Canada Vigilance: 1 | 647258 879127 | CTD Canada Vigilance |
| 70 | Exanthema | 647258 879127 6214246 | CTD | |
| 71 | Exfoliative rash | Canada Vigilance: 1 | Canada Vigilance | |
| 72 | Fatigue | Canada Vigilance: 3 | 4611579 | CTD Canada Vigilance |
| 73 | Fatty Liver | 7744695 | CTD | |
| 74 | Feeling abnormal | Canada Vigilance: 1 | Canada Vigilance | |
| 75 | Fever | 647258 6130055 6214246 | CTD | |
| 76 | Flatulence | Canada Vigilance: 1 | Canada Vigilance | |
| 77 | Flushing | Canada Vigilance: 1 | Canada Vigilance | |
| 78 | Gastric ulcer | Canada Vigilance: 2 | Canada Vigilance | |
| 79 | Gastritis | Canada Vigilance: 6 | Canada Vigilance | |
| 80 | Gastrointestinal Diseases | 6869982 | CTD | |
| 81 | Gastrointestinal Hemorrhage | 316351 4548752 | CTD | |
| 82 | Glomerulonephritis | 3157355 6130055 | CTD | |
| 83 | Glossitis | Canada Vigilance: 1 | Canada Vigilance | |
| 84 | Granulomatous liver disease | Canada Vigilance: 1 | Canada Vigilance | |
| 85 | Granuloma | 879127 2356241 7286906 | CTD | |
| 86 | Headache | Canada Vigilance: 4 | 2573801 4611579 | CTD Canada Vigilance |
| 87 | Heart Diseases | 4830208 | CTD | |
| 88 | Heartburn | 1065802 | CTD | |
| 89 | Hematuria | 5569932 16211908 | CTD | |
| 90 | Hepatitis | Canada Vigilance: 5 | 1145012 4029887 | CTD Canada Vigilance |
| 91 | Hepatomegaly | Canada Vigilance: 1 | 7744695 28108177 | CTD Canada Vigilance |
| 92 | Hepatosplenomegaly | Canada Vigilance: 1 | Canada Vigilance | |
| 93 | Hyperplasia | 7744695 | CTD | |
| 94 | Hypersensitivity | Canada Vigilance: 4 | Canada Vigilance | |
| 95 | Inflammation | 1065802 7053221 | CTD | |
| 96 | Intestinal Perforation | Canada Vigilance: 1 | Canada Vigilance | |
| 97 | Jaundice, Obstructive | 7333419 | CTD | |
| 98 | Kidney Diseases | CTD | ||
| 99 | Kidney Papillary Necrosis | CTD | ||
| 100 | Laryngospasm | Canada Vigilance: 1 | Canada Vigilance | |
| 101 | Lethargy | Canada Vigilance: 1 | Canada Vigilance | |
| 102 | Leukemia, Plasma Cell | 4779657 | CTD | |
| 103 | Leukopenia | Canada Vigilance: 3 | 6071896 | CTD Canada Vigilance |
| 104 | Lip swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 105 | Liver neoplasms | 7744695 | CTD | |
| 106 | Lupus Erythematosus, Systemic | 577907 | CTD | |
| 107 | Lymphadenopathy | Canada Vigilance: 2 | Canada Vigilance | |
| 108 | Malaise | Canada Vigilance: 4 | Canada Vigilance | |
| 109 | Metabolic acidosis | Canada Vigilance: 1 | Canada Vigilance | |
| 110 | Myalgia | Canada Vigilance: 1 | Canada Vigilance | |
| 111 | Myocardial fibrosis | Canada Vigilance: 1 | Canada Vigilance | |
| 112 | Nausea | Canada Vigilance: 7 | Canada Vigilance | |
| 113 | Necrosis | 7744695 23142791 | CTD | |
| 114 | Nephritis, Interstitial | CTD | ||
| 115 | Nephrotic Syndrome | Canada Vigilance: 1 | 2934808 6071127 6781669 | CTD Canada Vigilance |
| 116 | Nervousness | Canada Vigilance: 1 | Canada Vigilance | |
| 117 | Neutropenia | Canada Vigilance: 3 | 6869982 | CTD Canada Vigilance |
| 118 | Oliguria | CTD | ||
| 119 | Ototoxicity | Canada Vigilance: 1 | Canada Vigilance | |
| 120 | Pain | Canada Vigilance: 2 | 6781669 18022734 | CTD Canada Vigilance |
| 121 | Pallor | 989582 | CTD | |
| 122 | Palpitations | Canada Vigilance: 1 | Canada Vigilance | |
| 123 | Pancytopenia | Canada Vigilance: 2 | 6071896 7257098 | CTD Canada Vigilance |
| 124 | Papilloma | 7744695 | CTD | |
| 125 | Peptic Ulcer | Canada Vigilance: 1 | 3764320 7744695 | CTD Canada Vigilance |
| 126 | Pericarditis | Canada Vigilance: 1 | 5825420 6214246 | CTD Canada Vigilance |
| 127 | Petechiae | Canada Vigilance: 3 | Canada Vigilance | |
| 128 | Pharyngitis | Canada Vigilance: 1 | Canada Vigilance | |
| 129 | Phlebitis | 330156 1247773 | CTD | |
| 130 | Pleurisy | 6214246 | CTD | |
| 131 | Polymyositis | 5755571 | CTD | |
| 132 | Primary Myelofibrosis | 6071896 | CTD | |
| 133 | Proteinuria | 2934808 6781669 | CTD | |
| 134 | Pruritus | Canada Vigilance: 16 | Canada Vigilance | |
| 135 | Psoriasis | 4611579 | CTD | |
| 136 | Purpura, Hyperglobulinemic | 5755571 | CTD | |
| 137 | Renal Insufficiency | 718323 2934808 7763130 | CTD | |
| 138 | Salivary Gland Diseases | 4830208 | CTD | |
| 139 | Salivary gland pain | Canada Vigilance: 1 | Canada Vigilance | |
| 140 | Seizures | 3191389 | CTD | |
| 141 | Sepsis | Canada Vigilance: 2 | Canada Vigilance | |
| 142 | Septic Shock | Canada Vigilance: 1 | Canada Vigilance | |
| 143 | Serum sickness-like reaction | Canada Vigilance: 2 | Canada Vigilance | |
| 144 | Sialadenitis | 6214246 11937933 | CTD | |
| 145 | Signs and Symptoms, Digestive | 7053221 | CTD | |
| 146 | Somnolence | Canada Vigilance: 1 | Canada Vigilance | |
| 147 | Spinal Diseases | 2573801 | CTD | |
| 148 | Splenomegaly | Canada Vigilance: 2 | Canada Vigilance | |
| 149 | Stomatitis | Canada Vigilance: 3 | Canada Vigilance | |
| 150 | Substance-Related Disorders | 989582 7763130 | CTD | |
| 151 | Syncope | Canada Vigilance: 2 | Canada Vigilance | |
| 152 | Tachycardia | Canada Vigilance: 1 | Canada Vigilance | |
| 153 | Taste Disorders | 623418 | CTD | |
| 154 | Thrombocytopenia | Canada Vigilance: 5 | 6071896 7257098 | CTD Canada Vigilance |
| 155 | Thrombosis | 6869982 | CTD | |
| 156 | Tinnitus | Canada Vigilance: 3 | Canada Vigilance | |
| 157 | Toxic Epidermal Necrolysis | Canada Vigilance: 3 | Canada Vigilance | |
| 158 | Ulcer | 6869982 | CTD | |
| 159 | Urticaria | Canada Vigilance: 11 | Canada Vigilance | |
| 160 | Vascular purpura | Canada Vigilance: 1 | Canada Vigilance | |
| 161 | Vasculitis, Leukocytoclastic, Cutaneous | 4224583 | CTD | |
| 162 | Vasculitis | 3157355 | CTD | |
| 163 | Vertigo | Canada Vigilance: 1 | Canada Vigilance | |
| 164 | Vomiting | Canada Vigilance: 7 | Canada Vigilance | |
| 165 | jaundice | Canada Vigilance: 4 | 879127 6668168 | CTD Canada Vigilance |
Powered by :
Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120329
Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.