MetaADEDB 2.0 @ LMMD
Ketoprofen
(DKYWVDODHFEZIM-UHFFFAOYSA-N)
Structure
SMILES
OC(=O)C(c1cccc(c1)C(=O)c1ccccc1)C
Type(s)
Approved; Vet_approved
ATC code(s)
M01AE03; M01AE53; M02AA10
Molecular Formula:
C16H14O3
Molecular Weight:
254.281
Log P:
3.1057
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
1
TPSA:
54.37
CAS Number(s):
22071-15-4
Synonym(s)
1.
Ketoprofen
2.
Benzoylhydratropic Acid
3.
19,583 RP
4.
2-(3-Benzoylphenyl)propionic Acid
5.
Alrheumat
6.
Alrheumum
7.
Orudis
8.
Profenid
9.
RP-19583
10.
RP 19583
11.
RP, 19,583
12.
RP19583
External Link(s)
MeSHD007660
PubChem Compound3825
BindingDB50022271
ChEBI6128
CHEMBLCHEMBL571
DrugBankDB01009
DrugCentral1528
IUPHAR/BPS Guide to PHARMACOLOGY4795
KEGGcpd:C01716
dr:D00132
Therapeutic Target DatabaseD0W9WF
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1AngioedemaFAERS: 35
Canada Vigilance: 2		81404CTD
SIDER
Canada Vigilance
US FAERS
2UrticariaFAERS: 29
Canada Vigilance: 3		81404
11792017		CTD
SIDER
Canada Vigilance
US FAERS
3ErythemaFAERS: 14
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
4HypersensitivityFAERS: 14SIDER
US FAERS
5PruritusFAERS: 8SIDER
US FAERS
6Abdominal PainFAERS: 6
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
7AphasiaFAERS: 5US FAERS
8BronchospasmFAERS: 5SIDER
US FAERS
9Contraindicated drug prescribedFAERS: 5US FAERS
10Drug abuseFAERS: 5US FAERS
11HypotensionFAERS: 5US FAERS
12NauseaFAERS: 5SIDER
US FAERS
13Anaphylactic shockFAERS: 4SIDER
US FAERS
14CholestasisFAERS: 4US FAERS
15Incorrect dose administeredFAERS: 4OFFSIDES
US FAERS
16PresyncopeFAERS: 4US FAERS
17Toxic Epidermal NecrolysisFAERS: 4SIDER
US FAERS
18Transaminases increasedFAERS: 4US FAERS
19Acute kidney injuryFAERS: 3

View details

1859237
3071148
3080108
6310774
7121702
10625264
15067231
 		CTD
US FAERS
20AstheniaFAERS: 3OFFSIDES
SIDER
US FAERS
21Brain empyemaFAERS: 3US FAERS
22CellulitisFAERS: 3US FAERS
23Chest PainFAERS: 3US FAERS
24Drug ineffectiveFAERS: 3US FAERS
25HypertransaminasaemiaFAERS: 3US FAERS
26Kounis SyndromeFAERS: 3US FAERS
27MediastinitisFAERS: 3US FAERS
28PancreatitisFAERS: 39881281CTD
SIDER
US FAERS
29PancytopeniaFAERS: 3US FAERS
30Product administration errorFAERS: 3US FAERS
31Septic ShockFAERS: 3OFFSIDES
US FAERS
32jaundiceFAERS: 3SIDER
US FAERS
33Back PainFAERS: 2US FAERS
34Choking sensationFAERS: 2US FAERS
35ColitisFAERS: 2SIDER
US FAERS
36Duodenal UlcerFAERS: 2US FAERS
37DysphoniaFAERS: 2US FAERS
38EndocarditisFAERS: 2US FAERS
39EosinophiliaFAERS: 2US FAERS
40Erosive DuodenitisFAERS: 2US FAERS
41Exposure during breast feedingFAERS: 2US FAERS
42Food AllergyFAERS: 2US FAERS
43Gastric ulcerFAERS: 2OFFSIDES
US FAERS
44GastritisFAERS: 2
Canada Vigilance: 1		16080005CTD
SIDER
Canada Vigilance
US FAERS
45General physical health deteriorationFAERS: 2OFFSIDES
US FAERS
46Laryngeal discomfortFAERS: 2US FAERS
47Lung AbscessFAERS: 2US FAERS
48Metabolic acidosisFAERS: 2US FAERS
49Nephritis allergicFAERS: 2US FAERS
50PallorFAERS: 2OFFSIDES
US FAERS
51Predisposition to diseaseFAERS: 2US FAERS
52Pulmonary HypertensionFAERS: 2OFFSIDES
US FAERS
53ThrombocytopeniaFAERS: 2SIDER
US FAERS
54TremorFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
55WheezingFAERS: 2US FAERS
56Accidental overdoseFAERS: 1US FAERS
57AngerFAERS: 1US FAERS
58Apallic syndromeFAERS: 1US FAERS
59Application site rashFAERS: 1US FAERS
60ArthralgiaFAERS: 1US FAERS
61ArthritisFAERS: 1OFFSIDES
US FAERS
62AsphyxiaFAERS: 1US FAERS
63CardiomegalyFAERS: 1US FAERS
64Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
65Contraindicated product administeredFAERS: 1US FAERS
66Contraindicated product prescribedFAERS: 1US FAERS
67Coronary Artery DiseaseFAERS: 1US FAERS
68CystFAERS: 1US FAERS
69Decompression SicknessFAERS: 1US FAERS
70DeliriumFAERS: 1US FAERS
71DiscomfortFAERS: 1SIDER
US FAERS
72Disease recurrenceFAERS: 1US FAERS
73Drug screen false positiveFAERS: 1US FAERS
74Ductus arteriosus premature closureFAERS: 1US FAERS
75DuodenitisFAERS: 1US FAERS
76DyspepsiaFAERS: 1SIDER
US FAERS
77Dyspnoea exacerbatedFAERS: 1US FAERS
78Ejection Fraction DecreasedFAERS: 1US FAERS
79Expired drug administeredFAERS: 1US FAERS
80Expired product administeredFAERS: 1US FAERS
81Extra dose administeredFAERS: 1US FAERS
82Fixed eruptionFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
83FlushingFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
84GastroenteritisFAERS: 1US FAERS
85Hypertrophic CardiomyopathyFAERS: 1US FAERS
86InfarctionFAERS: 1US FAERS
87Injection site painFAERS: 1US FAERS
88Joint Range of Motion DecreasedFAERS: 1US FAERS
89Maternal exposure during pregnancyFAERS: 1US FAERS
90Medication ErrorFAERS: 1US FAERS
91MeningorrhagiaFAERS: 1US FAERS
92Myocardial InfarctionFAERS: 1SIDER
US FAERS
93OliguriaFAERS: 1US FAERS
94OverdoseFAERS: 1US FAERS
95PainFAERS: 1

View details

7735198
7908807
8751014
11406335
12572528
17650636
19617648
22236721
24008352
24128752
 		CTD
US FAERS
96Pericardial effusionFAERS: 1OFFSIDES
US FAERS
97Peripheral swellingFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
98PhotodermatosisFAERS: 1US FAERS
99Product availability issueFAERS: 1US FAERS
100QuadriplegiaFAERS: 1US FAERS
101Rash erythematousFAERS: 1US FAERS
102Right Ventricular HypertrophyFAERS: 1US FAERS
103SepsisFAERS: 1SIDER
US FAERS
104Skin necrosisFAERS: 1US FAERS
105Status AsthmaticusFAERS: 1US FAERS
106Stevens-Johnson SyndromeFAERS: 125811541CTD
SIDER
US FAERS
107SyncopeFAERS: 1US FAERS
108UlcerFAERS: 1US FAERS
109VomitingFAERS: 1SIDER
US FAERS
110Weight decreasedFAERS: 1SIDER
US FAERS
111Abdominal discomfortCanada Vigilance: 2Canada Vigilance
112AbuseOFFSIDES
113AcanthomaOFFSIDES
114AcidosisOFFSIDES
115Acute Coronary SyndromeSIDER
116AgranulocytosisSIDER
117Alanine Aminotransferase IncreasedOFFSIDES
118AlopeciaSIDER
119AmnesiaSIDER
120Anal sphincter atonyOFFSIDES
121Anorectal discomfortSIDER
122AnorexiaOFFSIDES
SIDER
123AnoxiaOFFSIDES
124AnuriaOFFSIDES
125AnxietySIDER
126Application site eczemaOFFSIDES
127Application site pustulesOFFSIDES
128AscitesOFFSIDES
129Asthma11300144CTD
SIDER
130Autoimmune hepatitisOFFSIDES
131Bacterial sepsisOFFSIDES
132Bladder prolapseOFFSIDES
133Blood GlucoseOFFSIDES
134Blood Platelet Disorders10414674CTD
135Blood alkaline phosphatase increasedOFFSIDES
136Blood beta-D-glucan increasedOFFSIDES
137Blood creatinine increasedOFFSIDES
138Blood iron increasedOFFSIDES
139Blood urea abnormalOFFSIDES
140Blood urea increasedOFFSIDES
SIDER
141Bone erosionOFFSIDES
142Bone painOFFSIDES
143Breast necrosisOFFSIDES
144Bulbar palsyOFFSIDES
145Cardioactive drug level above therapeuticOFFSIDES
146Cardiomyopathies17325706CTD
147Chemical and Drug Induced Liver Injury1914425
11673741
15066135		CTD
148ChillsSIDER
149CholangiolitisOFFSIDES
150Cold sweatOFFSIDES
151Congenital tricuspid valve incompetenceOFFSIDES
152ConjunctivitisSIDER
153ConstipationSIDER
154ContractureOFFSIDES
155Corneal dystrophyOFFSIDES
156CyanosisOFFSIDES
157Cystitis15322343CTD
158CystoceleOFFSIDES
159Cytolytic hepatitisOFFSIDES
160DeafnessSIDER
161Dental abscessOFFSIDES
162Dental cariesOFFSIDES
163Depressive disorder24008352CTD
164DermatitisCanada Vigilance: 1Canada Vigilance
SIDER
165Device occlusionOFFSIDES
166Diabetes MellitusSIDER
167DiarrheaOFFSIDES
168DiverticulitisCanada Vigilance: 1Canada Vigilance
169DizzinessSIDER
170DrowsinessSIDER
171Drug Eruptions11792017CTD
172Drug withdrawal headacheOFFSIDES
173Dry skinOFFSIDES
174Duodenal ulcer perforationOFFSIDES
175DysgeusiaSIDER
176Dyspnea81404CTD
177EczemaCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
178Edema7735198
7990266
12572528		CTD
179Embolic strokeOFFSIDES
180Epidural AbscessOFFSIDES
181EpistaxisSIDER
182Erectile dysfunctionSIDER
183EructationSIDER
184Erythema MultiformeSIDER
185ExcoriationOFFSIDES
186Eye painCanada Vigilance: 1Canada Vigilance
SIDER
187FatigueOFFSIDES
SIDER
188Fatty LiverOFFSIDES
189Feeling abnormalSIDER
190Fever22236721CTD
191FibromyalgiaOFFSIDES
192FlatulenceSIDER
193Focal glomerulosclerosisOFFSIDES
194Food cravingOFFSIDES
195Gamma-Glutamyltransferase IncreasedOFFSIDES
196Gastrointestinal Diseases8222739
17485922		CTD
197Gastrointestinal PainSIDER
198Gastrointestinal perforationSIDER
199GranulocytosisOFFSIDES
200HeadacheCanada Vigilance: 1Canada Vigilance
SIDER
201Heat ExhaustionOFFSIDES
202Heat illnessOFFSIDES
203Hematoma10414674CTD
204Hepatitis B positiveOFFSIDES
205HepatitisSIDER
206HyperkeratosisOFFSIDES
207HypophagiaOFFSIDES
208HysterectomyOFFSIDES
209Ileal ulcerOFFSIDES
210IncontinenceOFFSIDES
211InfectionOFFSIDES
SIDER
212Inflammation22236721
24128752		CTD
213IritisCanada Vigilance: 1Canada Vigilance
214Joint injuryOFFSIDES
215Joint prosthesis userOFFSIDES
216Kidney Diseases17485922CTD
217Kidney Failure, Chronic3173609CTD
218Kidney Papillary Necrosis6953356CTD
219LacerationOFFSIDES
220Leukopenia neonatalOFFSIDES
221Liver AbscessOFFSIDES
222Liver Failure, Acute9881281CTD
223Localized erythemaSIDER
224Low Back Pain11300144CTD
225MalaiseSIDER
226Malignant neoplasm progressionOFFSIDES
227Mastication disorderOFFSIDES
228Mitral Valve StenosisOFFSIDES
229Multiple SclerosisOFFSIDES
230Muscle necrosisOFFSIDES
231Musculoskeletal PainOFFSIDES
232Musculoskeletal discomfortSIDER
233Musculoskeletal stiffnessOFFSIDES
234MyalgiaSIDER
235MyringitisOFFSIDES
236NecrosisSIDER
237Nephritis, Interstitial3071148CTD
238Nephrotic SyndromeSIDER
239NervousnessSIDER
240Neutrophil count decreasedOFFSIDES
241Oligohydramnios15067231CTD
242OnycholysisSIDER
243PROTHROMBIN TIMEOFFSIDES
244Pain, Postoperative

View details

8279252
9615847
10805057
10992828
11012958
11273950
11697757
11732515
15918387
19229379
 		CTD
245PalpitationsCanada Vigilance: 1Canada Vigilance
SIDER
246Pancreatic CystOFFSIDES
247Pancreatic PseudocystOFFSIDES
248ParanoiaCanada Vigilance: 1Canada Vigilance
249ParaparesisOFFSIDES
250Peptic Ulcer15322343CTD
SIDER
251PetechiaeCanada Vigilance: 1Canada Vigilance
252PharyngitisSIDER
253PhotophobiaCanada Vigilance: 1Canada Vigilance
254Photosensitivity Disorders10830251CTD
255Pneumocystis jiroveci pneumoniaOFFSIDES
256PolyneuropathyOFFSIDES
257Polyuria16208259CTD
258Portal HypertensionOFFSIDES
259Portal Vein ThrombosisOFFSIDES
260Pregnancy on oral contraceptiveOFFSIDES
261ProctitisOFFSIDES
262ProctocolitisOFFSIDES
SIDER
263Proteinuria17485922CTD
264Pulmonary vascular disorderOFFSIDES
265PurpuraSIDER
266Purpuric rashSIDER
267Rash bullousSIDER
268Reaction gastrointestinalSIDER
269Rectal tenesmusSIDER
270RectoceleOFFSIDES
271Renal Colic1914425CTD
272Renal Insufficiency6953356
9881281		CTD
273Renal interstitial fibrosisOFFSIDES
274Restrictive pulmonary diseaseOFFSIDES
275Retinal Artery OcclusionOFFSIDES
276RhinitisSIDER
277RhinorrheaOFFSIDES
278SacroiliitisOFFSIDES
279Secretion dischargeOFFSIDES
280Seizures8872509
18178179		CTD
281SepticemiaSIDER
282ShockSIDER
283Sinus headacheOFFSIDES
284Sjogren's SyndromeSIDER
285Skin neoplasm excisionOFFSIDES
286Soft Tissue Injuries8294170CTD
287SomnolenceSIDER
288Staphylococcal abscessOFFSIDES
289Stomach Diseases15996031
16817730
17650636		CTD
290Stomach acheSIDER
291StomatitisSIDER
292SubileusOFFSIDES
293SweatingSIDER
294TachycardiaSIDER
295TensionSIDER
296ThirstSIDER
297Thoracic cavity drainageOFFSIDES
298ThrombocytosisCanada Vigilance: 1Canada Vigilance
299TinnitusSIDER
300Tooth LossOFFSIDES
301TracheobronchitisOFFSIDES
302Upper gastrointestinal symptomsSIDER
303Vascular purpuraSIDER
304Vasodilation procedureSIDER
305VasodilationSIDER
306VertigoSIDER
307Visual ImpairmentSIDER
308Visual disturbanceSIDER
309Wound infection staphylococcalOFFSIDES
310furuncleOFFSIDES
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120295

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.