MetaADEDB 2.0 @ LMMD
ioversol
(AMDBBAQNWSUWGN-UHFFFAOYSA-N)
Structure
SMILES
OCCN(c1c(I)c(C(=O)NCC(CO)O)c(c(c1I)C(=O)NCC(CO)O)I)C(=O)CO
Type(s)
Approved
ATC code(s)
V08AB07
Molecular Formula:
C18H24I3N3O9
Molecular Weight:
807.111
Log P:
-1.2342
Hydrogen Bond Acceptor:
12
Hydrogen Bond Donor:
8
TPSA:
199.89
CAS Number(s):
8771-40-2; 87771-40-2
Synonym(s)
1.
ioversol
2.
Optiray
3.
Optiray 300
4.
Optiray 320
External Link(s)
MeSHC054871
PubChem Compound3741
ChEBI31717
CHEMBLCHEMBL1200614
DrugBankDB09134
DrugCentral1471
KEGGdr:D01555
Therapeutic Target DatabaseD0U1ZD
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1UrticariaFAERS: 345
Canada Vigilance: 13
2917833CTD
SIDER
Canada Vigilance
US FAERS
2PruritusFAERS: 248
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
3Throat irritationFAERS: 169US FAERS
4SneezingFAERS: 145
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
5Anaphylactic shockFAERS: 137SIDER
US FAERS
6ErythemaFAERS: 136
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
7NauseaFAERS: 134
Canada Vigilance: 1
2917833CTD
SIDER
Canada Vigilance
US FAERS
8VomitingFAERS: 121
Canada Vigilance: 1
2917833CTD
SIDER
Canada Vigilance
US FAERS
9Chest discomfortFAERS: 92US FAERS
10HypersensitivityFAERS: 79US FAERS
11ShockFAERS: 64SIDER
US FAERS
12Cardiac ArrestFAERS: 60SIDER
US FAERS
13Contrast media reactionFAERS: 56
Canada Vigilance: 1
Canada Vigilance
US FAERS
14Drug administration errorFAERS: 52OFFSIDES
US FAERS
15DizzinessFAERS: 46SIDER
US FAERS
16Air EmbolismFAERS: 43OFFSIDES
US FAERS
17BronchospasmFAERS: 43SIDER
US FAERS
18MalaiseFAERS: 43US FAERS
19WheezingFAERS: 42
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
20Chest PainFAERS: 41SIDER
US FAERS
21FlushingFAERS: 38SIDER
US FAERS
22HypotensionFAERS: 36SIDER
US FAERS
23CyanosisFAERS: 35OFFSIDES
SIDER
US FAERS
24Lip swellingFAERS: 33US FAERS
25TremorFAERS: 33SIDER
US FAERS
26HeadacheFAERS: 32SIDER
US FAERS
27Injection site extravasationFAERS: 31US FAERS
28TachycardiaFAERS: 31SIDER
US FAERS
29DysphoniaFAERS: 30US FAERS
30Procedural complicationFAERS: 30OFFSIDES
US FAERS
31ChillsFAERS: 28SIDER
US FAERS
32Respiratory arrestFAERS: 27US FAERS
33Respiratory distressFAERS: 26US FAERS
34AngioedemaFAERS: 25SIDER
US FAERS
35Oral pruritusFAERS: 25
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
36PallorFAERS: 25OFFSIDES
SIDER
US FAERS
37Unresponsive to stimuliFAERS: 24
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
38ExtravasationFAERS: 23SIDER
US FAERS
39Anaphylactoid ReactionFAERS: 21US FAERS
40AstheniaFAERS: 20US FAERS
41Burning sensationFAERS: 19US FAERS
42Depressed Level of ConsciousnessFAERS: 17
Canada Vigilance: 1
Canada Vigilance
US FAERS
43Post procedural complicationFAERS: 17US FAERS
44Feeling abnormalFAERS: 16SIDER
US FAERS
45PainFAERS: 16SIDER
US FAERS
46RetchingFAERS: 16US FAERS
47Medication ErrorFAERS: 15US FAERS
48Oropharyngeal painFAERS: 14OFFSIDES
US FAERS
49PapuleFAERS: 14US FAERS
50Rash erythematousFAERS: 14US FAERS
51Ventricular FibrillationFAERS: 1410823730CTD
OFFSIDES
SIDER
US FAERS
52AnxietyFAERS: 13SIDER
US FAERS
53BradycardiaFAERS: 13SIDER
US FAERS
54AgitationFAERS: 12SIDER
US FAERS
55Respiratory FailureFAERS: 12US FAERS
56SyncopeFAERS: 12SIDER
US FAERS
57Abdominal PainFAERS: 11US FAERS
58Contrast media allergyFAERS: 11US FAERS
59Oropharyngeal discomfortFAERS: 11US FAERS
60Accidental exposureFAERS: 10OFFSIDES
US FAERS
61SwellingFAERS: 10US FAERS
62Blood pressure immeasurableFAERS: 9US FAERS
63Myocardial InfarctionFAERS: 9SIDER
US FAERS
64PalpitationsFAERS: 9US FAERS
65PneumoniaFAERS: 9US FAERS
66Wrong technique in drug usage processFAERS: 9OFFSIDES
US FAERS
67AsthmaFAERS: 8OFFSIDES
SIDER
US FAERS
68Injection site painFAERS: 8US FAERS
69Injection site vesiclesFAERS: 8OFFSIDES
US FAERS
70PetechiaeFAERS: 8US FAERS
71AphasiaFAERS: 7SIDER
US FAERS
72FatigueFAERS: 7US FAERS
73Foaming at mouthFAERS: 7OFFSIDES
US FAERS
74IncontinenceFAERS: 7US FAERS
75LaryngospasmFAERS: 7SIDER
US FAERS
76RestlessnessFAERS: 7US FAERS
77ChokingFAERS: 6OFFSIDES
SIDER
US FAERS
78Cold sweatFAERS: 6US FAERS
79Incorrect route of drug administrationFAERS: 6OFFSIDES
US FAERS
80Injection site erythemaFAERS: 6US FAERS
81Injection site necrosisFAERS: 6US FAERS
82Laryngeal discomfortFAERS: 6US FAERS
83Nasal discomfortFAERS: 6OFFSIDES
US FAERS
84Urinary IncontinenceFAERS: 6US FAERS
85Altered state of consciousnessFAERS: 5US FAERS
86ArthralgiaFAERS: 5US FAERS
87Cardiac procedure complicationFAERS: 5OFFSIDES
US FAERS
88Drug ineffectiveFAERS: 5US FAERS
89DysgeusiaFAERS: 5SIDER
US FAERS
90Eye irritationFAERS: 5US FAERS
91Feeling ColdFAERS: 5US FAERS
92General physical health deteriorationFAERS: 5US FAERS
93Hypoaesthesia facialFAERS: 5US FAERS
94Iatrogenic injuryFAERS: 5OFFSIDES
US FAERS
95LethargyFAERS: 5US FAERS
96Peripheral swellingFAERS: 5US FAERS
97Product quality issueFAERS: 5US FAERS
98VertigoFAERS: 5SIDER
US FAERS
99Back PainFAERS: 4US FAERS
100Coronary Artery DiseaseFAERS: 4US FAERS
101HyperventilationFAERS: 4US FAERS
102HypothyroidismFAERS: 4US FAERS
103Musculoskeletal stiffnessFAERS: 4SIDER
US FAERS
104Pharmaceutical product complaintFAERS: 4US FAERS
105Pharyngolaryngeal discomfortFAERS: 4US FAERS
106PresyncopeFAERS: 4US FAERS
107Pulmonary EmbolismFAERS: 4US FAERS
108RalesFAERS: 4OFFSIDES
US FAERS
109Skin reactionFAERS: 4US FAERS
110SomnolenceFAERS: 4SIDER
US FAERS
111Tongue pruritusFAERS: 4US FAERS
112Upper respiratory tract congestionFAERS: 4US FAERS
113Band sensationFAERS: 3US FAERS
114Blood creatinine increasedFAERS: 3US FAERS
115Brain DeathFAERS: 3OFFSIDES
US FAERS
116Cerebrovascular accidentFAERS: 3SIDER
US FAERS
117Coronary artery perforationFAERS: 3OFFSIDES
US FAERS
118DehydrationFAERS: 3SIDER
US FAERS
119DiscomfortFAERS: 3SIDER
US FAERS
120Drug exposure during pregnancyFAERS: 3US FAERS
121Drug toxicityFAERS: 3US FAERS
122Ear discomfortFAERS: 3US FAERS
123EpistaxisFAERS: 3US FAERS
124ExophthalmosFAERS: 3OFFSIDES
US FAERS
125Facial PainFAERS: 3US FAERS
126Heart sounds abnormalFAERS: 3OFFSIDES
US FAERS
127HemiparesisFAERS: 3SIDER
US FAERS
128HypoventilationFAERS: 3US FAERS
129HypoxiaFAERS: 3US FAERS
130Immediate post-injection reactionFAERS: 3OFFSIDES
US FAERS
131Injection site inflammationFAERS: 3OFFSIDES
US FAERS
132LacerationFAERS: 3US FAERS
133Medical device complicationFAERS: 3OFFSIDES
US FAERS
134Mouth swellingFAERS: 3US FAERS
135No adverse eventFAERS: 3US FAERS
136Post procedural hypothyroidismFAERS: 3US FAERS
137Pulmonary congestionFAERS: 3US FAERS
138Renal painFAERS: 3US FAERS
139Renal tubular necrosisFAERS: 3SIDER
US FAERS
140ScreamingFAERS: 3US FAERS
141SepsisFAERS: 3US FAERS
142StridorFAERS: 3US FAERS
143Syringe issueFAERS: 3US FAERS
144ThrombosisFAERS: 3SIDER
US FAERS
145Vessel puncture site dischargeFAERS: 3OFFSIDES
US FAERS
146Visual ImpairmentFAERS: 3US FAERS
147Vulvovaginal pruritusFAERS: 3OFFSIDES
US FAERS
148YawningFAERS: 3OFFSIDES
US FAERS
149Abdominal discomfortFAERS: 2OFFSIDES
US FAERS
150Accidental exposure to productFAERS: 2US FAERS
151AlopeciaFAERS: 2US FAERS
152AmnesiaFAERS: 2OFFSIDES
SIDER
US FAERS
153Anal sphincter atonyFAERS: 2US FAERS
154AnuriaFAERS: 2SIDER
US FAERS
155Atrioventricular BlockFAERS: 2SIDER
US FAERS
156Cardiac perforationFAERS: 2OFFSIDES
US FAERS
157Cardiovascular insufficiencyFAERS: 2US FAERS
158CellulitisFAERS: 2US FAERS
159Device breakageFAERS: 2OFFSIDES
US FAERS
160DisorientationFAERS: 2SIDER
US FAERS
161Documented hypersensitivity to administered drugFAERS: 2US FAERS
162Dry skinFAERS: 2US FAERS
163Electrocardiogram ST segment abnormalFAERS: 2US FAERS
164EmbolismFAERS: 2SIDER
US FAERS
165Emotional distressFAERS: 2US FAERS
166EpidermolysisFAERS: 2US FAERS
167EpilepsyFAERS: 2OFFSIDES
SIDER
US FAERS
168Eye painFAERS: 2US FAERS
169Idiosyncratic drug reactionFAERS: 2US FAERS
170Increased bronchial secretionFAERS: 2OFFSIDES
US FAERS
171Injection site urticariaFAERS: 2US FAERS
172Memory impairmentFAERS: 2US FAERS
173Muscle RigidityFAERS: 2US FAERS
174Muscle tightnessFAERS: 2US FAERS
175MyalgiaFAERS: 2US FAERS
176Nerve injuryFAERS: 2US FAERS
177OverdoseFAERS: 2US FAERS
178Procedural hypotensionFAERS: 2US FAERS
179PurpuraFAERS: 2SIDER
US FAERS
180Retinal artery spasmFAERS: 2OFFSIDES
US FAERS
181RhinitisFAERS: 2US FAERS
182Secretion dischargeFAERS: 2OFFSIDES
US FAERS
183Septic ShockFAERS: 2US FAERS
184Skin tightnessFAERS: 2US FAERS
185TinnitusFAERS: 2SIDER
US FAERS
186Ventricular arrhythmiaFAERS: 2US FAERS
187jaundiceFAERS: 2US FAERS
188nervous system disorderFAERS: 2US FAERS
189Acute myocardial infarctionFAERS: 1US FAERS
190Acute respiratory failureFAERS: 1US FAERS
191AkathisiaFAERS: 1US FAERS
192Anoxic EncephalopathyFAERS: 1US FAERS
193Aortic AneurysmFAERS: 1US FAERS
194AphoniaFAERS: 1US FAERS
195AppendicitisFAERS: 1US FAERS
196AsphyxiaFAERS: 1US FAERS
197Bladder sphincter atonyFAERS: 1US FAERS
198Blood creatine increasedFAERS: 1US FAERS
199Blood glucose increasedFAERS: 1US FAERS
200Blood urea increasedFAERS: 1US FAERS
201Bone painFAERS: 1US FAERS
202CatatoniaFAERS: 1US FAERS
203Catheter related complicationFAERS: 1US FAERS
204Catheter site dischargeFAERS: 1US FAERS
205CheilitisFAERS: 1US FAERS
206CholestasisFAERS: 1US FAERS
207ClonusFAERS: 1US FAERS
208CryingFAERS: 1US FAERS
209Deep Vein ThrombosisFAERS: 1US FAERS
210DermatitisFAERS: 1SIDER
US FAERS
211Device FailureFAERS: 1OFFSIDES
US FAERS
212Disease ProgressionFAERS: 1US FAERS
213DroolingFAERS: 1US FAERS
214Drug dispensing errorFAERS: 1US FAERS
215DysarthriaFAERS: 1US FAERS
216EcchymosisFAERS: 1SIDER
US FAERS
217Ejection Fraction DecreasedFAERS: 1US FAERS
218Electrocardiogram abnormalFAERS: 1US FAERS
219Electrocardiogram changeFAERS: 1US FAERS
220Electroencephalogram abnormalFAERS: 1US FAERS
221Electrolyte imbalanceFAERS: 1US FAERS
222Electromechanical dissociationFAERS: 1US FAERS
223Endotracheal intubation complicationFAERS: 1US FAERS
224EructationFAERS: 1US FAERS
225Expired drug administeredFAERS: 1US FAERS
226Exposure via eye contactFAERS: 1US FAERS
227Eyelids pruritusFAERS: 1US FAERS
228FlatulenceFAERS: 1US FAERS
229FormicationFAERS: 1US FAERS
230Genital rashFAERS: 1OFFSIDES
US FAERS
231Head discomfortFAERS: 1US FAERS
232HypercalciuriaFAERS: 1US FAERS
233HypercapniaFAERS: 1US FAERS
234HyperreflexiaFAERS: 1US FAERS
235HypokinesiaFAERS: 1US FAERS
236IncoherentFAERS: 1US FAERS
237Incorrect route of product administrationFAERS: 1US FAERS
238Increased upper airway secretionFAERS: 1US FAERS
239Infrequent bowel movementsFAERS: 1US FAERS
240Infusion site reactionFAERS: 1US FAERS
241Injection site discomfortFAERS: 1US FAERS
242Injection site irritationFAERS: 1US FAERS
243Iodine allergyFAERS: 1US FAERS
244Kounis SyndromeFAERS: 1US FAERS
245Latent tetanyFAERS: 1US FAERS
246Left Ventricular HypertrophyFAERS: 1US FAERS
247Lip erosionFAERS: 1US FAERS
248Lip pruritusFAERS: 1US FAERS
249LividityFAERS: 1US FAERS
250Musculoskeletal chest painFAERS: 1US FAERS
251MydriasisFAERS: 1US FAERS
252MyoclonusFAERS: 1US FAERS
253Nasal sinus drainageFAERS: 1OFFSIDES
US FAERS
254Neck PainFAERS: 1US FAERS
255NecrosisFAERS: 1SIDER
US FAERS
256NeuralgiaFAERS: 1US FAERS
257No reaction on previous exposure to drugFAERS: 1US FAERS
258Occupational exposure to productFAERS: 1US FAERS
259Oral mucosal eruptionFAERS: 1US FAERS
260Oral painFAERS: 1US FAERS
261Oropharyngeal swellingFAERS: 1US FAERS
262Pain of skinFAERS: 1US FAERS
263Periorbital swellingFAERS: 1US FAERS
264PeritonitisFAERS: 1US FAERS
265Pharyngeal swellingFAERS: 1US FAERS
266PneumopericardiumFAERS: 1US FAERS
267PolyarthritisFAERS: 1US FAERS
268Poor quality drug administeredFAERS: 1US FAERS
269Postresuscitation encephalopathyFAERS: 1US FAERS
270PosturingFAERS: 1US FAERS
271Primary HypothyroidismFAERS: 1US FAERS
272Product depositFAERS: 1US FAERS
273Product use in unapproved indicationFAERS: 1US FAERS
274Product use issueFAERS: 1US FAERS
275Productive CoughFAERS: 1US FAERS
276Radiation exposure during pregnancyFAERS: 1US FAERS
277Respiratory DepressionFAERS: 1US FAERS
278Respiratory tract congestionFAERS: 1US FAERS
279Saliva alteredFAERS: 1US FAERS
280Simple Partial SeizuresFAERS: 1US FAERS
281Sinus TachycardiaFAERS: 1US FAERS
282Sinus bradycardiaFAERS: 1SIDER
US FAERS
283Sinus headacheFAERS: 1US FAERS
284Skin WrinklingFAERS: 1US FAERS
285Skin irritationFAERS: 1US FAERS
286Skin test positiveFAERS: 1US FAERS
287Small bowel angioedemaFAERS: 1US FAERS
288SnoringFAERS: 1US FAERS
289Stevens-Johnson SyndromeFAERS: 1US FAERS
290SuperinfectionFAERS: 1US FAERS
291Supraventricular tachycardiaFAERS: 1US FAERS
292TachyarrhythmiaFAERS: 1US FAERS
293Tension HeadacheFAERS: 1US FAERS
294Therapy non-responderFAERS: 1US FAERS
295Thermal burnFAERS: 1US FAERS
296ThrombocytopeniaFAERS: 1US FAERS
297ThrombophlebitisFAERS: 1SIDER
US FAERS
298Transaminases decreasedFAERS: 1US FAERS
299Trigeminal NeuralgiaFAERS: 1US FAERS
300Troponin I increasedFAERS: 1US FAERS
301Troponin T increasedFAERS: 1US FAERS
302Type II hypersensitivityFAERS: 1US FAERS
303Unevaluable eventFAERS: 1US FAERS
304Unresponsive to verbal stimuliFAERS: 1US FAERS
305Urinary tract infectionFAERS: 1US FAERS
306Ventricular hypokinesiaFAERS: 1US FAERS
307Vital functions abnormalFAERS: 1US FAERS
308Weaning failureFAERS: 1US FAERS
309Weight decreasedFAERS: 1US FAERS
310Wrong drug administeredFAERS: 1US FAERS
311Abnormal visionOFFSIDES
312AcidosisSIDER
313AcneOFFSIDES
314Acute Coronary SyndromeSIDER
315AgraphiaOFFSIDES
316Alcoholic IntoxicationOFFSIDES
317Angina PectorisSIDER
318Ankle FractureOFFSIDES
319AnoxiaSIDER
320Aortic Valve StenosisSIDER
321Arterial thrombosisSIDER
322ArteriosclerosisSIDER
323Arteriovenous fistulaOFFSIDES
SIDER
324ArthritisOFFSIDES
325AtheromaSIDER
326AtherosclerosisSIDER
327Band neutrophil percentage increasedOFFSIDES
328Basophil percentage increasedOFFSIDES
329BlindnessSIDER
330Blood magnesium decreasedOFFSIDES
331Blood pressure fluctuationSIDER
332Blood triglycerides increasedOFFSIDES
333Cardiac TamponadeSIDER
334Cerebral InfarctionSIDER
335Choking sensationOFFSIDES
336Circumstance or information capable of leading to medication errorOFFSIDES
337Concomitant disease aggravatedOFFSIDES
338Conjunctival depositOFFSIDES
339ConjunctivitisSIDER
340Coronary angioplastyOFFSIDES
341DiplegiaSIDER
342Disseminated Intravascular CoagulationSIDER
343DrowsinessSIDER
344Drug prescribing errorOFFSIDES
345DysphasiaSIDER
346Dyspnea8761866CTD
347Ejection fraction abnormalOFFSIDES
348EscharOFFSIDES
349Foreign body traumaOFFSIDES
350GangreneSIDER
351Gingival erythemaOFFSIDES
352GoiterOFFSIDES
353Graft infectionOFFSIDES
354HemiplegiaSIDER
355Hypertensive crisisSIDER
356HypotensiveSIDER
357InfarctionSIDER
358Injection site dermatitisOFFSIDES
359Intention tremorOFFSIDES
360Kidney Diseases16444061CTD
361LacrimationSIDER
362LightheadednessSIDER
363LordosisSIDER
364LymphomaOFFSIDES
365MonoplegiaSIDER
366NasopharyngitisOFFSIDES
367Neck stiffnessSIDER
368Neurologic reactionSIDER
369NeutropeniaSIDER
370Nuchal RigiditySIDER
371NystagmusSIDER
372ObstructionSIDER
373OliguriaSIDER
374ParaplegiaSIDER
375PolyuriaSIDER
376Prostate cancer recurrentOFFSIDES
377Protein urine presentSIDER
378ProteinuriaSIDER
379QuadriplegiaSIDER
380Renal ColicSIDER
381Renal Insufficiency9169676CTD
382ScotomaSIDER
383Seizures8761866CTD
384Sensation of warmthSIDER
385Septic arthritis staphylococcalOFFSIDES
386Skin lesionOFFSIDES
387Swelling of eyelidCanada Vigilance: 1Canada Vigilance
388TraumaSIDER
389Urinary RetentionSIDER
390Urine output increasedSIDER
391Vascular insufficiencySIDER
392Vascular procedure complicationOFFSIDES
393Vascular purpuraSIDER
394Vasodilation procedureSIDER
395VasodilationSIDER
396Venous ThrombosisSIDER
397Vessel perforationSIDER
398bad tasteSIDER
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