MetaADEDB 2.0 @ LMMD
montelukast
(LBFBRXGCXUHRJY-HKHDRNBDSA-M)
Structure
SMILES
[O-]C(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1.[Na+]
Molecular Formula:
C35H35ClNNaO3S
Molecular Weight:
608.165
Log P:
7.6133
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
1
TPSA:
98.55
CAS Number(s):
142522-81-4; 151767-02-1
Synonym(s)
1.
montelukast
2.
MK 0476
3.
MK-0476
4.
Singulair
5.
montelukast sodium
6.
sodium 1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropylacetate
External Link(s)
MeSHC093875
PubChem Compound23663996
ChEBI6993
CHEMBLCHEMBL1200681
KEGGdr:D00529
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 88
Canada Vigilance: 42
Canada Vigilance
US FAERS
2Product substitution issueFAERS: 56US FAERS
3AnxietyFAERS: 43US FAERS
4AsthmaFAERS: 36OFFSIDES
US FAERS
5HeadacheFAERS: 32
Canada Vigilance: 1
Canada Vigilance
US FAERS
6Product quality issueFAERS: 25OFFSIDES
US FAERS
7NauseaFAERS: 21
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
8HypersensitivityFAERS: 18US FAERS
9Chest discomfortFAERS: 17US FAERS
10DizzinessFAERS: 17
Canada Vigilance: 2
Canada Vigilance
US FAERS
11MalaiseFAERS: 17US FAERS
12FatigueFAERS: 16OFFSIDES
US FAERS
13WheezingFAERS: 16US FAERS
14Feeling abnormalFAERS: 15US FAERS
15Depressed moodFAERS: 14US FAERS
16PalpitationsFAERS: 13
Canada Vigilance: 1
Canada Vigilance
US FAERS
17UrticariaFAERS: 13US FAERS
18AngerFAERS: 12US FAERS
19No adverse eventFAERS: 12US FAERS
20CryingFAERS: 11US FAERS
21Mood swingsFAERS: 10US FAERS
22Therapeutic response unexpectedFAERS: 10US FAERS
23AgitationFAERS: 9US FAERS
24VomitingFAERS: 9US FAERS
25ArthralgiaFAERS: 8US FAERS
26Eosinophilic granulomatosis with polyangiitisFAERS: 8
Canada Vigilance: 1
Canada Vigilance
US FAERS
27NervousnessFAERS: 8US FAERS
28PainFAERS: 8OFFSIDES
US FAERS
29Product taste abnormalFAERS: 8US FAERS
30Abdominal PainFAERS: 7OFFSIDES
US FAERS
31MetamorphopsiaFAERS: 7US FAERS
32PruritusFAERS: 7US FAERS
33Suicide attemptFAERS: 7US FAERS
34Chest PainFAERS: 6
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
35DiscomfortFAERS: 6US FAERS
36EnuresisFAERS: 6US FAERS
37Mononeuropathy MultiplexFAERS: 6US FAERS
38Adverse eventFAERS: 5US FAERS
39DissociationFAERS: 5US FAERS
40DyspepsiaFAERS: 5OFFSIDES
US FAERS
41Memory impairmentFAERS: 5US FAERS
42Personality ChangeFAERS: 5US FAERS
43Reaction to drug excipientsFAERS: 5US FAERS
44AlopeciaFAERS: 4US FAERS
45Completed SuicideFAERS: 4US FAERS
46Eosinophilic PneumoniaFAERS: 4US FAERS
47ErythemaFAERS: 4US FAERS
48Negative thoughtsFAERS: 4US FAERS
49Oropharyngeal painFAERS: 4OFFSIDES
US FAERS
50ScreamingFAERS: 4US FAERS
51SomnambulismFAERS: 4US FAERS
52TachyphreniaFAERS: 4US FAERS
53Throat irritationFAERS: 4US FAERS
54Abdominal discomfortFAERS: 3OFFSIDES
US FAERS
55Alanine Aminotransferase IncreasedFAERS: 3US FAERS
56AphasiaFAERS: 3US FAERS
57Aspartate Aminotransferase IncreasedFAERS: 3US FAERS
58AstheniaFAERS: 3US FAERS
59CholelithiasisFAERS: 3US FAERS
60ConstipationFAERS: 3US FAERS
61Drug dose omissionFAERS: 3US FAERS
62Drug ineffective for unapproved indicationFAERS: 3US FAERS
63Incorrect dose administeredFAERS: 3US FAERS
64Incorrect drug administration durationFAERS: 3US FAERS
65LethargyFAERS: 3US FAERS
66Lip swellingFAERS: 3US FAERS
67MyalgiaFAERS: 3US FAERS
68Nephrotic SyndromeFAERS: 3US FAERS
69Night sweatsFAERS: 3US FAERS
70Peak expiratory flow rate abnormalFAERS: 3US FAERS
71Product use in unapproved indicationFAERS: 3US FAERS
72Pulmonary congestionFAERS: 3US FAERS
73Respiratory distressFAERS: 3US FAERS
74RestlessnessFAERS: 3US FAERS
75SinusitisFAERS: 3OFFSIDES
US FAERS
76SneezingFAERS: 3US FAERS
77SwellingFAERS: 3US FAERS
78TremorFAERS: 3US FAERS
79Abdominal tendernessFAERS: 2US FAERS
80Activities of daily living impairedFAERS: 2OFFSIDES
US FAERS
81Alice in Wonderland SyndromeFAERS: 2US FAERS
82AngioedemaFAERS: 2OFFSIDES
US FAERS
83Bladder painFAERS: 2US FAERS
84BronchospasmFAERS: 2US FAERS
85Burning sensationFAERS: 2OFFSIDES
US FAERS
86ChromaturiaFAERS: 2OFFSIDES
US FAERS
87DisorientationFAERS: 2US FAERS
88Drug abuseFAERS: 2US FAERS
89Drug administration errorFAERS: 2US FAERS
90Drug dispensing errorFAERS: 2US FAERS
91Drug effect incompleteFAERS: 2US FAERS
92DysgeusiaFAERS: 2OFFSIDES
US FAERS
93DysphemiaFAERS: 2US FAERS
94Ear discomfortFAERS: 2US FAERS
95Emotional disorderFAERS: 2US FAERS
96EpicondylitisFAERS: 2US FAERS
97FlatulenceFAERS: 2OFFSIDES
US FAERS
98FlushingFAERS: 2US FAERS
99General symptomFAERS: 2OFFSIDES
US FAERS
100HostilityFAERS: 2US FAERS
101Joint swellingFAERS: 2US FAERS
102LeukopeniaFAERS: 2US FAERS
103Multiple allergiesFAERS: 2US FAERS
104NegativismFAERS: 2US FAERS
105NeutropeniaFAERS: 2US FAERS
106Obsessive-Compulsive DisorderFAERS: 2US FAERS
107PallorFAERS: 2US FAERS
108ParanoiaFAERS: 2OFFSIDES
US FAERS
109PneumoniaFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
110PneumothoraxFAERS: 2OFFSIDES
US FAERS
111PoisoningFAERS: 2US FAERS
112Primary Biliary CholangitisFAERS: 2US FAERS
113Product use issueFAERS: 2US FAERS
114Productive CoughFAERS: 2OFFSIDES
US FAERS
115Sinus TachycardiaFAERS: 2US FAERS
116Skin irritationFAERS: 2US FAERS
117SluggishnessFAERS: 2US FAERS
118StressFAERS: 2US FAERS
119Subcutaneous EmphysemaFAERS: 2OFFSIDES
US FAERS
120TachycardiaFAERS: 2US FAERS
121TalipesFAERS: 2US FAERS
122Therapeutic response unexpected with drug substitutionFAERS: 2US FAERS
123Unevaluable eventFAERS: 2US FAERS
124Vanishing bile duct syndromeFAERS: 2US FAERS
125Abdominal rigidityFAERS: 1US FAERS
126AcneFAERS: 1US FAERS
127Allergy to animalFAERS: 1OFFSIDES
US FAERS
128Altered visual depth perceptionFAERS: 1US FAERS
129Anaphylactic shockFAERS: 1US FAERS
130AphagiaFAERS: 1US FAERS
131AphoniaFAERS: 1US FAERS
132AsterixisFAERS: 1US FAERS
133Atrial FibrillationFAERS: 1US FAERS
134Back PainFAERS: 1US FAERS
135Bipolar DisorderFAERS: 1US FAERS
136Blood alkaline phosphatase increasedFAERS: 1US FAERS
137Blood glucose abnormalFAERS: 1US FAERS
138Blood glucose decreasedFAERS: 1OFFSIDES
US FAERS
139Blood glucose increasedFAERS: 1US FAERS
140Body fat disorderFAERS: 1US FAERS
141BronchiectasisFAERS: 1OFFSIDES
US FAERS
142Bullous lung diseaseFAERS: 1US FAERS
143Cardiac discomfortFAERS: 1US FAERS
144CheilitisFAERS: 1US FAERS
145Clostridium difficile infectionFAERS: 1US FAERS
146ColitisFAERS: 1US FAERS
147Conversion disorderFAERS: 1US FAERS
148Creutzfeldt-Jakob diseaseFAERS: 1US FAERS
149Deep Vein ThrombosisFAERS: 1US FAERS
150Drug diversionFAERS: 1US FAERS
151Drug exposure during pregnancyFAERS: 1US FAERS
152Drug withdrawal syndromeFAERS: 1US FAERS
153DysmetropsiaFAERS: 1US FAERS
154EcchymosisFAERS: 1US FAERS
155Economic problemFAERS: 1US FAERS
156Electrocardiogram ST segment abnormalFAERS: 1US FAERS
157Emotional distressFAERS: 1US FAERS
158EosinophiliaFAERS: 1US FAERS
159Eosinophilic bronchitisFAERS: 1US FAERS
160EpilepsyFAERS: 1US FAERS
161EpistaxisFAERS: 1US FAERS
162Eustachian tube disorderFAERS: 1US FAERS
163Excessive eye blinkingFAERS: 1US FAERS
164ExophthalmosFAERS: 1US FAERS
165Expired drug administeredFAERS: 1US FAERS
166Exposure via breast milkFAERS: 1US FAERS
167Eye irritationFAERS: 1US FAERS
168Feeling jitteryFAERS: 1US FAERS
169Food AllergyFAERS: 1US FAERS
170Food PoisoningFAERS: 1US FAERS
171Foreign body sensation in eyesFAERS: 1US FAERS
172FormicationFAERS: 1OFFSIDES
US FAERS
173Gluten sensitivityFAERS: 1US FAERS
174HyperreflexiaFAERS: 1US FAERS
175HypophagiaFAERS: 1US FAERS
176HypotensionFAERS: 1US FAERS
177Impaired reasoningFAERS: 1US FAERS
178Increased tendency to bruiseFAERS: 1US FAERS
179InfectionFAERS: 1US FAERS
180Initial insomniaFAERS: 1US FAERS
181Intentional product use issueFAERS: 1US FAERS
182Intentional self-injuryFAERS: 1US FAERS
183Limb discomfortFAERS: 1US FAERS
184LymphadenopathyFAERS: 1US FAERS
185Maternal exposure during pregnancyFAERS: 1US FAERS
186Mental impairmentFAERS: 1US FAERS
187Middle insomniaFAERS: 1US FAERS
188Muscle tightnessFAERS: 1US FAERS
189Musculoskeletal PainFAERS: 1US FAERS
190Musculoskeletal stiffnessFAERS: 1OFFSIDES
US FAERS
191ObesityFAERS: 1US FAERS
192Oppositional Defiant DisorderFAERS: 1US FAERS
193Oral candidiasisFAERS: 1US FAERS
194Palmar erythemaFAERS: 1US FAERS
195Pericardial effusionFAERS: 1US FAERS
196PeriodontitisFAERS: 1US FAERS
197Perioral DermatitisFAERS: 1US FAERS
198Peripheral swellingFAERS: 1US FAERS
199PharyngitisFAERS: 1US FAERS
200Platelet dysfunctionFAERS: 1US FAERS
201Product comminglingFAERS: 1US FAERS
202Product dispensing errorFAERS: 1US FAERS
203Product dose omissionFAERS: 1US FAERS
204Product measured potency issueFAERS: 1US FAERS
205Product packaging confusionFAERS: 1US FAERS
206Product physical issueFAERS: 1US FAERS
207Pulmonary EmbolismFAERS: 1US FAERS
208Pulmonary HypertensionFAERS: 1US FAERS
209Pulmonary painFAERS: 1US FAERS
210Respiratory tract congestionFAERS: 1US FAERS
211Skin reactionFAERS: 1US FAERS
212Skin test positiveFAERS: 1US FAERS
213SomnolenceFAERS: 1US FAERS
214StarvationFAERS: 1US FAERS
215SyncopeFAERS: 1US FAERS
216Tension HeadacheFAERS: 1US FAERS
217Therapeutic response changedFAERS: 1US FAERS
218Therapy cessationFAERS: 1US FAERS
219Therapy non-responderFAERS: 1US FAERS
220ThrombosisFAERS: 1US FAERS
221Toxicity to various agentsFAERS: 1US FAERS
222Typhoid FeverFAERS: 1US FAERS
223Upper-airway cough syndromeFAERS: 1US FAERS
224VertigoFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
225Violence-related symptomFAERS: 1US FAERS
226Visual ImpairmentFAERS: 1US FAERS
227Wrong technique in product usage processFAERS: 1US FAERS
228jaundiceFAERS: 1US FAERS
229Abdominal massOFFSIDES
230AbscessOFFSIDES
231AbuseOFFSIDES
232AcanthosisOFFSIDES
233Acid refluxOFFSIDES
234Acute sinusitisOFFSIDES
235Adnexa uteri painOFFSIDES
236Adrenal massOFFSIDES
237AgeusiaOFFSIDES
238AmnesiaOFFSIDES
239AneurysmOFFSIDES
240Animal biteOFFSIDES
241ApathyOFFSIDES
242Aphthous StomatitisOFFSIDES
243Application site burnOFFSIDES
244Application site erythemaOFFSIDES
245Application site irritationOFFSIDES
246Application site painOFFSIDES
247Application site pruritusOFFSIDES
248Application site vesiclesOFFSIDES
249ArteriosclerosisOFFSIDES
250ArthritisOFFSIDES
251AtelectasisOFFSIDES
252AuraOFFSIDES
253Back disorderOFFSIDES
254Benign neoplasm of spinal cordOFFSIDES
255Biliary dilatationOFFSIDES
256BlepharospasmOFFSIDES
257Blood GlucoseOFFSIDES
258Blood glucose fluctuationOFFSIDES
259Blood growth hormone decreasedOFFSIDES
260Blood immunoglobulin E increasedCanada Vigilance: 1Canada Vigilance
261Blood immunoglobulin G decreasedOFFSIDES
262Blood magnesium decreasedOFFSIDES
263Blood phosphorus increasedOFFSIDES
264Blood potassium decreasedOFFSIDES
265Blood prolactin increasedOFFSIDES
266Blurred visionOFFSIDES
267Bowel movement irregularityOFFSIDES
268Breast MicrocalcificationOFFSIDES
269BronchitisCanada Vigilance: 1Canada Vigilance
OFFSIDES
270BruxismOFFSIDES
271BunionOFFSIDES
272BursitisOFFSIDES
273Cardiac FlutterOFFSIDES
274Cardioactive drug level increasedOFFSIDES
275Carotid artery occlusionOFFSIDES
276CataractOFFSIDES
277CatatoniaOFFSIDES
278Catheter site infectionOFFSIDES
279CellulitisOFFSIDES
280Choking sensationOFFSIDES
281Chronic Fatigue SyndromeOFFSIDES
282Chronic Obstructive Airway DiseaseOFFSIDES
283Chronic sinusitisOFFSIDES
284ChylothoraxOFFSIDES
285Congenital tricuspid valve incompetenceOFFSIDES
286DehydrationOFFSIDES
287Delusional perceptionOFFSIDES
288DependenceOFFSIDES
289DermatitisCanada Vigilance: 2Canada Vigilance
290Device leakageOFFSIDES
291DiabetesOFFSIDES
292Diabetes mellitus inadequate controlOFFSIDES
293DiarrheaOFFSIDES
294Diet refusalOFFSIDES
295DiverticulitisOFFSIDES
296DiverticulumOFFSIDES
297DrowsinessOFFSIDES
298Drug level changedOFFSIDES
299Drug withdrawal headacheOFFSIDES
300Ethmoid sinus surgeryOFFSIDES
301Eyelid DiseasesOFFSIDES
302Fat redistributionOFFSIDES
303Fatty LiverOFFSIDES
304Febrile NeutropeniaOFFSIDES
305Feeling ColdOFFSIDES
306Flat affectOFFSIDES
307GangreneOFFSIDES
308GastroenteritisOFFSIDES
309Hepatitis B positiveOFFSIDES
310HydrocephalusOFFSIDES
311HyperkeratosisOFFSIDES
312HyperventilationOFFSIDES
313Hypoplastic Left Heart SyndromeOFFSIDES
314Impaired driving abilityOFFSIDES
315Impaired gastric emptyingOFFSIDES
316Inappropriate schedule of drug administrationOFFSIDES
317IncontinenceOFFSIDES
318Increased viscosity of bronchial secretionOFFSIDES
319Infusion site mobility decreasedOFFSIDES
320Injection site dermatitisOFFSIDES
321Injection site infectionOFFSIDES
322Injection site irritationOFFSIDES
323Intentional drug misuseOFFSIDES
324Intervertebral Disc DegenerationOFFSIDES
325Intracranial AneurysmOFFSIDES
326Joint Range of Motion DecreasedOFFSIDES
327LaryngitisCanada Vigilance: 1Canada Vigilance
328Loose toothOFFSIDES
329Loss of personal independence in daily activitiesCanada Vigilance: 1Canada Vigilance
330Lyme DiseaseOFFSIDES
331LymphedemaOFFSIDES
332MastectomyOFFSIDES
333Medication residueOFFSIDES
334Mental status changesOFFSIDES
335Metabolic acidosisOFFSIDES
336Mitral Valve StenosisOFFSIDES
337Mitral valve sclerosisOFFSIDES
338MononeuritisOFFSIDES
339Muscle WeaknessOFFSIDES
340MyelitisOFFSIDES
341OculogyrationOFFSIDES
342OnychoclasisOFFSIDES
343Oral infectionOFFSIDES
344Oral torusOFFSIDES
345Oropharyngeal discomfortOFFSIDES
346OsteomyelitisOFFSIDES
347OsteopeniaOFFSIDES
348OsteoradionecrosisOFFSIDES
349PancreatitisOFFSIDES
350Patellofemoral Pain SyndromeOFFSIDES
351Polysubstance dependenceOFFSIDES
352Post procedural complicationOFFSIDES
353PsoriasisOFFSIDES
354Rectal polypOFFSIDES
355Renal cystOFFSIDES
356Respiratory FailureOFFSIDES
357RetrocollisOFFSIDES
358RhinorrheaOFFSIDES
359SchizophreniaOFFSIDES
360SclerodermaOFFSIDES
361Sinus antrostomyOFFSIDES
362Skeletal injuryOFFSIDES
363Skin lacerationOFFSIDES
364Sleep TalkingOFFSIDES
365Splenic InfarctionOFFSIDES
366Swelling of eyelidCanada Vigilance: 1Canada Vigilance
367Tardive DyskinesiaOFFSIDES
368TendinitisOFFSIDES
369Therapeutic product effect incompleteCanada Vigilance: 1Canada Vigilance
370Thrombosis in deviceOFFSIDES
371ThymomaOFFSIDES
372TinnitusOFFSIDES
373Urinary tract infection enterococcalOFFSIDES
374Urinary tract infection staphylococcalOFFSIDES
375Urine output increasedOFFSIDES
376Vaginal lesionOFFSIDES
377Venous InsufficiencyOFFSIDES
378Ventricular FibrillationOFFSIDES
379Vitamin B 12 DeficiencyOFFSIDES
380Weight GainOFFSIDES
381XerosisOFFSIDES
382effusionOFFSIDES
383muscle injuryOFFSIDES
384treatment failureCanada Vigilance: 1Canada Vigilance
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