MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Acebutolol

(GOEMGAFJFRBGGG-UHFFFAOYSA-N)

Structure

SMILES: CCCC(=O)Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O
Type(s): Approved; Investigational
ATC code(s): C07AB04; C07BB04
Molecular Formula:: C18H28N2O4
Molecular Weight:: 336.426
Log P:: 2.8294
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 3
TPSA:: 87.66
CAS Number(s):: 28197-63-9; 37517-30-9; 68107-82-4

Synonym(s)

Acebutolol

Acebutolol Hydrochloride

Acetobutolol

Apo-Acebutolol

M & B 17803A

M&B-17803 A

Monitan

Neptal

Novo-Acebutolol

10.

Prent

11.

Rhotral

12.

Sectral

13.

Apo Acebutolol

14.

ApoAcebutolol

15.

M&B 17803 A

16.

M&B17803 A

17.

Novo Acebutolol

18.

NovoAcebutolol

External Link(s)

MeSH	D000070
PubChem Compound	1978
BindingDB	25755
ChEBI	2379
CHEMBL	CHEMBL642
DrugBank	DB01193
DrugCentral	40
IUPHAR/BPS Guide to PHARMACOLOGY	7107
KEGG	cpd:C06803 dr:D02338
Therapeutic Target Database	D0HD9K

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 11		US FAERS
2	Palpitations	FAERS: 6 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
3	Pharmaceutical product complaint	FAERS: 5		OFFSIDES US FAERS
4	Toxicity to various agents	FAERS: 4		US FAERS
5	Shock	FAERS: 3		SIDER US FAERS
6	Drug dispensing error	FAERS: 2		US FAERS
7	Headache	FAERS: 2		SIDER US FAERS
8	No adverse event	FAERS: 2		US FAERS
9	Product quality issue	FAERS: 2		US FAERS
10	Product substitution issue	FAERS: 2 Canada Vigilance: 3		Canada Vigilance US FAERS
11	Tachycardia	FAERS: 2 Canada Vigilance: 1	815887	CTD Canada Vigilance US FAERS
12	Abasia	FAERS: 1		US FAERS
13	Activities of daily living impaired	FAERS: 1		US FAERS
14	Angina Pectoris	FAERS: 1 Canada Vigilance: 1	3943932	CTD Canada Vigilance US FAERS
15	Arthralgia	FAERS: 1		SIDER US FAERS
16	Blood pressure inadequately controlled	FAERS: 1		US FAERS
17	Bone pain	FAERS: 1		US FAERS
18	Cardiotoxicity	FAERS: 1		US FAERS
19	Chest Pain	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
20	Constipation	FAERS: 1		SIDER US FAERS
21	Drug ineffective for unapproved indication	FAERS: 1		US FAERS
22	Drug name confusion	FAERS: 1		US FAERS
23	Expired product administered	FAERS: 1		US FAERS
24	Feeling abnormal	FAERS: 1		SIDER US FAERS
25	Hypersensitivity	FAERS: 1		US FAERS
26	Inadequate analgesia	FAERS: 1		US FAERS
27	Nausea	FAERS: 1		SIDER US FAERS
28	Poor quality drug administered	FAERS: 1		US FAERS
29	Pulmonary Fibrosis	FAERS: 1		US FAERS
30	Reaction to drug excipients	FAERS: 1		US FAERS
31	Therapeutic response changed	FAERS: 1		US FAERS
32	Therapeutic response unexpected with drug substitution	FAERS: 1		US FAERS
33	Abdominal Pain	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
34	Abdominal mass			OFFSIDES
35	Abnormal vision			SIDER
36	Acantholysis			OFFSIDES
37	Acanthoma			OFFSIDES
38	Ache			SIDER
39	Acidosis			OFFSIDES
40	Acne			OFFSIDES
41	Actinic keratosis			OFFSIDES
42	Acute Coronary Syndrome			OFFSIDES
43	Adenocarcinoma			OFFSIDES
44	Agranulocytosis			SIDER
45	Agraphia			OFFSIDES
46	Alanine aminotransferase abnormal			OFFSIDES
47	Allergy test positive			OFFSIDES
48	Allergy to arthropod sting			OFFSIDES
49	Allergy to chemicals			OFFSIDES
50	Alopecia reversible			SIDER
51	Alopecia	Canada Vigilance: 1		Canada Vigilance SIDER
52	Altered state of consciousness			OFFSIDES
53	Alveolitis			OFFSIDES
54	Amnesia			SIDER
55	Angioedema			OFFSIDES
56	Anorexia			SIDER
57	Anticonvulsant drug level above therapeutic			OFFSIDES
58	Anuria			OFFSIDES
59	Anxiety Disorders		6712870	CTD
60	Anxiety	Canada Vigilance: 1		Canada Vigilance SIDER
61	Apathy			OFFSIDES
62	Aphthous Stomatitis			OFFSIDES
63	Arterial thrombosis			SIDER
64	Arteriovenous fistula thrombosis			OFFSIDES
65	Arteritis			OFFSIDES
66	Arthritis	Canada Vigilance: 1		Canada Vigilance OFFSIDES
67	Arthropod bite			OFFSIDES
68	Aspartate Aminotransferase Increased			SIDER
69	Aspartate aminotransferase abnormal			OFFSIDES
70	Asthenia	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
71	Atrioventricular Block			SIDER
72	Autoimmune hepatitis			OFFSIDES
73	Autoimmune neutropenia			OFFSIDES
74	Autoimmune thyroiditis			OFFSIDES
75	Avascular necrosis			OFFSIDES
76	Axonal neuropathy			OFFSIDES
77	Babesiosis			OFFSIDES
78	Back Pain			SIDER
79	Benign biliary neoplasm			OFFSIDES
80	Beta 2 microglobulin increased			OFFSIDES
81	Bilirubin conjugated increased			OFFSIDES
82	Biopsy liver abnormal			OFFSIDES
83	Blood alkaline phosphatase increased			OFFSIDES
84	Blood bicarbonate abnormal			OFFSIDES
85	Blood bilirubin unconjugated increased			OFFSIDES
86	Blood chloride decreased			OFFSIDES
87	Blood cholesterol			OFFSIDES
88	Blood chromogranin A increased			OFFSIDES
89	Blood creatine phosphokinase increased			OFFSIDES
90	Blood creatinine increased			OFFSIDES
91	Blood immunoglobulin A increased			OFFSIDES
92	Blood immunoglobulin E			OFFSIDES
93	Blood immunoglobulin G decreased			OFFSIDES
94	Blood immunoglobulin M decreased			OFFSIDES
95	Blood osmolarity decreased			OFFSIDES
96	Blood sodium			OFFSIDES
97	Blood uric acid decreased			OFFSIDES
98	Blood uric acid			OFFSIDES
99	Blue Toe Syndrome			OFFSIDES
100	Body Temperature			OFFSIDES
101	Bone marrow depression			OFFSIDES
102	Bradycardia		6542785	CTD OFFSIDES SIDER
103	Brain natriuretic peptide increased			OFFSIDES
104	Bronchial Obstruction			OFFSIDES
105	Bronchospasm			SIDER
106	Calcification of muscle			OFFSIDES
107	Candida pneumonia			OFFSIDES
108	Candida sepsis			OFFSIDES
109	Carotid bruit			OFFSIDES
110	Catatonia			SIDER
111	Cell Death			OFFSIDES
112	Cerebral atrophy			OFFSIDES
113	Chest discomfort	Canada Vigilance: 1		Canada Vigilance
114	Chills			SIDER
115	Choking sensation			OFFSIDES
116	Cholangiolitis			OFFSIDES
117	Cholecystitis infective			OFFSIDES
118	Cholecystitis			OFFSIDES
119	Chronic left ventricular failure			OFFSIDES
120	Cirrhosis			OFFSIDES
121	Coagulation factor V level decreased			OFFSIDES
122	Cold sweat	Canada Vigilance: 1		Canada Vigilance
123	Concomitant disease progression			OFFSIDES
124	Confabulation			OFFSIDES
125	Congenital renal cyst			OFFSIDES
126	Conjunctival xerosis			SIDER
127	Conjunctivitis			SIDER
128	Creatinine renal clearance decreased			OFFSIDES
129	Creutzfeldt-Jakob disease			OFFSIDES
130	Cystocele			OFFSIDES
131	Cytolytic hepatitis			OFFSIDES
132	Dehydration			OFFSIDES
133	Demyelination			OFFSIDES
134	Depression suicidal			OFFSIDES
135	Dermatitis			SIDER
136	Device interaction			OFFSIDES
137	Discomfort			SIDER
138	Disease recurrence			OFFSIDES
139	Disorientation			SIDER
140	Dizziness	Canada Vigilance: 3		Canada Vigilance SIDER
141	Drowsiness			SIDER
142	Drug Eruptions		17659030	CTD
143	Duodenitis			OFFSIDES
144	Dyslogia			OFFSIDES
145	Dyspepsia			SIDER
146	Dysphemia			OFFSIDES
147	Dystonia			OFFSIDES
148	Dysuria			SIDER
149	Economic problem			OFFSIDES
150	Eczema			OFFSIDES
151	Ejection Fraction Decreased			OFFSIDES
152	Electrocardiogram repolarisation abnormality			OFFSIDES
153	Enzyme abnormality			OFFSIDES
154	Eosinophilic myocarditis			OFFSIDES
155	Epididymitis			OFFSIDES
156	Erectile dysfunction			SIDER
157	Erysipelas			OFFSIDES
158	Erythema Multiforme			OFFSIDES
159	Erythropenia			OFFSIDES
160	Eschar			OFFSIDES
161	Euphoric mood			OFFSIDES
162	Extremity contracture			OFFSIDES
163	Eye pain			SIDER
164	Fatigue			SIDER
165	Fatty Liver			OFFSIDES
166	Flatulence			OFFSIDES SIDER
167	Flushing	Canada Vigilance: 1		Canada Vigilance SIDER
168	Food Allergy			OFFSIDES
169	Formication			OFFSIDES
170	Gait inability	Canada Vigilance: 2		Canada Vigilance
171	Gamma-Glutamyltransferase Increased			OFFSIDES
172	Gammopathy			OFFSIDES
173	Gangrene			OFFSIDES
174	Gastric ulcer			OFFSIDES
175	Gastroenteritis			OFFSIDES
176	Gastrointestinal Pain			SIDER
177	Gastrointestinal mucosal disorder			OFFSIDES
178	Gastrointestinal ulcer			OFFSIDES
179	General physical health deterioration			OFFSIDES
180	Globulinuria			OFFSIDES
181	Glomerulonephritis			OFFSIDES
182	Granulocytopenia neonatal			OFFSIDES
183	Granulocytosis			OFFSIDES
184	Haematotoxicity			OFFSIDES
185	Heart Block		507735 3943932 6542785	CTD
186	Heart Diseases		6542785	CTD
187	Heartburn			SIDER
188	Heparin-induced thrombocytopenia			OFFSIDES
189	Hepatitis A			OFFSIDES
190	Hepatitis C			OFFSIDES
191	Hepatitis			OFFSIDES
192	Hepatojugular reflux			OFFSIDES
193	Hepatosplenomegaly			OFFSIDES
194	Hyaluronic acid increased			OFFSIDES
195	Hydronephrosis			OFFSIDES
196	Hyperosmolar state			OFFSIDES
197	Hyperparathyroidism			OFFSIDES
198	Hyperventilation			OFFSIDES
199	Hypotension		28810 6542785	CTD SIDER
200	Hypothermia neonatal			OFFSIDES
201	Hypoxia			OFFSIDES
202	Impetigo			OFFSIDES
203	Inappropriate affect			OFFSIDES
204	Increased bronchial secretion			OFFSIDES
205	Intermittent Claudication			SIDER
206	Intraductal papilloma of breast			OFFSIDES
207	Joint stiffness	Canada Vigilance: 1		Canada Vigilance
208	Keratitis sicca			OFFSIDES
209	Kidney Failure			OFFSIDES
210	Klebsiella sepsis			OFFSIDES
211	Laryngospasm			SIDER
212	Lethargy			SIDER
213	Leukostasis			OFFSIDES
214	Lightheadedness			SIDER
215	Limb discomfort			OFFSIDES
216	Lipase decreased			OFFSIDES
217	Lipase			OFFSIDES
218	Lipodystrophy acquired			OFFSIDES
219	Locked-In Syndrome			OFFSIDES
220	Low Cardiac Output Syndrome			OFFSIDES
221	Lupus-like syndrome			OFFSIDES SIDER
222	Lyme Disease			OFFSIDES
223	Lymphocele			OFFSIDES
224	Malaise			SIDER
225	Medical device change			OFFSIDES
226	Meningeal disorder			OFFSIDES
227	Milk Allergy			OFFSIDES
228	Mononeuritis			OFFSIDES
229	Mood swings			SIDER
230	Motor retardation			OFFSIDES
231	Muscle necrosis			OFFSIDES
232	Musculoskeletal discomfort			SIDER
233	Mutism			OFFSIDES
234	Myalgia			SIDER
235	Myasthenia Gravis		2269319	CTD
236	Mycobacterium chelonei infection			OFFSIDES
237	Myocardial Ischemia		6890361	CTD
238	Myoclonic Epilepsy			OFFSIDES
239	Nephrolithiasis			OFFSIDES
240	Nephrotic Syndrome			OFFSIDES
241	Neuralgia			OFFSIDES
242	Nocturia			SIDER
243	Nutritional condition abnormal			OFFSIDES
244	Obstruction			OFFSIDES
245	Oliguria			OFFSIDES
246	Optic Neuropathy			OFFSIDES
247	Oropharyngeal discomfort			SIDER
248	Oropharyngeal pain			SIDER
249	Orthopnea			OFFSIDES
250	Otosclerosis			OFFSIDES
251	Ototoxicity			OFFSIDES
252	Overdose			OFFSIDES
253	Pain			SIDER
254	Pallor	Canada Vigilance: 1		Canada Vigilance OFFSIDES
255	Panic Disorder			OFFSIDES
256	Paradoxical drug reaction			OFFSIDES
257	Pelvic Floor Muscle Weakness			OFFSIDES
258	Pemphigus			OFFSIDES
259	Perianal abscess			OFFSIDES
260	Peritonitis			OFFSIDES
261	Personality Change			OFFSIDES
262	Pharyngitis			SIDER
263	Pharyngolaryngeal Pain			OFFSIDES
264	Phlebitis			OFFSIDES
265	Pierre Robin Syndrome			OFFSIDES
266	Pleuritic pain			SIDER
267	Pneumonia			SIDER
268	Polymyositis			OFFSIDES
269	Post procedural bile leak			OFFSIDES
270	Prothrombin level decreased			OFFSIDES
271	Prothrombin time abnormal			OFFSIDES
272	Prothrombin time ratio decreased			OFFSIDES
273	Pruritus			SIDER
274	Pseudomonal sepsis			OFFSIDES
275	Purpura	Canada Vigilance: 1		Canada Vigilance
276	Pyelonephritis			OFFSIDES
277	Pyonephrosis			OFFSIDES
278	Rash erythematous	Canada Vigilance: 1		Canada Vigilance SIDER
279	Rectosigmoid cancer			OFFSIDES
280	Reflex Sympathetic Dystrophy			OFFSIDES
281	Renal Artery Stenosis			OFFSIDES
282	Respiratory distress			SIDER
283	Retinal Vein Occlusion			OFFSIDES
284	Rhinitis			OFFSIDES SIDER
285	Scotoma			OFFSIDES
286	Septic Shock			OFFSIDES
287	Shivering			SIDER
288	Sick Sinus Syndrome			OFFSIDES
289	Sinoatrial Block			OFFSIDES
290	Sinus bradycardia			OFFSIDES
291	Skin necrosis			OFFSIDES
292	Skin test negative			OFFSIDES
293	Skin tightness			OFFSIDES
294	Somnolence	Canada Vigilance: 1		Canada Vigilance SIDER
295	Stridor			OFFSIDES
296	Subileus			OFFSIDES
297	Sweating			SIDER
298	Syncope			SIDER
299	Tachycardia, Ventricular		10465245	CTD
300	Therapeutic procedure			OFFSIDES
301	Therapeutic response unexpected	Canada Vigilance: 3		Canada Vigilance
302	Thrombocytopenic purpura			SIDER
303	Tinnitus			SIDER
304	Tonic clonic movements			OFFSIDES
305	Toxic Optic Neuropathy			OFFSIDES
306	Transaminases increased			OFFSIDES
307	Unemployment			OFFSIDES
308	Urine arsenic increased			OFFSIDES
309	Urticaria			SIDER
310	Vasculitis, Leukocytoclastic, Cutaneous		70680 17659030	CTD
311	Ventricular Fibrillation		4850183	CTD
312	Ventricular hypokinesia			OFFSIDES
313	Vertigo	Canada Vigilance: 1		Canada Vigilance SIDER
314	Visual Impairment			SIDER
315	Visual disturbance			OFFSIDES SIDER
316	Vitamin A Deficiency			OFFSIDES
317	Vomiting	Canada Vigilance: 3		Canada Vigilance SIDER
318	Wheezing			SIDER
319	Xanthopsia			OFFSIDES
320	Xerosis			SIDER
321	angiogram			OFFSIDES
322	muscle injury			OFFSIDES
323	nervous system disorder			SIDER

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