MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Formoterol Fumarate

(BPZSYCZIITTYBL-YJYMSZOUSA-N)

Structure

SMILES: O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O
Type(s): Approved; Investigational
Molecular Formula:: C19H24N2O4
Molecular Weight:: 344.405
Log P:: 3.3231
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 4
TPSA:: 90.82
CAS Number(s):: 67346-49-0; 73573-87-2

Synonym(s)

Formoterol Fumarate

3-Formylamino-4-hydroxy-alpha-(N-1-methyl-2-p-methoxyphenethylaminomethyl)benzyl alcohol.hemifumarate

Arformoterol

BD 40A

Eformoterol

Foradil

Formoterol

Formoterol Fumarate, ((R*,R*)-(+-))-isomer

Formoterol, ((R*,R*)-(+-))-isomer

10.

Oxis

External Link(s)

MeSH	D000068759
PubChem Compound	3083544
BindingDB	50151720
ChEBI	408174
CHEMBL	CHEMBL1363
DrugBank	DB01274
DrugCentral	4943
IUPHAR/BPS Guide to PHARMACOLOGY	7479
KEGG	dr:D07463
Therapeutic Target Database	D0P2AG D0E5FY D0D1DI
ZINC	2599970

Adverse Drug Event(s)

	Name	Number of Reports	Data Source
1	Drug ineffective	FAERS: 19	OFFSIDES US FAERS
2	Headache	FAERS: 10	SIDER US FAERS
3	Malaise	FAERS: 10	SIDER US FAERS
4	Foreign body aspiration	FAERS: 9	US FAERS
5	Angina Pectoris	FAERS: 7	SIDER US FAERS
6	Pneumonia	FAERS: 7	US FAERS
7	Back Pain	FAERS: 6	SIDER US FAERS
8	Device malfunction	FAERS: 6	OFFSIDES US FAERS
9	Expired product administered	FAERS: 6	US FAERS
10	Product storage error	FAERS: 6	US FAERS
11	Asthma	FAERS: 5	OFFSIDES SIDER US FAERS
12	Atrial Fibrillation	FAERS: 5	SIDER US FAERS
13	Chest Pain	FAERS: 5	SIDER US FAERS
14	Chest discomfort	FAERS: 5	US FAERS
15	Nausea	FAERS: 5	SIDER US FAERS
16	Tremor	FAERS: 5	SIDER US FAERS
17	Arthralgia	FAERS: 4	SIDER US FAERS
18	Myalgia	FAERS: 4	SIDER US FAERS
19	Pain	FAERS: 4	SIDER US FAERS
20	Peripheral swelling	FAERS: 4	US FAERS
21	Throat irritation	FAERS: 4	SIDER US FAERS
22	Aortic valve calcification	FAERS: 3	OFFSIDES US FAERS
23	Asthenia	FAERS: 3	SIDER US FAERS
24	Dizziness	FAERS: 3	SIDER US FAERS
25	Drug Tolerance	FAERS: 3	US FAERS
26	Fatigue	FAERS: 3	OFFSIDES SIDER US FAERS
27	Hypersensitivity	FAERS: 3	SIDER US FAERS
28	Left Ventricular Hypertrophy	FAERS: 3	US FAERS
29	Peripheral venous disease	FAERS: 3	US FAERS
30	Pruritus	FAERS: 3	SIDER US FAERS
31	Pulmonary congestion	FAERS: 3	OFFSIDES US FAERS
32	Respiratory tract congestion	FAERS: 3	OFFSIDES US FAERS
33	Right atrial dilatation	FAERS: 3	OFFSIDES US FAERS
34	Syncope	FAERS: 3	US FAERS
35	Accidental exposure to product	FAERS: 2	US FAERS
36	Agitation	FAERS: 2	SIDER US FAERS
37	Angioedema	FAERS: 2	OFFSIDES SIDER US FAERS
38	Anxiety	FAERS: 2	SIDER US FAERS
39	Blood glucose increased	FAERS: 2	US FAERS
40	Drug Dependence	FAERS: 2	US FAERS
41	Drug administration error	FAERS: 2	US FAERS
42	Drug dose omission	FAERS: 2	US FAERS
43	Dysphonia	FAERS: 2	OFFSIDES SIDER US FAERS
44	Eye irritation	FAERS: 2	US FAERS
45	Inappropriate schedule of drug administration	FAERS: 2	US FAERS
46	No adverse event	FAERS: 2	US FAERS
47	Product use in unapproved indication	FAERS: 2	US FAERS
48	Productive Cough	FAERS: 2	OFFSIDES US FAERS
49	Swelling	FAERS: 2	US FAERS
50	Wheezing	FAERS: 2	US FAERS
51	Wrong technique in product usage process	FAERS: 2	US FAERS
52	Abdominal Pain	FAERS: 1	SIDER US FAERS
53	Abdominal discomfort	FAERS: 1	US FAERS
54	Accidental overdose	FAERS: 1	US FAERS
55	Acne	FAERS: 1	US FAERS
56	Acute kidney injury	FAERS: 1	US FAERS
57	Ageusia	FAERS: 1	US FAERS
58	Alopecia	FAERS: 1	US FAERS
59	Aphonia	FAERS: 1	US FAERS
60	Arteriosclerosis	FAERS: 1	SIDER US FAERS
61	Arthritis	FAERS: 1	SIDER US FAERS
62	Atrial Flutter	FAERS: 1	SIDER US FAERS
63	Blood potassium decreased	FAERS: 1	US FAERS
64	Blood potassium increased	FAERS: 1	US FAERS
65	Blood urine present	FAERS: 1	US FAERS
66	Bronchitis	FAERS: 1	OFFSIDES SIDER US FAERS
67	Cardiac Arrest	FAERS: 1	US FAERS
68	Cataract	FAERS: 1	US FAERS
69	Cerebrovascular accident	FAERS: 1	US FAERS
70	Cheilitis	FAERS: 1	US FAERS
71	Choking sensation	FAERS: 1	OFFSIDES US FAERS
72	Coating in mouth	FAERS: 1	US FAERS
73	Dehydration	FAERS: 1	SIDER US FAERS
74	Delirium	FAERS: 1	US FAERS
75	Diabetes Mellitus	FAERS: 1	US FAERS
76	Discomfort	FAERS: 1	SIDER US FAERS
77	Drug dispensing error	FAERS: 1	US FAERS
78	Drug ineffective for unapproved indication	FAERS: 1	US FAERS
79	Drug prescribing error	FAERS: 1	US FAERS
80	Dry skin	FAERS: 1	SIDER US FAERS
81	Dysgeusia	FAERS: 1	OFFSIDES SIDER US FAERS
82	Dysgraphia	FAERS: 1	US FAERS
83	Dyspepsia	FAERS: 1	SIDER US FAERS
84	Dysuria	FAERS: 1	US FAERS
85	Epistaxis	FAERS: 1	US FAERS
86	Erythema	FAERS: 1	US FAERS
87	Essential Tremor	FAERS: 1	US FAERS
88	Euphoric mood	FAERS: 1	US FAERS
89	Exposure to toxic agent	FAERS: 1	US FAERS
90	Exposure via eye contact	FAERS: 1	US FAERS
91	Flank Pain	FAERS: 1	US FAERS
92	Fracture	FAERS: 1	US FAERS
93	Gastrointestinal Pain	FAERS: 1	SIDER US FAERS
94	Hyperventilation	FAERS: 1	US FAERS
95	Hypotension	FAERS: 1	SIDER US FAERS
96	Impaired work ability	FAERS: 1	US FAERS
97	Incorrect dose administered	FAERS: 1	US FAERS
98	Influenza	FAERS: 1	SIDER US FAERS
99	Intentional product misuse	FAERS: 1	US FAERS
100	Lethargy	FAERS: 1	US FAERS
101	Lip swelling	FAERS: 1	US FAERS
102	Lung perforation	FAERS: 1	US FAERS
103	Macular degeneration	FAERS: 1	US FAERS
104	Milk Allergy	FAERS: 1	US FAERS
105	Musculoskeletal Pain	FAERS: 1	US FAERS
106	Myasthenia Gravis	FAERS: 1	US FAERS
107	Myocardial Infarction	FAERS: 1	SIDER US FAERS
108	Nasopharyngitis	FAERS: 1	OFFSIDES SIDER US FAERS
109	Nervousness	FAERS: 1	SIDER US FAERS
110	Night sweats	FAERS: 1	US FAERS
111	Oral infection	FAERS: 1	US FAERS
112	Oral pain	FAERS: 1	US FAERS
113	Oropharyngeal pain	FAERS: 1	US FAERS
114	Oxygen saturation abnormal	FAERS: 1	US FAERS
115	Palpitations	FAERS: 1	SIDER US FAERS
116	Paranasal sinus hypersecretion	FAERS: 1	US FAERS
117	Poor quality sleep	FAERS: 1	US FAERS
118	Product packaging issue	FAERS: 1	US FAERS
119	Psoriasis	FAERS: 1	US FAERS
120	Pulmonary Fibrosis	FAERS: 1	US FAERS
121	Respiratory Failure	FAERS: 1	OFFSIDES US FAERS
122	Respiratory distress	FAERS: 1	US FAERS
123	Retching	FAERS: 1	US FAERS
124	Sinusitis	FAERS: 1	OFFSIDES SIDER US FAERS
125	Sneezing	FAERS: 1	US FAERS
126	Somnolence	FAERS: 1	SIDER US FAERS
127	Thermal burn	FAERS: 1	US FAERS
128	Tongue discomfort	FAERS: 1	US FAERS
129	Trichorrhexis	FAERS: 1	US FAERS
130	Weight decreased	FAERS: 1	US FAERS
131	Abdominal Infection		OFFSIDES
132	Abnormal vision		OFFSIDES SIDER
133	Abscess		SIDER
134	Acute Coronary Syndrome		OFFSIDES SIDER
135	Acute bronchitis		OFFSIDES SIDER
136	Acute respiratory failure		OFFSIDES
137	Acute sinusitis		SIDER
138	Alveolitis		OFFSIDES
139	Anaphylactic shock		SIDER
140	Aneurysm		OFFSIDES
141	Anhedonia		OFFSIDES
142	Antiphospholipid antibodies positive		OFFSIDES
143	Apathy		OFFSIDES
144	Appendicitis		OFFSIDES
145	Application site dryness		OFFSIDES
146	Arteriogram coronary abnormal		OFFSIDES
147	Arteritis		OFFSIDES
148	Atrioventricular Block		SIDER
149	Bacteria blood identified		OFFSIDES
150	Bacterial rhinitis		OFFSIDES
151	Bacterial test positive		OFFSIDES
152	Bladder pain		SIDER
153	Blood cortisol decreased		OFFSIDES
154	Blood creatine phosphokinase MB increased		OFFSIDES
155	Blood fibrinogen increased		OFFSIDES
156	Blood immunoglobulin E		OFFSIDES
157	Blood uric acid		OFFSIDES
158	Bone density decreased		OFFSIDES
159	Brain Concussion		OFFSIDES
160	Bronchial Fistula		OFFSIDES
161	Bronchial Obstruction		OFFSIDES
162	Bronchial irritation		OFFSIDES
163	Bronchiectasis		OFFSIDES
164	Bronchospasm		SIDER
165	Bulimia		OFFSIDES
166	COPD exacerbation		SIDER
167	Campylobacter infection		OFFSIDES
168	Cancer Pain		OFFSIDES
169	Carcinoma of lung		SIDER
170	Cardiac asthma		OFFSIDES
171	Cardiac enzymes increased		OFFSIDES
172	Cardiac infection		OFFSIDES
173	Cardioactive drug level increased		OFFSIDES
174	Catheter placement		OFFSIDES
175	Causalgia		OFFSIDES
176	Cerebral Amyloid Angiopathy		OFFSIDES
177	Cerebral Arteriosclerosis		OFFSIDES
178	Cerebral Infarction		SIDER
179	Cervical laser therapy		OFFSIDES
180	Chronic Obstructive Airway Disease		OFFSIDES
181	Chronic left ventricular failure		OFFSIDES
182	Circumoral paresthesia		SIDER
183	Circumstance or information capable of leading to medication error		OFFSIDES
184	Clostridium difficile colitis		OFFSIDES
185	Cold sweat		OFFSIDES
186	Colectomy		OFFSIDES
187	Complications of maternal exposure to therapeutic drugs		OFFSIDES
188	Concomitant disease progression		OFFSIDES
189	Conjunctival irritation		SIDER
190	Conjunctivitis		SIDER
191	Constipation		SIDER
192	Coronary artery embolism		OFFSIDES
193	Cramps of lower extremities		SIDER
194	Creatinine renal clearance increased		OFFSIDES
195	Crystalluria calcium		SIDER
196	Cystitis		SIDER
197	Deafness Neurosensory		OFFSIDES
198	Delusional perception		OFFSIDES
199	Dermatitis		SIDER
200	Device Failure		OFFSIDES
201	Device occlusion		OFFSIDES
202	Diabetes		OFFSIDES
203	Diabetic Nephropathy		OFFSIDES
204	Digitalis intoxication (NOS)		SIDER
205	Diverticulum		OFFSIDES
206	Drug effect delayed		OFFSIDES
207	Drug exposure during pregnancy		OFFSIDES
208	Drug exposure via breast milk		OFFSIDES
209	Drug toxicity		OFFSIDES
210	Dysmorphism		OFFSIDES
211	Dysphemia		OFFSIDES
212	Dyspnoea exacerbated		OFFSIDES
213	Echocardiogram abnormal		OFFSIDES
214	Economic problem		OFFSIDES
215	Eczema		OFFSIDES
216	Ejection Fraction Decreased		OFFSIDES
217	Embolism		OFFSIDES
218	Empyema		OFFSIDES
219	Endocarditis		OFFSIDES
220	Enterovesical Fistula		OFFSIDES
221	Eosinophil percentage increased		OFFSIDES
222	Epidural lipomatosis		OFFSIDES
223	Erosive gastritis		OFFSIDES
224	Erythema Nodosum		OFFSIDES
225	Exacerbation of asthma		SIDER
226	Excoriation		SIDER
227	Eye Redness		OFFSIDES
228	Fat necrosis		OFFSIDES
229	Fatty Liver		OFFSIDES
230	Feeding disorder neonatal		OFFSIDES
231	Feeling abnormal		SIDER
232	Foreign body trauma		OFFSIDES
233	Fundoscopy abnormal		OFFSIDES
234	Gastritis		SIDER
235	Gastroenteritis		OFFSIDES SIDER
236	General physical condition		OFFSIDES
237	General physical health deterioration		OFFSIDES
238	Glaucoma		OFFSIDES SIDER
239	Glycosuria		SIDER
240	Gout		SIDER
241	Granuloma		OFFSIDES
242	Hearing aid user		OFFSIDES
243	Hepatitis C		OFFSIDES
244	Hepatosplenomegaly		OFFSIDES
245	Hernia		OFFSIDES SIDER
246	Hilar lymphadenopathy		OFFSIDES
247	Hypercalciuria		SIDER
248	Hyperlipasaemia		OFFSIDES
249	Hypertensive heart disease		OFFSIDES
250	Hypokinesia		SIDER
251	Hypoxia		OFFSIDES
252	Ileitis		OFFSIDES
253	Implantable defibrillator insertion		OFFSIDES
254	Incorrect route of drug administration		OFFSIDES
255	Increased bronchial secretion		SIDER
256	Increased upper airway secretion		OFFSIDES
257	Increased viscosity of bronchial secretion		OFFSIDES
258	Infection		SIDER
259	Inflammation		SIDER
260	Infusion site swelling		OFFSIDES
261	Infusion site urticaria		OFFSIDES
262	Injection site pain		SIDER
263	Intention tremor		OFFSIDES
264	Intra-aortic balloon placement		OFFSIDES
265	Joint Range of Motion Decreased		OFFSIDES
266	Laryngospasm		OFFSIDES
267	Left atrial dilatation		OFFSIDES
268	Leukocytosis		SIDER
269	Lip erosion		OFFSIDES
270	Lipohypertrophy		OFFSIDES
271	Loose tooth		OFFSIDES
272	Lower respiratory tract infection		SIDER
273	Lung Abscess		OFFSIDES
274	Lymphatic system neoplasm		OFFSIDES
275	Lymphocyte percentage decreased		OFFSIDES
276	Malnutrition		SIDER
277	Mastication disorder		OFFSIDES
278	Medical device complication		OFFSIDES
279	Metabolic acidosis		SIDER
280	Mitral Valve Stenosis		OFFSIDES
281	Monoparesis		OFFSIDES
282	Motion Sickness		OFFSIDES
283	Mucosal erosion		OFFSIDES
284	Muscle Weakness		OFFSIDES
285	Muscle fibrosis		OFFSIDES
286	Musculoskeletal chest pain		OFFSIDES
287	Musculoskeletal discomfort		SIDER
288	Musculoskeletal stiffness		SIDER
289	Myoglobin blood increased		OFFSIDES
290	Neck stiffness		SIDER
291	Nephrolithiasis		SIDER
292	Nervous tension		OFFSIDES
293	Neurological examination abnormal		OFFSIDES
294	Nocturia		SIDER
295	Nuchal Rigidity		SIDER
296	Oral candidiasis		SIDER
297	Oral fungal infection		OFFSIDES
298	Oral pruritus		OFFSIDES
299	Osteopenia		OFFSIDES
300	Ovarian adenoma		OFFSIDES
301	Overweight		OFFSIDES
302	Parkinsonian rest tremor		OFFSIDES
303	Pedal pulse decreased		OFFSIDES
304	Pelvic Pain		SIDER
305	Percutaneous Coronary Intervention		OFFSIDES
306	Perianal abscess		OFFSIDES
307	Pericardial effusion		OFFSIDES
308	Pharmaceutical product complaint		OFFSIDES
309	Pharyngitis		SIDER
310	Pigmentary retinopathy		OFFSIDES
311	Placental Insufficiency		OFFSIDES
312	Pneumopericardium		OFFSIDES
313	Polyuria		OFFSIDES
314	Positron emission tomogram abnormal		OFFSIDES
315	Post procedural infection		OFFSIDES
316	Primary sequestrum		OFFSIDES
317	Pulmonary arterial hypertension		OFFSIDES
318	Pulmonary function test decreased		OFFSIDES
319	Pulmonary radiation injury		OFFSIDES
320	Pyuria		SIDER
321	Recall phenomenon		OFFSIDES
322	Regurgitation of food		OFFSIDES
323	Renal vein occlusion		OFFSIDES
324	Respiratory arrest		SIDER
325	Respiratory fume inhalation disorder		OFFSIDES
326	Respiratory tract infection fungal		OFFSIDES
327	Respiratory tract irritation		OFFSIDES
328	Retinal Degeneration		OFFSIDES
329	Rheumatoid Arthritis		SIDER
330	Rhinitis		OFFSIDES SIDER
331	Rhinolaryngitis		OFFSIDES
332	Rhinorrhea		OFFSIDES
333	Rhonchi		OFFSIDES
334	Saliva altered		OFFSIDES
335	Senile dementia		OFFSIDES
336	Septic Shock		OFFSIDES
337	Sinus rhythm		OFFSIDES
338	Skin Induration		OFFSIDES
339	Skin hypertrophy		OFFSIDES SIDER
340	Skin test positive		OFFSIDES
341	Skin tightness		OFFSIDES
342	Spinal fusion surgery		OFFSIDES
343	Splenic Infarction		OFFSIDES
344	Supraventricular tachycardia		SIDER
345	Surgical Stapling		OFFSIDES
346	Tachyarrhythmia		SIDER
347	Tachycardia		SIDER
348	Tension		SIDER
349	Tongue biting		OFFSIDES
350	Tonsillitis		SIDER
351	Tooth repair		OFFSIDES
352	Toxicity to various agents		SIDER
353	Tracheobronchitis		OFFSIDES SIDER
354	Transmission of an infectious agent via a medicinal product		OFFSIDES
355	Trauma		SIDER
356	Urinary bladder polyp		OFFSIDES
357	Urinary tract infection		SIDER
358	Urticaria		SIDER
359	Vaginal abscess		OFFSIDES
360	Vascular calcification		OFFSIDES
361	Vasculitic rash		OFFSIDES
362	Vasospasm		OFFSIDES
363	Viral upper respiratory tract infection		SIDER
364	Visual Impairment		SIDER
365	Vomiting		SIDER
366	Wound infection staphylococcal		OFFSIDES
367	muscle injury		OFFSIDES
368	nervous system disorder		SIDER

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