MetaADEDB 2.0 @ LMMD
Bisoprolol
(VHYCDWMUTMEGQY-UHFFFAOYSA-N)
Structure
SMILES
OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C
Type(s)
Approved
ATC code(s)
C07AB07; C07BB07; C07FB07; C07FX04; C09BX02
Molecular Formula:
C18H31NO4
Molecular Weight:
325.443
Log P:
2.7568
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
59.95
CAS Number(s):
66722-44-9
Synonym(s)
1.
Bisoprolol
2.
Bisoprolol Fumarate
3.
Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer
4.
Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer
5.
Bisoprolol Hydrochloride
6.
Bisoprolol Methanesulfonate Salt
7.
Bisoprolol, (+-)-Isomer
8.
Bisoprolol, (-)-Isomer
9.
Bisoprolol, Fumarate (1:1) Salt
10.
Bisoprolol, Fumarate (2:1) Salt
11.
CL-297939
12.
Concor
13.
EMD-33512
14.
CL 297939
15.
CL297939
16.
EMD 33512
17.
EMD33512
18.
Fumarate, Bisoprolol
19.
Hydrochloride, Bisoprolol
External Link(s)
MeSHD017298
PubChem Compound2405
BindingDB25751
ChEBI3127
CHEMBLCHEMBL645
DrugBankDB00612
DrugCentral380
IUPHAR/BPS Guide to PHARMACOLOGY7129
KEGGcpd:C06852
dr:D02342
Therapeutic Target DatabaseD0K3ZR
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1BradycardiaFAERS: 43
Canada Vigilance: 8
15662077
19903982
CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
2DizzinessFAERS: 39
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
3SyncopeFAERS: 29SIDER
US FAERS
4Atrial FibrillationFAERS: 24
Canada Vigilance: 3
21129714CTD
SIDER
Canada Vigilance
US FAERS
5FatigueFAERS: 22
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
6Feeling abnormalFAERS: 19
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
7MalaiseFAERS: 19
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
8NauseaFAERS: 19
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
9PalpitationsFAERS: 17SIDER
US FAERS
10AnxietyFAERS: 11
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
11HeadacheFAERS: 11
Canada Vigilance: 4
Canada Vigilance
SIDER
US FAERS
12HypotensionFAERS: 11
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
13AstheniaFAERS: 102967187CTD
SIDER
US FAERS
14Atrioventricular BlockFAERS: 10SIDER
US FAERS
15Product substitution issueFAERS: 10
Canada Vigilance: 1
Canada Vigilance
US FAERS
16TachycardiaFAERS: 10
Canada Vigilance: 2
2897299CTD
SIDER
Canada Vigilance
US FAERS
17UrticariaFAERS: 10SIDER
US FAERS
18Chest PainFAERS: 9
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
19Drug ineffectiveFAERS: 9
Canada Vigilance: 5
Canada Vigilance
US FAERS
20DeafnessFAERS: 7OFFSIDES
US FAERS
21Lower respiratory tract infectionFAERS: 7US FAERS
22OverdoseFAERS: 7US FAERS
23Basal cell carcinomaFAERS: 6US FAERS
24Cardiac ArrestFAERS: 6
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
25DiscomfortFAERS: 6SIDER
US FAERS
26Feeling ColdFAERS: 6SIDER
US FAERS
27LethargyFAERS: 6US FAERS
28Maternal exposure during pregnancyFAERS: 6US FAERS
29MyalgiaFAERS: 6SIDER
US FAERS
30Product quality issueFAERS: 6US FAERS
31Sinus bradycardiaFAERS: 6US FAERS
32SomnolenceFAERS: 6
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
33nervous system disorderFAERS: 6SIDER
US FAERS
34AmnesiaFAERS: 5
Canada Vigilance: 2
Canada Vigilance
US FAERS
35Angina PectorisFAERS: 52439788
2967185
CTD
US FAERS
36AngioedemaFAERS: 5
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
37ArthralgiaFAERS: 5SIDER
US FAERS
38ErythemaFAERS: 5SIDER
US FAERS
39PresyncopeFAERS: 5US FAERS
40StressFAERS: 5US FAERS
41Suicide attemptFAERS: 5US FAERS
42Trifascicular blockFAERS: 5US FAERS
43AsthmaFAERS: 4SIDER
US FAERS
44Autonomic nervous system imbalanceFAERS: 4US FAERS
45Limb discomfortFAERS: 4US FAERS
46LymphomaFAERS: 4US FAERS
47NephrolithiasisFAERS: 4US FAERS
48Ocular discomfortFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
49SepsisFAERS: 4US FAERS
50Skin tightnessFAERS: 4US FAERS
51Toxicity to various agentsFAERS: 4SIDER
US FAERS
52Urinary IncontinenceFAERS: 4US FAERS
53VitiligoFAERS: 4US FAERS
54Wrong patient received medicationFAERS: 4US FAERS
55Abdominal PainFAERS: 32967187CTD
SIDER
US FAERS
56Accidental overdoseFAERS: 3US FAERS
57Acute psychosisFAERS: 3US FAERS
58AlopeciaFAERS: 3
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
59ChokingFAERS: 3US FAERS
60DisorientationFAERS: 3SIDER
US FAERS
61General physical health deteriorationFAERS: 3OFFSIDES
US FAERS
62Live BirthFAERS: 3US FAERS
63Liver AbscessFAERS: 3US FAERS
64Metastatic NeoplasmFAERS: 3OFFSIDES
US FAERS
65MonoparesisFAERS: 3US FAERS
66PainFAERS: 3SIDER
US FAERS
67PneumoniaFAERS: 3SIDER
US FAERS
68PoisoningFAERS: 3US FAERS
69Skin UlcerFAERS: 3US FAERS
70Therapy non-responderFAERS: 3US FAERS
71TinnitusFAERS: 3OFFSIDES
SIDER
US FAERS
72Ventricular failureFAERS: 3US FAERS
73Visual ImpairmentFAERS: 3SIDER
US FAERS
74VomitingFAERS: 3SIDER
US FAERS
75Accidental exposure to productFAERS: 2US FAERS
76Acute kidney injuryFAERS: 215662077CTD
US FAERS
77AphasiaFAERS: 2SIDER
US FAERS
78Atrial tachycardiaFAERS: 2US FAERS
79Back PainFAERS: 2SIDER
US FAERS
80Cardiac FlutterFAERS: 2US FAERS
81Cerebrovascular accidentFAERS: 2US FAERS
82Contraindicated product prescribedFAERS: 2US FAERS
83DehydrationFAERS: 2US FAERS
84Depressed Level of ConsciousnessFAERS: 2OFFSIDES
US FAERS
85Drug administration errorFAERS: 2US FAERS
86Drug prescribing errorFAERS: 2US FAERS
87Drug withdrawal syndromeFAERS: 2US FAERS
88ErysipelasFAERS: 2OFFSIDES
US FAERS
89Heat StrokeFAERS: 2US FAERS
90Lacrimation decreasedFAERS: 2US FAERS
91Lung hyperinflationFAERS: 2US FAERS
92No adverse eventFAERS: 2US FAERS
93PolyhydramniosFAERS: 2US FAERS
94PolyuriaFAERS: 2SIDER
US FAERS
95Precancerous skin lesionFAERS: 2US FAERS
96Pulmonary HypertensionFAERS: 2OFFSIDES
US FAERS
97Reaction to drug excipientsFAERS: 2US FAERS
98Sinus TachycardiaFAERS: 2US FAERS
99StuporFAERS: 2US FAERS
100Ventricular arrhythmiaFAERS: 2US FAERS
101Acute respiratory failureFAERS: 1US FAERS
102AgitationFAERS: 1SIDER
US FAERS
103ApathyFAERS: 1US FAERS
104AphoniaFAERS: 1US FAERS
105AsphyxiaFAERS: 1OFFSIDES
US FAERS
106Bifascicular blockFAERS: 1US FAERS
107Bipolar I disorderFAERS: 1US FAERS
108Blood creatine phosphokinase MB increasedFAERS: 1US FAERS
109Blood creatinine increasedFAERS: 1US FAERS
110Carcinoma in situ of skinFAERS: 1US FAERS
111Charles Bonnet SyndromeFAERS: 1US FAERS
112Chest discomfortFAERS: 1US FAERS
113ChromatopsiaFAERS: 1US FAERS
114Chronotropic incompetenceFAERS: 1US FAERS
115Coma scale abnormalFAERS: 1US FAERS
116Contraindicated drug prescribedFAERS: 1US FAERS
117Deep Vein ThrombosisFAERS: 1US FAERS
118Drug DependenceFAERS: 1US FAERS
119Drug abuseFAERS: 1US FAERS
120Drug dispensing errorFAERS: 1US FAERS
121Drug exposure during pregnancyFAERS: 1US FAERS
122Dry skinFAERS: 1OFFSIDES
US FAERS
123DysgeusiaFAERS: 1SIDER
US FAERS
124DyspepsiaFAERS: 1SIDER
US FAERS
125DysphasiaFAERS: 1US FAERS
126DysphoniaFAERS: 1US FAERS
127DysuriaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
128Electrocardiogram abnormalFAERS: 1US FAERS
129Eye BurnsFAERS: 1US FAERS
130Eye irritationFAERS: 1US FAERS
131Eye painFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
132Fluid overloadFAERS: 1OFFSIDES
US FAERS
133FlushingFAERS: 1SIDER
US FAERS
134Foreign body sensation in eyesFAERS: 1US FAERS
135GlossitisFAERS: 1US FAERS
136HypersensitivityFAERS: 1SIDER
US FAERS
137HypospadiasFAERS: 1US FAERS
138IncontinenceFAERS: 1US FAERS
139Incorrect dose administeredFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
140LeukocytosisFAERS: 1US FAERS
141LeukopeniaFAERS: 1US FAERS
142LymphadenopathyFAERS: 1US FAERS
143Medication ErrorFAERS: 1US FAERS
144Mental impairmentFAERS: 1US FAERS
145Mental status changesFAERS: 1US FAERS
146Musculoskeletal PainFAERS: 1US FAERS
147MyocarditisFAERS: 1US FAERS
148NasopharyngitisFAERS: 1US FAERS
149NeuritisFAERS: 1US FAERS
150NeutropeniaFAERS: 1US FAERS
151PanniculitisFAERS: 1US FAERS
152Paradoxical drug reactionFAERS: 1US FAERS
153Patent ductus arteriosusFAERS: 1US FAERS
154Pericardial effusionFAERS: 1OFFSIDES
US FAERS
155Personality ChangeFAERS: 1US FAERS
156PregnancyFAERS: 1US FAERS
157Product packaging issueFAERS: 1US FAERS
158Product use in unapproved indicationFAERS: 1
Canada Vigilance: 2
Canada Vigilance
US FAERS
159PruritusFAERS: 1SIDER
US FAERS
160SarcoidosisFAERS: 1US FAERS
161SluggishnessFAERS: 1US FAERS
162SneezingFAERS: 1US FAERS
163SoporFAERS: 1US FAERS
164Spinal column injuryFAERS: 1US FAERS
165Stasis dermatitisFAERS: 1US FAERS
166Therapeutic response unexpectedFAERS: 1US FAERS
167Throat irritationFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
168ThrombocytopeniaFAERS: 1SIDER
US FAERS
169TremorFAERS: 1SIDER
US FAERS
170Troponin I increasedFAERS: 1US FAERS
171Vagus Nerve DisorderFAERS: 1US FAERS
172Ventricular FibrillationFAERS: 1SIDER
US FAERS
173Ventricular hypokinesiaFAERS: 1US FAERS
174VertigoFAERS: 1
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
175Abnormal visionSIDER
176AcheSIDER
177Acute Coronary SyndromeOFFSIDES
SIDER
178AgeusiaSIDER
179AgranulocytosisSIDER
180Alanine Aminotransferase IncreasedOFFSIDES
181AlveolitisOFFSIDES
182Anaphylactic shockCanada Vigilance: 1Canada Vigilance
183AngioplastyOFFSIDES
184AnosmiaSIDER
185Anticonvulsant drug level increasedOFFSIDES
186Aphthous StomatitisOFFSIDES
187Application site vesiclesOFFSIDES
188Arterial thrombosisSIDER
189ArthropathyOFFSIDES
SIDER
190Atrial thrombosisOFFSIDES
191BedriddenOFFSIDES
192Biliary cirrhosisOFFSIDES
193Bilirubin conjugated abnormalOFFSIDES
194Bladder painSIDER
195BlindnessCanada Vigilance: 1Canada Vigilance
196Blood creatine phosphokinase increasedOFFSIDES
197Blood sodiumOFFSIDES
198Blood triglycerides increasedSIDER
199Blood urea increasedOFFSIDES
200Bone painOFFSIDES
201BronchitisSIDER
202Bronchoalveolar lavage abnormalOFFSIDES
203BronchospasmCanada Vigilance: 1Canada Vigilance
SIDER
204Cardiomyopathies10410811CTD
205CatatoniaSIDER
206Choking sensationOFFSIDES
207CholelithotomyOFFSIDES
208Chronic left ventricular failureOFFSIDES
209Concomitant disease aggravatedOFFSIDES
210Concomitant disease progressionOFFSIDES
211Congenital tricuspid valve incompetenceOFFSIDES
212ConjunctivitisSIDER
213ConstipationSIDER
214Corneal abscessOFFSIDES
215CystitisSIDER
216Deafness NeurosensoryOFFSIDES
217DermatitisSIDER
218Diarrhea15662077CTD
OFFSIDES
219Disturbance in sexual arousalSIDER
220DrowsinessSIDER
221Dyspnea2967187CTD
222Ear and labyrinth disordersSIDER
223EczemaSIDER
224Ejection Fraction DecreasedOFFSIDES
225EmbolismOFFSIDES
SIDER
226EmpyemaOFFSIDES
227EnuresisOFFSIDES
228Epigastric pain not food-relatedSIDER
229EpistaxisCanada Vigilance: 1Canada Vigilance
OFFSIDES
230Erectile dysfunctionSIDER
231Extremity necrosisOFFSIDES
232FlatulenceCanada Vigilance: 1Canada Vigilance
OFFSIDES
233FractureSIDER
234Frustration tolerance decreasedCanada Vigilance: 1Canada Vigilance
235GangreneOFFSIDES
236GastritisSIDER
237GastroduodenitisOFFSIDES
238Gastrointestinal PainSIDER
239GoutOFFSIDES
SIDER
240Granulocyte count decreasedOFFSIDES
241Heart failure11336626
11835035
18528751
CTD
242Heparin-induced thrombocytopeniaOFFSIDES
243HepatitisOFFSIDES
SIDER
244HepatomegalySIDER
245Hormone level abnormalCanada Vigilance: 1Canada Vigilance
246Hypokalemia8098220
12795776
CTD
247HypoxiaOFFSIDES
248Ileal ulcerOFFSIDES
249Immunosuppressant drug levelOFFSIDES
250Incorrect drug administration durationOFFSIDES
251InfectionSIDER
252Intermittent ClaudicationSIDER
253Intestinal FistulaOFFSIDES
254Intestinal PerforationOFFSIDES
255Intestinal mucosal hypertrophyOFFSIDES
256IritisOFFSIDES
257Ischemia2967185CTD
258Joint swellingCanada Vigilance: 1Canada Vigilance
259Kidney FailureOFFSIDES
260Klebsiella sepsisOFFSIDES
261Lacrimation abnormal NOSSIDER
262LaryngospasmSIDER
263LeukoaraiosisOFFSIDES
264LividityOFFSIDES
265Long QT Syndrome14579055CTD
266Loose toothOFFSIDES
267Lung AbscessOFFSIDES
268MeningiomaOFFSIDES
269Migraine Disorders19708964CTD
270Mood swingsSIDER
271Multiple drug overdose intentionalOFFSIDES
272Muscle fibrosisOFFSIDES
273Musculoskeletal discomfortSIDER
274Myocardial Infarction21697605CTD
SIDER
275MyopericarditisOFFSIDES
276Neck PainSIDER
277Necrolysis epidermalSIDER
278Nephrotic SyndromeOFFSIDES
279NeuralgiaSIDER
280Non-cardiac chest painOFFSIDES
281Numbness of limbsSIDER
282Optic Disc EdemaOFFSIDES
283Optic NeuropathyOFFSIDES
284Oropharyngeal discomfortSIDER
285Oropharyngeal painSIDER
286OrthopneaOFFSIDES
287OsteolysisOFFSIDES
288PallorOFFSIDES
289ParesisSIDER
290Peptic UlcerSIDER
291Peripheral Vascular Diseases2967187CTD
292Peripheral swellingCanada Vigilance: 1Canada Vigilance
293PeritonitisOFFSIDES
294PharyngitisSIDER
295Pneumocystis jiroveci pneumoniaOFFSIDES
296Polymyalgia RheumaticaOFFSIDES
297Postoperative Complications21129714CTD
298Postural Orthostatic Tachycardia Syndrome11198485CTD
299PsoriasisSIDER
300PurpuraSIDER
301Quadriplegia15313766CTD
302RalesOFFSIDES
303Rash erythematousCanada Vigilance: 1Canada Vigilance
304Raynaud-like disorderSIDER
305Renal ColicSIDER
306Respiratory FailureOFFSIDES
SIDER
307Respiratory InsufficiencySIDER
308Respiratory distressSIDER
309ReticulocytosisOFFSIDES
310Retinal Artery OcclusionOFFSIDES
311Retinal pigment epithelial tearOFFSIDES
312RhabdomyolysisOFFSIDES
313RhinitisSIDER
314Ruptured cerebral aneurysmOFFSIDES
315SclerodermaSIDER
316ScotomaOFFSIDES
317Septic ShockOFFSIDES
318Serum triglycerides increasedSIDER
319ShockSIDER
320SinusitisSIDER
321Skin irritationSIDER
322Sleep Wake Disorders10527042CTD
323SpondylolysisOFFSIDES
324Stevens-Johnson SyndromeOFFSIDES
325StillbirthSIDER
326StridorSIDER
327SweatingSIDER
328Temperature intoleranceCanada Vigilance: 1Canada Vigilance
329Therapeutic product effect decreasedCanada Vigilance: 2Canada Vigilance
330Thrombocytopenic purpuraSIDER
331Torsades de Pointes14579055CTD
332Toxic Epidermal NecrolysisSIDER
333Transaminases increasedOFFSIDES
334Upper respiratory tract inflammationOFFSIDES
335Urinary tract infectionSIDER
336Urination Disorders16225113CTD
337Urine output increasedSIDER
338Vascular purpuraSIDER
339VasculitisSIDER
340Venous thrombosis limbOFFSIDES
341Ventricular Dysfunction21273767CTD
342Ventricular Remodeling20668454CTD
343Visual disturbanceSIDER
344overdose effectSIDER
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.