MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Vinblastine

(JXLYSJRDGCGARV-XQKSVPLYSA-N)

Structure

SMILES: COc1cc2N(C)[C@@H]3[C@@]4(c2cc1[C@]1(C[C@@H]2CN(CCc5c1[nH]c1c5cccc1)C[C@](C2)(O)CC)C(=O)OC)CCN1[C@H]4[C@@]([C@H]([C@]3(O)C(=O)OC)OC(=O)C)(CC)C=CC1
Molecular Formula:: C46H58N4O9
Molecular Weight:: 810.974
Log P:: 3.9317
Hydrogen Bond Acceptor:: 12
Hydrogen Bond Donor:: 3
TPSA:: 154.1
CAS Number(s):: 865-21-4

Synonym(s)

Vinblastine

Vincaleukoblastine

Cellblastin

Lemblastine

Velban

Velbe

Vinblastin Hexal

Vinblastina Lilly

Vinblastine Sulfate

10.

Vinblastinsulfat-Gry

11.

Sulfate, Vinblastine

External Link(s)

MeSH	D014747
PubChem Compound	241903
BindingDB	227643
ChEBI	27375
CHEMBL	CHEMBL22969
KEGG	cpd:C07201 dr:D08675
ZINC	85555528

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Alopecia	FAERS: 2	5768441 11104554	CTD SIDER US FAERS
2	Abdominal Pain	FAERS: 1	4163141	CTD OFFSIDES SIDER US FAERS
3	Autonomic neuropathy	FAERS: 1		US FAERS
4	Constipation	FAERS: 1	4163141 11104554	CTD SIDER US FAERS
5	Intestinal Obstruction	FAERS: 1		US FAERS
6	Nerve injury	FAERS: 1		US FAERS
7	Neuralgia	FAERS: 1		OFFSIDES US FAERS
8	Abdominal Abscess			OFFSIDES
9	Abdominal discomfort			OFFSIDES
10	Acute Coronary Syndrome			SIDER
11	Acute left ventricular failure			OFFSIDES
12	Adenoiditis			OFFSIDES
13	Adnexa uteri mass			OFFSIDES
14	Agranulocytosis		3978656 7105387	CTD SIDER
15	Amniotic fluid volume decreased			OFFSIDES
16	Aneuploidy		28087838	CTD
17	Angina Pectoris		2456930	CTD SIDER
18	Anhidrosis			OFFSIDES
19	Anorexia			SIDER
20	Anosmia			OFFSIDES
21	Anti-GAD antibody			OFFSIDES
22	Apoptosis			OFFSIDES
23	Appendectomy			OFFSIDES
24	Arterial insufficiency			OFFSIDES
25	Arthralgia		5768441	CTD
26	Asthenia			SIDER
27	Atelectasis			OFFSIDES
28	Azoospermia			OFFSIDES
29	Bacterial sepsis			OFFSIDES
30	Band neutrophil count increased			OFFSIDES
31	Blindness, Cortical		6085288 7683015	CTD
32	Blood parathyroid hormone increased			OFFSIDES
33	Blood potassium increased			OFFSIDES
34	Body Temperature			OFFSIDES
35	Bone marrow toxicity			OFFSIDES
36	Bone pain			SIDER
37	Bradycardia		7636536	CTD
38	Bronchiolitis			OFFSIDES
39	Bronchoalveolar lavage abnormal			OFFSIDES
40	Budd-Chiari Syndrome		509400	CTD
41	Burning sensation			OFFSIDES
42	Cancer Pain			OFFSIDES
43	Carcinoma, Transitional Cell		1949449 11104554	CTD
44	Carcinoma		3686684 7105387	CTD
45	Catheter related complication			OFFSIDES
46	Catheter site erythema			OFFSIDES
47	Cellulitis			OFFSIDES SIDER
48	Central nervous system lesion			OFFSIDES
49	Cerebrovascular accident			SIDER
50	Chemotherapeutic drug level increased			OFFSIDES
51	Chest Pain		2467791	CTD
52	Chills		3091246	CTD
53	Choking sensation			OFFSIDES
54	Chondrosarcoma			OFFSIDES
55	Chronic peptic ulcer			SIDER
56	Circumstance or information capable of leading to medication error			OFFSIDES
57	Colorectal Neoplasms		18802399	CTD
58	Complete Hearing Loss			SIDER
59	Contact Dermatitis			OFFSIDES
60	Coronary Artery Disease		87274 6161700 6166992	CTD
61	Creatinine renal clearance decreased			OFFSIDES
62	Cytolytic hepatitis			OFFSIDES
63	Deafness			SIDER
64	Demyelination			OFFSIDES
65	Diarrhea		11104554	CTD
66	Diffuse Large B-Cell Lymphoma			OFFSIDES
67	Discomfort			SIDER
68	Disease complication			OFFSIDES
69	Disease recurrence			OFFSIDES
70	Diverticulum			OFFSIDES
71	Dizziness			SIDER
72	Drug Overdose		7105387	CTD
73	Drug exposure during pregnancy			OFFSIDES
74	Drug toxicity			OFFSIDES
75	Dysgerminoma		7683015	CTD
76	Dysmenorrhea			OFFSIDES
77	Dysphonia			OFFSIDES
78	Dystrophic calcification			OFFSIDES
79	Dysuria			OFFSIDES
80	Eczema			OFFSIDES
81	Erectile dysfunction		1690581	CTD
82	Erythema Infectiosum			OFFSIDES
83	Extravasation			SIDER
84	Facial Pain		4163141	CTD
85	Fanconi Syndrome			OFFSIDES
86	Fatigue			OFFSIDES
87	Fatty Liver			OFFSIDES
88	Feeling abnormal			OFFSIDES SIDER
89	Fever		3091246	CTD
90	Fibrinolysis			OFFSIDES
91	Gangrene		9415644	CTD
92	Gastrointestinal Pain			SIDER
93	Haematotoxicity			OFFSIDES
94	Head and Neck Neoplasms		6173125	CTD
95	Headache			SIDER
96	Heart failure		3091246 7636536	CTD
97	Hemolytic-Uremic Syndrome		7679450 8483557	CTD
98	Hepatic Vein Thrombosis			OFFSIDES
99	Hepatic Veno-Occlusive Disease		15591910	CTD
100	Hepatitis B Virus			OFFSIDES
101	Hepatitis		3091246	CTD
102	Histiocytosis haematophagic			OFFSIDES
103	Histiocytosis, Langerhans-Cell		12571475	CTD
104	Histoplasmosis			OFFSIDES
105	Hodgkin Disease		View details 509400 1329697 4163141 4301062 4336128 4688040 4821134 5013538 5768441 15922437 18180244 18501091	CTD
106	Hyperbilirubinemia		54212	CTD
107	Hypersensitivity			SIDER
108	Hypertension, Renovascular		6181679	CTD
109	Hypesthesia		1329697	CTD
110	Hypokalemia		3686684	CTD
111	Hyponatremia		3091246 7105387	CTD
112	Hypotension		3091246 7636536	CTD
113	Hypoxia			OFFSIDES
114	Idiosyncratic drug reaction			OFFSIDES
115	Ileus		5768441	CTD SIDER
116	Immunosuppression			OFFSIDES
117	Impetigo			OFFSIDES
118	Incision site infection			OFFSIDES
119	Infective spondylitis			OFFSIDES
120	Intervertebral Disc Degeneration			OFFSIDES
121	Ischemia		2456930 6168223	CTD
122	Joint sprain			OFFSIDES
123	Keratitis sicca			OFFSIDES
124	Kidney Diseases		2413982 6181679	CTD
125	Klebsiella sepsis			OFFSIDES
126	Leukopenia neonatal			OFFSIDES
127	Leukopenia		54212 3686684 5768441	CTD SIDER
128	Limb injury			OFFSIDES
129	Liver Cirrhosis, Experimental		25380136	CTD
130	Liver neoplasms		3686684	CTD
131	Malaise			SIDER
132	Malaria			OFFSIDES
133	Malignant neoplasm of spinal cord			OFFSIDES
134	Melanosis			OFFSIDES
135	Metastatic Neoplasm			OFFSIDES
136	Micronuclei, Chromosome-Defective		23249641 28833575	CTD
137	Migraine Disorders		2456930	CTD
138	Mononeuritis			OFFSIDES
139	Mouth Breathing			OFFSIDES
140	Movement Disorders		21494842	CTD
141	Mucormycosis			OFFSIDES
142	Muscle Cramp		5768441	CTD
143	Muscle Weakness		1329697 4301062	CTD
144	Muscle tightness			OFFSIDES
145	Musculoskeletal chest pain			OFFSIDES
146	Musculoskeletal discomfort			OFFSIDES
147	Musculoskeletal stiffness			OFFSIDES
148	Myelitis, Transverse		4688040	CTD
149	Myelocytosis			OFFSIDES
150	Myeloid maturation arrest			OFFSIDES
151	Myelosuppression			SIDER
152	Myocardial Infarction		6106802	CTD SIDER
153	Myocardial Ischemia		3708625	CTD
154	Nausea		3091246	CTD OFFSIDES SIDER
155	Neoplasm Metastasis		3686684	CTD
156	Neoplasms, Experimental		2188316	CTD
157	Neoplasms, Germ Cell and Embryonal		View details 1690581 2413982 2447295 2472472 2476531 6168223 12078977	CTD
158	Nephrogenic Fibrosing Dermopathy			OFFSIDES
159	Neuritis		5768441	CTD SIDER
160	Neurotoxicity Syndromes		3978656	CTD
161	Neutropenia	Canada Vigilance: 2	9256128 11104554 17378895	CTD Canada Vigilance
162	Neutropenic sepsis			OFFSIDES
163	Neutrophil count decreased			OFFSIDES
164	Numbness			SIDER
165	Nystagmus			SIDER
166	Oligohydramnios			OFFSIDES
167	Oliguria			OFFSIDES
168	Osteolysis			OFFSIDES
169	Pain		1329697 11104554	CTD OFFSIDES SIDER
170	Pallor			OFFSIDES
171	Pancreatic Neoplasm			OFFSIDES
172	Pancytopenia			SIDER
173	Papillary serous endometrial carcinoma			OFFSIDES
174	Paresis		1329697	CTD
175	Paresthesia		View details 1329697 2476531 4301062 5768441 11104554	CTD
176	Peptic Ulcer			SIDER
177	Performance status decreased			OFFSIDES
178	Peripheral Nervous System Diseases		View details 2476531 4301062 5768441 11104554	CTD
179	Peritonitis		4688040	CTD
180	Pharyngitis			SIDER
181	Phlebitis			SIDER
182	Photophobia			SIDER
183	Plasmacytosis			OFFSIDES
184	Pneumonia		54212	CTD
185	Pneumopericardium			OFFSIDES
186	Pneumothorax			OFFSIDES
187	Polyneuropathy			OFFSIDES
188	Post procedural hypothyroidism			OFFSIDES
189	Posterior Leukoencephalopathy Syndrome		12078977	CTD
190	Prostatic Neoplasms		4016795	CTD
191	Proteinuria		3091246	CTD
192	Pseudomonas Infections		4688040	CTD
193	Pulmonary Fibrosis		4688040	CTD
194	Pulmonary Hypertension			OFFSIDES
195	Pulmonary function test decreased			OFFSIDES
196	Pulmonary interstitial emphysema syndrome			OFFSIDES
197	Pulmonary toxicity			OFFSIDES
198	Purulent discharge			OFFSIDES
199	Radiation Pneumonitis			OFFSIDES
200	Raynaud Disease		View details 70274 77726 81878 1702313 2413982 2423995 2456930 2472472 6162955 6163385 6168223 6173125 6174061 6183087 6846998 9415644	CTD
201	Reflex, Abnormal		1329697 4301062	CTD
202	Relapsing Fever			OFFSIDES
203	Renal Artery Obstruction		6181679	CTD
204	Renal Artery Stenosis			OFFSIDES
205	Renal Insufficiency		3091246 11104554	CTD
206	Reticulocytopenia			OFFSIDES
207	Rhabdomyosarcoma		15591910	CTD
208	Sarcoidosis			OFFSIDES
209	Scleroderma			OFFSIDES
210	Seizures		6209833 7683015 12078977	CTD
211	Senile dementia			OFFSIDES
212	Sense of oppression			OFFSIDES
213	Sepsis pasteurella			OFFSIDES
214	Sepsis		4688040	CTD
215	Shoulder Pain			OFFSIDES
216	Sinus polyp			OFFSIDES
217	Sinusitis			OFFSIDES
218	Somatoform Disorder			OFFSIDES
219	Subcutaneous Emphysema			OFFSIDES
220	Superior Vena Cava Syndrome			OFFSIDES
221	Synovial Cyst			OFFSIDES
222	Teratocarcinoma		7420580	CTD
223	Testicular Neoplasms		View details 54212 70274 2447295 2456930 6174061 7105387 7420580	CTD
224	Therapy non-responder			OFFSIDES
225	Thrombocytopenia		54212 7105387	CTD SIDER
226	Thrombosis		7742194	CTD
227	Transmission of an infectious agent via a medicinal product			OFFSIDES
228	Treatment related secondary malignancy			OFFSIDES
229	Urethral Neoplasms		7742194	CTD
230	Vaginal Neoplasms		15577323	CTD
231	Vanishing bile duct syndrome			OFFSIDES
232	Vascular Diseases		6173125	CTD
233	Vascular encephalopathy			OFFSIDES
234	Vertigo			SIDER
235	Vomiting		3091246 8635092	CTD SIDER
236	Wound Infection			OFFSIDES
237	kyphosis			OFFSIDES
238	melanoma		View details 12374674 15577320 15577323 16248763 16432458 16809738 17761969 18176117 18332650 18505091 19459849	CTD

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