MetaADEDB 2.0 @ LMMD
Neomycin
(PGBHMTALBVVCIT-VCIWKGPPSA-N)
Structure
SMILES
OC[C@H]1O[C@H]([C@@H]([C@@H]1O[C@H]1O[C@@H](CN)[C@H]([C@@H]([C@H]1N)O)O)O)O[C@@H]1[C@@H](O)[C@H](N)C[C@@H]([C@H]1O[C@H]1O[C@H](CN)[C@H]([C@@H]([C@H]1N)O)O)N
Type(s)
Approved
ATC code(s)
D09AA01; R01AX08; S01AA07
Molecular Formula:
C23H46N6O13
Molecular Weight:
614.644
Log P:
-4.6935
Hydrogen Bond Acceptor:
19
Hydrogen Bond Donor:
13
TPSA:
353.11
CAS Number(s):
119-04-0; 1404-04-2; 11004-65-2
Synonym(s)
1.
Neomycin
2.
Fradiomycin Sulfate
3.
Neomycin Palmitate
4.
Neomycin Sulfate
External Link(s)
MeSHD009355
PubChem Compound8378
BindingDB19
ChEBI7508
CHEMBLCHEMBL184618
DrugBankDB00452
DrugCentral1896
IUPHAR/BPS Guide to PHARMACOLOGY709
KEGGcpd:C01737
dr:D05140
Therapeutic Target DatabaseD0RD0N
D05JNI
ZINC71928291
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1HypersensitivityFAERS: 3
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
2DeafnessFAERS: 2
Canada Vigilance: 1

View details

65671
312051
436029
646445
812603
938230
965261
2419818
2860376
3372368
4382091
4590103
4761050
5028411
5410647
5455989
5548981
5551880
5681689
5771781
6282040
7551886
7744715
8040097
8371390
9669013
15372491
16680765
18590947
19902297
23429292
 		CTD
OFFSIDES
Canada Vigilance
US FAERS
3ErythemaFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
4PainFAERS: 2
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
5TinnitusFAERS: 2

View details

3360820
6491505
7551886
15318963
 		CTD
OFFSIDES
US FAERS
6UrticariaFAERS: 2
Canada Vigilance: 2		Canada Vigilance
US FAERS
7Adverse eventFAERS: 1US FAERS
8Application site rashFAERS: 1US FAERS
9AstheniaFAERS: 1
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
US FAERS
10Auricular swellingFAERS: 1US FAERS
11CellulitisFAERS: 1OFFSIDES
US FAERS
12DermatitisFAERS: 1
Canada Vigilance: 4		Canada Vigilance
US FAERS
13DiscomfortFAERS: 1US FAERS
14Ear discomfortFAERS: 1US FAERS
15Emotional distressFAERS: 1US FAERS
16Eustachian tube disorderFAERS: 1US FAERS
17FlushingFAERS: 1US FAERS
18LacerationFAERS: 1US FAERS
19NauseaFAERS: 1
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
20Product use in unapproved indicationFAERS: 1US FAERS
21VomitingFAERS: 1SIDER
US FAERS
22Abdominal PainOFFSIDES
23Abnormal visionOFFSIDES
24Acid refluxOFFSIDES
25AcneOFFSIDES
26Activated partial thromboplastin time shortenedOFFSIDES
27Acute kidney injuryCanada Vigilance: 1436029
938230
7391838		CTD
Canada Vigilance
28Acute prerenal failureOFFSIDES
29AdenomaOFFSIDES
30Alanine Aminotransferase IncreasedOFFSIDES
31Ammonia increasedOFFSIDES
32AmnesiaOFFSIDES
33AmphetaminesOFFSIDES
34Anaphylactic shockSIDER
35AngerOFFSIDES
36AnhedoniaOFFSIDES
37Anuria5681689CTD
38AnxietyOFFSIDES
39Arterial bypass operationOFFSIDES
40ArteriosclerosisOFFSIDES
41ArthritisOFFSIDES
42ArthropathyOFFSIDES
43AsterixisOFFSIDES
44AsthmaOFFSIDES
45AtelectasisOFFSIDES
46AuraOFFSIDES
47Basal cell carcinomaOFFSIDES
48Bladder prolapseOFFSIDES
49BlepharitisCanada Vigilance: 1Canada Vigilance
OFFSIDES
50BlepharoptosisOFFSIDES
51BlepharospasmOFFSIDES
52Blood GlucoseOFFSIDES
53Blood albumin decreasedOFFSIDES
54Blood amylase increasedOFFSIDES
55Blood cholesterolOFFSIDES
56Blood creatinine increasedOFFSIDES
57Blood glucose decreasedOFFSIDES
58Blood sodium increasedOFFSIDES
59Blood sodiumOFFSIDES
60Blood thyroid stimulating hormoneOFFSIDES
61Blood urea increasedOFFSIDES
62Bone fistulaOFFSIDES
63Brain Diseases5548981CTD
64Brain natriuretic peptide increasedOFFSIDES
65BronchopneumoniaOFFSIDES
66BruxismOFFSIDES
67Burning sensationCanada Vigilance: 1Canada Vigilance
68Cerebral atrophyOFFSIDES
69Chest PainOFFSIDES
70CholangiolitisOFFSIDES
71CirrhosisOFFSIDES
72Cochlear Diseases6282040CTD
73ConjunctivitisCanada Vigilance: 2Canada Vigilance
74Corneal ScarOFFSIDES
75Corneal UlcerOFFSIDES
76CyanosisOFFSIDES
77Cystitis6245359CTD
78DEAFNESS, AMINOGLYCOSIDE-INDUCED29292089CTD
79DebridementOFFSIDES
80DehydrationOFFSIDES
81DemyelinationOFFSIDES
82Depression suicidalOFFSIDES
83Dermatitis, Allergic Contact18383004CTD
84Device FailureOFFSIDES
85Diabetes mellitus inadequate controlOFFSIDES
86DiarrheaOFFSIDES
87DiverticulitisOFFSIDES
88DizzinessOFFSIDES
89DrowsinessOFFSIDES
90Drug Overdose5015918CTD
91Drug abuserOFFSIDES
92Drug addictOFFSIDES
93Drug withdrawal headacheOFFSIDES
94DyspepsiaOFFSIDES
95Dysthymic DisorderOFFSIDES
96Ear Diseases

View details

621488
646289
4094324
5440810
10821231
 		CTD
97Economic problemOFFSIDES
98EczemaCanada Vigilance: 1Canada Vigilance
99Emotional disorderOFFSIDES
100Empyema7356805CTD
101EncephalitisOFFSIDES
102EndophthalmitisOFFSIDES
103Enterococcal infectionOFFSIDES
104Escherichia infectionOFFSIDES
105Ethmoid sinus surgeryOFFSIDES
106ExophthalmosOFFSIDES
107Eye InfectionSIDER
108Eye irritationCanada Vigilance: 2Canada Vigilance
109Eye painCanada Vigilance: 1Canada Vigilance
110Femoral artery occlusionOFFSIDES
111Flat affectOFFSIDES
112Gamma-Glutamyltransferase IncreasedOFFSIDES
113Gastric ulcerOFFSIDES
114Gastrointestinal infectionOFFSIDES
115General physical conditionOFFSIDES
116GlaucomaSIDER
117Global AmnesiaOFFSIDES
118GoiterOFFSIDES
119Hearing Loss, High-Frequency3092343
7551886		CTD
120Hearing Loss

View details

3360820
3864349
6491505
6659116
8060454
8946832
9387991
13679429
15318963
 		CTD
121Helicobacter pylori identification test positiveOFFSIDES
122Hemorrhage6245359CTD
123Hepatic Encephalopathy5028411
5455989		CTD
124Hepatitis COFFSIDES
125Hyperalgesia2128375CTD
126Hyperammonemia11430560CTD
127Hypercholesterolemia2492189CTD
128Hypocalcemia646445CTD
129Hypokalemia646445CTD
130HypotensionCanada Vigilance: 1Canada Vigilance
131IncontinenceOFFSIDES
132InfectionOFFSIDES
SIDER
133Intention tremorOFFSIDES
134Intermittent ClaudicationOFFSIDES
135IridocyclitisOFFSIDES
136Keratitis siccaOFFSIDES
137Keratitis4232838CTD
138LaryngospasmOFFSIDES
139LegionellaOFFSIDES
140LethargyOFFSIDES
141LipaseOFFSIDES
142MalabsorptionSIDER
143Maxillofacial operationOFFSIDES
144Mediastinitis5548981CTD
145MeningiomaOFFSIDES
146Mental status changesOFFSIDES
147Metabolic acidosisOFFSIDES
148Metastatic NeoplasmOFFSIDES
149Micrographic skin surgeryOFFSIDES
150MucormycosisOFFSIDES
151Multi-organ disorderOFFSIDES
152Multiple drug overdoseOFFSIDES
153Muscle WeaknessOFFSIDES
154Musculoskeletal chest painOFFSIDES
155Neck PainCanada Vigilance: 1Canada Vigilance
156Necrosis5548981CTD
157NephrolithiasisOFFSIDES
158Nerve Degeneration

View details

3372368
6282040
9263032
9387991
10627579
13679429
 		CTD
159Nerve injurySIDER
160Neutropenic sepsisOFFSIDES
161Ocular Hypertension9227220CTD
162Optic NeuritisOFFSIDES
163Orbital infectionOFFSIDES
164Osteomyelitis621488CTD
OFFSIDES
165OsteopeniaOFFSIDES
166OsteoporosisOFFSIDES
167OtotoxicityCanada Vigilance: 1Canada Vigilance
SIDER
168Pancreatitis1134796
1227178		CTD
169Panic DisorderOFFSIDES
170ParophthalmiaOFFSIDES
171Pelvic abscessOFFSIDES
172PeritonitisOFFSIDES
173PlasmapheresisOFFSIDES
174PolydactylyOFFSIDES
175Polysubstance abuseOFFSIDES
176Post procedural complicationOFFSIDES
177Posterior subcapsular cataractSIDER
178Postoperative Complications9669013CTD
179Prenatal Exposure Delayed Effects6186586CTD
180Prescribed overdoseOFFSIDES
181Pressure Ulcer3360820CTD
182Prolapse repairOFFSIDES
183PruritusCanada Vigilance: 4Canada Vigilance
SIDER
184PsoriasisOFFSIDES
185PyelonephritisCanada Vigilance: 1Canada Vigilance
186Rash erythematousCanada Vigilance: 1Canada Vigilance
187Rectal ProlapseOFFSIDES
188Renal Insufficiency4590103
5015918
5548981		CTD
189Renal tubular necrosisOFFSIDES
190Respiratory DepressionCanada Vigilance: 1Canada Vigilance
191Respiratory FailureOFFSIDES
192Respiratory Insufficiency9669013CTD
193Retinal vascular occlusionOFFSIDES
194RetinitisOFFSIDES
195RhinitisCanada Vigilance: 1Canada Vigilance
196SchizophreniaOFFSIDES
197Self MutilationOFFSIDES
198Shoulder PainOFFSIDES
199Sinus antrostomyOFFSIDES
200Sinus operationOFFSIDES
201SinusitisCanada Vigilance: 1Canada Vigilance
OFFSIDES
202Skin lacerationOFFSIDES
203Somatosensory Disorders30626089CTD
204Staphylococcal impetigoOFFSIDES
205Surgical Wound Infection965261CTD
206SwellingSIDER
207SyncopeCanada Vigilance: 1Canada Vigilance
208Tetany646445CTD
209Tooth ExtractionOFFSIDES
210Toxic anterior segment syndromeOFFSIDES
211Tympanic Membrane PerforationOFFSIDES
212Unresponsive to stimuliOFFSIDES
213Urine sodium abnormalOFFSIDES
214Uterovaginal prolapseOFFSIDES
215Venoocclusive diseaseOFFSIDES
216VertigoCanada Vigilance: 22419818CTD
Canada Vigilance
217Vestibulocochlear Nerve Diseases5349292CTD
218Vulvovaginal discomfortOFFSIDES
219Weight decreasedCanada Vigilance: 1Canada Vigilance
220Wound decompositionOFFSIDES
221bone marrow fibrosisOFFSIDES
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