MetaADEDB 2.0 @ LMMD
Thiopental
(IUJDSEJGGMCXSG-UHFFFAOYSA-N)
Structure
SMILES
CCCC(C1(CC)C(=O)NC(=S)NC1=O)C
Type(s)
Approved; Vet_approved
ATC code(s)
N01AF03; N05CA19; N05CB01
Molecular Formula:
C11H18N2O2S
Molecular Weight:
242.338
Log P:
2.0075
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
90.29
CAS Number(s):
76-75-5
Synonym(s)
1.
Thiopental
2.
Penthiobarbital
3.
Thiomebumal
4.
Thiopentobarbital
5.
Bomathal
6.
Nesdonal
7.
Pentothal
8.
Pentothal Sodico
9.
Sodipental
10.
Thionembutal
11.
Thiopental Nycomed
12.
Thiopental Sodium
13.
Thiopentone
14.
Tiobarbital Braun
15.
Trapanal
External Link(s)
MeSHD013874
PubChem Compound3000715
BindingDB50058058
ChEBI102166
CHEMBLCHEMBL441
DrugBankDB00599
DrugCentral2633
IUPHAR/BPS Guide to PHARMACOLOGY2579
KEGGcpd:C07521
Therapeutic Target DatabaseD00MYT
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Abdominal AbscessOFFSIDES
2Abdominal sepsisOFFSIDES
3Accidental drug intake by childOFFSIDES
4Acidosis16242831
17369903		CTD
OFFSIDES
5Acute respiratory failureOFFSIDES
6Agranulocytosis9832294CTD
7AgraphiaOFFSIDES
8Air EmbolismOFFSIDES
9Angioedema1166949CTD
10AnisocoriaOFFSIDES
11Anticonvulsant drug level below therapeuticOFFSIDES
12Antipsychotic drug level below therapeuticOFFSIDES
13Antipsychotic drug level increasedOFFSIDES
14Apallic syndromeOFFSIDES
15Apnea

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352195
3500735
4025853
5792883
7102237
7352669
8881624
11261909
11263701
 		CTD
OFFSIDES
16Ataxia7900578CTD
17Atrial tachycardiaOFFSIDES
18Beta 2 microglobulin decreasedOFFSIDES
19Beta 2 microglobulin increasedOFFSIDES
20Blood creatine phosphokinase increasedOFFSIDES
21Blood creatinine increasedOFFSIDES
22Blood pH decreasedOFFSIDES
23Blood pressure fluctuationOFFSIDES
24Blood uric acid decreasedOFFSIDES
25Bone Marrow Diseases9832294CTD
26Bone marrow depressionOFFSIDES
27Bradycardia2873831CTD
OFFSIDES
28Brain Injuries1595344CTD
29Brain Ischemia

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8559304
10522791
10704975
16192539
 		CTD
30Brain scan abnormalOFFSIDES
31Bronchial ObstructionOFFSIDES
32Bulbar palsyOFFSIDES
33Cardiopulmonary BypassOFFSIDES
34Cell DeathOFFSIDES
35Chemotherapeutic drug level increasedOFFSIDES
36ChokingOFFSIDES
37CholangiolitisOFFSIDES
38ChromaturiaOFFSIDES
39Complex partial seizuresOFFSIDES
40ConfabulationOFFSIDES
41Congenital pyelocaliectasisOFFSIDES
42Cyanosis1897443
5550850		CTD
43Cytolytic hepatitisOFFSIDES
44Delayed Emergence from Anesthesia19583708CTD
45Delirium24068571CTD
46Device occlusionOFFSIDES
47Diarrhea7900578CTD
48Disorders of Excessive Somnolence7900578CTD
49Disseminated Intravascular Coagulation2917103CTD
50Drug Eruptions2974255
11792017		CTD
51Drug Overdose15337580
19583708		CTD
52Drug chemical incompatibilityOFFSIDES
53Drug exposure during pregnancyOFFSIDES
54Drug resistanceOFFSIDES
55Drug toxicityOFFSIDES
56Duodenal atresiaOFFSIDES
57DysphasiaOFFSIDES
58Dystonia9557916CTD
59Electrocardiogram ST-T changeOFFSIDES
60Enterococcal infectionOFFSIDES
61Erythema9052314CTD
OFFSIDES
62Fatigue7867110CTD
63Fluid imbalanceOFFSIDES
64Flushing9052314CTD
65Glasgow coma scaleOFFSIDES
66GranulocytosisOFFSIDES
67Headache7867110CTD
68Heart valve stenosisOFFSIDES
69HemiplegiaOFFSIDES
70Hepatic Encephalopathy2759548CTD
71Hepatic necrosisOFFSIDES
72Hepatitis AOFFSIDES
73HepatosplenomegalyOFFSIDES
74Histiocytosis haematophagicOFFSIDES
75HydrocephalusOFFSIDES
76HydronephrosisOFFSIDES
77Hyperalgesia9239313CTD
78Hyperammonemia16704891
18225757		CTD
79Hypercapnia16242831CTD
OFFSIDES
80Hyperkalemia6322557
12209290		CTD
81Hypocoagulable stateOFFSIDES
82Hypokalemia12209290CTD
83Hypotension

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1897443
2759548
2974255
5115033
5550850
7139398
7512805
10470387
11261909
17233371
19583708
20171707
 		CTD
84HypoxiaOFFSIDES
85Iatrogenic injuryOFFSIDES
86Ileus16704891CTD
87Incorrect route of drug administrationOFFSIDES
88Increased bronchial secretionOFFSIDES
89Infant, Premature, Diseases19583708CTD
90Intracranial Hypertension2759548
19646967		CTD
91Labile blood pressureOFFSIDES
92LacerationOFFSIDES
93Large intestine perforationOFFSIDES
94LaryngospasmOFFSIDES
95LethargyOFFSIDES
96Liver Failure, Acute16116121CTD
97Lung diseases16116121CTD
98Mechanical ventilationOFFSIDES
99Memory Disorders9357875CTD
100Metabolic acidosisOFFSIDES
101MicrostomiaOFFSIDES
102Mixed liver injuryOFFSIDES
103Mood Disorders7048840CTD
104Muscle Rigidity1931065
2575721
4350546		CTD
105Muscle Spasticity900439CTD
106Mycoplasma Infections10773494CTD
107Myoclonus19448237
20018300		CTD
108Myoglobin blood increasedOFFSIDES
109Nausea1961958CTD
110Necrosis5556860
16129983		CTD
111Nerve Degeneration9690874CTD
112Neurologic Manifestations19646967CTD
113NystagmusOFFSIDES
114Ocular Motility Disorders3977040CTD
115OliguriaOFFSIDES
116PCO2 decreasedOFFSIDES
117PCO2 increasedOFFSIDES
118Pain, Postoperative4696413
20018300		CTD
119Pain

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352195
1090014
1961959
7978145
8595686
10470387
15274426
16385651
18044291
20456060
 		CTD
120Peripheral Vascular Diseases3564823CTD
121Peritoneal DialysisOFFSIDES
122PeritonitisOFFSIDES
123Phlebitis4095143
6108669		CTD
124PolyuriaOFFSIDES
125Post procedural complicationOFFSIDES
126Postoperative Complications24068571CTD
127Postoperative Nausea and Vomiting

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4025853
4696413
7867110
7900578
 		CTD
128Procedural complicationOFFSIDES
129Procedural hypotensionOFFSIDES
130Propofol Infusion SyndromeOFFSIDES
131Prothrombin time ratio decreasedOFFSIDES
132Pulmonary HypertensionOFFSIDES
133Pulmonary congestionOFFSIDES
134Pulmonary vascular disorderOFFSIDES
135RalesOFFSIDES
136Refusal of treatment by relativeOFFSIDES
137Respiratory Aspiration9188120CTD
138Respiratory Insufficiency5115033CTD
139Respiratory Paralysis2893236CTD
140SclerodermaOFFSIDES
141Seizures

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444350
6422799
7634817
8251286
8413055
8434764
8936550
9427505
15616057
 		CTD
142Septic ShockOFFSIDES
143Sinus bradycardiaOFFSIDES
144Small intestine carcinomaOFFSIDES
145Soft Tissue Injuries5556860CTD
146Spasm3564823
4634748		CTD
147Status Epilepticus

View details

552491
16116121
17709190
19911151
20171707
 		CTD
OFFSIDES
148StridorOFFSIDES
149Stupor11226639CTD
150Substance Withdrawal Syndrome12209290CTD
151Tachycardia

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352195
1595920
1854047
2629043
2802216
5550850
 		CTD
152Tendon Injuries5556860CTD
153Thrombophlebitis

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4635835
4897470
6108669
6691878
 		CTD
154Thrombosis6108669CTD
155Torsades de Pointes12000977
15586745		CTD
156Torticollis3977040CTD
157ToxoplasmosisOFFSIDES
158Tryptase increasedOFFSIDES
159UrinomaOFFSIDES
160Urticaria11792017CTD
161Uterine InversionOFFSIDES
162Vascular Diseases16116121CTD
163Venous Thrombosis665951CTD
164Ventricular Fibrillation3777555CTD
OFFSIDES
165Ventricular hypokinesiaOFFSIDES
166Vocal Cord Paralysis9188120CTD
167anaphylaxis

View details

1166949
1897443
2917103
4654818
5550850
9105248
 		CTD
168effusionOFFSIDES
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