MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Physostigmine

(PIJVFDBKTWXHHD-HIFRSBDPSA-N)

Structure

SMILES: CNC(=O)Oc1ccc2c(c1)[C@]1(C)CCN([C@@H]1N2C)C
Type(s): Approved; Investigational
ATC code(s): S01EB05; V03AB19
Molecular Formula:: C15H21N3O2
Molecular Weight:: 275.346
Log P:: 2.1677
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 1
TPSA:: 44.81
CAS Number(s):: 57-47-6

Synonym(s)

Physostigmine

Eserine

External Link(s)

MeSH	D010830
PubChem Compound	5983
BindingDB	50004000 50222010 11023
ChEBI	27953
CHEMBL	CHEMBL94
DrugBank	DB00981
DrugCentral	2159
IUPHAR/BPS Guide to PHARMACOLOGY	6598
KEGG	cpd:C06535 dr:D00196
Therapeutic Target Database	D09JVV
ZINC	91689892

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Amnesia	View details 106402 1763119 7926587 8119309 9268086 9799963 16174677	CTD
2	Apnea	View details 1742831 6196992 6940962 7032671 7270862 31175885	CTD
3	Athetosis	8123277	CTD
4	Atrial Fibrillation	6871781 17453877	CTD
5	Atrioventricular Block	7001962	CTD
6	Bradycardia	View details 6148684 7001962 7018912 11740913 15741579 17453877	CTD SIDER
7	Brain Ischemia	8102038	CTD
8	Catalepsy	View details 40649 119254 1033567 3362916 6540616 6891961 9264077 10893700	CTD
9	Cataplexy	8008205	CTD
10	Chills	8202114	CTD
11	Chorea	4358998	CTD
12	Cocaine-Related Disorders	20393457	CTD
13	Cognition Disorders	11337201 14729117 28499986	CTD
14	Confusion	762851 1267895	CTD
15	Consciousness Disorders	242240	CTD
16	Delayed Emergence from Anesthesia	16905092	CTD
17	Delirium	View details 54535 241267 559431 2927404 3605428 4189068 4424019 5102638 6026788 6833524 7340135 8202114 12827117 15038335 16749552 20930599	CTD
18	Depressive disorder	7012883	CTD
19	Disorders of Excessive Somnolence	1267895 14999367	CTD
20	Drug Overdose	View details 6269268 6614520 7001962 11529713 12369036	CTD
21	Dyskinesia, Drug-Induced	4358998 8106150	CTD
22	Dystonia	1742831	CTD
23	Fever	8202114	CTD
24	Hallucinations	7497894	CTD
25	Huntington Disease	4358998	CTD
26	Hypokalemia	7497894	CTD
27	Hypotension, Orthostatic	1665057	CTD
28	Hypotension	7001962 8010419 17453877	CTD
29	Lethargy	762851	CTD
30	Mammary Neoplasms, Experimental	11401758	CTD
31	Memory Disorders	2083362 9040502	CTD
32	Mental disorders	11109424	CTD
33	Mood Disorders	40018	CTD
34	Motor Skills Disorders	30682440	CTD
35	Movement Disorders	20072119	CTD
36	Mydriasis	6892185 16104118	CTD
37	Myoclonus	View details 1620139 3808321 6890654 15038335	CTD
38	Nausea	40018 3354874	CTD SIDER
39	Neurologic Manifestations	11109424	CTD
40	Ophthalmoplegia	6890654 11975095	CTD
41	Organophosphate poisoning	30682440	CTD
42	Pain	19260335	CTD
43	Personality Disorders	145765 573894	CTD
44	Plant Poisoning	11109424	CTD
45	Poisoning	17157343 30176331	CTD
46	Postoperative Complications	1267895 5102638 7091735	CTD
47	Postoperative Nausea and Vomiting	17655781	CTD
48	Psychomotor Agitation	242240 6833524	CTD
49	Psychomotor Disorders	40018	CTD
50	Psychoses, Substance-Induced	1115577 4027811 7497894	CTD
51	Respiratory Insufficiency	7085965 14999367	CTD
52	Seizures	View details 1173100 6215091 6269268 6301005 6421394 6446956 6892185 8224101 11824763 15741579 17157343 22310180 23959147	CTD
53	Sialorrhea	8119309	CTD
54	Sleep Apnea Syndromes	16625567	CTD
55	Sleep Apnea, Obstructive	12958052	CTD
56	Speech Disorders	7497894	CTD
57	Status Epilepticus	2824229 7001962	CTD
58	Stupor	108720 470064 8202114	CTD
59	Substance Withdrawal Syndrome	8829152	CTD
60	Tachycardia, Ventricular	1787292	CTD
61	Tachycardia	View details 54535 3354874 3996883 4003595 11740913	CTD
62	Torsades de Pointes	11529713	CTD
63	Tremor	View details 2576144 2984330 3202815 3362916 4048228 4651776 6258692 6621715 6791238 6892185 7639639 8119309 8205054 10762688	CTD
64	Ventricular Fibrillation	5040657	CTD
65	Vomiting	40018 3354874	CTD SIDER
66	Xerostomia	16104118	CTD

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