MetaADEDB 2.0 @ LMMD
Chlorthalidone
(JIVPVXMEBJLZRO-UHFFFAOYSA-N)
Structure
SMILES
O=C1NC(c2c1cccc2)(O)c1ccc(c(c1)S(=O)(=O)N)Cl
Type(s)
Approved
ATC code(s)
C03BA04; C03BB04; C03EA06; G01AE10
Molecular Formula:
C14H11ClN2O4S
Molecular Weight:
338.766
Log P:
3.0341
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
3
TPSA:
117.87
CAS Number(s):
77-36-1
Synonym(s)
1.
Chlorthalidone
2.
Chlorphthalidolone
3.
Phthalamudine
4.
Chlortalidone
5.
Hygroton
6.
Oxodoline
7.
Thalitone
External Link(s)
MeSHD002752
PubChem Compound2732
BindingDB25900
ChEBI3654
CHEMBLCHEMBL1055
DrugBankDB00310
DrugCentral625
IUPHAR/BPS Guide to PHARMACOLOGY7147
KEGGdr:D00272
Therapeutic Target DatabaseD09NIA
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1AstheniaFAERS: 9
Canada Vigilance: 3		Canada Vigilance
OFFSIDES
SIDER
US FAERS
2DizzinessFAERS: 8
Canada Vigilance: 1		2700322CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
3SyncopeFAERS: 8
Canada Vigilance: 2		Canada Vigilance
US FAERS
4Drug ineffectiveFAERS: 7US FAERS
5HypotensionFAERS: 7US FAERS
6VomitingFAERS: 7
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
7NauseaFAERS: 6
Canada Vigilance: 3		Canada Vigilance
OFFSIDES
SIDER
US FAERS
8Abdominal PainFAERS: 4OFFSIDES
SIDER
US FAERS
9Blood potassium decreasedFAERS: 4OFFSIDES
US FAERS
10DehydrationFAERS: 4
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
11Acute kidney injuryFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
12Angle Closure GlaucomaFAERS: 3OFFSIDES
US FAERS
13Blood glucose increasedFAERS: 3US FAERS
14Blood sodium decreasedFAERS: 3US FAERS
15FatigueFAERS: 3OFFSIDES
US FAERS
16GoutFAERS: 3SIDER
US FAERS
17HeadacheFAERS: 3SIDER
US FAERS
18MyopiaFAERS: 3
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
19PainFAERS: 3US FAERS
20ArthralgiaFAERS: 2US FAERS
21Blood pressure inadequately controlledFAERS: 2OFFSIDES
US FAERS
22BradycardiaFAERS: 2OFFSIDES
US FAERS
23ConstipationFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
24Drug effect delayedFAERS: 2US FAERS
25DysuriaFAERS: 2US FAERS
26Erectile dysfunctionFAERS: 2
Canada Vigilance: 2		1224274
7427412
9039073		CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
27Feeling abnormalFAERS: 2OFFSIDES
US FAERS
28HypersensitivityFAERS: 2SIDER
US FAERS
29Musculoskeletal stiffnessFAERS: 2US FAERS
30PalpitationsFAERS: 2US FAERS
31Peripheral swellingFAERS: 2US FAERS
32Product substitution issueFAERS: 2US FAERS
33ThirstFAERS: 2US FAERS
34VertigoFAERS: 2SIDER
US FAERS
35Activities of daily living impairedFAERS: 1US FAERS
36AmnesiaFAERS: 1OFFSIDES
US FAERS
37Anaphylactic shockFAERS: 1US FAERS
38Blood creatinine increasedFAERS: 1US FAERS
39Blood electrolytes abnormalFAERS: 1US FAERS
40Blood glucose decreasedFAERS: 1OFFSIDES
US FAERS
41Blood magnesium decreasedFAERS: 1US FAERS
42Blood pH increasedFAERS: 1US FAERS
43Blood urea increasedFAERS: 1US FAERS
44Carbon dioxide decreasedFAERS: 1US FAERS
45Chest PainFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
46CystFAERS: 1US FAERS
47Depressed Level of ConsciousnessFAERS: 1US FAERS
48Drug DependenceFAERS: 1US FAERS
49Dry skinFAERS: 1US FAERS
50DysgeusiaFAERS: 1OFFSIDES
US FAERS
51DyspepsiaFAERS: 1US FAERS
52DysphoniaFAERS: 1US FAERS
53Eye painFAERS: 1US FAERS
54Feeling jitteryFAERS: 1US FAERS
55Head discomfortFAERS: 1US FAERS
56HypophagiaFAERS: 1OFFSIDES
US FAERS
57InfectionFAERS: 1US FAERS
58InfluenzaFAERS: 1US FAERS
59Intentional product misuseFAERS: 1US FAERS
60Intentional product use issueFAERS: 1US FAERS
61Intercepted product prescribing errorFAERS: 1US FAERS
62Irritable Bowel SyndromeFAERS: 1US FAERS
63Joint swellingFAERS: 1US FAERS
64LethargyFAERS: 1US FAERS
65Musculoskeletal PainFAERS: 1US FAERS
66MyalgiaFAERS: 1US FAERS
67OliguriaFAERS: 1OFFSIDES
US FAERS
68Oropharyngeal painFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
69PancreatitisFAERS: 1SIDER
US FAERS
70Personality ChangeFAERS: 1US FAERS
71Product dispensing errorFAERS: 1US FAERS
72Product prescribing errorFAERS: 1US FAERS
73Product solubility abnormalFAERS: 1US FAERS
74Product use in unapproved indicationFAERS: 1US FAERS
75PruritusFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
76Pulmonary EmbolismFAERS: 1US FAERS
77Reaction to drug excipientsFAERS: 1US FAERS
78Reflux gastritisFAERS: 1US FAERS
79RhabdomyolysisFAERS: 1OFFSIDES
US FAERS
80SwellingFAERS: 1US FAERS
81TachycardiaFAERS: 1790007
7137653		CTD
US FAERS
82Visual ImpairmentFAERS: 1US FAERS
83Weight decreasedFAERS: 1US FAERS
84nervous system disorderFAERS: 1US FAERS
85Abdominal discomfortOFFSIDES
SIDER
86Abdominal sepsisOFFSIDES
87ActinomycosisOFFSIDES
88Acute Coronary SyndromeOFFSIDES
89Acute myocardial infarctionOFFSIDES
90AdenocarcinomaOFFSIDES
91AgitationSIDER
92AgranulocytosisSIDER
93AlkalosisCanada Vigilance: 2Canada Vigilance
OFFSIDES
94AmyloidosisOFFSIDES
95Anaphylactoid ReactionCanada Vigilance: 1Canada Vigilance
96Angioedema16957427CTD
97Anorexia2602249
3115369		CTD
SIDER
98Anoxic EncephalopathyOFFSIDES
99Anticonvulsant drug level increasedOFFSIDES
100Antipsychotic drug level below therapeuticOFFSIDES
101Aphthous StomatitisOFFSIDES
102ApneaOFFSIDES
103Apparent deathOFFSIDES
104AppendicitisOFFSIDES
105Application site painOFFSIDES
106ArteriosclerosisOFFSIDES
107Arteriovenous graft thrombosisOFFSIDES
108ArthritisOFFSIDES
109AtelectasisOFFSIDES
110Atrial tachycardiaOFFSIDES
111Bacterial rhinitisOFFSIDES
112Benign NeoplasmOFFSIDES
113Blood GlucoseOFFSIDES
114Blood cholesterolOFFSIDES
115Blood potassium abnormalCanada Vigilance: 1Canada Vigilance
116Blood sodium abnormalCanada Vigilance: 1Canada Vigilance
117Blood sodiumOFFSIDES
118Blurred visionOFFSIDES
119Bone erosionOFFSIDES
120BronchopneumoniaOFFSIDES
121Cardiomegaly6241622CTD
122Cardiovascular Diseases10818057CTD
123CataractOFFSIDES
124Cauda Equina SyndromeOFFSIDES
125Central nervous system lesionOFFSIDES
126Central venous catheter removalOFFSIDES
127Cerebral atrophyOFFSIDES
128Cervical laser therapyOFFSIDES
129Chemical and Drug Induced Liver Injury2602249CTD
130Chemotherapeutic drug level increasedOFFSIDES
131Choking sensationOFFSIDES
132CholestasisSIDER
133ChondrectomyOFFSIDES
134Chronic left ventricular failureOFFSIDES
135Clostridium colitisOFFSIDES
136ColectomyOFFSIDES
137DebridementOFFSIDES
138Dental FistulaOFFSIDES
139DermatitisSIDER
140DiabetesOFFSIDES
141Diabetes Mellitus18981326CTD
SIDER
142Diabetic FootOFFSIDES
143DiarrheaOFFSIDES
144Disease ProgressionOFFSIDES
145Disorders of Excessive Somnolence1164125CTD
146Distress gastrointestinalSIDER
147DiverticulitisOFFSIDES
148DiverticulosisOFFSIDES
149DrowsinessOFFSIDES
150Drug withdrawal headacheOFFSIDES
151DuodenitisOFFSIDES
152Economic problemOFFSIDES
153Edema3115369
5124256		CTD
154Electrolyte imbalanceCanada Vigilance: 2Canada Vigilance
155Emotional distressOFFSIDES
156EndophthalmitisOFFSIDES
157Enterocutaneous FistulaOFFSIDES
158EosinophiliaSIDER
159Eosinophilic PneumoniaOFFSIDES
160Epigastric discomfortSIDER
161EpistaxisCanada Vigilance: 1Canada Vigilance
OFFSIDES
162Erythema2602249CTD
OFFSIDES
163Fatty LiverOFFSIDES
164Gastric irritationSIDER
165GastroenteritisCanada Vigilance: 1Canada Vigilance
166Gastrointestinal toxicityOFFSIDES
167General physical conditionOFFSIDES
168GlaucomaOFFSIDES
169GlycosuriaSIDER
170GranulocytosisOFFSIDES
171HoarsenessOFFSIDES
172Hyperaldosteronism1103606CTD
173Hypercalcemia650822
4406789		CTD
174HypercapniaOFFSIDES
175Hypercholesterolemia6869207CTD
176Hypertrichosis3836295
7137653		CTD
177Hypokalemia

View details

28952
29653
361988
697472
796642
883995
1686258
3546168
3704734
3894256
4041299
5108572
6366805
7158222
7332917
10818057
18981326
 		CTD
178Hyponatremia3704734
8440286		CTD
179Hypotension, Orthostatic1164125
2700322		CTD
180Intestinal PerforationOFFSIDES
181Joint ligament ruptureOFFSIDES
182Joint sprainOFFSIDES
183Joint stiffnessCanada Vigilance: 1Canada Vigilance
184Kidney FailureOFFSIDES
185LeukoaraiosisOFFSIDES
186Leukopenia neonatalOFFSIDES
187LeukopeniaSIDER
188Ligament ruptureOFFSIDES
189Limb operationOFFSIDES
190Lung InjuryOFFSIDES
191Malignant HypertensionOFFSIDES
192MastoiditisOFFSIDES
193Medical device implantationOFFSIDES
194MicroalbuminuriaOFFSIDES
195Microvascular AnginaOFFSIDES
196Multiple System AtrophyOFFSIDES
197Muscle Weakness1224274CTD
198Muscle necrosisOFFSIDES
199Muscle strainOFFSIDES
200Myasthenia GravisOFFSIDES
201MyelodysplasiaOFFSIDES
202Nephrogenic Diabetes InsipidusOFFSIDES
203Nephrotic SyndromeOFFSIDES
204Nervous tensionOFFSIDES
205NoduleOFFSIDES
206Non-cardiac chest painOFFSIDES
207Open woundOFFSIDES
208Oral mucosal petechiaeOFFSIDES
209Oropharyngeal candidiasisOFFSIDES
210OsteoporosisOFFSIDES
211PallorOFFSIDES
212PancytopeniaCanada Vigilance: 1Canada Vigilance
213Pericardial effusion3836295CTD
214PeriodontitisOFFSIDES
215Peripheral nerve lesionOFFSIDES
216PetechiaeCanada Vigilance: 1Canada Vigilance
217PneumothoraxOFFSIDES
218PolyuriaOFFSIDES
219Post procedural complicationOFFSIDES
220PresbyopiaOFFSIDES
221Proteinuria3115369CTD
222PurpuraSIDER
223RalesOFFSIDES
224Renal Insufficiency2602249
3546168		CTD
225Renal cystOFFSIDES
226Respiratory FailureOFFSIDES
227Rheumatic FeverOFFSIDES
228Septic arthritis staphylococcalOFFSIDES
229Skin tightnessOFFSIDES
230SnoringOFFSIDES
231SomnolenceCanada Vigilance: 1Canada Vigilance
232Spontaneous penile erectionOFFSIDES
233Stem cell transplantOFFSIDES
234Stomach acheSIDER
235StomatitisCanada Vigilance: 3Canada Vigilance
236Superior Vena Cava SyndromeOFFSIDES
237ThrombocytopeniaCanada Vigilance: 1Canada Vigilance
SIDER
238ThyroidectomyOFFSIDES
239Toe operationOFFSIDES
240Tooth LossOFFSIDES
241Torsades de Pointes1686258CTD
242Toxic Epidermal NecrolysisSIDER
243UrticariaSIDER
244Vascular purpuraSIDER
245VasculitisSIDER
246Ventricular hypokinesiaOFFSIDES
247Worsening of diabetesSIDER
248Wound infection staphylococcalOFFSIDES
249XanthopsiaSIDER
250Xerostomia1164125CTD
251jaundice2602249CTD
SIDER
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