Felodipine
(RZTAMFZIAATZDJ-UHFFFAOYSA-N)
Structure
- SMILES
- CCOC(=O)C1=C(C)NC(=C(C1c1cccc(c1Cl)Cl)C(=O)OC)C
- Type(s)
- Approved; Investigational
- ATC code(s)
- C07FB02; C08CA02; C09BB05
- Molecular Formula:
- C18H19Cl2NO4
- Molecular Weight:
- 384.254
- Log P:
- 4.2931
- Hydrogen Bond Acceptor:
- 5
- Hydrogen Bond Donor:
- 1
- TPSA:
- 64.63
- CAS Number(s):
- 72509-76-3; 105618-03-9; 119945-59-4
Synonym(s)
1.
Felodipine
2.
Agon
3.
Felo Biochemie
4.
Felo-Puren
5.
Felobeta
6.
Felocor
7.
Felodipin 1A Pharma
8.
Felodipin AL
9.
Felodipin AZU
10.
Felodipin AbZ
11.
Felodipin Dura
12.
Felodipin Heumann
13.
Felodipin Stada
14.
Felodipin Von Ct
15.
Felodipin-Ratiopharm
16.
Felodur
17.
Felogamma
18.
Fensel
19.
Flodil
20.
H 154-82
21.
Modip
22.
Munobal
23.
Perfudal
24.
Plendil
25.
Renedil
26.
Felo Puren
27.
Felodipin Ratiopharm
28.
H 154 82
29.
H 15482
30.
Heumann, Felodipin
31.
Von Ct, Felodipin
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Dizziness | FAERS: 22 Canada Vigilance: 4 | 1763537 8466725 11074327 | CTD OFFSIDES SIDER Canada Vigilance US FAERS |
| 2 | Drug ineffective | FAERS: 16 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 3 | Hypotension | FAERS: 14 | CTD US FAERS | |
| 4 | Fatigue | FAERS: 13 Canada Vigilance: 1 | 1763537 | CTD SIDER Canada Vigilance US FAERS |
| 5 | Headache | FAERS: 13 Canada Vigilance: 9 | CTD SIDER Canada Vigilance US FAERS | |
| 6 | Nausea | FAERS: 11 Canada Vigilance: 4 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 7 | Pruritus | FAERS: 11 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 8 | Anaphylactoid Reaction | FAERS: 10 | US FAERS | |
| 9 | Palpitations | FAERS: 9 Canada Vigilance: 3 | Canada Vigilance SIDER US FAERS | |
| 10 | Flushing | FAERS: 8 Canada Vigilance: 4 | CTD SIDER Canada Vigilance US FAERS | |
| 11 | Asthenia | FAERS: 7 | OFFSIDES SIDER US FAERS | |
| 12 | Hypersensitivity | FAERS: 6 | SIDER US FAERS | |
| 13 | Overdose | FAERS: 6 | US FAERS | |
| 14 | Accidental overdose | FAERS: 5 | US FAERS | |
| 15 | Chest discomfort | FAERS: 5 | US FAERS | |
| 16 | Erythema | FAERS: 5 | SIDER US FAERS | |
| 17 | Vertigo | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 18 | Vomiting | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 19 | Abasia | FAERS: 4 | US FAERS | |
| 20 | Anxiety | FAERS: 4 | OFFSIDES US FAERS | |
| 21 | Joint swelling | FAERS: 4 | SIDER US FAERS | |
| 22 | Pain | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 23 | Pharmaceutical product complaint | FAERS: 4 | US FAERS | |
| 24 | Tachycardia | FAERS: 4 Canada Vigilance: 3 | 2401128 8369003 8466725 | CTD SIDER Canada Vigilance US FAERS |
| 25 | Tremor | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 26 | Activities of daily living impaired | FAERS: 3 | US FAERS | |
| 27 | Adverse event | FAERS: 3 | US FAERS | |
| 28 | Atrial Fibrillation | FAERS: 3 | US FAERS | |
| 29 | Blood pressure fluctuation | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 30 | Bradycardia | FAERS: 3 | SIDER US FAERS | |
| 31 | Constipation | FAERS: 3 | SIDER US FAERS | |
| 32 | Drug administration error | FAERS: 3 | US FAERS | |
| 33 | Feeling abnormal | FAERS: 3 | SIDER US FAERS | |
| 34 | Intentional product misuse | FAERS: 3 | US FAERS | |
| 35 | Malaise | FAERS: 3 | US FAERS | |
| 36 | Mental impairment | FAERS: 3 | US FAERS | |
| 37 | Product substitution issue | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 38 | Swelling | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 39 | Syncope | FAERS: 3 | SIDER US FAERS | |
| 40 | Tinnitus | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 41 | Urinary Retention | FAERS: 3 | US FAERS | |
| 42 | Angina Pectoris | FAERS: 2 | 1763537 6613867 | CTD SIDER US FAERS |
| 43 | Blindness | FAERS: 2 | US FAERS | |
| 44 | Cerebrovascular accident | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 45 | Chills | FAERS: 2 | US FAERS | |
| 46 | Cyanosis | FAERS: 2 | US FAERS | |
| 47 | Diabetes Mellitus | FAERS: 2 | US FAERS | |
| 48 | Drug effect incomplete | FAERS: 2 | US FAERS | |
| 49 | Gingival Hyperplasia | FAERS: 2 | 8369003 | CTD SIDER US FAERS |
| 50 | Hypokinesia | FAERS: 2 | US FAERS | |
| 51 | Infarction | FAERS: 2 | US FAERS | |
| 52 | Metabolic acidosis | FAERS: 2 | US FAERS | |
| 53 | Myalgia | FAERS: 2 | SIDER US FAERS | |
| 54 | Oral cavity neoplasm surgery | FAERS: 2 | US FAERS | |
| 55 | Oropharyngeal pain | FAERS: 2 | US FAERS | |
| 56 | Renal tubular disorder | FAERS: 2 | US FAERS | |
| 57 | Sinoatrial Block | FAERS: 2 | US FAERS | |
| 58 | Suicide attempt | FAERS: 2 | US FAERS | |
| 59 | Thrombocytopenia | FAERS: 2 | US FAERS | |
| 60 | Visual Impairment | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 61 | Wrong technique in drug usage process | FAERS: 2 | OFFSIDES US FAERS | |
| 62 | Abdominal Compartment Syndrome | FAERS: 1 | US FAERS | |
| 63 | Abdominal Pain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 64 | Abdominal discomfort | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance SIDER US FAERS | |
| 65 | Accidental drug intake by child | FAERS: 1 | US FAERS | |
| 66 | Ageusia | FAERS: 1 | OFFSIDES US FAERS | |
| 67 | Agitation | FAERS: 1 | US FAERS | |
| 68 | Anaphylactic shock | FAERS: 1 | US FAERS | |
| 69 | Anger | FAERS: 1 | US FAERS | |
| 70 | Angioedema | FAERS: 1 | OFFSIDES SIDER US FAERS | |
| 71 | Anuria | FAERS: 1 | US FAERS | |
| 72 | Arthritis | FAERS: 1 | US FAERS | |
| 73 | Asphyxia | FAERS: 1 | US FAERS | |
| 74 | Atrioventricular Block | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 75 | Blood creatinine increased | FAERS: 1 | OFFSIDES US FAERS | |
| 76 | Blood potassium decreased | FAERS: 1 | OFFSIDES US FAERS | |
| 77 | Blood pressure inadequately controlled | FAERS: 1 | US FAERS | |
| 78 | Breast infection | FAERS: 1 | US FAERS | |
| 79 | Bronchitis | FAERS: 1 | SIDER US FAERS | |
| 80 | Burning sensation | FAERS: 1 | US FAERS | |
| 81 | Cardiac Flutter | FAERS: 1 | US FAERS | |
| 82 | Cardiac enzymes increased | FAERS: 1 | US FAERS | |
| 83 | Cardiomegaly | FAERS: 1 | US FAERS | |
| 84 | Carpal Tunnel Syndrome | FAERS: 1 | US FAERS | |
| 85 | Catatonia | FAERS: 1 | US FAERS | |
| 86 | Cerebral Arteriosclerosis | FAERS: 1 | US FAERS | |
| 87 | Cerebral circulatory failure | FAERS: 1 | US FAERS | |
| 88 | Chest Pain | FAERS: 1 | OFFSIDES SIDER US FAERS | |
| 89 | Choking | FAERS: 1 | US FAERS | |
| 90 | Chromaturia | FAERS: 1 | US FAERS | |
| 91 | Cluster Headache | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 92 | Cold sweat | FAERS: 1 | US FAERS | |
| 93 | Dehydration | FAERS: 1 | US FAERS | |
| 94 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 95 | Depressed mood | FAERS: 1 | US FAERS | |
| 96 | Disorientation | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 97 | Drug dose omission | FAERS: 1 | US FAERS | |
| 98 | Dysgeusia | FAERS: 1 | US FAERS | |
| 99 | Eczema | FAERS: 1 | US FAERS | |
| 100 | Epistaxis | FAERS: 1 | OFFSIDES SIDER US FAERS | |
| 101 | Eructation | FAERS: 1 | US FAERS | |
| 102 | Erythema Multiforme | FAERS: 1 | SIDER US FAERS | |
| 103 | Flatulence | FAERS: 1 | SIDER US FAERS | |
| 104 | Foreign body in respiratory tract | FAERS: 1 | US FAERS | |
| 105 | Gingival Hypertrophy | FAERS: 1 | US FAERS | |
| 106 | Gingival erythema | FAERS: 1 | US FAERS | |
| 107 | Gingivitis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 108 | Hydrocephalus | FAERS: 1 | US FAERS | |
| 109 | Ileus | FAERS: 1 | US FAERS | |
| 110 | Intentional drug misuse | FAERS: 1 | US FAERS | |
| 111 | Intentional product use issue | FAERS: 1 | US FAERS | |
| 112 | Intracranial Aneurysm | FAERS: 1 | US FAERS | |
| 113 | Joint injury | FAERS: 1 | US FAERS | |
| 114 | Left atrial dilatation | FAERS: 1 | US FAERS | |
| 115 | Lichen Planus | FAERS: 1 | US FAERS | |
| 116 | Limb discomfort | FAERS: 1 | US FAERS | |
| 117 | Loose tooth | FAERS: 1 | US FAERS | |
| 118 | Lupus-like syndrome | FAERS: 1 | US FAERS | |
| 119 | Mastication disorder | FAERS: 1 | US FAERS | |
| 120 | Medication residue | FAERS: 1 | US FAERS | |
| 121 | Merycism | FAERS: 1 | US FAERS | |
| 122 | Myocardial Infarction | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 123 | Oral pain | FAERS: 1 | US FAERS | |
| 124 | Pancytopenia | FAERS: 1 | US FAERS | |
| 125 | Pericardial effusion | FAERS: 1 | US FAERS | |
| 126 | Periodontitis | FAERS: 1 | US FAERS | |
| 127 | Peripheral swelling | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 128 | Peripheral venous disease | FAERS: 1 | US FAERS | |
| 129 | Photodermatosis | FAERS: 1 | US FAERS | |
| 130 | Polyuria | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 131 | Product quality issue | FAERS: 1 | US FAERS | |
| 132 | Protein total increased | FAERS: 1 | US FAERS | |
| 133 | Purpura | FAERS: 1 | US FAERS | |
| 134 | Rash erythematous | FAERS: 1 | US FAERS | |
| 135 | Sepsis | FAERS: 1 | US FAERS | |
| 136 | Sexual Dysfunction | FAERS: 1 | SIDER US FAERS | |
| 137 | Shock | FAERS: 1 | SIDER US FAERS | |
| 138 | Sinusitis | FAERS: 1 | SIDER US FAERS | |
| 139 | Skin Ulcer | FAERS: 1 | US FAERS | |
| 140 | Skin irritation | FAERS: 1 | US FAERS | |
| 141 | Somnolence | FAERS: 1 | SIDER US FAERS | |
| 142 | Subileus | FAERS: 1 | US FAERS | |
| 143 | Tension Headache | FAERS: 1 | OFFSIDES US FAERS | |
| 144 | Tension | FAERS: 1 | SIDER US FAERS | |
| 145 | Therapeutic response unexpected with drug substitution | FAERS: 1 | US FAERS | |
| 146 | Thirst | FAERS: 1 | US FAERS | |
| 147 | Tooth Loss | FAERS: 1 | US FAERS | |
| 148 | Urinary Incontinence | FAERS: 1 | US FAERS | |
| 149 | Urticaria | FAERS: 1 | SIDER US FAERS | |
| 150 | Vasculitis | FAERS: 1 | US FAERS | |
| 151 | Venous Insufficiency | FAERS: 1 | US FAERS | |
| 152 | Vertebrobasilar Insufficiency | FAERS: 1 | US FAERS | |
| 153 | Weight decreased | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 154 | Wrong drug administered | FAERS: 1 | US FAERS | |
| 155 | Wrong technique in product usage process | FAERS: 1 | US FAERS | |
| 156 | Acute myocardial infarction | OFFSIDES | ||
| 157 | Acute respiratory failure | OFFSIDES | ||
| 158 | Adrenal mass | OFFSIDES | ||
| 159 | Aldolase increased | OFFSIDES | ||
| 160 | Amphetamines | OFFSIDES | ||
| 161 | Angle Closure Glaucoma | OFFSIDES | ||
| 162 | Apathy | OFFSIDES | ||
| 163 | Aphthous Stomatitis | OFFSIDES | ||
| 164 | Arteriosclerosis | 18287887 | CTD | |
| 165 | Arthralgia | SIDER | ||
| 166 | Back Pain | SIDER | ||
| 167 | Benign Prostatic Hyperplasia | OFFSIDES | ||
| 168 | Bladder neck obstruction | OFFSIDES | ||
| 169 | Blepharospasm | OFFSIDES | ||
| 170 | Blood Glucose | OFFSIDES | ||
| 171 | Blood phosphorus decreased | OFFSIDES | ||
| 172 | Blood phosphorus increased | OFFSIDES | ||
| 173 | Blood potassium increased | OFFSIDES | ||
| 174 | Blood sodium | OFFSIDES | ||
| 175 | Blurred vision | OFFSIDES | ||
| 176 | Cardiac Arrest | Canada Vigilance: 1 | Canada Vigilance | |
| 177 | Cellulitis | OFFSIDES | ||
| 178 | Cerebral artery occlusion | OFFSIDES | ||
| 179 | Cholangiolitis | OFFSIDES | ||
| 180 | Cholecystitis | OFFSIDES | ||
| 181 | Chronic Obstructive Airway Disease | OFFSIDES | ||
| 182 | Chronic sinusitis | OFFSIDES | ||
| 183 | Circumstance or information capable of leading to medication error | OFFSIDES | ||
| 184 | Cirrhosis | OFFSIDES | ||
| 185 | Congenital tricuspid valve incompetence | OFFSIDES | ||
| 186 | Cyst | OFFSIDES | ||
| 187 | Deafness | OFFSIDES | ||
| 188 | Demyelination | OFFSIDES | ||
| 189 | Dental abscess | OFFSIDES | ||
| 190 | Dermatitis | SIDER | ||
| 191 | Device malfunction | OFFSIDES | ||
| 192 | Diabetes | OFFSIDES | ||
| 193 | Diabetic Foot | OFFSIDES | ||
| 194 | Diastolic dysfunction | OFFSIDES | ||
| 195 | Disturbance in sexual arousal | SIDER | ||
| 196 | Diverticulitis | OFFSIDES | ||
| 197 | Diverticulum | OFFSIDES | ||
| 198 | Duodenal ulcer perforation | OFFSIDES | ||
| 199 | Duodenitis | OFFSIDES | ||
| 200 | Dyspepsia | Canada Vigilance: 3 | Canada Vigilance SIDER | |
| 201 | Dysuria | SIDER | ||
| 202 | Edema | CTD | ||
| 203 | Endocarditis enterococcal | OFFSIDES | ||
| 204 | Erectile dysfunction | OFFSIDES SIDER | ||
| 205 | Erythema Nodosum | SIDER | ||
| 206 | Ethmoid sinus surgery | OFFSIDES | ||
| 207 | External ear pain | OFFSIDES | ||
| 208 | Eyelid Diseases | OFFSIDES | ||
| 209 | Facial Dermatoses | 11464208 | CTD | |
| 210 | Factor V deficiency | OFFSIDES | ||
| 211 | Febrile Neutropenia | OFFSIDES | ||
| 212 | Feeling Cold | SIDER | ||
| 213 | Feeling jittery | Canada Vigilance: 1 | Canada Vigilance | |
| 214 | Fibrosis | 18504504 | CTD | |
| 215 | Foot pain | SIDER | ||
| 216 | Gastrointestinal Pain | SIDER | ||
| 217 | Globulinuria | OFFSIDES | ||
| 218 | Glomerulonephritis | OFFSIDES | ||
| 219 | Gout | OFFSIDES | ||
| 220 | Granulocytosis | OFFSIDES | ||
| 221 | Heart failure | 1763537 | CTD | |
| 222 | Hepatomegaly | Canada Vigilance: 1 | Canada Vigilance | |
| 223 | Hernia | OFFSIDES | ||
| 224 | Hyperemia | 8369003 | CTD | |
| 225 | Hyperplasia | SIDER | ||
| 226 | Hypertension, Renovascular | 1614060 | CTD | |
| 227 | Hypertensive emergency | OFFSIDES | ||
| 228 | Iliac artery stenosis | OFFSIDES | ||
| 229 | Immunosuppressant drug level | OFFSIDES | ||
| 230 | Inappropriate schedule of drug administration | OFFSIDES | ||
| 231 | Influenza | SIDER | ||
| 232 | Intention tremor | OFFSIDES | ||
| 233 | Intervertebral Disc Degeneration | OFFSIDES | ||
| 234 | Joint Range of Motion Decreased | OFFSIDES | ||
| 235 | Kidney Failure | OFFSIDES | ||
| 236 | Knee pain | SIDER | ||
| 237 | Laceration | OFFSIDES | ||
| 238 | Lethargy | Canada Vigilance: 1 | Canada Vigilance | |
| 239 | Leukocytoclastic vasculitis | SIDER | ||
| 240 | Lichenification | OFFSIDES | ||
| 241 | Limb injury | OFFSIDES | ||
| 242 | Lymphedema | OFFSIDES | ||
| 243 | Lymphocele | OFFSIDES | ||
| 244 | Lymphoma | OFFSIDES | ||
| 245 | Malabsorption | Canada Vigilance: 2 | Canada Vigilance | |
| 246 | Malignant Hypertension | OFFSIDES | ||
| 247 | Malignant neoplasm progression | OFFSIDES | ||
| 248 | Mastectomy | OFFSIDES | ||
| 249 | Mitral valve sclerosis | OFFSIDES | ||
| 250 | Multiple drug overdose | OFFSIDES | ||
| 251 | Muscle Weakness | OFFSIDES | ||
| 252 | Musculoskeletal discomfort | SIDER | ||
| 253 | Musculoskeletal stiffness | OFFSIDES | ||
| 254 | Nasopharyngitis | OFFSIDES SIDER | ||
| 255 | Nephrogenic Fibrosing Dermopathy | OFFSIDES | ||
| 256 | Nephrolithiasis | OFFSIDES | ||
| 257 | Nervousness | SIDER | ||
| 258 | Neutropenic infection | OFFSIDES | ||
| 259 | Neutropenic sepsis | OFFSIDES | ||
| 260 | Nocturia | OFFSIDES | ||
| 261 | Oligospermia | Canada Vigilance: 1 | Canada Vigilance | |
| 262 | Oliguria | OFFSIDES | ||
| 263 | Osteopenia | OFFSIDES | ||
| 264 | PROTHROMBIN TIME | OFFSIDES | ||
| 265 | Parasomnia | OFFSIDES | ||
| 266 | Peritonitis | OFFSIDES | ||
| 267 | Pharyngitis | SIDER | ||
| 268 | Polyomavirus-associated nephropathy | OFFSIDES | ||
| 269 | Poverty | OFFSIDES | ||
| 270 | Product dose omission | Canada Vigilance: 1 | Canada Vigilance | |
| 271 | Pulmonary function test decreased | OFFSIDES | ||
| 272 | Rectal examination abnormal | OFFSIDES | ||
| 273 | Regurgitation | SIDER | ||
| 274 | Renal Artery Stenosis | OFFSIDES | ||
| 275 | Renal cyst | OFFSIDES | ||
| 276 | Renal tubular necrosis | OFFSIDES | ||
| 277 | Respiratory Failure | OFFSIDES | ||
| 278 | Retinal Artery Occlusion | OFFSIDES | ||
| 279 | Retinal cyst | OFFSIDES | ||
| 280 | Rhabdomyolysis | OFFSIDES | ||
| 281 | Rhinorrhea | OFFSIDES | ||
| 282 | Seizures | 9662735 | CTD | |
| 283 | Sensation of warmth | SIDER | ||
| 284 | Sinus antrostomy | OFFSIDES | ||
| 285 | Skin Induration | OFFSIDES | ||
| 286 | Skin hypertrophy | OFFSIDES | ||
| 287 | Skin laceration | OFFSIDES | ||
| 288 | Skin tightness | OFFSIDES | ||
| 289 | Sleep inertia | OFFSIDES | ||
| 290 | Sneezing | SIDER | ||
| 291 | Spondylolisthesis | OFFSIDES | ||
| 292 | Staring | OFFSIDES | ||
| 293 | Synovial Cyst | OFFSIDES | ||
| 294 | Telangiectasis | 11464208 | CTD | |
| 295 | Therapeutic response changed | Canada Vigilance: 1 | Canada Vigilance | |
| 296 | Transaminases decreased | SIDER | ||
| 297 | Ulcer | OFFSIDES | ||
| 298 | Upset stomach | SIDER | ||
| 299 | Urinary tract inflammation | OFFSIDES | ||
| 300 | Urine output increased | SIDER | ||
| 301 | Vasodilation procedure | SIDER | ||
| 302 | Vasodilation | SIDER | ||
| 303 | Ventricular hypokinesia | OFFSIDES | ||
| 304 | Visual disturbance | SIDER | ||
| 305 | effusion | OFFSIDES | ||
| 306 | treatment failure | OFFSIDES |
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