MetaADEDB 2.0 @ LMMD
3-ingenyl angelate
(VDJHFHXMUKFKET-WDUFCVPESA-N)
Structure
SMILES
C/C=C(\C(=O)O[C@H]1C(=C[C@]23[C@]1(O)[C@H](O)C(=C[C@H](C3=O)[C@H]1[C@@H](C[C@H]2C)C1(C)C)CO)C)/C
Type(s)
Approved
ATC code(s)
D06BX02
Molecular Formula:
C25H34O6
Molecular Weight:
430.534
Log P:
2.3323
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
3
TPSA:
104.06
CAS Number(s):
75567-37-2
Synonym(s)
1.
3-ingenyl angelate
2.
3-ingenol angelate
3.
PEP 005
4.
PEP-005
5.
PEP005
6.
ingenol mebutate
7.
picato
External Link(s)
MeSHC486592
PubChem Compound6918670
CHEMBLCHEMBL1863513
DrugBankDB05013
DrugCentral4226
IUPHAR/BPS Guide to PHARMACOLOGY7443
KEGGdr:D09393
Therapeutic Target DatabaseD0E9KA
D06HNG
ZINC100037855
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Application site erythemaFAERS: 1662
Canada Vigilance: 5
Canada Vigilance
SIDER
US FAERS
2Application site painFAERS: 1166
Canada Vigilance: 8
Canada Vigilance
SIDER
US FAERS
3Application site vesiclesFAERS: 1013
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
4Drug administered at inappropriate siteFAERS: 739US FAERS
5Application site exfoliationFAERS: 728
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
6Application site swellingFAERS: 567
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
7Application site scabFAERS: 484
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
8Application site drynessFAERS: 414
Canada Vigilance: 1
Canada Vigilance
US FAERS
9Incorrect drug administration durationFAERS: 408US FAERS
10Application site pruritusFAERS: 357SIDER
US FAERS
11Drug administration errorFAERS: 313US FAERS
12Inappropriate schedule of drug administrationFAERS: 281US FAERS
13Incorrect dose administeredFAERS: 275US FAERS
14Application site dischargeFAERS: 186SIDER
US FAERS
15Application site reactionFAERS: 183
Canada Vigilance: 2
Canada Vigilance
US FAERS
16Drug ineffectiveFAERS: 171
Canada Vigilance: 9
Canada Vigilance
US FAERS
17Application site burnFAERS: 139
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
18ErythemaFAERS: 130
Canada Vigilance: 5
Canada Vigilance
SIDER
US FAERS
19Application site erosionFAERS: 119
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
20Application site pustulesFAERS: 107SIDER
US FAERS
21Accidental exposure to productFAERS: 103US FAERS
22HeadacheFAERS: 97
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
23Eye irritationFAERS: 83
Canada Vigilance: 1
Canada Vigilance
US FAERS
24Product use issueFAERS: 83US FAERS
25Application site discomfortFAERS: 75US FAERS
26Application site warmthFAERS: 74
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
27Incorrect product storageFAERS: 72US FAERS
28Application site irritationFAERS: 68SIDER
US FAERS
29Product use in unapproved indicationFAERS: 58
Canada Vigilance: 2
Canada Vigilance
US FAERS
30No adverse eventFAERS: 56
Canada Vigilance: 4
Canada Vigilance
US FAERS
31Product packaging quantity issueFAERS: 56
Canada Vigilance: 1
Canada Vigilance
US FAERS
32Application site inflammationFAERS: 54
Canada Vigilance: 1
Canada Vigilance
US FAERS
33SwellingFAERS: 51SIDER
US FAERS
34PainFAERS: 48
Canada Vigilance: 2
Canada Vigilance
US FAERS
35Burning sensationFAERS: 46US FAERS
36Eye painFAERS: 42
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
37Wrong technique in product usage processFAERS: 40US FAERS
38Application site papulesFAERS: 34US FAERS
39Application site scarFAERS: 32US FAERS
40Application site rashFAERS: 31US FAERS
41Application site ulcerFAERS: 31SIDER
US FAERS
42Incorrect product administration durationFAERS: 31
Canada Vigilance: 4
Canada Vigilance
US FAERS
43Medication ErrorFAERS: 30US FAERS
44Product storage errorFAERS: 30
Canada Vigilance: 1
Canada Vigilance
US FAERS
45HypersensitivityFAERS: 27US FAERS
46Multiple use of single-use productFAERS: 27US FAERS
47PruritusFAERS: 27
Canada Vigilance: 1
Canada Vigilance
US FAERS
48NauseaFAERS: 25
Canada Vigilance: 1
Canada Vigilance
US FAERS
49Drug dispensing errorFAERS: 24US FAERS
50Lip swellingFAERS: 24US FAERS
51ScabFAERS: 24
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
52Squamous cell carcinomaFAERS: 23
Canada Vigilance: 2
Canada Vigilance
US FAERS
53Visual ImpairmentFAERS: 22
Canada Vigilance: 4
Canada Vigilance
US FAERS
54Squamous cell carcinoma of skinFAERS: 21US FAERS
55Inappropriate schedule of product administrationFAERS: 20
Canada Vigilance: 2
Canada Vigilance
US FAERS
56Wrong technique in drug usage processFAERS: 20US FAERS
57Disease recurrenceFAERS: 19US FAERS
58DizzinessFAERS: 18
Canada Vigilance: 1
Canada Vigilance
US FAERS
59Drug prescribing errorFAERS: 18US FAERS
60Application site infectionFAERS: 17SIDER
US FAERS
61Skin reactionFAERS: 17
Canada Vigilance: 1
Canada Vigilance
US FAERS
62DiscomfortFAERS: 16US FAERS
63Oropharyngeal painFAERS: 16US FAERS
64Dry skinFAERS: 15US FAERS
65Product quality issueFAERS: 15US FAERS
66Application site indurationFAERS: 14US FAERS
67Skin tightnessFAERS: 14US FAERS
68Actinic keratosisFAERS: 13US FAERS
69Periorbital swellingFAERS: 11US FAERS
70Product administration errorFAERS: 11
Canada Vigilance: 2
Canada Vigilance
US FAERS
71Throat irritationFAERS: 11US FAERS
72Application site hypersensitivityFAERS: 10US FAERS
73FatigueFAERS: 10US FAERS
74Basal cell carcinomaFAERS: 9US FAERS
75Accidental overdoseFAERS: 8US FAERS
76Application site urticariaFAERS: 8US FAERS
77AstheniaFAERS: 8US FAERS
78Disease ProgressionFAERS: 8
Canada Vigilance: 4
Canada Vigilance
US FAERS
79Product container issueFAERS: 8US FAERS
80Skin lesionFAERS: 8US FAERS
81Therapeutic response unexpectedFAERS: 8US FAERS
82VomitingFAERS: 8US FAERS
83AngioedemaFAERS: 7US FAERS
84Blister ruptureFAERS: 7
Canada Vigilance: 1
Canada Vigilance
US FAERS
85Drug dose omissionFAERS: 7US FAERS
86InflammationFAERS: 7US FAERS
87Skin UlcerFAERS: 7US FAERS
88Tongue discomfortFAERS: 7US FAERS
89AnxietyFAERS: 6US FAERS
90ChillsFAERS: 6US FAERS
91DysgeusiaFAERS: 6US FAERS
92Oral painFAERS: 6US FAERS
93OverdoseFAERS: 6US FAERS
94Product packaging issueFAERS: 6US FAERS
95Unevaluable eventFAERS: 6US FAERS
96UrticariaFAERS: 6US FAERS
97Application site acneFAERS: 5US FAERS
98ConjunctivitisFAERS: 5SIDER
US FAERS
99InfectionFAERS: 5SIDER
US FAERS
100MalaiseFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
101MyalgiaFAERS: 5US FAERS
102PalpitationsFAERS: 5US FAERS
103PapuleFAERS: 5US FAERS
104PhotophobiaFAERS: 5US FAERS
105Rash erythematousFAERS: 5US FAERS
106SunburnFAERS: 5US FAERS
107Adverse eventFAERS: 4US FAERS
108Application site fissureFAERS: 4US FAERS
109Application site woundFAERS: 4US FAERS
110Chest PainFAERS: 4US FAERS
111Chest discomfortFAERS: 4US FAERS
112DermatitisFAERS: 4
Canada Vigilance: 2
Canada Vigilance
US FAERS
113Expired product administeredFAERS: 4US FAERS
114Loss of personal independence in daily activitiesFAERS: 4US FAERS
115Post inflammatory pigmentation changeFAERS: 4US FAERS
116Product physical consistency issueFAERS: 4US FAERS
117SepsisFAERS: 4US FAERS
118TremorFAERS: 4US FAERS
119AcneFAERS: 3US FAERS
120Activities of daily living impairedFAERS: 3US FAERS
121AlopeciaFAERS: 3US FAERS
122Chemical burn of skinFAERS: 3US FAERS
123Eye BurnsFAERS: 3US FAERS
124Eye inflammationFAERS: 3US FAERS
125Eyelid irritationFAERS: 3US FAERS
126Eyelid painFAERS: 3US FAERS
127Facial PainFAERS: 3US FAERS
128HyperkeratosisFAERS: 3US FAERS
129Impaired work abilityFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
130ImpetigoFAERS: 3US FAERS
131Intentional product misuseFAERS: 3US FAERS
132NasopharyngitisFAERS: 3SIDER
US FAERS
133Product label confusionFAERS: 3US FAERS
134Product label issueFAERS: 3US FAERS
135Skin ErosionFAERS: 3US FAERS
136Skin irritationFAERS: 3US FAERS
137UlcerFAERS: 3SIDER
US FAERS
138VIIth nerve paralysisFAERS: 3US FAERS
139skin abrasionFAERS: 3US FAERS
140Abdominal PainFAERS: 2US FAERS
141Abdominal discomfortFAERS: 2US FAERS
142Administration site scarFAERS: 2US FAERS
143AgeusiaFAERS: 2US FAERS
144Anaphylactic shockFAERS: 2US FAERS
145AnosmiaFAERS: 2US FAERS
146Application site folliculitisFAERS: 2US FAERS
147Application site massFAERS: 2US FAERS
148Application site necrosisFAERS: 2US FAERS
149Application site noduleFAERS: 2US FAERS
150Application site telangiectasiaFAERS: 2US FAERS
151Atrial FibrillationFAERS: 2US FAERS
152BlindnessFAERS: 2US FAERS
153Bowen's DiseaseFAERS: 2US FAERS
154CellulitisFAERS: 2US FAERS
155Chemical eye injuryFAERS: 2US FAERS
156DeformityFAERS: 2US FAERS
157DiplopiaFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
158Drug ineffective for unapproved indicationFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
159EczemaFAERS: 2US FAERS
160ExcoriationFAERS: 2US FAERS
161Foreign body sensation in eyesFAERS: 2US FAERS
162Genital cystFAERS: 2US FAERS
163HordeolumFAERS: 2US FAERS
164HypokinesiaFAERS: 2US FAERS
165Infected cystFAERS: 2US FAERS
166Intestinal ObstructionFAERS: 2US FAERS
167Keratosis pilarisFAERS: 2US FAERS
168Lacrimation decreasedFAERS: 2US FAERS
169LethargyFAERS: 2US FAERS
170LeukopeniaFAERS: 2US FAERS
171Lip exfoliationFAERS: 2US FAERS
172MiliariaFAERS: 2US FAERS
173Muscle tightnessFAERS: 2US FAERS
174Nasal discomfortFAERS: 2US FAERS
175Neutrophil count decreasedFAERS: 2US FAERS
176Oral fungal infectionFAERS: 2US FAERS
177Oral mucosal exfoliationFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
178Prescribed overdoseFAERS: 2US FAERS
179Product container seal issueFAERS: 2US FAERS
180Product prescribing errorFAERS: 2US FAERS
181Psychiatric symptomFAERS: 2US FAERS
182PurulenceFAERS: 2US FAERS
183Rebound effectFAERS: 2US FAERS
184RosaceaFAERS: 2US FAERS
185Sinus painFAERS: 2US FAERS
186SneezingFAERS: 2US FAERS
187Solar lentigoFAERS: 2US FAERS
188SomnolenceFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
189StressFAERS: 2US FAERS
190Toxicity to various agentsFAERS: 2US FAERS
191Trigeminal Nerve DisorderFAERS: 2US FAERS
192keratoacanthomaFAERS: 2US FAERS
193Administration site indentationFAERS: 1US FAERS
194AngerFAERS: 1US FAERS
195Anorectal discomfortFAERS: 1US FAERS
196Aphthous StomatitisFAERS: 1US FAERS
197Application site abscessFAERS: 1US FAERS
198Application site cellulitisFAERS: 1US FAERS
199Application site perspirationFAERS: 1US FAERS
200ArthralgiaFAERS: 1US FAERS
201AsthmaFAERS: 1US FAERS
202Bed restFAERS: 1US FAERS
203BlepharospasmFAERS: 1US FAERS
204Blood blisterFAERS: 1US FAERS
205Bone painFAERS: 1US FAERS
206Capillary FragilityFAERS: 1US FAERS
207Cerebrovascular accidentFAERS: 1US FAERS
208CheilitisFAERS: 1US FAERS
209Chemical injuryFAERS: 1US FAERS
210ChloasmaFAERS: 1US FAERS
211Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
212Cold sweatFAERS: 1US FAERS
213ConstipationFAERS: 1US FAERS
214Corneal InfectionFAERS: 1US FAERS
215Corneal graft rejectionFAERS: 1US FAERS
216CryingFAERS: 1US FAERS
217DeafnessFAERS: 1US FAERS
218Dental discomfortFAERS: 1US FAERS
219Depressed moodFAERS: 1US FAERS
220Dermatitis acneiformFAERS: 1US FAERS
221Drug administered to patient of inappropriate ageFAERS: 1US FAERS
222Drug effect incompleteFAERS: 1US FAERS
223DyspepsiaFAERS: 1US FAERS
224Ear discomfortFAERS: 1US FAERS
225Economic problemFAERS: 1US FAERS
226EntropionFAERS: 1US FAERS
227EpistaxisFAERS: 1US FAERS
228Erectile dysfunctionFAERS: 1US FAERS
229Exfoliative rashFAERS: 1US FAERS
230Exposure via direct contactFAERS: 1US FAERS
231Extra dose administeredFAERS: 1US FAERS
232Eye InfectionFAERS: 1US FAERS
233Eyelid margin crustingFAERS: 1US FAERS
234Eyelids pruritusFAERS: 1US FAERS
235Facial paralysisFAERS: 1US FAERS
236Feeling abnormalFAERS: 1US FAERS
237FlushingFAERS: 1US FAERS
238Genital HerpesFAERS: 1US FAERS
239Genital painFAERS: 1US FAERS
240Gingival discomfortFAERS: 1US FAERS
241GlossitisFAERS: 1US FAERS
242Head discomfortFAERS: 1US FAERS
243Herpes zoster cutaneous disseminatedFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
244Impaired driving abilityFAERS: 1US FAERS
245Inability to afford medicationFAERS: 1US FAERS
246Incorrect route of drug administrationFAERS: 1US FAERS
247IndurationFAERS: 1US FAERS
248Intercepted drug prescribing errorFAERS: 1US FAERS
249Intercepted medication errorFAERS: 1US FAERS
250KeratitisFAERS: 1US FAERS
251LacerationFAERS: 1US FAERS
252Limb discomfortFAERS: 1US FAERS
253Lip erythemaFAERS: 1US FAERS
254Macular degenerationFAERS: 1US FAERS
255Medication residue presentFAERS: 1US FAERS
256Middle insomniaFAERS: 1US FAERS
257Musculoskeletal stiffnessFAERS: 1US FAERS
258NervousnessFAERS: 1US FAERS
259NeuralgiaFAERS: 1US FAERS
260Nonspecific reactionFAERS: 1US FAERS
261OphthalmoplegiaFAERS: 1US FAERS
262Oral pruritusFAERS: 1US FAERS
263Pain of skinFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
264PallorFAERS: 1US FAERS
265Penile necrosisFAERS: 1US FAERS
266Periorbital InfectionFAERS: 1US FAERS
267Periorbital contusionFAERS: 1US FAERS
268Periorbital inflammationFAERS: 1US FAERS
269Physical disabilityFAERS: 1US FAERS
270PneumoniaFAERS: 1US FAERS
271PorokeratosisFAERS: 1US FAERS
272Precancerous cells presentFAERS: 1US FAERS
273Precancerous skin lesionFAERS: 1US FAERS
274Product adhesion issueFAERS: 1US FAERS
275Product formulation issueFAERS: 1US FAERS
276Product lot number issueFAERS: 1US FAERS
277Product size issueFAERS: 1US FAERS
278PsoriasisFAERS: 1US FAERS
279Pulmonary congestionFAERS: 1US FAERS
280Punctate keratitisFAERS: 1US FAERS
281Purulent dischargeFAERS: 1US FAERS
282Quality of life decreasedFAERS: 1US FAERS
283RestlessnessFAERS: 1US FAERS
284Retinal DetachmentFAERS: 1US FAERS
285RhinalgiaFAERS: 1US FAERS
286Saliva alteredFAERS: 1US FAERS
287Sarcoma of skinFAERS: 1US FAERS
288SinusitisFAERS: 1US FAERS
289Skin WrinklingFAERS: 1US FAERS
290Skin discomfortFAERS: 1US FAERS
291Skin texture abnormalFAERS: 1US FAERS
292StomatitisFAERS: 1US FAERS
293Superficial injury of eyeFAERS: 1US FAERS
294Superinfection bacterialFAERS: 1US FAERS
295Swelling of eyelidFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
296TachycardiaFAERS: 1US FAERS
297Temperature intoleranceFAERS: 1US FAERS
298TensionFAERS: 1US FAERS
299Therapy cessationFAERS: 1US FAERS
300Thermal burnFAERS: 1US FAERS
301ThirstFAERS: 1US FAERS
302Tongue exfoliationFAERS: 1US FAERS
303Tongue pruritusFAERS: 1US FAERS
304Toxic Epidermal NecrolysisFAERS: 1US FAERS
305Urinary RetentionFAERS: 1US FAERS
306Vitreous DetachmentFAERS: 1US FAERS
307Vitreous floatersFAERS: 1US FAERS
308Vulvovaginal burning sensationFAERS: 1US FAERS
309Weight decreasedFAERS: 1US FAERS
310furuncleFAERS: 1US FAERS
311InfestationSIDER
312Instillation site painSIDER
313Product administered at inappropriate siteCanada Vigilance: 3Canada Vigilance
314Product dispensing errorCanada Vigilance: 1Canada Vigilance
315nervous system disorderSIDER
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