ciclesonide
(LUKZNWIVRBCLON-GXOBDPJESA-N)
Structure
- SMILES
- O=C(C(C)C)OCC(=O)[C@@]12O[C@@H](O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@H]2[C@H]1CCC1=CC(=O)C=C[C@]21C)C1CCCCC1
- Type(s)
- Approved; Investigational
- ATC code(s)
- R01AD13; R03BA08
- Molecular Formula:
- C32H44O7
- Molecular Weight:
- 540.688
- Log P:
- 4.7039
- Hydrogen Bond Acceptor:
- 7
- Hydrogen Bond Donor:
- 1
- TPSA:
- 99.13
- CAS Number(s):
- 126544-47-6; 141845-82-1
Synonym(s)
1.
ciclesonide
2.
(R)-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde, 21-isobutyrate
3.
Alvesco
4.
Omnaris
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Headache | FAERS: 15 Canada Vigilance: 7 | Canada Vigilance SIDER US FAERS | |
| 2 | Drug ineffective | FAERS: 9 Canada Vigilance: 34 | Canada Vigilance US FAERS | |
| 3 | Hypersensitivity | FAERS: 9 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 4 | Asthma | FAERS: 8 Canada Vigilance: 6 | Canada Vigilance OFFSIDES US FAERS | |
| 5 | Dizziness | FAERS: 8 Canada Vigilance: 3 | Canada Vigilance SIDER US FAERS | |
| 6 | Chest discomfort | FAERS: 7 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 7 | Device malfunction | FAERS: 7 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 8 | Anxiety | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 9 | Drug dose omission | FAERS: 5 | US FAERS | |
| 10 | Fatigue | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 11 | Product quality issue | FAERS: 5 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 12 | Vomiting | FAERS: 5 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 13 | Bronchospasm | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 14 | Nausea | FAERS: 4 Canada Vigilance: 3 | Canada Vigilance SIDER US FAERS | |
| 15 | Nervousness | FAERS: 4 | US FAERS | |
| 16 | Pruritus | FAERS: 4 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 17 | Wheezing | FAERS: 4 Canada Vigilance: 3 | Canada Vigilance SIDER US FAERS | |
| 18 | Blindness | FAERS: 3 | US FAERS | |
| 19 | Cataract | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 20 | Device Failure | FAERS: 3 | US FAERS | |
| 21 | Dysphonia | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 22 | Malaise | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 23 | Nasopharyngitis | FAERS: 3 | OFFSIDES SIDER US FAERS | |
| 24 | Throat irritation | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 25 | Unevaluable event | FAERS: 3 | US FAERS | |
| 26 | Anosmia | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance OFFSIDES US FAERS | |
| 27 | Asthenia | FAERS: 2 | SIDER US FAERS | |
| 28 | Chest Pain | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 29 | Chills | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 30 | Circumstance or information capable of leading to medication error | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 31 | Dysgeusia | FAERS: 2 | OFFSIDES SIDER US FAERS | |
| 32 | Feeling abnormal | FAERS: 2 | US FAERS | |
| 33 | Macular degeneration | FAERS: 2 | US FAERS | |
| 34 | Overdose | FAERS: 2 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 35 | Pain | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance OFFSIDES US FAERS | |
| 36 | Palpitations | FAERS: 2 | SIDER US FAERS | |
| 37 | Pharyngitis | FAERS: 2 | SIDER US FAERS | |
| 38 | Pulmonary Embolism | FAERS: 2 | US FAERS | |
| 39 | Syncope | FAERS: 2 | US FAERS | |
| 40 | Toothache | FAERS: 2 | US FAERS | |
| 41 | Urticaria | FAERS: 2 Canada Vigilance: 4 | Canada Vigilance SIDER US FAERS | |
| 42 | Visual Impairment | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 43 | Acne | FAERS: 1 | US FAERS | |
| 44 | Alcohol interaction | FAERS: 1 | US FAERS | |
| 45 | Alcohol poisoning | FAERS: 1 | US FAERS | |
| 46 | Allergic sinusitis | FAERS: 1 | US FAERS | |
| 47 | Anaphylactic shock | FAERS: 1 | US FAERS | |
| 48 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 49 | Angioedema | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 50 | Angle Closure Glaucoma | FAERS: 1 | US FAERS | |
| 51 | Arthralgia | FAERS: 1 | SIDER US FAERS | |
| 52 | Arthropathy | FAERS: 1 | OFFSIDES US FAERS | |
| 53 | Back Pain | FAERS: 1 | SIDER US FAERS | |
| 54 | Bone pain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 55 | Bronchoscopy | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 56 | Burning sensation | FAERS: 1 | US FAERS | |
| 57 | Cerebrovascular accident | FAERS: 1 | US FAERS | |
| 58 | Chronic sinusitis | FAERS: 1 | OFFSIDES US FAERS | |
| 59 | Crying | FAERS: 1 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 60 | Deep Vein Thrombosis | FAERS: 1 | US FAERS | |
| 61 | Deformity | FAERS: 1 | US FAERS | |
| 62 | Delirium | FAERS: 1 | US FAERS | |
| 63 | Device use issue | FAERS: 1 | US FAERS | |
| 64 | Discomfort | FAERS: 1 | US FAERS | |
| 65 | Disease Progression | FAERS: 1 | US FAERS | |
| 66 | Disease recurrence | FAERS: 1 | US FAERS | |
| 67 | Embolic pneumonia | FAERS: 1 | US FAERS | |
| 68 | Epistaxis | FAERS: 1 Canada Vigilance: 7 | Canada Vigilance SIDER US FAERS | |
| 69 | Eye pain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 70 | Failure to Thrive | FAERS: 1 | US FAERS | |
| 71 | Flushing | FAERS: 1 | US FAERS | |
| 72 | General physical health deterioration | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 73 | Glaucoma | FAERS: 1 | OFFSIDES US FAERS | |
| 74 | Hemiplegia | FAERS: 1 | US FAERS | |
| 75 | Incorrect dose administered by device | FAERS: 1 | US FAERS | |
| 76 | Incorrect route of drug administration | FAERS: 1 | US FAERS | |
| 77 | Infection | FAERS: 1 | OFFSIDES SIDER US FAERS | |
| 78 | Intentional device misuse | FAERS: 1 | US FAERS | |
| 79 | Joint stiffness | FAERS: 1 | OFFSIDES US FAERS | |
| 80 | Limb injury | FAERS: 1 | US FAERS | |
| 81 | Lip swelling | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 82 | Lower respiratory tract congestion | FAERS: 1 | US FAERS | |
| 83 | Lymphoma | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance OFFSIDES US FAERS | |
| 84 | Medication Error | FAERS: 1 | US FAERS | |
| 85 | Migraine with Aura | FAERS: 1 | US FAERS | |
| 86 | Musculoskeletal chest pain | FAERS: 1 | SIDER US FAERS | |
| 87 | Myalgia | FAERS: 1 | US FAERS | |
| 88 | Nasal discomfort | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 89 | Oral pain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 90 | Oropharyngeal pain | FAERS: 1 | OFFSIDES SIDER US FAERS | |
| 91 | Osteoporosis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 92 | Pain of skin | FAERS: 1 | US FAERS | |
| 93 | Patent ductus arteriosus | FAERS: 1 | US FAERS | |
| 94 | Personality Change | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 95 | Pneumothorax | FAERS: 1 | OFFSIDES US FAERS | |
| 96 | Presyncope | FAERS: 1 | US FAERS | |
| 97 | Product dose omission | FAERS: 1 | US FAERS | |
| 98 | Product packaging quantity issue | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 99 | Product substitution issue | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 100 | Product taste abnormal | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 101 | Product use in unapproved indication | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 102 | Pulmonary Fibrosis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 103 | Pulmonary Infarction | FAERS: 1 | US FAERS | |
| 104 | Respiratory Failure | FAERS: 1 | US FAERS | |
| 105 | Respiratory tract congestion | FAERS: 1 | OFFSIDES US FAERS | |
| 106 | Rheumatoid Arthritis | FAERS: 1 | US FAERS | |
| 107 | Rhinalgia | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 108 | Sinusitis | FAERS: 1 | OFFSIDES SIDER US FAERS | |
| 109 | Somnolence | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 110 | Tachycardia | FAERS: 1 | US FAERS | |
| 111 | Thrombosis | FAERS: 1 | US FAERS | |
| 112 | Tinnitus | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 113 | Urinary tract infection | FAERS: 1 | SIDER US FAERS | |
| 114 | Vasculitis | FAERS: 1 | US FAERS | |
| 115 | Vertigo | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 116 | Vitreous floaters | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 117 | Vulvovaginal mycotic infection | FAERS: 1 | US FAERS | |
| 118 | Wrong patient received medication | FAERS: 1 | US FAERS | |
| 119 | treatment failure | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 120 | Abnormal weight gain | Canada Vigilance: 1 | Canada Vigilance | |
| 121 | Acute myocardial infarction | OFFSIDES | ||
| 122 | Acute respiratory failure | OFFSIDES | ||
| 123 | Acute sinusitis | OFFSIDES | ||
| 124 | Adverse event | Canada Vigilance: 1 | Canada Vigilance | |
| 125 | Ageusia | Canada Vigilance: 1 | Canada Vigilance | |
| 126 | Alanine Aminotransferase Increased | SIDER | ||
| 127 | Amaurosis Fugax | OFFSIDES | ||
| 128 | Angioplasty | OFFSIDES | ||
| 129 | Aortic valve calcification | OFFSIDES | ||
| 130 | Apathy | OFFSIDES | ||
| 131 | Aphonia | OFFSIDES | ||
| 132 | Atrial Flutter | OFFSIDES | ||
| 133 | Blood chloride decreased | OFFSIDES | ||
| 134 | Blood creatine phosphokinase increased | OFFSIDES | ||
| 135 | Body Temperature | OFFSIDES | ||
| 136 | Bronchitis | OFFSIDES SIDER | ||
| 137 | Cardiac Flutter | OFFSIDES | ||
| 138 | Cardiac asthma | OFFSIDES | ||
| 139 | Cataract operation | OFFSIDES | ||
| 140 | Choking sensation | OFFSIDES | ||
| 141 | Choking | OFFSIDES | ||
| 142 | Concomitant disease progression | OFFSIDES | ||
| 143 | Conjunctival deposit | OFFSIDES | ||
| 144 | Conjunctivitis | SIDER | ||
| 145 | Cortisol decreased | Canada Vigilance: 14 | Canada Vigilance | |
| 146 | Dermatitis | SIDER | ||
| 147 | Device defective | Canada Vigilance: 1 | Canada Vigilance | |
| 148 | Diabetes | OFFSIDES | ||
| 149 | Diabetes Mellitus | SIDER | ||
| 150 | Drug withdrawal headache | OFFSIDES | ||
| 151 | Dysgraphia | OFFSIDES | ||
| 152 | Dysmenorrhea | OFFSIDES | ||
| 153 | Dyspepsia | SIDER | ||
| 154 | Erythema Multiforme | OFFSIDES | ||
| 155 | Escherichia urinary tract infection | OFFSIDES | ||
| 156 | Eye irritation | Canada Vigilance: 1 | Canada Vigilance | |
| 157 | Eyelid Function Disorder | Canada Vigilance: 1 | Canada Vigilance | |
| 158 | Foreign body in respiratory tract | Canada Vigilance: 1 | Canada Vigilance | |
| 159 | Fracture | SIDER | ||
| 160 | Gamma-Glutamyltransferase Increased | SIDER | ||
| 161 | Gastroenteritis | SIDER | ||
| 162 | Glossitis | OFFSIDES | ||
| 163 | Hepatitis C | OFFSIDES | ||
| 164 | Hoarseness | SIDER | ||
| 165 | Incorrect dose administered | Canada Vigilance: 1 | Canada Vigilance | |
| 166 | Incorrect route of product administration | Canada Vigilance: 1 | Canada Vigilance | |
| 167 | Increased upper airway secretion | OFFSIDES | ||
| 168 | Increased viscosity of bronchial secretion | OFFSIDES | ||
| 169 | Infestation | SIDER | ||
| 170 | Influenza | SIDER | ||
| 171 | Infusion site erythema | OFFSIDES | ||
| 172 | Infusion site swelling | OFFSIDES | ||
| 173 | Infusion site urticaria | OFFSIDES | ||
| 174 | Iritis | OFFSIDES | ||
| 175 | Left atrial dilatation | OFFSIDES | ||
| 176 | Lethargy | OFFSIDES | ||
| 177 | Leukopenia neonatal | OFFSIDES | ||
| 178 | Mood swings | Canada Vigilance: 1 | Canada Vigilance | |
| 179 | Muscle Fatigue | OFFSIDES | ||
| 180 | Muscle strain | SIDER | ||
| 181 | Musculoskeletal discomfort | SIDER | ||
| 182 | Myelodysplasia | OFFSIDES | ||
| 183 | Nasal passage irritation | SIDER | ||
| 184 | Nephrolithiasis | OFFSIDES | ||
| 185 | No adverse event | Canada Vigilance: 2 | Canada Vigilance | |
| 186 | Oral candidiasis | SIDER | ||
| 187 | Oral fungal infection | SIDER | ||
| 188 | Oropharyngeal swelling | OFFSIDES | ||
| 189 | Osteolysis | OFFSIDES | ||
| 190 | Osteopenia | SIDER | ||
| 191 | Peripheral swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 192 | Pharyngeal candidiasis | OFFSIDES | ||
| 193 | Pharyngolaryngeal Pain | SIDER | ||
| 194 | Pneumonia | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 195 | Polypoidal choroidal vasculopathy | OFFSIDES | ||
| 196 | Product administration error | Canada Vigilance: 1 | Canada Vigilance | |
| 197 | Product label issue | Canada Vigilance: 1 | Canada Vigilance | |
| 198 | Product substitution | Canada Vigilance: 1 | Canada Vigilance | |
| 199 | Product use issue | Canada Vigilance: 3 | Canada Vigilance | |
| 200 | Productive Cough | OFFSIDES | ||
| 201 | Pulmonary congestion | OFFSIDES | ||
| 202 | Rales | Canada Vigilance: 1 | Canada Vigilance | |
| 203 | Rhinitis | SIDER | ||
| 204 | Sinus headache | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 205 | Spirometry abnormal | Canada Vigilance: 1 | Canada Vigilance | |
| 206 | Swelling | SIDER | ||
| 207 | Therapeutic product effect decreased | Canada Vigilance: 2 | Canada Vigilance | |
| 208 | Therapeutic product ineffective | Canada Vigilance: 1 | Canada Vigilance | |
| 209 | Tonsillitis | SIDER | ||
| 210 | Ulcer | SIDER | ||
| 211 | Venous Insufficiency | OFFSIDES | ||
| 212 | Viral upper respiratory tract infection | SIDER | ||
| 213 | Weight Gain | OFFSIDES | ||
| 214 | Weight decreased | Canada Vigilance: 1 | Canada Vigilance | |
| 215 | effusion | OFFSIDES |
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