MetaADEDB 2.0 @ LMMD
Acarbose
(XUFXOAAUWZOOIT-UGEKTDRHSA-N)
Structure
SMILES
OC[C@H]1O[C@H](O[C@@H]2[C@@H](CO)OC([C@@H]([C@H]2O)O)O)[C@@H]([C@H]([C@@H]1O[C@H]1O[C@H](C)[C@H]([C@@H]([C@H]1O)O)N[C@H]1C=C(CO)[C@H]([C@@H]([C@H]1O)O)O)O)O
Molecular Formula:
C25H43NO18
Molecular Weight:
645.605
Log P:
-8.1736
Hydrogen Bond Acceptor:
19
Hydrogen Bond Donor:
14
TPSA:
321.17
CAS Number(s):
56180-94-0
Synonym(s)
1.
Acarbose
2.
Bay g 5421
3.
Glucobay
4.
Glucor
5.
Glumida
6.
Prandase
7.
Precose
External Link(s)
MeSHD020909
PubChem Compound41774
BindingDB50180587
23406
ChEBI2376
CHEMBLCHEMBL404271
DrugCentral39
KEGGcpd:C06802
dr:D00216
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Pneumatosis intestinalisFAERS: 14SIDER
US FAERS
2DizzinessFAERS: 12US FAERS
3PruritusFAERS: 8US FAERS
4PneumoperitoneumFAERS: 6SIDER
US FAERS
5Portal venous gasFAERS: 6OFFSIDES
US FAERS
6NauseaFAERS: 5SIDER
US FAERS
7Weight decreasedFAERS: 5US FAERS
8FlatulenceFAERS: 4OFFSIDES
SIDER
US FAERS
9VomitingFAERS: 4SIDER
US FAERS
10Abdominal PainFAERS: 3SIDER
US FAERS
11AgranulocytosisFAERS: 3US FAERS
12Drug ineffective for unapproved indicationFAERS: 3US FAERS
13AngioedemaFAERS: 2OFFSIDES
US FAERS
14Chest discomfortFAERS: 2US FAERS
15CholestasisFAERS: 2US FAERS
16ConstipationFAERS: 2SIDER
US FAERS
17DehydrationFAERS: 2US FAERS
18DiscomfortFAERS: 2US FAERS
19EosinophiliaFAERS: 2US FAERS
20ErythemaFAERS: 2SIDER
US FAERS
21HepatitisFAERS: 2SIDER
US FAERS
22Intestinal ObstructionFAERS: 2OFFSIDES
SIDER
US FAERS
23LeukocytosisFAERS: 2US FAERS
24MalaiseFAERS: 2US FAERS
25Ocular icterusFAERS: 2US FAERS
26PalpitationsFAERS: 2US FAERS
27SunburnFAERS: 2US FAERS
28Abdominal discomfortFAERS: 1US FAERS
29Abdominal tendernessFAERS: 1US FAERS
30Alanine Aminotransferase IncreasedFAERS: 1OFFSIDES
US FAERS
31AlopeciaFAERS: 1US FAERS
32Anorectal discomfortFAERS: 1US FAERS
33Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
34AstheniaFAERS: 1US FAERS
35Chest PainFAERS: 1US FAERS
36ColitisFAERS: 1US FAERS
37DeliriumFAERS: 1US FAERS
38Drug ineffectiveFAERS: 1US FAERS
39DyspepsiaFAERS: 1SIDER
US FAERS
40Gamma-Glutamyltransferase IncreasedFAERS: 1OFFSIDES
US FAERS
41GastritisFAERS: 1US FAERS
42HeadacheFAERS: 1US FAERS
43HepatomegalyFAERS: 1US FAERS
44InfectionFAERS: 1US FAERS
45LethargyFAERS: 1US FAERS
46Low birth weight babyFAERS: 1US FAERS
47Maternal exposure during pregnancyFAERS: 1US FAERS
48Metabolic acidosisFAERS: 1OFFSIDES
US FAERS
49MyalgiaFAERS: 1US FAERS
50NeutropeniaFAERS: 1US FAERS
51Oculogyric crisisFAERS: 1US FAERS
52Product label issueFAERS: 1US FAERS
53Product physical issueFAERS: 1US FAERS
54Product use in unapproved indicationFAERS: 1US FAERS
55Abdominal Compartment SyndromeOFFSIDES
56AcantholysisOFFSIDES
57Accidental overdoseOFFSIDES
58AcidosisOFFSIDES
59Activated partial thromboplastin time shortenedOFFSIDES
60Acute prerenal failureOFFSIDES
61Acute respiratory failureOFFSIDES
62AdenocarcinomaOFFSIDES
63Altered state of consciousnessOFFSIDES
64AmyloidosisOFFSIDES
65Anal abscessOFFSIDES
66AnhedoniaOFFSIDES
67AnorexiaOFFSIDES
68Anterior chamber inflammationOFFSIDES
69Anti-insulin antibody positiveOFFSIDES
70Aortic occlusionOFFSIDES
71ApathyOFFSIDES
72ArteriosclerosisOFFSIDES
73AtaxiaOFFSIDES
74AtelectasisOFFSIDES
75Autonomic neuropathyOFFSIDES
76Bacillus infectionOFFSIDES
77Benign Prostatic HyperplasiaOFFSIDES
78Biliary dilatationOFFSIDES
79Bladder NeoplasmOFFSIDES
80Blast cell count increasedOFFSIDES
81Blood 25-hydroxycholecalciferol decreasedOFFSIDES
82Blood GlucoseOFFSIDES
83Blood albumin abnormalOFFSIDES
84Blood albumin increasedOFFSIDES
85Blood alcohol increasedOFFSIDES
86Blood and lymphatic system disordersSIDER
87Blood chloride decreasedOFFSIDES
88Blood creatine phosphokinase MB increasedOFFSIDES
89Blood creatine phosphokinase increasedOFFSIDES
90Blood creatinine increasedOFFSIDES
91Blood glucose abnormalOFFSIDES
92Blood glucose decreasedOFFSIDES
93Blood glucose fluctuationOFFSIDES
94Blood immunoglobulin A increasedOFFSIDES
95Blood ketone bodyOFFSIDES
96Blood phosphorus decreasedOFFSIDES
97Blood potassium increasedOFFSIDES
98Blood pressure inadequately controlledOFFSIDES
99Blood sodium increasedOFFSIDES
100Blood uric acid abnormalOFFSIDES
101Blood uric acidOFFSIDES
102Bone marrow depressionOFFSIDES
103Brain natriuretic peptide increasedOFFSIDES
104BronchopneumoniaOFFSIDES
105Bullous lung diseaseOFFSIDES
106C-reactive protein abnormalOFFSIDES
107Cardioactive drug level increasedOFFSIDES
108Cardiovascular Diseases17133782CTD
109CarotidyniaOFFSIDES
110Chemical and Drug Induced Liver Injury15324623CTD
111ChromaturiaOFFSIDES
112Chronic respiratory failureOFFSIDES
113Coronary angioplastyOFFSIDES
114Coronary artery reocclusionOFFSIDES
115Cytolytic hepatitisOFFSIDES
116DemyelinationOFFSIDES
117Depressed Level of ConsciousnessOFFSIDES
118DermatitisSIDER
119DermatomyositisOFFSIDES
120DiabetesOFFSIDES
121Diabetes mellitus inadequate controlOFFSIDES
122Diabetic NephropathyOFFSIDES
123Diabetic RetinopathyOFFSIDES
124Diaphragmatic HerniaOFFSIDES
125Diffuse Large B-Cell LymphomaOFFSIDES
126Disease ProgressionOFFSIDES
127Disseminated Intravascular CoagulationOFFSIDES
128Duodenal UlcerOFFSIDES
129DyscheziaOFFSIDES
130Early satietyOFFSIDES
131Economic problemOFFSIDES
132EczemaOFFSIDES
133Electrocardiogram QT corrected interval shortenedOFFSIDES
134Electrocardiogram poor R-wave progressionOFFSIDES
135Electrocardiogram repolarisation abnormalityOFFSIDES
136Electromechanical dissociationOFFSIDES
137EmbolismOFFSIDES
138Endomyocardial Fibrosis20703014CTD
139Escherichia urinary tract infectionOFFSIDES
140Exfoliative rashOFFSIDES
141Fatty Liver14975757
19207582		CTD
142Febrile bone marrow aplasiaOFFSIDES
143Femoral artery occlusionOFFSIDES
144Food AllergyOFFSIDES
145Gastrointestinal Neoplasms9617344CTD
146Gastrointestinal PainSIDER
147Gastrointestinal perforationOFFSIDES
148General physical health deteriorationOFFSIDES
149GoutOFFSIDES
150Head deformityOFFSIDES
151Heart valve calcificationOFFSIDES
152Herpes pharyngitisOFFSIDES
153Hyperglycemia20667563CTD
154Hyperosmolar stateOFFSIDES
155HypersensitivitySIDER
156Hypocoagulable stateOFFSIDES
157IleusSIDER
158IndurationOFFSIDES
159Inflammation14975757CTD
160Injection site inflammationOFFSIDES
161Injection site urticariaOFFSIDES
162Insulin-requiring type 2 diabetes mellitusOFFSIDES
163Intestinal PerforationSIDER
164Intestinal cystOFFSIDES
165Intestinal hypomotilityOFFSIDES
166IntussusceptionSIDER
167IritisOFFSIDES
168Joint sprainOFFSIDES
169Kidney FailureOFFSIDES
170LeptospirosisOFFSIDES
171Life expectancy shortenedOFFSIDES
172Liver Failure, Acute18648179CTD
173Lung infection pseudomonalOFFSIDES
174MacroglossiaOFFSIDES
175Malignant melanoma of sites other than skinOFFSIDES
176Malignant tumour excisionOFFSIDES
177Markedly reduced dietary intakeOFFSIDES
178MastectomyOFFSIDES
179Mechanical ventilationOFFSIDES
180MeningorrhagiaOFFSIDES
181Motor retardationOFFSIDES
182Mouth BreathingOFFSIDES
183Myeloid maturation arrestOFFSIDES
184Necrosis of arteryOFFSIDES
185Nephritis allergicOFFSIDES
186Neurological examination abnormalOFFSIDES
187Nicotine DependenceOFFSIDES
188Non-alcoholic Fatty Liver Disease14975757CTD
189Obesity19207582CTD
190OrchitisOFFSIDES
191Pancreatic enzymes increasedOFFSIDES
192ParaparesisOFFSIDES
193PemphigusOFFSIDES
194Pericardial effusionOFFSIDES
195Peripheral arterial occlusive diseaseOFFSIDES
196Peripheral embolismOFFSIDES
197Peroneal nerve injuryOFFSIDES
198Pneumatosis Cystoides IntestinalisOFFSIDES
SIDER
199Poor peripheral circulationOFFSIDES
200Productive CoughOFFSIDES
201Psychiatric symptomOFFSIDES
202Quality of life decreasedOFFSIDES
203Renal tubular disorderOFFSIDES
204Respiratory tract congestionOFFSIDES
205Retinal Artery OcclusionOFFSIDES
206Retrograde amnesiaOFFSIDES
207RhabdomyolysisOFFSIDES
208RhinitisOFFSIDES
209Right ventricular systolic pressure increasedOFFSIDES
210Septic ShockOFFSIDES
211Similar reaction on previous exposure to drugOFFSIDES
212Skeletal injuryOFFSIDES
213SnoringOFFSIDES
214Stent occlusionOFFSIDES
215Stent related infectionOFFSIDES
216Stevens-Johnson SyndromeOFFSIDES
217SubileusSIDER
218Sudden Cardiac DeathOFFSIDES
219Testicular massOFFSIDES
220ThrombocytopeniaSIDER
221ThrombophlebitisOFFSIDES
222Thrombotic strokeOFFSIDES
223TracheobronchitisOFFSIDES
224Traumatic liver injurySIDER
225Ulnar NeuritisOFFSIDES
226Unevaluable eventOFFSIDES
227UrticariaSIDER
228VitrectomyOFFSIDES
229Vocal Cord ParalysisOFFSIDES
230Weight GainOFFSIDES
231jaundiceSIDER
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