MetaADEDB 2.0 @ LMMD
Doripenem
(AVAACINZEOAHHE-VFZPANTDSA-N)
Structure
SMILES
C[C@H]([C@H]1C(=O)N2[C@@H]1[C@@H](C)C(=C2C(=O)O)S[C@@H]1CN[C@@H](C1)CNS(=O)(=O)N)O
Type(s)
Approved; Investigational
ATC code(s)
J01DH04
Molecular Formula:
C15H24N4O6S2
Molecular Weight:
420.504
Log P:
0.8356
Hydrogen Bond Acceptor:
11
Hydrogen Bond Donor:
5
TPSA:
195.74
CAS Number(s):
148016-81-3; 364622-82-2
Synonym(s)
1.
Doripenem
2.
2-(5-sulfamoylaminomethylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylic acid
3.
S 4661
4.
S-4661
5.
S4661
External Link(s)
MeSHD000077726
PubChem Compound73303
6918242
BindingDB50088382
ChEBI135928
CHEMBLCHEMBL491571
DrugBankDB06211
DrugCentral4149
KEGGdr:D03895
Therapeutic Target DatabaseD03QWT
ZINC3922770
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1PneumoniaFAERS: 12SIDER
US FAERS
2SepsisFAERS: 7US FAERS
3PancytopeniaFAERS: 6US FAERS
4Respiratory FailureFAERS: 5OFFSIDES
US FAERS
5AnuriaFAERS: 4US FAERS
6BradycardiaFAERS: 4US FAERS
7ArthralgiaFAERS: 3US FAERS
8ArthropathyFAERS: 3US FAERS
9Drug resistanceFAERS: 3US FAERS
10InfectionFAERS: 3OFFSIDES
SIDER
US FAERS
11Oropharyngeal painFAERS: 3US FAERS
12Accidental overdoseFAERS: 2US FAERS
13Angina PectorisFAERS: 2US FAERS
14CellulitisFAERS: 2US FAERS
15ChillsFAERS: 2US FAERS
16LeukopeniaFAERS: 2SIDER
US FAERS
17Mental status changesFAERS: 2US FAERS
18OverdoseFAERS: 2US FAERS
19ShockFAERS: 2US FAERS
20ThrombocytopeniaFAERS: 2SIDER
US FAERS
21White blood cell count decreasedFAERS: 2US FAERS
22jaundiceFAERS: 2US FAERS
23pseudomembranous colitisFAERS: 2US FAERS
24treatment failureFAERS: 2US FAERS
25Abdominal PainFAERS: 1US FAERS
26AcarodermatitisFAERS: 1US FAERS
27Acute Coronary SyndromeFAERS: 1US FAERS
28Acute kidney injuryFAERS: 1US FAERS
29Acute respiratory failureFAERS: 1US FAERS
30Adverse eventFAERS: 1US FAERS
31Anaphylactic shockFAERS: 1SIDER
US FAERS
32Blood creatine phosphokinase increasedFAERS: 1US FAERS
33Blood creatinine increasedFAERS: 1US FAERS
34Blood urea increasedFAERS: 1US FAERS
35Bronchopulmonary AspergillosisFAERS: 1US FAERS
36CholestasisFAERS: 1US FAERS
37Clostridium difficile colitisFAERS: 1SIDER
US FAERS
38Complex partial seizuresFAERS: 1US FAERS
39Creatinine renal clearance decreasedFAERS: 1US FAERS
40DeliriumFAERS: 1US FAERS
41Depressed Level of ConsciousnessFAERS: 1US FAERS
42Disseminated Intravascular CoagulationFAERS: 1OFFSIDES
US FAERS
43Drug prescribing errorFAERS: 1US FAERS
44Duodenal UlcerFAERS: 1US FAERS
45EmpyemaFAERS: 1US FAERS
46EosinophiliaFAERS: 1US FAERS
47Granulocyte count decreasedFAERS: 1US FAERS
48HepatomegalyFAERS: 1US FAERS
49IleusFAERS: 1US FAERS
50Incorrect dose administeredFAERS: 1US FAERS
51Incorrect drug administration rateFAERS: 1US FAERS
52Infusion site rashFAERS: 1US FAERS
53Large intestine perforationFAERS: 1US FAERS
54Myocardial InfarctionFAERS: 1US FAERS
55Prescribed overdoseFAERS: 1US FAERS
56Pulmonary EmbolismFAERS: 1US FAERS
57Pulmonary sepsisFAERS: 1US FAERS
58Rash erythematousFAERS: 1US FAERS
59RhabdomyolysisFAERS: 1US FAERS
60Septic ShockFAERS: 1OFFSIDES
US FAERS
61SuperinfectionFAERS: 1US FAERS
62TachycardiaFAERS: 1US FAERS
63ThrombocytosisFAERS: 1US FAERS
64Toxic Epidermal NecrolysisFAERS: 1SIDER
US FAERS
65UrticariaFAERS: 1US FAERS
66Wound infection fungalFAERS: 1OFFSIDES
US FAERS
67AbscessOFFSIDES
68Alanine Aminotransferase IncreasedOFFSIDES
69AmyloidosisOFFSIDES
70AphagiaOFFSIDES
71Aspiration PneumoniaOFFSIDES
72AutomatismOFFSIDES
73Blood alkaline phosphatase increasedOFFSIDES
74Blood and lymphatic system disordersSIDER
75Blood immunoglobulin G increasedOFFSIDES
76Blood potassium increasedOFFSIDES
77Blood sodium increasedOFFSIDES
78Blood uric acidOFFSIDES
79Blood urine presentOFFSIDES
80Bronchoalveolar LavageOFFSIDES
81Catheter placementOFFSIDES
82Clamping of blood vesselOFFSIDES
83ColitisSIDER
84Dental cleaningOFFSIDES
85Dental discomfortOFFSIDES
86DermatitisSIDER
87Endoscopy abnormalOFFSIDES
88Endotoxic shockOFFSIDES
89Engraftment syndromeOFFSIDES
90Enterococcal sepsisOFFSIDES
91EnterocolitisOFFSIDES
92Erythema MultiformeSIDER
93GlossitisOFFSIDES
94HeadacheSIDER
95HemiplegiaOFFSIDES
96Hepatic vein occlusionOFFSIDES
97Histiocytosis haematophagicOFFSIDES
98HypercapniaOFFSIDES
99HypersensitivitySIDER
100HypoxiaOFFSIDES
101Incisional herniaOFFSIDES
102InfestationSIDER
103Leukopenia neonatalOFFSIDES
104Lung AbscessOFFSIDES
105Lung infection pseudomonalOFFSIDES
106MediastinitisOFFSIDES
107Muscle necrosisOFFSIDES
108NauseaSIDER
109Necrolysis epidermalSIDER
110NeutropeniaSIDER
111Neutrophil count decreasedOFFSIDES
112Oculomucocutaneous syndromeOFFSIDES
113Oral candidiasisSIDER
114PhlebitisSIDER
115Platelet TransfusionOFFSIDES
116PleurisyOFFSIDES
117Post procedural complicationOFFSIDES
118PruritusSIDER
119Purulent dischargeOFFSIDES
120RhinorrheaOFFSIDES
121Skin ErosionOFFSIDES
122Stevens-Johnson Syndrome25811541CTD
OFFSIDES
SIDER
123T-Cell LymphomaOFFSIDES
124Thrombocytopenia toxicSIDER
125Venous thrombosis limbOFFSIDES
126Ventricular FibrillationOFFSIDES
127nervous system disorderSIDER
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