Muscle Fatigue
(UMLS:C0242979)
- Definition:
- A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.
- UMLS ID:
- C0242979
- MeSH ID:
- D018763
Classification:
- Musculoskeletal and Neural Physiological Phenomena
- MeSH Tree Number(s):
- G11.427.550
Synonym(s)
1.
Muscle Fatigue
2.
Muscle fatigue
3.
Muscle tiredness
4.
Muscles tire easily
5.
Muscular fatigue, NOS
6.
fatigue muscle
7.
fatigue muscles
8.
fatigue; muscle
9.
muscle fatigue
10.
muscle tiredness
11.
muscle; fatigue
12.
muscular fatigue
Associated Drug(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Atorvastatin | FAERS: 42 | US FAERS | |
| 2 | Thyroxine | FAERS: 42 | US FAERS | |
| 3 | Teriparatide | FAERS: 35 | US FAERS | |
| 4 | Fingolimod Hydrochloride | FAERS: 23 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 5 | Dimethyl Fumarate | FAERS: 21 | US FAERS | |
| 6 | Levofloxacin | FAERS: 21 | US FAERS | |
| 7 | Rosuvastatin Calcium | FAERS: 15 | US FAERS | |
| 8 | MDV 3100 | FAERS: 12 | US FAERS | |
| 9 | Simvastatin | FAERS: 11 | OFFSIDES US FAERS | |
| 10 | 4-Aminopyridine | FAERS: 10 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 11 | Sorafenib | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 12 | teriflunomide | FAERS: 10 | US FAERS | |
| 13 | Duloxetine Hydrochloride | FAERS: 9 | US FAERS | |
| 14 | Atorvastatin | FAERS: 8 | SIDER US FAERS | |
| 15 | Ciprofloxacin | FAERS: 7 | US FAERS | |
| 16 | Glatiramer Acetate | FAERS: 7 | US FAERS | |
| 17 | Pregabalin | FAERS: 7 | US FAERS | |
| 18 | Sertraline | FAERS: 7 | US FAERS | |
| 19 | ambrisentan | FAERS: 7 | US FAERS | |
| 20 | Baclofen | FAERS: 6 | US FAERS | |
| 21 | Lenalidomide | FAERS: 6 | US FAERS | |
| 22 | Rivaroxaban | FAERS: 6 | US FAERS | |
| 23 | Zoledronic Acid | FAERS: 6 | US FAERS | |
| 24 | apremilast | FAERS: 6 | US FAERS | |
| 25 | etonogestrel | FAERS: 6 | US FAERS | |
| 26 | 2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride | FAERS: 5 | US FAERS | |
| 27 | 4-hydroxybutyric acid | FAERS: 5 | US FAERS | |
| 28 | Norgestrel | FAERS: 5 | US FAERS | |
| 29 | Valsartan | FAERS: 5 | OFFSIDES US FAERS | |
| 30 | apixaban | FAERS: 5 | US FAERS | |
| 31 | 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide | FAERS: 4 | US FAERS | |
| 32 | Finasteride | FAERS: 4 | US FAERS | |
| 33 | Gadolinium DTPA | FAERS: 4 | US FAERS | |
| 34 | HhAntag691 | FAERS: 4 | US FAERS | |
| 35 | Isotretinoin | FAERS: 4 | US FAERS | |
| 36 | Niacin | FAERS: 4 | US FAERS | |
| 37 | Octreotide | FAERS: 4 | US FAERS | |
| 38 | Tenofovir | FAERS: 4 | US FAERS | |
| 39 | Varenicline | FAERS: 4 | US FAERS | |
| 40 | ledipasvir, sofosbuvir drug combination | FAERS: 4 | US FAERS | |
| 41 | niraparib | FAERS: 4 | US FAERS | |
| 42 | palbociclib | FAERS: 4 | US FAERS | |
| 43 | Aripiprazole | FAERS: 3 | OFFSIDES US FAERS | |
| 44 | Dasatinib | FAERS: 3 | US FAERS | |
| 45 | Digoxin | FAERS: 3 | US FAERS | |
| 46 | Exenatide | FAERS: 3 | US FAERS | |
| 47 | Ezetimibe | FAERS: 3 | US FAERS | |
| 48 | Gabapentin | FAERS: 3 | US FAERS | |
| 49 | Ibandronic Acid | FAERS: 3 | US FAERS | |
| 50 | Ibandronic Acid | FAERS: 3 | OFFSIDES US FAERS | |
| 51 | Imatinib Mesylate | FAERS: 3 | US FAERS | |
| 52 | Pramipexole | FAERS: 3 | US FAERS | |
| 53 | Pravastatin | FAERS: 3 | US FAERS | |
| 54 | Ruxolitinib phosphate | FAERS: 3 | US FAERS | |
| 55 | Telbivudine | FAERS: 3 | US FAERS | |
| 56 | Thyroxine | FAERS: 3 | US FAERS | |
| 57 | Venlafaxine Hydrochloride | FAERS: 3 | US FAERS | |
| 58 | pirfenidone | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 59 | regorafenib | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 60 | Amlodipine | FAERS: 2 | OFFSIDES US FAERS | |
| 61 | Asenapine | FAERS: 2 | US FAERS | |
| 62 | Atomoxetine Hydrochloride | FAERS: 2 | US FAERS | |
| 63 | Axitinib | FAERS: 2 | US FAERS | |
| 64 | CH5424802 | FAERS: 2 | US FAERS | |
| 65 | Cabozantinib S-malate | FAERS: 2 | US FAERS | |
| 66 | Capecitabine | FAERS: 2 | US FAERS | |
| 67 | Cinacalcet | FAERS: 2 | US FAERS | |
| 68 | Citalopram | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 69 | Clarithromycin | FAERS: 2 | US FAERS | |
| 70 | Dabigatran | FAERS: 2 | US FAERS | |
| 71 | Diclofenac | FAERS: 2 | US FAERS | |
| 72 | Ezetimibe, Simvastatin Drug Combination | FAERS: 2 | US FAERS | |
| 73 | Furosemide | FAERS: 2 | US FAERS | |
| 74 | Gemfibrozil | FAERS: 2 | US FAERS | |
| 75 | Linezolid | FAERS: 2 | US FAERS | |
| 76 | Lisdexamfetamine Dimesylate | FAERS: 2 | US FAERS | |
| 77 | Methylphenidate | FAERS: 2 | US FAERS | |
| 78 | Methylprednisolone Acetate | FAERS: 2 | US FAERS | |
| 79 | Olmesartan Medoxomil | FAERS: 2 | US FAERS | |
| 80 | PCI 32765 | FAERS: 2 | US FAERS | |
| 81 | Quetiapine Fumarate | FAERS: 2 | US FAERS | |
| 82 | Risperidone | FAERS: 2 | US FAERS | |
| 83 | Sertraline | FAERS: 2 | US FAERS | |
| 84 | Tadalafil | FAERS: 2 | US FAERS | |
| 85 | Telmisartan | FAERS: 2 | US FAERS | |
| 86 | Terbinafine | FAERS: 2 | US FAERS | |
| 87 | Tiotropium Bromide | FAERS: 2 | US FAERS | |
| 88 | brexpiprazole | FAERS: 2 | US FAERS | |
| 89 | eletriptan | FAERS: 2 | OFFSIDES US FAERS | |
| 90 | gadobutrol | FAERS: 2 | US FAERS | |
| 91 | montelukast | FAERS: 2 | US FAERS | |
| 92 | zolmitriptan | FAERS: 2 | US FAERS | |
| 93 | 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol | FAERS: 1 | US FAERS | |
| 94 | Abiraterone Acetate | FAERS: 1 | US FAERS | |
| 95 | Alendronate | FAERS: 1 | US FAERS | |
| 96 | Anastrozole | FAERS: 1 | US FAERS | |
| 97 | Benicar hct | FAERS: 1 | US FAERS | |
| 98 | Bisoprolol | FAERS: 1 | US FAERS | |
| 99 | Breo Ellipta | FAERS: 1 | US FAERS | |
| 100 | Buprenorphine, Naloxone Drug Combination | FAERS: 1 | US FAERS | |
| 101 | CID 129626832 | FAERS: 1 | US FAERS | |
| 102 | Canagliflozin | FAERS: 1 | US FAERS | |
| 103 | Carbamazepine | FAERS: 1 | US FAERS | |
| 104 | Cefdinir | FAERS: 1 | OFFSIDES US FAERS | |
| 105 | Choline fenofibrate | FAERS: 1 | US FAERS | |
| 106 | Ciprofloxacin | FAERS: 1 | US FAERS | |
| 107 | Cisapride | FAERS: 1 | US FAERS | |
| 108 | Clonazepam | FAERS: 1 | US FAERS | |
| 109 | Desmopressin acetate trihydrate | FAERS: 1 | US FAERS | |
| 110 | Desvenlafaxine Succinate | FAERS: 1 | US FAERS | |
| 111 | Dichlorphenamide | FAERS: 1 | US FAERS | |
| 112 | Doxycycline | FAERS: 1 | US FAERS | |
| 113 | Droxidopa | FAERS: 1 | US FAERS | |
| 114 | Erlotinib Hydrochloride | FAERS: 1 | US FAERS | |
| 115 | Ertapenem | FAERS: 1 | US FAERS | |
| 116 | Estrogens, Conjugated (USP) | FAERS: 1 | US FAERS | |
| 117 | Ethylene Glycol | FAERS: 1 | US FAERS | |
| 118 | Everolimus | FAERS: 1 | US FAERS | |
| 119 | Febuxostat | FAERS: 1 | US FAERS | |
| 120 | Fentanyl | FAERS: 1 | US FAERS | |
| 121 | Fidaxomicin | FAERS: 1 | US FAERS | |
| 122 | Haloperidol | FAERS: 1 | US FAERS | |
| 123 | Hydrochlorothiazide | FAERS: 1 | US FAERS | |
| 124 | Hydroxychloroquine | FAERS: 1 | US FAERS | |
| 125 | Hydroxyurea | FAERS: 1 | US FAERS | |
| 126 | Insulin Glargine | FAERS: 1 | US FAERS | |
| 127 | Insulin | FAERS: 1 | US FAERS | |
| 128 | Lamivudine | FAERS: 1 | US FAERS | |
| 129 | Lamotrigine | FAERS: 1 | US FAERS | |
| 130 | Liraglutide | FAERS: 1 | US FAERS | |
| 131 | Lopinavir | FAERS: 1 | US FAERS | |
| 132 | Losartan | FAERS: 1 | US FAERS | |
| 133 | Losartan | FAERS: 1 | US FAERS | |
| 134 | Lovastatin | FAERS: 1 | US FAERS | |
| 135 | Lurasidone Hydrochloride | FAERS: 1 | US FAERS | |
| 136 | Magnesium Sulfate | FAERS: 1 | US FAERS | |
| 137 | Mechlorethamine | FAERS: 1 | US FAERS | |
| 138 | Meloxicam | FAERS: 1 | US FAERS | |
| 139 | Metformin | FAERS: 1 | US FAERS | |
| 140 | Methadone | FAERS: 1 | US FAERS | |
| 141 | Methimazole | FAERS: 1 | US FAERS | |
| 142 | Methylprednisolone Hemisuccinate | FAERS: 1 | US FAERS | |
| 143 | Minocycline | FAERS: 1 | US FAERS | |
| 144 | Moxifloxacin | FAERS: 1 | US FAERS | |
| 145 | Naltrexone | FAERS: 1 | US FAERS | |
| 146 | Nicotine | FAERS: 1 | OFFSIDES US FAERS | |
| 147 | Nifedipine | FAERS: 1 | US FAERS | |
| 148 | Nortriptyline | FAERS: 1 | US FAERS | |
| 149 | NuvaRing | FAERS: 1 | US FAERS | |
| 150 | Octreotide | FAERS: 1 | US FAERS | |
| 151 | Olanzapine | FAERS: 1 | US FAERS | |
| 152 | Omeprazole | FAERS: 1 | US FAERS | |
| 153 | Oxcarbazepine | FAERS: 1 | US FAERS | |
| 154 | Pamidronate | FAERS: 1 | US FAERS | |
| 155 | Pioglitazone | FAERS: 1 | US FAERS | |
| 156 | Pravastatin | FAERS: 1 | US FAERS | |
| 157 | Prednisolone | FAERS: 1 | US FAERS | |
| 158 | Prednisone | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 159 | Pyridostigmine Bromide | FAERS: 1 | US FAERS | |
| 160 | Qlaira | FAERS: 1 | US FAERS | |
| 161 | Qsymia | FAERS: 1 | US FAERS | |
| 162 | Quetiapine Fumarate | FAERS: 1 | US FAERS | |
| 163 | Ranolazine | FAERS: 1 | US FAERS | |
| 164 | Simcor | FAERS: 1 | US FAERS | |
| 165 | Sitagliptin Phosphate | FAERS: 1 | US FAERS | |
| 166 | Sofosbuvir | FAERS: 1 | US FAERS | |
| 167 | Spironolactone | FAERS: 1 | OFFSIDES US FAERS | |
| 168 | Sulfasalazine | FAERS: 1 | US FAERS | |
| 169 | Sunitinib | FAERS: 1 | US FAERS | |
| 170 | Synjardy | FAERS: 1 | US FAERS | |
| 171 | Tamsulosin | FAERS: 1 | US FAERS | |
| 172 | Temozolomide | FAERS: 1 | US FAERS | |
| 173 | Tenofovir | FAERS: 1 | US FAERS | |
| 174 | Terbinafine | FAERS: 1 | US FAERS | |
| 175 | Testosterone | FAERS: 1 | US FAERS | |
| 176 | Tinidazole | FAERS: 1 | US FAERS | |
| 177 | Topiramate | FAERS: 1 | SIDER US FAERS | |
| 178 | Tramadol | FAERS: 1 | US FAERS | |
| 179 | Triamcinolone Acetonide | FAERS: 1 | OFFSIDES US FAERS | |
| 180 | Tribenzor | FAERS: 1 | US FAERS | |
| 181 | Triiodothyronine | FAERS: 1 | US FAERS | |
| 182 | Triumeq | FAERS: 1 | US FAERS | |
| 183 | Umeclidinium bromide | FAERS: 1 | US FAERS | |
| 184 | Valacyclovir | FAERS: 1 | US FAERS | |
| 185 | Valproic Acid | FAERS: 1 | US FAERS | |
| 186 | Varenicline | FAERS: 1 | US FAERS | |
| 187 | Vemurafenib | FAERS: 1 | US FAERS | |
| 188 | Venlafaxine Hydrochloride | FAERS: 1 | US FAERS | |
| 189 | Verapamil | FAERS: 1 | US FAERS | |
| 190 | Viekira Pak | FAERS: 1 | US FAERS | |
| 191 | Warfarin | FAERS: 1 | US FAERS | |
| 192 | deflazacort | FAERS: 1 | US FAERS | |
| 193 | edoxaban | FAERS: 1 | US FAERS | |
| 194 | eluxadoline | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 195 | empagliflozin | FAERS: 1 | US FAERS | |
| 196 | fexofenadine | FAERS: 1 | US FAERS | |
| 197 | flibanserin | FAERS: 1 | US FAERS | |
| 198 | fluticasone furoate | FAERS: 1 | US FAERS | |
| 199 | frovatriptan | FAERS: 1 | US FAERS | |
| 200 | gadoterate meglumine | FAERS: 1 | US FAERS | |
| 201 | iopromide | FAERS: 1 | US FAERS | |
| 202 | lanreotide | FAERS: 1 | US FAERS | |
| 203 | lumacaftor, ivacaftor drug combination | FAERS: 1 | US FAERS | |
| 204 | midostaurin | FAERS: 1 | US FAERS | |
| 205 | obeticholic acid | FAERS: 1 | US FAERS | |
| 206 | pomalidomide | FAERS: 1 | US FAERS | |
| 207 | regadenoson | FAERS: 1 | US FAERS | |
| 208 | rimexolone | FAERS: 1 | US FAERS | |
| 209 | rizatriptan | FAERS: 1 | US FAERS | |
| 210 | rofecoxib | FAERS: 1 | US FAERS | |
| 211 | sofosbuvir-velpatasvir drug combination | FAERS: 1 | US FAERS | |
| 212 | sumatriptan-naproxen | FAERS: 1 | US FAERS | |
| 213 | suvorexant | FAERS: 1 | US FAERS | |
| 214 | telithromycin | FAERS: 1 | US FAERS | |
| 215 | tofacitinib | FAERS: 1 | US FAERS | |
| 216 | torezolid phosphate | FAERS: 1 | US FAERS | |
| 217 | trametinib | FAERS: 1 | US FAERS | |
| 218 | Amiloride | OFFSIDES | ||
| 219 | Ascorbic Acid | OFFSIDES | ||
| 220 | Atenolol | OFFSIDES | ||
| 221 | Calcitriol | OFFSIDES | ||
| 222 | Calcium Compounds | OFFSIDES | ||
| 223 | Carvedilol | OFFSIDES | ||
| 224 | Chlorpromazine | OFFSIDES | ||
| 225 | Cinacalcet | OFFSIDES | ||
| 226 | Clopidogrel | OFFSIDES | ||
| 227 | Cyclosporine | OFFSIDES | ||
| 228 | Dimenhydrinate | OFFSIDES | ||
| 229 | Diphenoxylate | OFFSIDES | ||
| 230 | Dutasteride | OFFSIDES | ||
| 231 | Ferric Oxide, Saccharated | Canada Vigilance: 1 | Canada Vigilance | |
| 232 | Fluvastatin | OFFSIDES | ||
| 233 | Hydroxychloroquine | OFFSIDES | ||
| 234 | Iopamidol | OFFSIDES | ||
| 235 | Ipratropium | OFFSIDES | ||
| 236 | Irinotecan | OFFSIDES | ||
| 237 | Ketoconazole | OFFSIDES | ||
| 238 | Lactic Acid | OFFSIDES | ||
| 239 | Leuprolide | OFFSIDES | ||
| 240 | Melatonin | OFFSIDES | ||
| 241 | Minoxidil | OFFSIDES | ||
| 242 | Mycophenolic Acid | OFFSIDES | ||
| 243 | Norfloxacin | OFFSIDES | ||
| 244 | Nortriptyline | OFFSIDES | ||
| 245 | Ofloxacin | OFFSIDES | ||
| 246 | Orphenadrine | OFFSIDES | ||
| 247 | Perindopril | OFFSIDES | ||
| 248 | Quinidine | OFFSIDES | ||
| 249 | Ramipril | OFFSIDES | ||
| 250 | Rifampin | OFFSIDES | ||
| 251 | Rilmenidine | OFFSIDES | ||
| 252 | Rosiglitazone | OFFSIDES | ||
| 253 | Sevelamer | OFFSIDES | ||
| 254 | Sevelamer | OFFSIDES | ||
| 255 | Sildenafil Citrate | OFFSIDES | ||
| 256 | Sulfate | OFFSIDES | ||
| 257 | Sumatriptan | SIDER | ||
| 258 | Tamoxifen | Canada Vigilance: 1 | Canada Vigilance | |
| 259 | Thymidine | OFFSIDES | ||
| 260 | Tolbutamide | OFFSIDES | ||
| 261 | Ubiquinone | OFFSIDES | ||
| 262 | Verapamil | OFFSIDES SIDER | ||
| 263 | Vitamin E | OFFSIDES | ||
| 264 | alfuzosin | OFFSIDES | ||
| 265 | ciclesonide | OFFSIDES | ||
| 266 | gadobenic acid | OFFSIDES | ||
| 267 | gadodiamide | OFFSIDES | ||
| 268 | gadoteridol | OFFSIDES | ||
| 269 | gadoversetamide | OFFSIDES | ||
| 270 | nefazodone | OFFSIDES | ||
| 271 | periciazine | OFFSIDES | ||
| 272 | pirbuterol | OFFSIDES | ||
| 273 | rizatriptan | OFFSIDES | ||
| 274 | sitaxsentan | SIDER | ||
| 275 | tegaserod | OFFSIDES | ||
| 276 | tegaserod | OFFSIDES |
Similar ADE(s)
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