MetaADEDB 2.0 @ LMMD
Cinacalcet
(VDHAWDNDOKGFTD-MRXNPFEDSA-N)
Structure
SMILES
C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F
Type(s)
Approved
ATC code(s)
H05BX01
Molecular Formula:
C22H22F3N
Molecular Weight:
357.412
Log P:
6.5329
Hydrogen Bond Acceptor:
1
Hydrogen Bond Donor:
1
TPSA:
12.03
CAS Number(s):
226256-56-0
Synonym(s)
1.
Cinacalcet
2.
AMG 073
3.
AMG073
4.
Alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride
5.
Cinacalcet Hydrochloride
6.
KRN 1493
7.
Sensipar
External Link(s)
MeSHD000069449
PubChem Compound156419
BindingDB50432170
50416875
ChEBI48390
CHEMBLCHEMBL1201284
DrugBankDB01012
DrugCentral647
IUPHAR/BPS Guide to PHARMACOLOGY3308
KEGGdr:D03504
Therapeutic Target DatabaseD03YGR
ZINC1550499
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Myocardial InfarctionFAERS: 4US FAERS
2Abdominal PainFAERS: 2OFFSIDES
SIDER
US FAERS
3Acute Coronary SyndromeFAERS: 2US FAERS
4Bone painFAERS: 2OFFSIDES
US FAERS
5Coronary Artery DiseaseFAERS: 2US FAERS
6HyperparathyroidismFAERS: 2

View details

17060004
17315015
18775977
19715927
 		CTD
OFFSIDES
US FAERS
7Weight decreasedFAERS: 2US FAERS
8Angina PectorisFAERS: 1US FAERS
9Arteriovenous graft thrombosisFAERS: 1OFFSIDES
US FAERS
10ArthralgiaFAERS: 122118402CTD
SIDER
US FAERS
11AstheniaFAERS: 1OFFSIDES
SIDER
US FAERS
12Blood parathyroid hormone decreasedFAERS: 1OFFSIDES
US FAERS
13BradycardiaFAERS: 1OFFSIDES
US FAERS
14Catheter site infectionFAERS: 1US FAERS
15ConstipationFAERS: 1SIDER
US FAERS
16DehydrationFAERS: 1OFFSIDES
SIDER
US FAERS
17Gastric ulcerFAERS: 1US FAERS
18GastritisFAERS: 1US FAERS
19HypersensitivityFAERS: 1SIDER
US FAERS
20HypotensionFAERS: 1SIDER
US FAERS
21HypoxiaFAERS: 1US FAERS
22Joint swellingFAERS: 1US FAERS
23Mallory-Weiss SyndromeFAERS: 1OFFSIDES
US FAERS
24Mental status changesFAERS: 1US FAERS
25NauseaFAERS: 116680561CTD
OFFSIDES
SIDER
US FAERS
26Pleuritic painFAERS: 1US FAERS
27PneumoniaFAERS: 1US FAERS
28ProstatectomyFAERS: 1US FAERS
29Renal embolismFAERS: 1US FAERS
30SepsisFAERS: 1US FAERS
31Transaminases increasedFAERS: 1OFFSIDES
US FAERS
32Ventricular arrhythmiaFAERS: 1SIDER
US FAERS
33VomitingFAERS: 1SIDER
US FAERS
34AbasiaOFFSIDES
35Abdominal discomfortOFFSIDES
36Abdominal rigidityOFFSIDES
37AbscessOFFSIDES
38Acid refluxOFFSIDES
39Activities of daily living impairedOFFSIDES
40Acute bronchitisOFFSIDES
41Acute myocardial infarctionOFFSIDES
42AdenomaOFFSIDES
43Adrenal massOFFSIDES
44AlopeciaOFFSIDES
45Altered bowel functionOFFSIDES
46Altered state of consciousnessOFFSIDES
47Altered visual depth perceptionOFFSIDES
48Anastomotic complicationOFFSIDES
49AngioedemaOFFSIDES
SIDER
50AngiosclerosisOFFSIDES
51AnhedoniaOFFSIDES
52AnhidrosisOFFSIDES
53Ankle FractureOFFSIDES
54AnorexiaOFFSIDES
SIDER
55Anticoagulation drug level above therapeuticOFFSIDES
56AnxietyOFFSIDES
57ApathyOFFSIDES
58ApneaOFFSIDES
59Arteriovenous fistula site complicationOFFSIDES
60Arteriovenous fistula thrombosisOFFSIDES
61Aspartate aminotransferase abnormalOFFSIDES
62AtaxiaOFFSIDES
63AthetosisOFFSIDES
64Autonomic neuropathyOFFSIDES
65Benign bone neoplasmOFFSIDES
66BlepharitisOFFSIDES
67BlepharospasmOFFSIDES
68Blood GlucoseOFFSIDES
69Blood albumin decreasedOFFSIDES
70Blood alkaline phosphatase increasedOFFSIDES
71Blood calcium abnormalOFFSIDES
72Blood count abnormalOFFSIDES
73Blood electrolytes abnormalOFFSIDES
74Blood glucose decreasedOFFSIDES
75Blood iron increasedOFFSIDES
76Blood parathyroid hormoneOFFSIDES
77Blood parathyroid hormone increasedOFFSIDES
78Blood phosphorus decreasedOFFSIDES
79Blood phosphorus increasedOFFSIDES
80Blood phosphorusOFFSIDES
81Blood potassium decreasedOFFSIDES
82Bone callus excessiveOFFSIDES
83Brain natriuretic peptide increasedOFFSIDES
84Brain scan abnormalOFFSIDES
85Breast discomfortOFFSIDES
86BronchitisOFFSIDES
87Burning sensationOFFSIDES
88CalcinosisOFFSIDES
89CalciphylaxisOFFSIDES
90CarcinomaSIDER
91Cardiac TamponadeOFFSIDES
92Cardiac enzymes increasedOFFSIDES
93Cardiac infectionOFFSIDES
94Cardiac ventricular disorderOFFSIDES
95Cardioactive drug level increasedOFFSIDES
96Catheter placementOFFSIDES
97CellulitisOFFSIDES
98Cerebral atrophyOFFSIDES
99Chest PainOFFSIDES
SIDER
100Choking sensationOFFSIDES
101Cholecystitis infectiveOFFSIDES
102Clostridium difficile colitisOFFSIDES
103Cogwheel RigidityOFFSIDES
104Colon adenomaOFFSIDES
105ContractureOFFSIDES
106CraniotomyOFFSIDES
107CystOFFSIDES
108DeafnessOFFSIDES
109DebridementOFFSIDES
110DemyelinationOFFSIDES
111Dental abscessOFFSIDES
112Dental cariesOFFSIDES
113DermatitisSIDER
114Device FailureOFFSIDES
115Device intoleranceOFFSIDES
116Device related infectionOFFSIDES
117Diabetic RetinopathyOFFSIDES
118Diabetic ulcerOFFSIDES
119Dialysis disequilibrium syndromeOFFSIDES
120DiarrheaOFFSIDES
121Disease complicationOFFSIDES
122DiverticulitisOFFSIDES
123DiverticulosisOFFSIDES
124DiverticulumOFFSIDES
125DizzinessOFFSIDES
SIDER
126Drug Eruptions19560849CTD
127Drug withdrawal headacheOFFSIDES
128Dry skinOFFSIDES
129DysgraphiaOFFSIDES
130DyslaliaOFFSIDES
131DyspepsiaOFFSIDES
SIDER
132DysuriaOFFSIDES
133Economic problemOFFSIDES
134EczemaOFFSIDES
135Ejection Fraction DecreasedOFFSIDES
136Emotional disorderOFFSIDES
137Emotional distressOFFSIDES
138Endodontic procedureOFFSIDES
139Enteral NutritionOFFSIDES
140Enterococcal infectionOFFSIDES
141Epidural AbscessOFFSIDES
142EpistaxisOFFSIDES
143Epstein-Barr virus test positiveOFFSIDES
144Erectile dysfunctionOFFSIDES
145Erythema InduratumOFFSIDES
146Erythema InfectiosumOFFSIDES
147ErythemaOFFSIDES
148Essential HypertensionOFFSIDES
149Exfoliative rashOFFSIDES
150Extremity contractureOFFSIDES
151Failure to ThriveOFFSIDES
152FatigueOFFSIDES
SIDER
153Feeling ColdOFFSIDES
154Fibrin increasedOFFSIDES
155Flank PainOFFSIDES
156Fluid overloadOFFSIDES
157Focal glomerulosclerosisOFFSIDES
158FormicationOFFSIDES
159FractureSIDER
160Full blood count decreasedOFFSIDES
161Fungal peritonitisOFFSIDES
162Gamma-Glutamyltransferase IncreasedOFFSIDES
163Gamma-glutamyltransferase abnormalOFFSIDES
164GammopathyOFFSIDES
165GangreneOFFSIDES
166Gastrointestinal Diseases19715927CTD
167Gastrointestinal PainSIDER
168Gastrointestinal obstructionOFFSIDES
169Gastrointestinal stoma complicationOFFSIDES
170General physical health deteriorationOFFSIDES
171GlobulinuriaOFFSIDES
172GoutOFFSIDES
173Graft dysfunctionOFFSIDES
174Headache16680561CTD
SIDER
175HepatoblastomaOFFSIDES
176HepatosplenomegalyOFFSIDES
177High turnover osteopathyOFFSIDES
178Hungry bone syndromeOFFSIDES
179HydrothoraxOFFSIDES
180Hypercalcemia

View details

17060004
17315015
17472827
18721002
18775977
 		CTD
181HypercapniaOFFSIDES
182HyperkeratosisOFFSIDES
183Hyperparathyroidism, Primary17472827CTD
184Hyperparathyroidism, Secondary17472827
18721002
22118402		CTD
185HyperpigmentationOFFSIDES
186HypophagiaOFFSIDES
187Implantable defibrillator insertionOFFSIDES
188IndurationOFFSIDES
189InfectionOFFSIDES
SIDER
190Infusion site infectionOFFSIDES
191Infusion site mobility decreasedOFFSIDES
192Intention tremorOFFSIDES
193Intercostal neuralgiaOFFSIDES
194Intervertebral disc compressionOFFSIDES
195Joint Range of Motion DecreasedOFFSIDES
196Joint stiffnessOFFSIDES
197Klebsiella sepsisOFFSIDES
198LethargyOFFSIDES
199Ligament injuryOFFSIDES
200Limb injuryOFFSIDES
201Lipase abnormalOFFSIDES
202Livedo ReticularisOFFSIDES
203Low turnover osteopathyOFFSIDES
204Lower respiratory tract infection viralOFFSIDES
205Lung infection pseudomonalOFFSIDES
206LymphangitisOFFSIDES
207LymphedemaOFFSIDES
208MalnutritionSIDER
209Memory Disorders22118402CTD
210Meningeal disorderOFFSIDES
211Meningitis enterococcalOFFSIDES
212Mental RetardationOFFSIDES
213Metastatic CarcinomaSIDER
214Metastatic NeoplasmSIDER
215MorpheaOFFSIDES
216Multiple MyelomaOFFSIDES
217Muscle FatigueOFFSIDES
218Muscle WeaknessOFFSIDES
219Muscle abscessOFFSIDES
220Muscle necrosisOFFSIDES
221Muscle tightnessOFFSIDES
222Musculoskeletal PainOFFSIDES
223Musculoskeletal discomfortSIDER
224Musculoskeletal stiffnessOFFSIDES
225Myalgia22118402CTD
SIDER
226Myocardial fibrosisOFFSIDES
227Myoglobin blood increasedOFFSIDES
228Nephrogenic Fibrosing DermopathyOFFSIDES
229NephrolithiasisOFFSIDES
230NeuralgiaOFFSIDES
231NeurodermatitisOFFSIDES
232Nipple painOFFSIDES
233Nodular regenerative hyperplasiaOFFSIDES
234Nodule on extremityOFFSIDES
235Non-cardiac chest painOFFSIDES
236Ocular icterusOFFSIDES
237Open woundOFFSIDES
238Optic NeuropathyOFFSIDES
239Oral Cavity FistulaOFFSIDES
240OsteolysisOFFSIDES
241OsteopeniaOFFSIDES
242OsteoporosisOFFSIDES
243PainOFFSIDES
244Pancreatic PseudocystOFFSIDES
245PancreatitisOFFSIDES
246Papillary muscle disorderOFFSIDES
247ParathyroidectomyOFFSIDES
248Performance status decreasedOFFSIDES
249Pericardial effusionOFFSIDES
250PericarditisOFFSIDES
251Peritoneal DialysisOFFSIDES
252Peritoneal cloudy effluentOFFSIDES
253PeritonitisOFFSIDES
254Physical disabilityOFFSIDES
255PingueculaOFFSIDES
256Post inflammatory pigmentation changeOFFSIDES
257Post procedural complicationOFFSIDES
258Precocious PubertyOFFSIDES
259Procedural hypotensionOFFSIDES
260ProctitisOFFSIDES
261Pruritus22118402CTD
SIDER
262Pulmonary function test decreasedOFFSIDES
263Purpura19560849CTD
264PyelonephritisOFFSIDES
265QRS axis abnormalOFFSIDES
266Quality of life decreasedOFFSIDES
267Rebound effectOFFSIDES
268Renal ColicOFFSIDES
269SclerodactyliaOFFSIDES
270Secondary hyperthyroidismOFFSIDES
271Shock, Cardiogenic17472827CTD
272Shoulder PainOFFSIDES
273Shoulder deformityOFFSIDES
274Shunt thrombosisOFFSIDES
275Skin ErosionOFFSIDES
276Skin IndurationOFFSIDES
277Skin WrinklingOFFSIDES
278Skin hypertrophyOFFSIDES
279Skin lesionOFFSIDES
280Skin necrosisOFFSIDES
281Skin tightnessOFFSIDES
282Soft Tissue InfectionOFFSIDES
283Soft tissue necrosisOFFSIDES
284SpondylitisOFFSIDES
285Status EpilepticusOFFSIDES
286Subcutaneous AbscessOFFSIDES
287Sudden Cardiac DeathOFFSIDES
288Tardive DyskinesiaOFFSIDES
289TetanyOFFSIDES
SIDER
290ThrombectomyOFFSIDES
291ThrombosisSIDER
292ThyroidectomyOFFSIDES
293Tongue bitingOFFSIDES
294Tonic clonic movementsOFFSIDES
295Tooth ErosionOFFSIDES
296Tooth ExtractionOFFSIDES
297Unresponsive to stimuliOFFSIDES
298Upper respiratory tract inflammationOFFSIDES
299Ureteral stent insertionOFFSIDES
300Urge IncontinenceOFFSIDES
301UrticariaSIDER
302Uterine abscessOFFSIDES
303Vascular Access ComplicationOFFSIDES
304Vasculitis, Leukocytoclastic, Cutaneous19560849CTD
305Venous InsufficiencyOFFSIDES
306Vertebral column massOFFSIDES
307VertebroplastyOFFSIDES
308Very low density lipoprotein increasedOFFSIDES
309Wound ComplicationOFFSIDES
310Wound infection staphylococcalOFFSIDES
311XerosisOFFSIDES
312YawningOFFSIDES
313bone marrow fibrosisOFFSIDES
314effusionOFFSIDES
315nervous system disorderSIDER
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