edoxaban
(HGVDHZBSSITLCT-JLJPHGGASA-N)
Structure
- SMILES
- CN1CCc2c(C1)sc(n2)C(=O)N[C@@H]1C[C@H](CC[C@@H]1NC(=O)C(=O)Nc1ccc(cn1)Cl)C(=O)N(C)C
- Type(s)
- Approved
- ATC code(s)
- B01AF03
- Molecular Formula:
- C24H30ClN7O4S
- Molecular Weight:
- 548.058
- Log P:
- 2.0823
- Hydrogen Bond Acceptor:
- 12
- Hydrogen Bond Donor:
- 3
- TPSA:
- 164.87
- CAS Number(s):
- 480449-70-5; 912273-65-5
Synonym(s)
1.
edoxaban
2.
DU-176
3.
DU-176b
4.
N-(5-chloropyridin-2-yl)-N'-((1S,2R,4S)-4-(N,N-dimethylcarbamoyl)-2-(5-methyl-4,5,6,7- tetrahydro(1,3)thiazolo(5,4-c)pyridine-2-carboxamido)cyclohexyl)oxamide
5.
N-(5-chloropyridin-2-yl)-N'-((1S,2R,4S)-4-(N,N-dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridine-2-carboxamido)cyclohexyl)ethanediamide p-toluenesulfonate monohydrate
6.
edoxaban tosylate
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Cerebrovascular accident | FAERS: 110 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 2 | Cerebral Infarction | FAERS: 92 | US FAERS | |
| 3 | Embolic stroke | FAERS: 43 | US FAERS | |
| 4 | Pulmonary Embolism | FAERS: 42 | US FAERS | |
| 5 | Epistaxis | FAERS: 41 | US FAERS | |
| 6 | Nausea | FAERS: 35 | US FAERS | |
| 7 | Dizziness | FAERS: 28 | US FAERS | |
| 8 | Thrombosis | FAERS: 25 | US FAERS | |
| 9 | Headache | FAERS: 23 | US FAERS | |
| 10 | Deep Vein Thrombosis | FAERS: 22 | US FAERS | |
| 11 | Incorrect dose administered | FAERS: 18 | US FAERS | |
| 12 | Fatigue | FAERS: 17 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 13 | Pneumonia | FAERS: 16 | US FAERS | |
| 14 | No adverse event | FAERS: 15 | US FAERS | |
| 15 | Vomiting | FAERS: 15 | US FAERS | |
| 16 | Abdominal discomfort | FAERS: 14 | US FAERS | |
| 17 | Pruritus | FAERS: 14 | US FAERS | |
| 18 | Atrial thrombosis | FAERS: 13 | US FAERS | |
| 19 | Chest Pain | FAERS: 13 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 20 | Blood urine present | FAERS: 11 | US FAERS | |
| 21 | Asthenia | FAERS: 9 | US FAERS | |
| 22 | Arthralgia | FAERS: 8 | US FAERS | |
| 23 | Malaise | FAERS: 8 | US FAERS | |
| 24 | Drug administration error | FAERS: 7 | US FAERS | |
| 25 | Drug ineffective | FAERS: 7 | US FAERS | |
| 26 | Embolism | FAERS: 7 | US FAERS | |
| 27 | Gastric ulcer | FAERS: 7 | US FAERS | |
| 28 | Myalgia | FAERS: 7 | US FAERS | |
| 29 | Pain | FAERS: 7 | US FAERS | |
| 30 | Peripheral swelling | FAERS: 7 | US FAERS | |
| 31 | Abdominal Pain | FAERS: 6 | US FAERS | |
| 32 | Aphasia | FAERS: 6 | US FAERS | |
| 33 | Atrial Fibrillation | FAERS: 6 | US FAERS | |
| 34 | Hemiparesis | FAERS: 6 | US FAERS | |
| 35 | Sudden death | FAERS: 6 | US FAERS | |
| 36 | Unevaluable event | FAERS: 6 | US FAERS | |
| 37 | Urticaria | FAERS: 6 | US FAERS | |
| 38 | Visual Impairment | FAERS: 6 | US FAERS | |
| 39 | Acute kidney injury | FAERS: 5 | US FAERS | |
| 40 | Back Pain | FAERS: 5 | US FAERS | |
| 41 | Cerebral artery occlusion | FAERS: 5 | US FAERS | |
| 42 | Diplopia | FAERS: 5 | US FAERS | |
| 43 | Disseminated Intravascular Coagulation | FAERS: 5 | US FAERS | |
| 44 | Drug dose omission | FAERS: 5 | US FAERS | |
| 45 | Gastrostomy | FAERS: 5 | US FAERS | |
| 46 | Overdose | FAERS: 5 | US FAERS | |
| 47 | Weight decreased | FAERS: 5 | US FAERS | |
| 48 | Alopecia | FAERS: 4 | US FAERS | |
| 49 | Chromaturia | FAERS: 4 | US FAERS | |
| 50 | Delirium | FAERS: 4 | US FAERS | |
| 51 | Dyspepsia | FAERS: 4 | US FAERS | |
| 52 | Embolic cerebral infarction | FAERS: 4 | US FAERS | |
| 53 | Fracture | FAERS: 4 | US FAERS | |
| 54 | Hypersensitivity | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 55 | Ileus | FAERS: 4 | US FAERS | |
| 56 | Product dose omission | FAERS: 4 | US FAERS | |
| 57 | Sepsis | FAERS: 4 | US FAERS | |
| 58 | Syncope | FAERS: 4 | US FAERS | |
| 59 | Thrombocytopenia | FAERS: 4 | US FAERS | |
| 60 | Thrombotic cerebral infarction | FAERS: 4 | US FAERS | |
| 61 | Tinnitus | FAERS: 4 | US FAERS | |
| 62 | Urinary tract infection | FAERS: 4 | US FAERS | |
| 63 | Cardiac Arrest | FAERS: 3 | US FAERS | |
| 64 | Cardiac Tamponade | FAERS: 3 | US FAERS | |
| 65 | Creatinine renal clearance decreased | FAERS: 3 | US FAERS | |
| 66 | Dementia | FAERS: 3 | US FAERS | |
| 67 | Duodenal Ulcer | FAERS: 3 | US FAERS | |
| 68 | Dysarthria | FAERS: 3 | US FAERS | |
| 69 | Epilepsy | FAERS: 3 | US FAERS | |
| 70 | Gastritis | FAERS: 3 | US FAERS | |
| 71 | Hemiplegia | FAERS: 3 | US FAERS | |
| 72 | Hip surgery | FAERS: 3 | US FAERS | |
| 73 | Hypotension | FAERS: 3 | US FAERS | |
| 74 | Infection | FAERS: 3 | US FAERS | |
| 75 | Laceration | FAERS: 3 | US FAERS | |
| 76 | Maternal exposure during pregnancy | FAERS: 3 | US FAERS | |
| 77 | Medication Error | FAERS: 3 | US FAERS | |
| 78 | Memory impairment | FAERS: 3 | US FAERS | |
| 79 | Myocardial Infarction | FAERS: 3 | US FAERS | |
| 80 | Palpitations | FAERS: 3 | US FAERS | |
| 81 | Petechiae | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 82 | Respiratory Failure | FAERS: 3 | US FAERS | |
| 83 | Stomatitis | FAERS: 3 | US FAERS | |
| 84 | Therapeutic response unexpected | FAERS: 3 | US FAERS | |
| 85 | Ulcer | FAERS: 3 | US FAERS | |
| 86 | Urinary Retention | FAERS: 3 | US FAERS | |
| 87 | Uterine Cancer | FAERS: 3 | US FAERS | |
| 88 | Vasculitis | FAERS: 3 | US FAERS | |
| 89 | Vertigo | FAERS: 3 | US FAERS | |
| 90 | White blood cell count decreased | FAERS: 3 | US FAERS | |
| 91 | Amnesia | FAERS: 2 | US FAERS | |
| 92 | Angina Pectoris | FAERS: 2 | US FAERS | |
| 93 | Angioedema | FAERS: 2 | US FAERS | |
| 94 | Arterial thrombosis | FAERS: 2 | US FAERS | |
| 95 | Arthritis | FAERS: 2 | US FAERS | |
| 96 | Arthropathy | FAERS: 2 | US FAERS | |
| 97 | Asthma | FAERS: 2 | US FAERS | |
| 98 | Blood glucose increased | FAERS: 2 | US FAERS | |
| 99 | Blood triglycerides increased | FAERS: 2 | US FAERS | |
| 100 | Bradycardia | FAERS: 2 | US FAERS | |
| 101 | Bronchitis | FAERS: 2 | US FAERS | |
| 102 | Cardiac ablation | FAERS: 2 | US FAERS | |
| 103 | Carotid artery occlusion | FAERS: 2 | US FAERS | |
| 104 | Cerebral ventricular rupture | FAERS: 2 | US FAERS | |
| 105 | Cholecystitis | FAERS: 2 | US FAERS | |
| 106 | Cholestasis | FAERS: 2 | US FAERS | |
| 107 | Compression fracture | FAERS: 2 | US FAERS | |
| 108 | Constipation | FAERS: 2 | US FAERS | |
| 109 | Creatinine renal clearance increased | FAERS: 2 | US FAERS | |
| 110 | Deafness | FAERS: 2 | US FAERS | |
| 111 | Dehydration | FAERS: 2 | US FAERS | |
| 112 | Drug prescribing error | FAERS: 2 | US FAERS | |
| 113 | Dysgeusia | FAERS: 2 | US FAERS | |
| 114 | Eczema | FAERS: 2 | US FAERS | |
| 115 | Feeling Cold | FAERS: 2 | US FAERS | |
| 116 | Fibrin D dimer increased | FAERS: 2 | US FAERS | |
| 117 | Gamma-Glutamyltransferase Increased | FAERS: 2 | US FAERS | |
| 118 | Hernia | FAERS: 2 | US FAERS | |
| 119 | Hypertensive crisis | FAERS: 2 | US FAERS | |
| 120 | Inappropriate schedule of drug administration | FAERS: 2 | US FAERS | |
| 121 | Inappropriate schedule of product administration | FAERS: 2 | US FAERS | |
| 122 | Increased tendency to bruise | FAERS: 2 | US FAERS | |
| 123 | Joint swelling | FAERS: 2 | US FAERS | |
| 124 | Macular degeneration | FAERS: 2 | US FAERS | |
| 125 | Medication residue present | FAERS: 2 | US FAERS | |
| 126 | Menorrhagia | FAERS: 2 | US FAERS | |
| 127 | Muscle tightness | FAERS: 2 | US FAERS | |
| 128 | Musculoskeletal Pain | FAERS: 2 | US FAERS | |
| 129 | Nasopharyngitis | FAERS: 2 | US FAERS | |
| 130 | Nephrolithiasis | FAERS: 2 | US FAERS | |
| 131 | Pallor | FAERS: 2 | US FAERS | |
| 132 | Paranoia | FAERS: 2 | US FAERS | |
| 133 | Paresis | FAERS: 2 | US FAERS | |
| 134 | Product administered to patient of inappropriate age | FAERS: 2 | US FAERS | |
| 135 | Product administration error | FAERS: 2 | US FAERS | |
| 136 | Stridor | FAERS: 2 | US FAERS | |
| 137 | Tachycardia | FAERS: 2 | US FAERS | |
| 138 | Therapy non-responder | FAERS: 2 | US FAERS | |
| 139 | Uterine myoma expulsion | FAERS: 2 | US FAERS | |
| 140 | cancer surgery | FAERS: 2 | US FAERS | |
| 141 | Abasia | FAERS: 1 | US FAERS | |
| 142 | Acute myocardial infarction | FAERS: 1 | US FAERS | |
| 143 | Acute respiratory failure | FAERS: 1 | US FAERS | |
| 144 | Adverse event | FAERS: 1 | US FAERS | |
| 145 | Agranulocytosis | FAERS: 1 | US FAERS | |
| 146 | Alanine Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 147 | Alanine aminotransferase abnormal | FAERS: 1 | US FAERS | |
| 148 | Amaurosis Fugax | FAERS: 1 | US FAERS | |
| 149 | Antiphospholipid Syndrome | FAERS: 1 | US FAERS | |
| 150 | Aortic Valve Stenosis | FAERS: 1 | US FAERS | |
| 151 | Ascites | FAERS: 1 | US FAERS | |
| 152 | Aspartate aminotransferase abnormal | FAERS: 1 | US FAERS | |
| 153 | Atrial Flutter | FAERS: 1 | US FAERS | |
| 154 | Back disorder | FAERS: 1 | US FAERS | |
| 155 | Benign Prostatic Hyperplasia | FAERS: 1 | US FAERS | |
| 156 | Blood alkaline phosphatase increased | FAERS: 1 | US FAERS | |
| 157 | Blood blister | FAERS: 1 | US FAERS | |
| 158 | Blood count abnormal | FAERS: 1 | US FAERS | |
| 159 | Blood creatinine increased | FAERS: 1 | US FAERS | |
| 160 | Blood iron decreased | FAERS: 1 | US FAERS | |
| 161 | Blood sodium increased | FAERS: 1 | US FAERS | |
| 162 | Bone pain | FAERS: 1 | US FAERS | |
| 163 | Bowen's Disease | FAERS: 1 | US FAERS | |
| 164 | Burning sensation | FAERS: 1 | US FAERS | |
| 165 | Bursitis | FAERS: 1 | US FAERS | |
| 166 | Capillary Fragility | FAERS: 1 | US FAERS | |
| 167 | Cardiac Death | FAERS: 1 | US FAERS | |
| 168 | Cardiac dysfunction | FAERS: 1 | US FAERS | |
| 169 | Cardiac ventricular thrombosis | FAERS: 1 | US FAERS | |
| 170 | Carotid Artery Thrombosis | FAERS: 1 | US FAERS | |
| 171 | Carpal Tunnel Syndrome | FAERS: 1 | US FAERS | |
| 172 | Cataract | FAERS: 1 | US FAERS | |
| 173 | Catarrh | FAERS: 1 | US FAERS | |
| 174 | Catheter site thrombosis | FAERS: 1 | US FAERS | |
| 175 | Cellulitis | FAERS: 1 | US FAERS | |
| 176 | Cerebellar infarction | FAERS: 1 | US FAERS | |
| 177 | Cerebral Thrombosis | FAERS: 1 | US FAERS | |
| 178 | Chest discomfort | FAERS: 1 | US FAERS | |
| 179 | Choking sensation | FAERS: 1 | US FAERS | |
| 180 | Cholangiocarcinoma | FAERS: 1 | US FAERS | |
| 181 | Colitis | FAERS: 1 | US FAERS | |
| 182 | Coronary angioplasty | FAERS: 1 | US FAERS | |
| 183 | Cyanopsia | FAERS: 1 | US FAERS | |
| 184 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 185 | Diabetes Insipidus | FAERS: 1 | US FAERS | |
| 186 | Diabetes Mellitus | FAERS: 1 | US FAERS | |
| 187 | Drug dispensing error | FAERS: 1 | US FAERS | |
| 188 | Drug ineffective for unapproved indication | FAERS: 1 | US FAERS | |
| 189 | Drug level below therapeutic | FAERS: 1 | US FAERS | |
| 190 | Drug resistance | FAERS: 1 | US FAERS | |
| 191 | Duodenal Obstruction | FAERS: 1 | US FAERS | |
| 192 | Ear canal injury | FAERS: 1 | US FAERS | |
| 193 | Ejection Fraction Decreased | FAERS: 1 | US FAERS | |
| 194 | Emotional distress | FAERS: 1 | US FAERS | |
| 195 | Eosinophilia | FAERS: 1 | US FAERS | |
| 196 | Exposure via body fluid | FAERS: 1 | US FAERS | |
| 197 | Eye pain | FAERS: 1 | US FAERS | |
| 198 | Facial Neuralgia | FAERS: 1 | US FAERS | |
| 199 | Facial paralysis | FAERS: 1 | US FAERS | |
| 200 | Factor VIII Deficiency | FAERS: 1 | US FAERS | |
| 201 | Feeling jittery | FAERS: 1 | US FAERS | |
| 202 | Feeling of body temperature change | FAERS: 1 | US FAERS | |
| 203 | Flatulence | FAERS: 1 | US FAERS | |
| 204 | Gaze palsy | FAERS: 1 | US FAERS | |
| 205 | General physical health deterioration | FAERS: 1 | US FAERS | |
| 206 | Genitourinary operation | FAERS: 1 | US FAERS | |
| 207 | Gout | FAERS: 1 | US FAERS | |
| 208 | Hepatitis C | FAERS: 1 | US FAERS | |
| 209 | Hepatitis | FAERS: 1 | US FAERS | |
| 210 | Hydrocephalus | FAERS: 1 | US FAERS | |
| 211 | Hypersomnia | FAERS: 1 | US FAERS | |
| 212 | Hypertransaminasaemia | FAERS: 1 | US FAERS | |
| 213 | Hyperventilation | FAERS: 1 | US FAERS | |
| 214 | Immune thrombocytopenic purpura | FAERS: 1 | US FAERS | |
| 215 | Incontinence | FAERS: 1 | US FAERS | |
| 216 | Intestinal Perforation | FAERS: 1 | US FAERS | |
| 217 | Intussusception | FAERS: 1 | US FAERS | |
| 218 | Joint stiffness | FAERS: 1 | US FAERS | |
| 219 | Kidney ablation | FAERS: 1 | US FAERS | |
| 220 | Laparotomy | FAERS: 1 | US FAERS | |
| 221 | Large intestine erosion | FAERS: 1 | US FAERS | |
| 222 | Lethargy | FAERS: 1 | US FAERS | |
| 223 | Leukocytosis | FAERS: 1 | US FAERS | |
| 224 | Limb operation | FAERS: 1 | US FAERS | |
| 225 | Lip swelling | FAERS: 1 | US FAERS | |
| 226 | Liver Abscess | FAERS: 1 | US FAERS | |
| 227 | Lower respiratory tract infection | FAERS: 1 | US FAERS | |
| 228 | Malignant neoplasm progression | FAERS: 1 | US FAERS | |
| 229 | Mallory-Weiss Syndrome | FAERS: 1 | US FAERS | |
| 230 | Marasmus | FAERS: 1 | US FAERS | |
| 231 | Metrorrhagia | FAERS: 1 | US FAERS | |
| 232 | Monoparesis | FAERS: 1 | US FAERS | |
| 233 | Monoplegia | FAERS: 1 | US FAERS | |
| 234 | Muscle Fatigue | FAERS: 1 | US FAERS | |
| 235 | Myomectomy | FAERS: 1 | US FAERS | |
| 236 | Neck Pain | FAERS: 1 | US FAERS | |
| 237 | Neutropenia | FAERS: 1 | US FAERS | |
| 238 | Occult blood positive | FAERS: 1 | US FAERS | |
| 239 | Overweight | FAERS: 1 | US FAERS | |
| 240 | Pancytopenia | FAERS: 1 | US FAERS | |
| 241 | Papule | FAERS: 1 | US FAERS | |
| 242 | Paracentesis | FAERS: 1 | US FAERS | |
| 243 | Pelvic venous thrombosis | FAERS: 1 | US FAERS | |
| 244 | Penile size reduced | FAERS: 1 | US FAERS | |
| 245 | Periorbital disorder | FAERS: 1 | US FAERS | |
| 246 | Poor quality sleep | FAERS: 1 | US FAERS | |
| 247 | Portal Vein Thrombosis | FAERS: 1 | US FAERS | |
| 248 | Post procedural persistent drain fluid | FAERS: 1 | US FAERS | |
| 249 | Prerenal failure | FAERS: 1 | US FAERS | |
| 250 | Prescribed underdose | FAERS: 1 | US FAERS | |
| 251 | Pulmonary amyloidosis | FAERS: 1 | US FAERS | |
| 252 | Purpura | FAERS: 1 | US FAERS | |
| 253 | Pyelonephritis | FAERS: 1 | US FAERS | |
| 254 | Pyuria | FAERS: 1 | US FAERS | |
| 255 | Rash erythematous | FAERS: 1 | US FAERS | |
| 256 | Reaction to drug excipients | FAERS: 1 | US FAERS | |
| 257 | Rebound effect | FAERS: 1 | US FAERS | |
| 258 | Renal embolism | FAERS: 1 | US FAERS | |
| 259 | Renal pain | FAERS: 1 | US FAERS | |
| 260 | Restlessness | FAERS: 1 | US FAERS | |
| 261 | Retinal Artery Occlusion | FAERS: 1 | US FAERS | |
| 262 | Rheumatoid Arthritis | FAERS: 1 | US FAERS | |
| 263 | Septic Shock | FAERS: 1 | US FAERS | |
| 264 | Skin Ulcer | FAERS: 1 | US FAERS | |
| 265 | Skin reaction | FAERS: 1 | US FAERS | |
| 266 | Somnolence | FAERS: 1 | US FAERS | |
| 267 | Splenic Rupture | FAERS: 1 | US FAERS | |
| 268 | Stent patency maintenance | FAERS: 1 | US FAERS | |
| 269 | Stillbirth | FAERS: 1 | US FAERS | |
| 270 | Stress | FAERS: 1 | US FAERS | |
| 271 | Sudden Cardiac Death | FAERS: 1 | US FAERS | |
| 272 | Swelling | FAERS: 1 | US FAERS | |
| 273 | Thalamic infarction | FAERS: 1 | US FAERS | |
| 274 | Throat irritation | FAERS: 1 | US FAERS | |
| 275 | Thrombotic stroke | FAERS: 1 | US FAERS | |
| 276 | Trousseau's syndrome | FAERS: 1 | US FAERS | |
| 277 | Vascular stent thrombosis | FAERS: 1 | US FAERS | |
| 278 | Venous thrombosis limb | FAERS: 1 | US FAERS | |
| 279 | Vitreous floaters | FAERS: 1 | US FAERS | |
| 280 | colonoscopy | FAERS: 1 | US FAERS | |
| 281 | jaundice | FAERS: 1 | US FAERS | |
| 282 | treatment failure | FAERS: 1 | US FAERS | |
| 283 | Hemorrhage | 28689179 | CTD | |
| 284 | Product substitution issue | Canada Vigilance: 1 | Canada Vigilance | |
| 285 | Venous Thromboembolism | 28689179 | CTD |
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