MetaADEDB 2.0 @ LMMD
Fidaxomicin
(ZVGNESXIJDCBKN-UUEYKCAUSA-N)
Structure
SMILES
CO[C@@H]1[C@H](OC/C/2=C\C=C\C[C@H](O)/C(=C/[C@H](CC)[C@H](/C(=C/C(=C/C[C@H](OC2=O)[C@H](O)C)/C)/C)O[C@@H]2OC(C)(C)[C@H]([C@@H]([C@@H]2O)O)OC(=O)C(C)C)/C)O[C@@H]([C@H]([C@@H]1O)OC(=O)c1c(O)c(Cl)c(c(c1CC)Cl)O)C
Type(s)
Approved
ATC code(s)
A07AA12
Molecular Formula:
C52H74Cl2O18
Molecular Weight:
1058.040
Log P:
6.2344
Hydrogen Bond Acceptor:
18
Hydrogen Bond Donor:
7
TPSA:
266.66
CAS Number(s):
873857-62-6
Synonym(s)
1.
Fidaxomicin
2.
Lipiarmycin
3.
Lipiarmycin A3
4.
Lipiarmycin A4
5.
Lipiarmycin B
6.
Lipiarmycin B3
7.
Lipiarmycin B4
8.
PAR 101
9.
PAR-101
10.
PAR101
11.
Tiacumicin B
12.
Tiacumicin C
External Link(s)
MeSHD000077732
PubChem Compound10034073
CHEMBLCHEMBL1255800
DrugBankDB08874
DrugCentral4180
Therapeutic Target DatabaseD06LNW
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 83US FAERS
2Clostridium difficile infectionFAERS: 73US FAERS
3Disease recurrenceFAERS: 67US FAERS
4treatment failureFAERS: 39US FAERS
5Clostridium difficile colitisFAERS: 31US FAERS
6NauseaFAERS: 20SIDER
US FAERS
7Abdominal PainFAERS: 14SIDER
US FAERS
8No adverse eventFAERS: 10US FAERS
9Blood creatinine increasedFAERS: 7US FAERS
10Product use issueFAERS: 7US FAERS
11General physical health deteriorationFAERS: 6US FAERS
12VomitingFAERS: 6SIDER
US FAERS
13Adverse eventFAERS: 5US FAERS
14DehydrationFAERS: 5US FAERS
15FatigueFAERS: 5US FAERS
16InfectionFAERS: 5US FAERS
17ChillsFAERS: 4US FAERS
18Clostridium test positiveFAERS: 4US FAERS
19DiscomfortFAERS: 4US FAERS
20Drug effect incompleteFAERS: 4US FAERS
21HeadacheFAERS: 4SIDER
US FAERS
22MegacolonFAERS: 4SIDER
US FAERS
23PainFAERS: 4US FAERS
24Probiotic therapyFAERS: 4US FAERS
25UrticariaFAERS: 4US FAERS
26Wrong technique in product usage processFAERS: 4US FAERS
27Alanine Aminotransferase IncreasedFAERS: 3SIDER
US FAERS
28ConstipationFAERS: 3SIDER
US FAERS
29DizzinessFAERS: 3SIDER
US FAERS
30Drug dose omissionFAERS: 3US FAERS
31Feeling abnormalFAERS: 3US FAERS
32FlatulenceFAERS: 3SIDER
US FAERS
33Inappropriate schedule of drug administrationFAERS: 3US FAERS
34MalaiseFAERS: 3US FAERS
35NeutropeniaFAERS: 3SIDER
US FAERS
36Product dose omissionFAERS: 3US FAERS
37Product packaging quantity issueFAERS: 3US FAERS
38PruritusFAERS: 3SIDER
US FAERS
39Weight decreasedFAERS: 3US FAERS
40Abdominal discomfortFAERS: 2US FAERS
41AstheniaFAERS: 2US FAERS
42Back PainFAERS: 2US FAERS
43Blood alkaline phosphatase increasedFAERS: 2US FAERS
44CholestasisFAERS: 2US FAERS
45Circumstance or information capable of leading to medication errorFAERS: 2US FAERS
46CystitisFAERS: 2US FAERS
47Drug dispensing errorFAERS: 2US FAERS
48Exposure via skin contactFAERS: 2US FAERS
49Gastrointestinal sounds abnormalFAERS: 2US FAERS
50Head discomfortFAERS: 2US FAERS
51Impaired work abilityFAERS: 2US FAERS
52Incorrect route of product administrationFAERS: 2US FAERS
53Musculoskeletal discomfortFAERS: 2US FAERS
54Occupational exposure to productFAERS: 2US FAERS
55Prescribed overdoseFAERS: 2US FAERS
56Product physical issueFAERS: 2US FAERS
57Product quality issueFAERS: 2US FAERS
58Product use in unapproved indicationFAERS: 2US FAERS
59SepsisFAERS: 2US FAERS
60TremorFAERS: 2US FAERS
61White blood cell count decreasedFAERS: 2US FAERS
62AbasiaFAERS: 1US FAERS
63AlopeciaFAERS: 1US FAERS
64AnxietyFAERS: 1US FAERS
65AphoniaFAERS: 1US FAERS
66Blood potassium increasedFAERS: 1US FAERS
67Burning sensationFAERS: 1US FAERS
68Cerebrovascular accidentFAERS: 1US FAERS
69Chest PainFAERS: 1US FAERS
70Chest discomfortFAERS: 1US FAERS
71Clostridium test negativeFAERS: 1US FAERS
72ColitisFAERS: 1US FAERS
73Colonic Pseudo-ObstructionFAERS: 1US FAERS
74DeafnessFAERS: 1US FAERS
75Depressed Level of ConsciousnessFAERS: 1US FAERS
76Disease ProgressionFAERS: 1US FAERS
77DisorientationFAERS: 1US FAERS
78Drug dispensing issueFAERS: 1US FAERS
79Drug effect delayedFAERS: 1US FAERS
80Drug ineffective for unapproved indicationFAERS: 1US FAERS
81Drug prescribing errorFAERS: 1US FAERS
82Drug resistanceFAERS: 1US FAERS
83EosinophiliaFAERS: 1US FAERS
84Epigastric discomfortFAERS: 1US FAERS
85EructationFAERS: 1US FAERS
86Fluid overloadFAERS: 1US FAERS
87Gamma-Glutamyltransferase IncreasedFAERS: 1US FAERS
88Gastrointestinal viral infectionFAERS: 1US FAERS
89General symptomFAERS: 1US FAERS
90HypophagiaFAERS: 1US FAERS
91IncoherentFAERS: 1US FAERS
92Incorrect drug administration durationFAERS: 1US FAERS
93Incorrect product administration durationFAERS: 1US FAERS
94Infectious peritonitisFAERS: 1US FAERS
95Intestinal ObstructionFAERS: 1SIDER
US FAERS
96Joint injuryFAERS: 1US FAERS
97Joint swellingFAERS: 1US FAERS
98Large intestine perforationFAERS: 1US FAERS
99Ligament ruptureFAERS: 1US FAERS
100Lip swellingFAERS: 1US FAERS
101Medication ErrorFAERS: 1US FAERS
102Muscle FatigueFAERS: 1US FAERS
103Musculoskeletal PainFAERS: 1US FAERS
104MyalgiaFAERS: 1US FAERS
105NervousnessFAERS: 1US FAERS
106PancytopeniaFAERS: 1US FAERS
107ParotitisFAERS: 1US FAERS
108Pathogen resistanceFAERS: 1US FAERS
109PneumoniaFAERS: 1US FAERS
110Poor quality drug administeredFAERS: 1US FAERS
111Poor quality product administeredFAERS: 1US FAERS
112Posterior reversible encephalopathy syndromeFAERS: 1US FAERS
113Prescribed underdoseFAERS: 1US FAERS
114Procedural complicationFAERS: 1US FAERS
115Product availability issueFAERS: 1US FAERS
116Product preparation errorFAERS: 1US FAERS
117Product storage errorFAERS: 1US FAERS
118Prothrombin time ratio increasedFAERS: 1US FAERS
119Pulmonary sepsisFAERS: 1US FAERS
120Rash erythematousFAERS: 1US FAERS
121Renal painFAERS: 1US FAERS
122RhonchiFAERS: 1US FAERS
123Secretion dischargeFAERS: 1US FAERS
124Septic ShockFAERS: 1US FAERS
125Shigella test positiveFAERS: 1US FAERS
126SinusitisFAERS: 1US FAERS
127SubileusFAERS: 1US FAERS
128TachycardiaFAERS: 1US FAERS
129Therapeutic response delayedFAERS: 1US FAERS
130Throat irritationFAERS: 1US FAERS
131TinnitusFAERS: 1US FAERS
132Unevaluable eventFAERS: 1US FAERS
133Urinary tract infectionFAERS: 1US FAERS
134VertebroplastyFAERS: 1US FAERS
135WheezingFAERS: 1US FAERS
136nervous system disorderFAERS: 1SIDER
US FAERS
137Abdominal tendernessSIDER
138AngioedemaSIDER
139Blood and lymphatic system disordersSIDER
140DermatitisSIDER
141DysgeusiaSIDER
142DyspepsiaSIDER
143Gastrointestinal PainSIDER
144HypersensitivitySIDER
145MalnutritionSIDER
146Metabolic acidosisSIDER
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120239

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.