MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

sitaxsentan

(PHWXUGHIIBDVKD-UHFFFAOYSA-N)

Structure

SMILES: O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C
Type(s): Approved; Investigational; Withdrawn
ATC code(s): C02KX03
Molecular Formula:: C18H15ClN2O6S2
Molecular Weight:: 454.904
Log P:: 5.1150
Hydrogen Bond Acceptor:: 9
Hydrogen Bond Donor:: 1
TPSA:: 144.35
CAS Number(s):: 184036-34-8; 210421-64-0

Synonym(s)

sitaxsentan

N-(4-chloro-3-methyl-5-isoxazolyl)-2-((4,5-(methylenedioxy)-O-toly)acetyl)-3-thiophenesulfonamide

N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3,4-(methylenedioxy)-6-methyl)phenylacetyl-3-thiophenesulfonamide

TBC 11251

TBC-11251

TBC11251

External Link(s)

MeSH	C106276
PubChem Compound	216235
BindingDB	50058126
ChEBI	135736
CHEMBL	CHEMBL282724
DrugBank	DB06268
DrugCentral	3548
IUPHAR/BPS Guide to PHARMACOLOGY	3950
KEGG	dr:D07171
Therapeutic Target Database	D0T1RG
ZINC	1481831 328577260

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Abdominal discomfort		SIDER
2	Abdominal strangulated hernia		SIDER
3	Abdominal tenderness		SIDER
4	Abscess		SIDER
5	Acute Coronary Syndrome		SIDER
6	Acute bronchitis		SIDER
7	Acute sinusitis		SIDER
8	Agitation		SIDER
9	Alanine Aminotransferase Increased		SIDER
10	Alopecia		SIDER
11	Angina Pectoris		SIDER
12	Animal bite		SIDER
13	Anorectal discomfort		SIDER
14	Anorexia		SIDER
15	Appendicitis		SIDER
16	Arteriovenous fistula		SIDER
17	Arthritis		SIDER
18	Arthropod bite		SIDER
19	Arthropod sting		SIDER
20	Ascites		SIDER
21	Aspartate Aminotransferase Increased		SIDER
22	Asthenia		SIDER
23	Asthma		SIDER
24	Ataxia		SIDER
25	Atrial Flutter		SIDER
26	Basal cell carcinoma		SIDER
27	Blood and lymphatic system disorders		SIDER
28	Blood creatine phosphokinase MB increased		SIDER
29	Blood creatine phosphokinase increased		SIDER
30	Blood creatinine increased		SIDER
31	Blood glucose increased		SIDER
32	Blood lactate dehydrogenase increased		SIDER
33	Blood phosphorus increased		SIDER
34	Blood potassium decreased		SIDER
35	Blood potassium increased		SIDER
36	Bradycardia		SIDER
37	Breast Microcalcification		SIDER
38	Breast tenderness		SIDER
39	Bronchitis		SIDER
40	Cardiac Flutter		SIDER
41	Cardiovascular Diseases	16219361	CTD
42	Cellulitis		SIDER
43	Chemical and Drug Induced Liver Injury	23721565 23956101 25900201	CTD
44	Chest Pain		SIDER
45	Chest discomfort		SIDER
46	Chest wall pain		SIDER
47	Cholelithiasis		SIDER
48	Cholestasis		SIDER
49	Colitis		SIDER
50	Conjunctivitis		SIDER
51	Connective tissue inflammation		SIDER
52	Constipation		SIDER
53	Crystalluria		SIDER
54	Cyst		SIDER
55	Deafness		SIDER
56	Dehydration		SIDER
57	Dermatitis		SIDER
58	Discomfort		SIDER
59	Diverticulum		SIDER
60	Dizziness		SIDER
61	Drug toxicity		SIDER
62	Dry skin		SIDER
63	Dyspepsia		SIDER
64	Dysphonia		SIDER
65	Dysuria		SIDER
66	Ear and labyrinth disorders		SIDER
67	Ear congestion		SIDER
68	Ear discomfort		SIDER
69	Endophthalmitis		SIDER
70	Enteritis		SIDER
71	Eosinophilia		SIDER
72	Epistaxis		SIDER
73	Eructation		SIDER
74	Eye Infection		SIDER
75	Eye irritation		SIDER
76	Facial Pain		SIDER
77	Facial paralysis		SIDER
78	Fatigue		SIDER
79	Feeling abnormal		SIDER
80	Fibromyalgia		SIDER
81	Flank Pain		SIDER
82	Flushing		SIDER
83	Food Poisoning		SIDER
84	Gastroenteritis		SIDER
85	Gastrointestinal discomfort		SIDER
86	Gastrointestinal infection		SIDER
87	Gingivitis		SIDER
88	Gout		SIDER
89	Head discomfort		SIDER
90	Headache		SIDER
91	Hepatitis		SIDER
92	Hepatomegaly		SIDER
93	Hoarseness		SIDER
94	Hypersensitivity		SIDER
95	Hypotension		SIDER
96	Hypoxia		SIDER
97	Infection		SIDER
98	Infestation		SIDER
99	Inflammation		SIDER
100	Injection site dermatitis		SIDER
101	Intertrigo		SIDER
102	Joint injury		SIDER
103	Joint sprain		SIDER
104	Joint stiffness		SIDER
105	Keratoconjunctivitis Sicca		SIDER
106	Laceration		SIDER
107	Leukopenia		SIDER
108	Ligament injury		SIDER
109	Limb discomfort		SIDER
110	Lobar Pneumonia		SIDER
111	Lower respiratory tract infection		SIDER
112	Lymphoma		SIDER
113	Malaise		SIDER
114	Malnutrition		SIDER
115	Memory impairment		SIDER
116	Menorrhagia		SIDER
117	Metrorrhagia		SIDER
118	Muscle Fatigue		SIDER
119	Musculoskeletal Pain		SIDER
120	Musculoskeletal chest pain		SIDER
121	Musculoskeletal stiffness		SIDER
122	Myocardial Infarction		SIDER
123	Nasal discomfort		SIDER
124	Nasal sinus drainage		SIDER
125	Nausea		SIDER
126	Nervousness		SIDER
127	Night sweats		SIDER
128	Nipple pain		SIDER
129	Onychomycosis		SIDER
130	Oral candidiasis		SIDER
131	Oral pruritus		SIDER
132	Osteochondrosis		SIDER
133	Otitis Media		SIDER
134	Pain		SIDER
135	Pallor		SIDER
136	Palmar erythema		SIDER
137	Pancreatic Pseudocyst		SIDER
138	Pancytopenia		SIDER
139	Panophthalmitis		SIDER
140	Paranasal sinus hypersecretion		SIDER
141	Peptic Ulcer		SIDER
142	Pericardial effusion		SIDER
143	Petechiae		SIDER
144	Photophobia		SIDER
145	Pleurisy		SIDER
146	Pleuritic pain		SIDER
147	Pneumothorax		SIDER
148	Polyarthritis		SIDER
149	Polydipsia		SIDER
150	Pregnancy test positive		SIDER
151	Pregnancy		SIDER
152	Protein urine present		SIDER
153	Proteinuria		SIDER
154	Psoriasis		SIDER
155	Pulmonary Embolism		SIDER
156	Respiratory Failure		SIDER
157	Restless Legs Syndrome		SIDER
158	Retching		SIDER
159	Rhinitis		SIDER
160	Right ventricular failure		SIDER
161	Rosacea		SIDER
162	Sciatica		SIDER
163	Sinus bradycardia		SIDER
164	Sinus headache		SIDER
165	Sinus operation		SIDER
166	Sinus pain		SIDER
167	Sinusitis		SIDER
168	Skin Papilloma		SIDER
169	Skin Ulcer		SIDER
170	Skin irritation		SIDER
171	Skin laceration		SIDER
172	Skin lesion		SIDER
173	Skin necrosis		SIDER
174	Sneezing		SIDER
175	Somnolence		SIDER
176	Stomatitis		SIDER
177	Subcutaneous Abscess		SIDER
178	Sunburn		SIDER
179	Supraventricular tachycardia		SIDER
180	Tachycardia		SIDER
181	Tension		SIDER
182	Thermal burn		SIDER
183	Throat irritation		SIDER
184	Thrombocytopenia		SIDER
185	Tinnitus		SIDER
186	Tongue blistering		SIDER
187	Toxicity to various agents		SIDER
188	Tracheobronchitis		SIDER
189	Tremor		SIDER
190	Urticaria		SIDER
191	VIIth nerve paralysis		SIDER
192	Vaginal Prolapse		SIDER
193	Vaginal mycosis		SIDER
194	Venous Insufficiency		SIDER
195	Venous Thrombosis		SIDER
196	Ventricular bigeminy		SIDER
197	Vertigo		SIDER
198	Vessel puncture site inflammation		SIDER
199	Visual Impairment		SIDER
200	Visual disturbance		SIDER
201	Vitreous floaters		SIDER
202	Vomiting		SIDER
203	Vulvovaginal mycotic infection		SIDER
204	Weight decreased		SIDER
205	Wheezing		SIDER
206	White blood cell count decreased		SIDER
207	furuncle		SIDER
208	jaundice		SIDER
209	nervous system disorder		SIDER

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