MetaADEDB 2.0 @ LMMD
trametinib
(LIRYPHYGHXZJBZ-UHFFFAOYSA-N)
Structure
SMILES
CC(=O)Nc1cccc(c1)n1c(=O)n(C2CC2)c(=O)c2c1c(C)c(=O)n(c2Nc1ccc(cc1F)I)C
Type(s)
Approved
ATC code(s)
L01XE25
Molecular Formula:
C26H23FIN5O4
Molecular Weight:
615.395
Log P:
4.0861
Hydrogen Bond Acceptor:
8
Hydrogen Bond Donor:
2
TPSA:
107.13
CAS Number(s):
871700-17-3
Synonym(s)
1.
trametinib
2.
GSK 1120212
3.
GSK-1120212
4.
GSK1120212
5.
JTP 74057
6.
JTP-74057
7.
JTP74057
External Link(s)
MeSHC560077
PubChem Compound11707110
ChEBI75998
CHEMBLCHEMBL2103875
DrugBankDB08911
DrugCentral4802
IUPHAR/BPS Guide to PHARMACOLOGY6495
KEGGdr:D10175
Therapeutic Target DatabaseD04XVN
D0F5RQ
ZINC43100709
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Product use in unapproved indicationFAERS: 76
Canada Vigilance: 6
Canada Vigilance
US FAERS
2NauseaFAERS: 48
Canada Vigilance: 1
25417902CTD
SIDER
Canada Vigilance
US FAERS
3Disease ProgressionFAERS: 41SIDER
US FAERS
4MalaiseFAERS: 40
Canada Vigilance: 1
Canada Vigilance
US FAERS
5Malignant neoplasm progressionFAERS: 39
Canada Vigilance: 2
Canada Vigilance
US FAERS
6AcneFAERS: 38US FAERS
7Product use issueFAERS: 37
Canada Vigilance: 1
Canada Vigilance
US FAERS
8VomitingFAERS: 36
Canada Vigilance: 1
25417902CTD
SIDER
Canada Vigilance
US FAERS
9Drug ineffectiveFAERS: 34
Canada Vigilance: 1
Canada Vigilance
US FAERS
10FatigueFAERS: 32
Canada Vigilance: 1
25417902CTD
SIDER
Canada Vigilance
US FAERS
11ChillsFAERS: 25SIDER
US FAERS
12Dermatitis acneiformFAERS: 24
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
13Visual ImpairmentFAERS: 23US FAERS
14Peripheral swellingFAERS: 18US FAERS
15PneumoniaFAERS: 18US FAERS
16StomatitisFAERS: 17SIDER
US FAERS
17Incorrect dose administeredFAERS: 16US FAERS
18ErythemaFAERS: 15
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
19PruritusFAERS: 14SIDER
US FAERS
20AlopeciaFAERS: 13US FAERS
21ArthralgiaFAERS: 13
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
22DehydrationFAERS: 13SIDER
US FAERS
23Dry skinFAERS: 13SIDER
US FAERS
24HeadacheFAERS: 13
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
25Incorrect product storageFAERS: 12US FAERS
26EpistaxisFAERS: 11SIDER
US FAERS
27Urinary tract infectionFAERS: 11SIDER
US FAERS
28Abdominal PainFAERS: 10SIDER
US FAERS
29Drug dose omissionFAERS: 10US FAERS
30HypersensitivityFAERS: 10US FAERS
31PainFAERS: 10US FAERS
32Skin lesionFAERS: 9
Canada Vigilance: 1
Canada Vigilance
US FAERS
33Ejection Fraction DecreasedFAERS: 8SIDER
US FAERS
34Abdominal discomfortFAERS: 7
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
35MyalgiaFAERS: 7
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
36OsteomyelitisFAERS: 7US FAERS
37Therapy cessationFAERS: 7US FAERS
38ThrombocytopeniaFAERS: 7SIDER
US FAERS
39TremorFAERS: 7US FAERS
40ConstipationFAERS: 6SIDER
US FAERS
41FolliculitisFAERS: 6SIDER
US FAERS
42Memory impairmentFAERS: 6US FAERS
43PneumonitisFAERS: 6US FAERS
44Skin UlcerFAERS: 6US FAERS
45Therapy changeFAERS: 6US FAERS
46Toxicity to various agentsFAERS: 6US FAERS
47Alanine Aminotransferase IncreasedFAERS: 5SIDER
US FAERS
48AstheniaFAERS: 5SIDER
US FAERS
49Blood creatine phosphokinase increasedFAERS: 5US FAERS
50DermatitisFAERS: 5SIDER
US FAERS
51DiplopiaFAERS: 5US FAERS
52DysgeusiaFAERS: 5SIDER
US FAERS
53HydrocephalusFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
54HypotensionFAERS: 5US FAERS
55HypoxiaFAERS: 5US FAERS
56OverdoseFAERS: 5US FAERS
57RhabdomyolysisFAERS: 5SIDER
US FAERS
58SepsisFAERS: 5US FAERS
59SomnolenceFAERS: 5US FAERS
60SwellingFAERS: 5US FAERS
61UrticariaFAERS: 5US FAERS
62Wrong technique in product usage processFAERS: 5US FAERS
63Accidental overdoseFAERS: 4US FAERS
64AmnesiaFAERS: 4US FAERS
65Chest PainFAERS: 4US FAERS
66DizzinessFAERS: 4SIDER
US FAERS
67Drug dispensing errorFAERS: 4US FAERS
68EczemaFAERS: 4
Canada Vigilance: 2
Canada Vigilance
US FAERS
69Febrile NeutropeniaFAERS: 4US FAERS
70Feeling abnormalFAERS: 4US FAERS
71General physical health deteriorationFAERS: 4US FAERS
72Joint swellingFAERS: 4US FAERS
73Musculoskeletal stiffnessFAERS: 4US FAERS
74Nail InfectionFAERS: 4US FAERS
75NasopharyngitisFAERS: 4US FAERS
76NephrolithiasisFAERS: 4US FAERS
77No adverse eventFAERS: 4US FAERS
78Pancreatic carcinomaFAERS: 4US FAERS
79Product storage errorFAERS: 4US FAERS
80ThrombosisFAERS: 4US FAERS
81Weight decreasedFAERS: 4US FAERS
82Acute kidney injuryFAERS: 3US FAERS
83Adverse eventFAERS: 3US FAERS
84Angular cheilitisFAERS: 3US FAERS
85AnxietyFAERS: 3US FAERS
86AphasiaFAERS: 3US FAERS
87Aspartate Aminotransferase IncreasedFAERS: 3SIDER
US FAERS
88Back PainFAERS: 3SIDER
US FAERS
89Blood creatinine increasedFAERS: 3SIDER
US FAERS
90Chest discomfortFAERS: 3US FAERS
91Disease complicationFAERS: 3US FAERS
92DysphoniaFAERS: 3US FAERS
93InfectionFAERS: 3SIDER
US FAERS
94InfluenzaFAERS: 3US FAERS
95Intestinal ObstructionFAERS: 3US FAERS
96Lower respiratory tract infectionFAERS: 3US FAERS
97Myocardial InfarctionFAERS: 3US FAERS
98Neck PainFAERS: 3US FAERS
99Nephrotic SyndromeFAERS: 3US FAERS
100PancreatitisFAERS: 3SIDER
US FAERS
101PancytopeniaFAERS: 3US FAERS
102Pulmonary thrombosisFAERS: 3US FAERS
103Rash erythematousFAERS: 3SIDER
US FAERS
104Skin irritationFAERS: 3US FAERS
105Tooth InfectionFAERS: 3US FAERS
106UveitisFAERS: 3US FAERS
107Ventricular hypokinesiaFAERS: 3US FAERS
108nervous system disorderFAERS: 3SIDER
US FAERS
109Activities of daily living impairedFAERS: 2US FAERS
110Ammonia abnormalFAERS: 2US FAERS
111Astrocytoma, low gradeFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
112BlindnessFAERS: 2US FAERS
113Blood alkaline phosphatase increasedFAERS: 2SIDER
US FAERS
114Blood glucose decreasedFAERS: 2US FAERS
115Blood lactate dehydrogenase increasedFAERS: 2US FAERS
116Blood urine presentFAERS: 2US FAERS
117BradycardiaFAERS: 2SIDER
US FAERS
118BronchitisFAERS: 2US FAERS
119Burning sensationFAERS: 2US FAERS
120CachexiaFAERS: 2US FAERS
121Cardiac ArrestFAERS: 2US FAERS
122CardiotoxicityFAERS: 2US FAERS
123Cerebrovascular accidentFAERS: 2US FAERS
124CheilitisFAERS: 2US FAERS
125Dropped head syndromeFAERS: 2US FAERS
126ErysipelasFAERS: 2US FAERS
127Extra dose administeredFAERS: 2US FAERS
128Feeling ColdFAERS: 2US FAERS
129Histiocytic sarcomaFAERS: 2US FAERS
130HypersomniaFAERS: 2US FAERS
131IleusFAERS: 2US FAERS
132Inappropriate schedule of product administrationFAERS: 2US FAERS
133Intestinal PerforationFAERS: 2US FAERS
134MyositisFAERS: 2US FAERS
135Nasal discomfortFAERS: 2US FAERS
136NeutropeniaFAERS: 2SIDER
US FAERS
137Non-cardiac chest painFAERS: 2US FAERS
138Oropharyngeal painFAERS: 2SIDER
US FAERS
139PanniculitisFAERS: 2US FAERS
140Product dose omissionFAERS: 2US FAERS
141Product quality issueFAERS: 2US FAERS
142Pulmonary congestionFAERS: 2US FAERS
143PurpuraFAERS: 2US FAERS
144PyelonephritisFAERS: 2US FAERS
145QuadriparesisFAERS: 2US FAERS
146Renal painFAERS: 2US FAERS
147Respiratory FailureFAERS: 2US FAERS
148SciaticaFAERS: 2US FAERS
149Sinus TachycardiaFAERS: 2US FAERS
150Skin toxicityFAERS: 2
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
151Supraventricular tachycardiaFAERS: 2US FAERS
152SyncopeFAERS: 2US FAERS
153TachycardiaFAERS: 2US FAERS
154Therapy non-responderFAERS: 2US FAERS
155Troponin T increasedFAERS: 2US FAERS
156Unevaluable eventFAERS: 2US FAERS
157White blood cell count decreasedFAERS: 2US FAERS
158XerosisFAERS: 2US FAERS
159AbasiaFAERS: 1US FAERS
160Abdominal adhesionsFAERS: 1US FAERS
161AbscessFAERS: 1US FAERS
162Accidental exposure to productFAERS: 1US FAERS
163Acute Coronary SyndromeFAERS: 1US FAERS
164Acute myocardial infarctionFAERS: 1US FAERS
165AdenocarcinomaFAERS: 1US FAERS
166Aeromonas infectionFAERS: 1US FAERS
167AgitationFAERS: 1US FAERS
168Allergic reaction to excipientFAERS: 1US FAERS
169AngerFAERS: 1US FAERS
170Ankle FractureFAERS: 1US FAERS
171AscitesFAERS: 1US FAERS
172Atrial FibrillationFAERS: 1US FAERS
173Bile Duct StenosisFAERS: 1US FAERS
174Blood creatine phosphokinase abnormalFAERS: 1US FAERS
175Blood glucose increasedFAERS: 1US FAERS
176Blood magnesium decreasedFAERS: 1US FAERS
177Blood pressure fluctuationFAERS: 1US FAERS
178Blood uric acid decreasedFAERS: 1US FAERS
179Carbon dioxide increasedFAERS: 1US FAERS
180CataractFAERS: 1US FAERS
181CellulitisFAERS: 1SIDER
US FAERS
182Cerebral disorderFAERS: 1US FAERS
183CholangitisFAERS: 1US FAERS
184ChromaturiaFAERS: 1US FAERS
185Clostridium difficile infectionFAERS: 1US FAERS
186Concomitant disease progressionFAERS: 1US FAERS
187Contrast media allergyFAERS: 1US FAERS
188DementiaFAERS: 1US FAERS
189Depressed Level of ConsciousnessFAERS: 1US FAERS
190Device related infectionFAERS: 1US FAERS
191Diabetes MellitusFAERS: 1US FAERS
192DiscomfortFAERS: 1US FAERS
193DisorientationFAERS: 1US FAERS
194Drug abuseFAERS: 1US FAERS
195Drug administered to patient of inappropriate ageFAERS: 1US FAERS
196Drug prescribing errorFAERS: 1US FAERS
197Drug resistanceFAERS: 1US FAERS
198Duodenal perforationFAERS: 1US FAERS
199DysarthriaFAERS: 1US FAERS
200DysenteryFAERS: 1US FAERS
201DyspepsiaFAERS: 1US FAERS
202DysuriaFAERS: 1US FAERS
203Ejection fraction abnormalFAERS: 1US FAERS
204Electrolyte imbalanceFAERS: 1US FAERS
205Emotional disorderFAERS: 1US FAERS
206EndocarditisFAERS: 1US FAERS
207EnterocolitisFAERS: 1US FAERS
208Escherichia infectionFAERS: 1US FAERS
209Exfoliative rashFAERS: 1US FAERS
210Eye irritationFAERS: 1US FAERS
211FlushingFAERS: 1US FAERS
212Food AllergyFAERS: 1US FAERS
213FractureFAERS: 1US FAERS
214Frustration tolerance decreasedFAERS: 1US FAERS
215Full blood count decreasedFAERS: 1US FAERS
216Gait inabilityFAERS: 1US FAERS
217Gamma radiation therapy to brainFAERS: 1US FAERS
218GangliogliomaFAERS: 1US FAERS
219Gastrointestinal infectionFAERS: 1US FAERS
220Germ Cell CancerFAERS: 1US FAERS
221Gingival HypertrophyFAERS: 1US FAERS
222GliomaFAERS: 1US FAERS
223HepatotoxicityFAERS: 1US FAERS
224HypophagiaFAERS: 1US FAERS
225ImmobileFAERS: 1US FAERS
226Inappropriate affectFAERS: 1US FAERS
227Inappropriate schedule of drug administrationFAERS: 1US FAERS
228IncontinenceFAERS: 1US FAERS
229Incorrect drug administration durationFAERS: 1US FAERS
230Incorrect drug administration rateFAERS: 1US FAERS
231Infected cystFAERS: 1US FAERS
232Intentional dose omissionFAERS: 1US FAERS
233Intentional product use issueFAERS: 1US FAERS
234Intracranial meningioma malignantFAERS: 1US FAERS
235LethargyFAERS: 1US FAERS
236LeukopeniaFAERS: 1SIDER
US FAERS
237Lip swellingFAERS: 1US FAERS
238LymphangitisFAERS: 1US FAERS
239Lymphocyte count decreasedFAERS: 1US FAERS
240Lymphocyte count increasedFAERS: 1US FAERS
241Malignant melanoma stage IVFAERS: 1US FAERS
242Manufacturing product shipping issueFAERS: 1US FAERS
243Medication ErrorFAERS: 1US FAERS
244Mental status changesFAERS: 1US FAERS
245MetamorphopsiaFAERS: 1US FAERS
246Metastatic ocular melanomaFAERS: 1US FAERS
247Monocyte count decreasedFAERS: 1US FAERS
248Mood swingsFAERS: 1US FAERS
249Mouth swellingFAERS: 1US FAERS
250Muscle FatigueFAERS: 1US FAERS
251Musculoskeletal PainFAERS: 1US FAERS
252MyocarditisFAERS: 1US FAERS
253Neutrophilic dermatosisFAERS: 1US FAERS
254Night sweatsFAERS: 1SIDER
US FAERS
255NoduleFAERS: 1US FAERS
256Noninfective gingivitisFAERS: 1US FAERS
257Ocular ToxicityFAERS: 1SIDER
US FAERS
258OnychoclasisFAERS: 1US FAERS
259Oral painFAERS: 1US FAERS
260Oropharyngeal blisteringFAERS: 1US FAERS
261Pain of skinFAERS: 1US FAERS
262Pancreatic enzymes increasedFAERS: 1US FAERS
263Pancreatic toxicityFAERS: 1US FAERS
264PapuleFAERS: 1US FAERS
265PhotophobiaFAERS: 1US FAERS
266PiloerectionFAERS: 1US FAERS
267Platelet count abnormalFAERS: 1US FAERS
268Polymerase chain reaction positiveFAERS: 1US FAERS
269Post procedural complicationFAERS: 1US FAERS
270PresyncopeFAERS: 1US FAERS
271Product size issueFAERS: 1US FAERS
272Product use complaintFAERS: 1US FAERS
273Pulmonary EmbolismFAERS: 1US FAERS
274Pulmonary HypertensionFAERS: 1US FAERS
275Pyogenic granulomaFAERS: 1US FAERS
276RalesFAERS: 1US FAERS
277Rash follicularFAERS: 1US FAERS
278Retinal DetachmentFAERS: 1US FAERS
279Retinal Vascular DisorderFAERS: 1US FAERS
280Retinal Vein OcclusionFAERS: 1US FAERS
281Retinal vascular thrombosisFAERS: 1US FAERS
282RetinoschisisFAERS: 1US FAERS
283Septic ShockFAERS: 1US FAERS
284Serous cystadenocarcinoma ovaryFAERS: 1US FAERS
285Shunt infectionFAERS: 1US FAERS
286Shunt occlusionFAERS: 1US FAERS
287Skin PapillomaFAERS: 1SIDER
US FAERS
288Squamous cell carcinoma of skinFAERS: 1US FAERS
289Staphylococcus test positiveFAERS: 1US FAERS
290Stem cell transplantFAERS: 1US FAERS
291StressFAERS: 1US FAERS
292Swelling of eyelidFAERS: 1US FAERS
293SyringomyeliaFAERS: 1US FAERS
294Temperature intoleranceFAERS: 1US FAERS
295Terminal stateFAERS: 1US FAERS
296Therapeutic procedureFAERS: 1US FAERS
297Throat cancerFAERS: 1US FAERS
298TrichomegalyFAERS: 1US FAERS
299Troponin I increasedFAERS: 1US FAERS
300Urinary IncontinenceFAERS: 1US FAERS
301Varicella Zoster Virus InfectionFAERS: 1US FAERS
302Venous ThrombosisFAERS: 1US FAERS
303VertigoFAERS: 1US FAERS
304Viral upper respiratory tract infectionFAERS: 1US FAERS
305Vitreous floatersFAERS: 1US FAERS
306WheezingFAERS: 1US FAERS
307White matter lesionFAERS: 1US FAERS
308Wrong patient received productFAERS: 1US FAERS
309Wrong product storedFAERS: 1US FAERS
310Wrong technique in device usage processFAERS: 1US FAERS
311YawningFAERS: 1US FAERS
312jaundiceFAERS: 1US FAERS
313treatment failureFAERS: 1US FAERS
314Abdominal tendernessSIDER
315Acneiform Eruptions25417902CTD
316Actinic keratosisSIDER
317Aphthous StomatitisSIDER
318Creatinine increasedSIDER
319CystSIDER
320Diarrhea25417902CTD
321Dyspnea25417902CTD
322Exanthema25417902CTD
323Gamma-Glutamyltransferase IncreasedSIDER
324Gastrointestinal PainSIDER
325HyperkeratosisSIDER
326InfestationSIDER
327Left ventricular ejection fraction decreasedSIDER
328LymphopeniaSIDER
329MalnutritionSIDER
330Musculoskeletal discomfortSIDER
331PrurigoSIDER
332Reaction febrileSIDER
333Refractory hypertensionSIDER
334Therapeutic product effect incompleteCanada Vigilance: 1Canada Vigilance
335Venous ThromboembolismSIDER
336melanoma23432625
23587417
CTD
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